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Issue Archive

Volume 99, Issue 3
February 1 2002
Blood Cover Image for Volume 99, Issue 3

Table of Contents

INSIDE BLOOD

ATF4: a novel regulator of cell growth
Paul A. Ney
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Neutrophils at the crossroads of cytokine and RA receptors
Trang Hoang
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Another piece of the puzzle
David G. Maloney
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PLENARY PAPERS

Comparison of 200 mg/m2 melphalan and 8 Gy total body irradiation plus 140 mg/m2 melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myélome 9502 randomized trial
Clinical Trials & Observations
Philippe Moreau,Thierry Facon,Michel Attal,Cyrille Hulin,Mauricette Michallet,Frédéric Maloisel,Jean-Jacques Sotto,François Guilhot,Gérald Marit,Chantal Doyen,Jérôme Jaubert,Jean-Gabriel Fuzibet,Sylvie François,Lotfi Benboubker,Matthieu Monconduit,Laurent Voillat,Margaret Macro,Christian Berthou,Véronique Dorvaux,Bernard Pignon,Bernard Rio,Thomas Matthes,Philippe Casassus,Denis Caillot,Norbert Najman,Bernard Grosbois,Régis Bataille,Jean-Luc Harousseau,for the Intergroupe Francophone du Myélome
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Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice
Howard C. Masuoka,Tim M. Townes
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The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation
Barton S. Johnson,LeMoyne Mueller,Jutong Si,Steven J. Collins
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Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
Guillaume Cartron,Laurent Dacheux,Gilles Salles,Philippe Solal-Celigny,Pierre Bardos,Philippe Colombat,Hervé Watier
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PERSPECTIVE

Acute promyelocytic leukemia: evolving therapeutic strategies
Clinical Trials & Observations
Martin S. Tallman,Chadi Nabhan,James H. Feusner,Jacob M. Rowe
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REVIEW ARTICLES

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
Richard K. Burt,Shimon Slavin,William H. Burns,Alberto M. Marmont
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CHEMOKINES

Pathways for internalization and recycling of the chemokine receptor CCR5
Anja Mueller,Eamonn Kelly,Philip G. Strange
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Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice
Johanne Cashman,Ian Clark-Lewis,Allen Eaves,Connie Eaves
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients
Clinical Trials & Observations
Regina Fink-Puches,Paulus Zenahlik,Barbara Bäck,Josef Smolle,Helmut Kerl,Lorenzo Cerroni
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Superior survival associated with transplantation of matched unrelated versus one-antigen–mismatched unrelated or highly human leukocyte antigen– disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies: establishing a treatment algorithm for recipients of alternative donor grafts
Clinical Trials & Observations
William R. Drobyski,John Klein,Neal Flomenberg,Daniel Pietryga,David H. Vesole,David A. Margolis,Carolyn A. Keever-Taylor
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De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Clinical Trials & Observations
Motoko Yamaguchi,Masao Seto,Masataka Okamoto,Ryo Ichinohasama,Naoya Nakamura,Tadashi Yoshino,Junji Suzumiya,Takuhei Murase,Ikuo Miura,Takashi Akasaka,Jun-ichi Tamaru,Ritsuro Suzuki,Yoshitoyo Kagami,Masami Hirano,Yasuo Morishima,Ryuzo Ueda,Hiroshi Shiku,Shigeo Nakamura
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Therapy-related myelodysplastic syndrome–acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem
Clinical Trials & Observations
Roberto Latagliata,Maria Concetta Petti,Susanna Fenu,Marco Mancini,Maria Antonietta Aloe Spiriti,Massimo Breccia,Gregorio A. Brunetti,Giuseppe Avvisati,Francesco Lo Coco,Franco Mandelli
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Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group
Clinical Trials & Observations
Beverly J. Lange,Bruce C. Bostrom,Joel M. Cherlow,Martha G. Sensel,Mei K. L. La,Wayne Rackoff,Nyla A. Heerema,Robert S. Wimmer,Michael E. Trigg,Harland N. Sather
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Efficacy and safety of thalidomide in patients with acute myeloid leukemia
Clinical Trials & Observations
Martin B. Steins,Teresa Padró,Ralf Bieker,Sandra Ruiz,Martin Kropff,Joachim Kienast,Torsten Kessler,Thomas Buechner,Wolfgang E. Berdel,Rolf M. Mesters
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Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients
Clinical Trials & Observations
Francesco Onida,Hagop M. Kantarjian,Terry L. Smith,Greg Ball,Michael J. Keating,Elihu H. Estey,Armand B. Glassman,Maher Albitar,Monica I. Kwari,Miloslav Beran
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Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait
Clinical Trials & Observations
Elizabeth M. Kang,Ellen M. Areman,Virginia David-Ocampo,Courtney Fitzhugh,Mary E. Link,Elizabeth J. Read,Susan F. Leitman,Griffin P. Rodgers,John F. Tisdale
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Monitoring of minimal residual disease after CHOP and rituximab in previously untreated patients with follicular lymphoma
Clinical Trials & Observations
Alessandro Rambaldi,Manuela Lazzari,Cristina Manzoni,Emanuela Carlotti,Luca Arcaini,Michele Baccarani,Tiziano Barbui,Carlo Bernasconi,Giuseppe Dastoli,Giovanna Fuga,Enrica Gamba,Livio Gargantini,Valter Gattei,Francesco Lauria,Mario Lazzarino,Franco Mandelli,Enrica Morra,Alessandro Pulsoni,Michela Ribersani,Pier Luigi Rossi-Ferrini,Maurizio Rupolo,Sante Tura,Vittorina Zagonel,Francesco Zaja,PierLuigi Zinzani,Gigliola Reato,Robin Foa
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Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study
Clinical Trials & Observations
Luciana Annino,Maria Luce Vegna,Andrea Camera,Giorgina Specchia,Giuseppe Visani,Giuseppe Fioritoni,Felicetto Ferrara,Antonio Peta,Stefania Ciolli,Wilma Deplano,Francesco Fabbiano,Simona Sica,Francesco Di Raimondo,Nicola Cascavilla,Antonio Tabilio,Pietro Leoni,Rosangela Invernizzi,Michele Baccarani,Bruno Rotoli,Sergio Amadori,Franco Mandelli,for the GIMEMA Group
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Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival
Clinical Trials & Observations
Laurie A. Myers,Dhavalkumar D. Patel,Jennifer M. Puck,Rebecca H. Buckley
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HEMATOPOIESIS

Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells
Shiva Akbarzadeh,Alister C. Ward,Dora O. M. McPhee,Warren S. Alexander,Graham J. Lieschke,Judith E. Layton
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Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release
Gianfranco Mattia,Francesca Vulcano,Luisa Milazzo,Alessandra Barca,Giampiero Macioce,Adele Giampaolo,H. Jane Hassan
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Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms
Chris P. Miller,Destin W. Heilman,Don M. Wojchowski
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Lineage-specific defect in gene expression in human platelet phospholipase C-β2 deficiency
Guang Fen Mao,Vijender R. Vaidyula,Satya P. Kunapuli,A. Koneti Rao
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Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells
Rainer Wiewrodt,Anu P. Thomas,Luca Cipelletti,Melpo Christofidou-Solomidou,David A. Weitz,Sheldon I. Feinstein,David Schaffer,Steven M. Albelda,Michael Koval,Vladimir R. Muzykantov
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Mechanism of factor VIIa–dependent coagulation in hemophilia blood: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA.
Saulius Butenas,Kathleen E. Brummel,Richard F. Branda,Sara G. Paradis,Kenneth G. Mann
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Missense mutations in the β3 subunit have a different impact on the expression and function between αIIbβ3 and αvβ3
Seiji Tadokoro,Yoshiaki Tomiyama,Shigenori Honda,Hirokazu Kashiwagi,Satoru Kosugi,Masamichi Shiraga,Teruo Kiyoi,Yoshiyuki Kurata,Yuji Matsuzawa
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Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition
Hong Wang,XiaoHua Jiang,Fan Yang,Gary B. Chapman,William Durante,Nicholas E. S. Sibinga,Andrew I. Schafer
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IMMUNOBIOLOGY

Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1
Gunther G. Pendl,Caroline Robert,Meike Steinert,Renate Thanos,Ruth Eytner,Eric Borges,Martin K. Wild,John B. Lowe,Robert C. Fuhlbrigge,Thomas S. Kupper,Dietmar Vestweber,Stephan Grabbe
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Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation
Duncan Howie,Marı́a Simarro,Joan Sayos,Maria Guirado,Jaime Sancho,Cox Terhorst
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Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins
Axel Lorentz,Detlef Schuppan,Andreas Gebert,Michael P. Manns,Stephan C. Bischoff
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Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3
Mette Nielsen,Mogens H. Nissen,Jens Gerwien,Mai-Britt Zocca,Helene M. Rasmussen,Koichi Nakajima,Carsten Röpke,Carsten Geisler,Keld Kaltoft,Niels Ødum
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Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function
Jaime Millán,Marı́a C. Montoya,David Sancho,Francisco Sánchez-Madrid,Miguel A. Alonso
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General T-cell receptor antagonists to immunomodulate HLA-A2–restricted minor histocompatibility antigen HA-1–specific T-cell responses
Joke M. M. den Haan,Tuna Mutis,Els Blokland,Ad P. IJzerman,Els Goulmy
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Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties
Christel Buelens,Emmanuel J. Bartholomé,Zoulikha Amraoui,Michael Boutriaux,Isabelle Salmon,Kris Thielemans,Fabienne Willems,Michel Goldman
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CD8α+ dendritic cells originate from the CD8α− dendritic cell subset by a maturation process involving CD8α, DEC-205, and CD24 up-regulation
Gloria Martı́nez del Hoyo,Pilar Martı́n,Cristina Fernández Arias,Alvaro Rodrı́guez Marı́n,Carlos Ardavı́n
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Adenosine deaminase deficiency with mosaicism for a “second-site suppressor” of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy
Francisco X. Arredondo-Vega,Ines Santisteban,Eva Richard,Pawan Bali,Majed Koleilat,Michael Loubser,Abdulaziz Al-Ghonaium,Mariam Al-Helali,Michael S. Hershfield
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NEOPLASIA

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk
Qi Zhu,Ji-Wang Zhang,Hai-Qing Zhu,Yu-Lei Shen,Maria Flexor,Pei-Ming Jia,Yun Yu,Xun Cai,Samuel Waxman,Michel Lanotte,Sai-Juan Chen,Zhu Chen,Jian-Hua Tong
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CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease
Terry J. Hamblin,Jenny A. Orchard,Rachel E. Ibbotson,Zadie Davis,Peter W. Thomas,Freda K. Stevenson,David G. Oscier
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Distinctive features of “nurselike” cells that differentiate in the context of chronic lymphocytic leukemia
Nobuhiro Tsukada,Jan A. Burger,Nathan J. Zvaifler,Thomas J. Kipps
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The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction
John C. Byrd,Shinichi Kitada,Ian W. Flinn,Jennifer L. Aron,Michael Pearson,David Lucas,John C. Reed
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PHAGOCYTES

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes
Oliver Werz,Eva Bürkert,Bengt Samuelsson,Olof Rådmark,Dieter Steinhilber
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Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo
Frank M. Szaba,Stephen T. Smiley
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RED CELLS

Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells
Fiona K. Glenister,Ross L. Coppel,Alan F. Cowman,Narla Mohandas,Brian M. Cooke
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Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients
Bruno Venerando,Amelia Fiorilli,Gianluigi Croci,Cristina Tringali,Giancarlo Goi,Laura Mazzanti,Giovanna Curatola,Giovanni Segalini,Luca Massaccesi,Adriana Lombardo,Guido Tettamanti
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TRANSPLANTATION

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen
Ronjon Chakraverty,Karl Peggs,Rajesh Chopra,Donald W. Milligan,Panagiotis D. Kottaridis,Stephanie Verfuerth,Johanne Geary,Dharsha Thuraisundaram,Kate Branson,Suparno Chakrabarti,Premini Mahendra,Charles Craddock,Anne Parker,Ann Hunter,Geoff Hale,Herman Waldmann,Catherine D. Williams,Kwee Yong,David C. Linch,Anthony H. Goldstone,Stephen Mackinnon
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BRIEF REPORTS

Partial deletion in the JK locus causing a Jknull phenotype
Brief Report
Nicole Lucien,Jacques Chiaroni,Jean-Pierre Cartron,Pascal Bailly
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Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region
Brief Report
Timothy Yu,David M. Thomas,Wei Zhu,Morris Goodman,Deborah L. Gumucio
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Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation
Clinical Trials & Observations Brief Report
Amelia A. Langston,Istvan Redei,Angela M. Caliendo,Jyoti Somani,Don Hutcherson,Sagar Lonial,Silvana Bucur,Judy Cherry,Andrew Allen,Edmund K. Waller
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Sustained suppression of hepatitis C virus by interferon and ribavirin in hemophilic patients not responding to interferon monotherapy
Clinical Trials & Observations Brief Report
Elena Santagostino,Maria Grazia Rumi,Monica Rivi,Massimo Colombo,Pier Mannuccio Mannucci,for the Hepatitis Study Group of the Association of Italian Hemophilia Centers
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Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia
Brief Report
Hassan Ghazal
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CORRESPONDENCE

Bone marrow–derived cells contribute to endothelial repair after thrombotic microangiopathy
Maarten B. Rookmaaker,Herman Tolboom,Roel Goldschmeding,Jaap-Jan Zwaginga,Ton J. Rabelink,Marianne C. Verhaar
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Treatment of painful sickle cell leg ulcers with topical opioids
Samir K. Ballas
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Sustained response of refractory chronic lymphocytic leukemia in progression complicated by acute hemolitic anemia to anti-CD20 monoclonal antibody
Emilio Iannitto,Emanuele Ammatuna,Carla Marino,Sonia Cirrincione,Gioacchino Greco,Gugcielmo Mariani
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Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis
Damian James Hussey,Alexander Dobrovic
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All Issues

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