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Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia
Additional chromosomal abnormalities in Philadelphia-positive clone: adverse prognostic influence on frontline imatinib therapy: a GIMEMA Working Party on CML analysis
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
A disease risk index for patients undergoing allogeneic stem cell transplantation
Issue Archive
July 26 2012
In this Issue
Table of Contents
Inside Blood
MYELOID NEOPLASIA
JAKing up AML1-ETO
In this issue of Blood, Chou et al1 and Pulikkan et al2 reveal that the (8;21)(q22;q22) translocation product AML1-ETO (RUNX1-RUNX1T1) leads to enhanced JAK/STAT signaling downstream of myeloproliferative leukemia (MPL) virus, which in turn contributes to increased survival of tumor cells. Hijacking of the JAK/STAT pathway through up-regulation of wild-type MPL is a new paradigm for hematologic malignancies.
CLINICAL TRIALS
PLADO and kids: earlier/increased bleeding after HSCT
In this issue of Blood, Josephson et al report age group analyses of patients enrolled in the prophylactic platelet dose trial (PLADO) that evaluated the relationship between platelet dose per transfusion and bleeding in hospitalized patients with treatment-induced hypoproliferative thrombocytopenia.1
THROMBOSIS & HEMOSTASIS
Factor VIIa: on its own and loving it
In this issue of Blood, Shibeko et al have used a variety of experimental studies and mathematical models to investigate the mechanism of action of high-dose factor VIIa as a bypassing agent in hemophilia.1
Blood Work
Plenary Paper
MYELOID NEOPLASIA
The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO
Fu-Sheng Chou,Andrea Griesinger,Mark Wunderlich,Shan Lin,Kevin A. Link,Mahesh Shrestha,Susumu Goyama,Benjamin Mizukawa,Shuhong Shen,Guido Marcucci,James C. Mulloy
Perspectives
Review Article
How I Treat
Clinical Trials and Observations
Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia
CME
Cassandra D. Josephson,Suzanne Granger,Susan F. Assmann,Marta-Inés Castillejo,Ronald G. Strauss,Sherrill J. Slichter,Marie E. Steiner,Janna M. Journeycake,Courtney D. Thornburg,James Bussel,Eric F. Grabowski,Ellis J. Neufeld,William Savage,Steven R. Sloan
Additional chromosomal abnormalities in Philadelphia-positive clone: adverse prognostic influence on frontline imatinib therapy: a GIMEMA Working Party on CML analysis
Clinical Trials & Observations
Simona Luatti,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Fausto Castagnetti,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Giulia Marzocchi,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Carmen Baldazzi,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Gabriele Gugliotta,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Ilaria Iacobucci,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Giorgina Specchia,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Lucia Zanatta,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Giovanna Rege-Cambrin,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Marco Mancini,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Elisabetta Abruzzese,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Alfonso Zaccaria,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Maria Grazia Grimoldi,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Alessandro Gozzetti,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Gaia Ameli,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Maria Adele Capucci,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Giandomenico Palka,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Paolo Bernasconi,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Francesca Palandri,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Fabrizio Pane,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Giuseppe Saglio,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Giovanni Martinelli,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Gianantonio Rosti,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Michele Baccarani,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML,Nicoletta Testoni,on behalf of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Working Party on CML
Immunobiology
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production
Najla Nasr,Susan Maddocks,Stuart G. Turville,Andrew N. Harman,Natalie Woolger,Karla J. Helbig,John Wilkinson,Chris R. Bye,Thomas K. Wright,Dharshini Rambukwelle,Heather Donaghy,Michael R. Beard,Anthony L. Cunningham
Lymphoid Neoplasia
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival
Kyung Hee Chang,Abel Sanchez-Aguilera,Shuhong Shen,Amitava Sengupta,Malav N. Madhu,Ashley M. Ficker,Susan K. Dunn,Ashley M. Kuenzi,Jorden L. Arnett,Rebecca A. Santho,Xabier Agirre,John P. Perentesis,Michael W. Deininger,Yi Zheng,Xose R. Bustelo,David A. Williams,Jose A. Cancelas
Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice
Julia I. Ellyard,Tiongsun Chia,Socorro-Maria Rodriguez-Pinilla,Jaime L. Martin,Xin Hu,Manuel Navarro-Gonzalez,Juan F. Garcia,Marie-Helene Delfau-Larue,Santiago Montes-Moreno,Philippe Gaulard,Matthew C. Cook,Giles Walters,Miguel A. Piris,Carola G. Vinuesa
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
Kamil Wolyniec,Jake Shortt,Elisa de Stanchina,Yaara Levav-Cohen,Osnat Alsheich-Bartok,Igal Louria-Hayon,Vincent Corneille,Beena Kumar,Simone J. Woods,Stephen Opat,Ricky W. Johnstone,Clare L. Scott,David Segal,Pier Paolo Pandolfi,Stephen Fox,Andreas Strasser,Yong-Hui Jiang,Scott W. Lowe,Sue Haupt,Ygal Haupt
Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia
Sarah K. Tasian,Michelle Y. Doral,Michael J. Borowitz,Brent L. Wood,I-Ming Chen,Richard C. Harvey,Julie M. Gastier-Foster,Cheryl L. Willman,Stephen P. Hunger,Charles G. Mullighan,Mignon L. Loh
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
Brief Report
Susan L. Slager,Christine F. Skibola,Maria Chiara Di Bernardo,Lucia Conde,Peter Broderick,Shannon K. McDonnell,Lynn R. Goldin,Naomi Croft,Amy Holroyd,Shelley Harris,Jacques Riby,Daniel J. Serie,Neil E. Kay,Timothy G. Call,Paige M. Bracci,Eran Halperin,Mark C. Lanasa,Julie M. Cunningham,Jose F. Leis,Vicki A. Morrison,Logan G. Spector,Celine M. Vachon,Tait D. Shanafelt,Sara S. Strom,Nicola J. Camp,J. Brice Weinberg,Estella Matutes,Neil E. Caporaso,Rachel Wade,Martin J. S. Dyer,Claire Dearden,James R. Cerhan,Daniel Catovsky,Richard S. Houlston
Myeloid Neoplasia
Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Jing Fang,Garrett Rhyasen,Lyndsey Bolanos,Christopher Rasch,Melinda Varney,Mark Wunderlich,Susumu Goyama,Gerrit Jansen,Jacqueline Cloos,Carmela Rigolino,Agostino Cortelezzi,James C. Mulloy,Esther N. Oliva,Maria Cuzzola,Daniel T. Starczynowski
Phagocytes, Granulocytes, and Myelopoiesis
Thrombosis and Hemostasis
Amelioration of the severity of heparin-binding antithrombin mutations by posttranslational mosaicism
Irene Martínez-Martínez,José Navarro-Fernández,Alice Østergaard,Ricardo Gutiérrez-Gallego,José Padilla,Nataliya Bohdan,Antonia Miñano,Cristina Pascual,Constantino Martínez,María Eugenia de la Morena-Barrio,Sonia Águila,Shona Pedersen,Søren Risom Kristensen,Vicente Vicente,Javier Corral
Transplantation
A disease risk index for patients undergoing allogeneic stem cell transplantation
Clinical Trials & Observations
Philippe Armand,Christopher J. Gibson,Corey Cutler,Vincent T. Ho,John Koreth,Edwin P. Alyea,Jerome Ritz,Mohamed L. Sorror,Stephanie J. Lee,H. Joachim Deeg,Barry E. Storer,Frederick R. Appelbaum,Joseph H. Antin,Robert J. Soiffer,Haesook T. Kim
Vascular Biology
Errata
Other Departments
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Cover Image
Cover Image
![issue cover]()
Genome-wide identification of highly expressed endothelial genes in the mouse embryo such as Arhgef15 validated by functional studies. Anti–Type IV collagen antibody staining (red) of basement membrane and isolectin B4 staining (blue) of endothelial cells from an Arhgef15 knockout mouse retina on postnatal day 5 demonstrates vascular regression is occurring in Arhgef15 KO mouse retina. See the article by Takase et al on page 914.
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