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John D. Shaughnessy
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Journal Articles

Minimal Residual Disease (MRD) Status and Its Impact on Clinical Outcome Is Highly Variable in Multiple Myeloma and Dependent on Molecular Subgroups Defined By Gene Expression Profiling (GEP)

Sharmilan Thanendrarajan, Phil Farmer, Clyde Bailey, Carolina Schinke, Samer Al Hadidi, Maurizio Zangari, Stephanie Rogers, Anne Williams, Fenghuang Zhan, John D Shaughnessy, Jr, Tanvi H. Patel, Anup Kumar Trikannad, Asis Shrestha, Syed Naqvi, Hira Imad Cheema, Trilok Shrivastava, Manozna Karri, Ramya Bachu, Frits van Rhee
Journal: Blood
Blood (2024) 144 (Supplement 1): 4713.
https://doi.org/10.1182/blood-2024-206152
Published: 2024
Journal Articles

Multi-Omics Reveal Immune Microenvironment Alterations in Multiple Myeloma and Its Precursor Stages

Yan Cheng, Fumou Sun, Daisy V. Alapat, Visanu Wanchai, David E. Mery, Eric Siegel, Hongwei Xu, Sarah K. Johnson, Wancheng Guo, Clyde Bailey, Cody Ashby, Michael Anton Bauer, Samer Al Hadidi, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4729.
https://doi.org/10.1182/blood-2024-193583
Published: 2024
Journal Articles

Prior Exposure to Belantamab Mafodotin Influences Outcomes with Idecabtagene Vicluecel in Patients with Multiple Myeloma

Bhavesh Mohan Lal, Marah Alzubi, Jawad Alrawabdeh, John D Shaughnessy, Jr, Fenghuang Zhan, Eric Siegel, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Samer Al Hadidi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3789.
https://doi.org/10.1182/blood-2024-204228
Published: 2024
Journal Articles

Of Seven Molecular Subtypes in MGUS the Low Bone Disease (LB) Subtype Exhibits Resistance to Multiple Myeloma Progression

Catherine Ma, Fumou Sun, Clyde Bailey, Hongwei Xu, Samer Al Hadidi, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Frits van Rhee, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4676.
https://doi.org/10.1182/blood-2024-204135
Published: 2024
Journal Articles

The Role of CST6 in Immunosuppression in the Multiple Myeloma Microenvironment

Zijun Zhang, Yan Cheng, David E. Mery, Hongwei Xu, Brian Koss, Behjatolah Monzavi Karbassi, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4661.
https://doi.org/10.1182/blood-2024-204026
Published: 2024
Journal Articles

Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma: A Real-World Experience

Bhavesh Mohan Lal, Toshali Pandey, Marah Alzubi, Jawad Alrawabdeh, John D Shaughnessy, Jr, Fenghuang Zhan, Eric Siegel, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Samer Al Hadidi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2405.
https://doi.org/10.1182/blood-2024-206497
Published: 2024
Journal Articles

The Low-Bone (LB) Subtype of Multiple Myeloma Exhibits an Inferior Outcome in African Americans

Yihao Zhan, Hongling Peng, David E. Mery, Eric Siegel, Clyde Bailey, Catherine Ma, Hongwei Xu, Daisy V. Alapat, Samer Al Hadidi, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 1904.
https://doi.org/10.1182/blood-2024-203848
Published: 2024
Journal Articles

Single Nuclei Multiomic Profiling of Transcriptional and Chromatin Accessibility of Tumor Cells Underlines Extensive Cis-Regulatory Interaction during Multiple Myeloma Progression

Visanu Wanchai, Hongwei Xu, Cody Ashby, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 1885.
https://doi.org/10.1182/blood-2024-205344
Published: 2024
Journal Articles

Identification of Risk Factors for Myeloma Progression in African American Patients

David E. Mery, Yihao Zhan, Hongling Peng, Eric Siegel, Cody Ashby, Clyde Bailey, Catherine Ma, Hongwei Xu, Samer Al Hadidi, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2024) 144 (Supplement 1): 1937.
https://doi.org/10.1182/blood-2024-212173
Published: 2024
Journal Articles

Psychological Impact in Individuals with Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

Tanvi H. Patel, Ramya Bachu, Trilok Shrivastava, Jawad Alrawabdeh, Marah Alzubi, Jael Hastings, Harold Dean, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Guido Tricot, Fenghuang Zhan, John D Shaughnessy, Jr, Frits van Rhee, Samer Al Hadidi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6764.
https://doi.org/10.1182/blood-2023-180964
Published: 2023
Journal Articles

Total Therapy (TT)-4: A Phase 3 Trial Comparing L-TT4 and S-TT4 and Tandem Auto Transplants in Standard Risk Multiple Myeloma

Samer Al Hadidi, Obada Ababneh, Carson W Ercanbrack, Carolina Schinke, Sharmilan Thanendrarajan, Clyde Bailey, Robert Smith, Susan Panozzo, Guido Tricot, Daisy V. Alapat, John D Shaughnessy, Jr, Fenghuang Zhan, Bart Barlogie, Maurizio Zangari, Frits van Rhee
Journal: Blood
Blood (2023) 142 (Supplement 1): 3594.
https://doi.org/10.1182/blood-2023-181034
Published: 2023
Journal Articles

The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting CST6 Against Multiple Myeloma and Suppresses Osteolytic Lesions

Fumou Sun, Yan Cheng, Jin-Ran Chen, Visanu Wanchai, David E. Mery, Hongwei Xu, Dongzheng Gai, Samer Al Hadidi, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, John D Shaughnessy, Jr, Guido Tricot, Fenghuang Zhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 452.
https://doi.org/10.1182/blood-2023-181853
Published: 2023
Journal Articles

Single Nuclei Multiomics Analysis of Transcriptional and Chromatin Accessibility of Tumor Cells Uncovers Molecular Signatures and Regulatory Elements of Malignant Clonal Evolution in Multiple Myeloma

Visanu Wanchai, Hongwei Xu, Cody Ashby, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 87.
https://doi.org/10.1182/blood-2023-181279
Published: 2023
Journal Articles

A 5-Stage System for ASCT Multiple Myeloma

Wancheng Guo, David E. Mery, Eric Siegel, Fumou Sun, Yan Cheng, Visanu Wanchai, Cody Ashby, Clyde Bailey, Daisy V. Alapat, Hongling Peng, Samer Al Hadidi, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3331.
https://doi.org/10.1182/blood-2023-181117
Published: 2023
Journal Articles

Tumor-Infiltrating Normal B Lymphocytes Have Remarkable Prognostic Effects and Are Crucial for Antitumor Immune Responses in Diffuse Large B-Cell Lymphoma

Zijun Y. Xu-Monette, Yong Li, Thomas Snyder, Tiantian Yu, Tingxun LU, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Wenbin Qian, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Frederick Hagemeister, Heounjeong Go, Maurilio Ponzoni, Andrés José María Ferreri, Michael Møller, Benjamin M. Parsons, Joannes H.J.M. Van Krieken, Yingjun Wang, Miguel Angel Piris, Jane Winter, Qingyan Au, Ilan Kirsch, Mingzhi Zhang, John D Shaughnessy, Jr, Bing Xu, Ken H. Young
Journal: Blood
Blood (2023) 142 (Supplement 1): 429.
https://doi.org/10.1182/blood-2023-179972
Published: 2023
Journal Articles

Sequential Imaging with Diffusion-Weighted Whole-Body MRI (DW-MRI) and PET-CT Identifies Patients at High Risk of Relapse in Multiple Myeloma

Carolina Schinke, Leo Rasche, Cody Ashby, Rudy van Hemert, Sharmilan Thanendrarajan, Samer Al Hadidi, Maurizio Zangari, Clyde Bailey, Daisy V. Alapat, John D Shaughnessy, Jr, Fenghuang Zhan, Bart Barlogie, Frits van Rhee, Niels Weinhold
Journal: Blood
Blood (2023) 142 (Supplement 1): 882.
https://doi.org/10.1182/blood-2023-180896
Published: 2023
Journal Articles

Suppression of TRIP13 Induces Metabolic Changes and Potentiates Ferroptosis in Multiple Myeloma

Yan Cheng, Fumou Sun, Wancheng Guo, Hongwei Xu, Prasanth Viswanathan, Mark Manzano, Eric Siegel, Samer Al Hadidi, Carolina Schinke, Maurizio Zangari, Marta Chesi, P. Leif Bergsagel, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3309.
https://doi.org/10.1182/blood-2023-187001
Published: 2023
Journal Articles

Development and Validation of an Individualized and Weighted Prognostic Model in Patients with Newly Diagnosed Multiple Myeloma

Wenqiang Yan, Xuehan Mao, David E. Mery, Yan Xu, Weiwei Sui, Shuhui Deng, Dehui Zou, John D Shaughnessy, Jr, Kenneth C. Anderson, Fenghuang Zhan, Lugui Qiu, Gang An
Journal: Blood
Blood (2023) 142 (Supplement 1): 1967.
https://doi.org/10.1182/blood-2023-182598
Published: 2023
Journal Articles

Global Proteomics Identifies CDK11A/B As Integral to Myeloma Proliferation and High-Risk Disease

David E. Mery, Visanu Wanchai, Cody Ashby, Hongwei Xu, Eric Siegel, Clyde Bailey, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1932.
https://doi.org/10.1182/blood-2023-187592
Published: 2023
Journal Articles

Prognostic Value of Ferritin in ASCT MM Patients: Integration with GEP Models and ISS Series Systems

Wancheng Guo, David E. Mery, Eric Siegel, Fumou Sun, Yan Cheng, Cody Ashby, Daisy V. Alapat, Hongling Peng, Samer Al Hadidi, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D Shaughnessy, Jr, Fenghuang Zhan
Journal: Blood
Blood (2023) 142 (Supplement 1): 6573.
https://doi.org/10.1182/blood-2023-181254
Published: 2023