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Timothy K. Lee
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Journal Articles

Characterization of Protein Unable to Bind Von Willebrand Factor in Recombinant Factor VIII Products: Can We Reduce Their Immunogenicity?

Haarin Chun, PhD, John R Pettersson, PhD, Svetlana A Shestopal, PhD, Wells W Wu, PhD, Ekaterina S Marakasova, Philip Olivares, PhD, Stepan S Surov, PhD, Mikhail V Ovanesov, PhD, Rong-Fong Shen, PhD, Timothy K Lee, PhD, Andrey G Sarafanov, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-133286
Published: 2020
Journal Articles

Characterization of Interaction of Factor VIII with Engineered Variants of a Single-Chain Variable Antibody Fragment

Svetlana A Shestopal, PhD, Leonid A Parunov, PhD, Mikhail V Ovanesov, PhD, Timothy K Lee, PhD, Andrey G Sarafanov, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1170.
https://doi.org/10.1182/blood-2018-99-115455
Published: 2018
Journal Articles

Von Willebrand Factor A1 Domain Binds to Clusters II and IV of Low-Density Lipoprotein Receptor-Related Protein 1

Gabriela Uceda Cortez, PhD, Svetlana A Shestopal, PhD, James H Kurasawa, MS, Timothy K Lee, PhD, Andrey G Sarafanov, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3660.
https://doi.org/10.1182/blood.V130.Suppl_1.3660.3660
Published: 2017
Journal Articles

Structural and Functional Characterization of a Codon Optimized Coagulation Factor VIII

Svetlana A Shestopal, PhD, James H Kurasawa, MS, Jian-Jiang Hao, PhD, Elena Karnaukhova, PhD, Yideng Liang, PhD, Min Lin, PhD, Mikhail V Ovanesov, PhD, Timothy K Lee, PhD, John H McVey, PhD, Andrey G Sarafanov, PhD
Journal: Blood
Blood (2016) 128 (22): 3765.
https://doi.org/10.1182/blood.V128.22.3765.3765
Published: 2016
Journal Articles

Characterization of Molecular Interaction of Blood Coagulation Factor VIII and Its Clearance Receptor, Low-Density Lipoprotein Receptor.

James H Kurasawa, MS, Svetlana A Shestopal, Ph.D., Elena Karnaukhova, Ph.D., Evi B Struble, PhD, Timothy K Lee, PhD, Andrey G Sarafanov, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 2206.
https://doi.org/10.1182/blood.V120.21.2206.2206
Published: 2012
Journal Articles

Inhibitory Effect of an Anti-Factor VIII Antibody Fragment On Factor VIII Activity in Different Functional Assays

Mikhail V Ovanesov, PhD, James H Kurasawa, MS, Naveen Jha, PhD, Svetlana A Shestopal, PhD, Timothy K Lee, PhD, Andrey G Sarafanov, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 4387.
https://doi.org/10.1182/blood.V120.21.4387.4387
Published: 2012
Journal Articles

Thrombin Generation Responses to Human Factor XIa in Plasma of Animal Species

Yideng Liang, MD, Evi B Struble, PhD, Li Ma, Samuel A Woodle, Naveen Jha, PhD, Dorothy Scott, MD, Timothy K Lee, PhD, Mikhail V Ovanesov, PhD
Journal: Blood
Blood (2012) 120 (21): 5142.
https://doi.org/10.1182/blood.V120.21.5142.5142
Published: 2012
Journal Articles

Unifying the mechanism of recombinant FVIIa action: dose dependence is regulated differently by tissue factor and phospholipids

Alexey M. Shibeko, Samuel A. Woodle, Timothy K. Lee, Mikhail V. Ovanesov
Journal: Blood
Blood (2012) 120 (4): 891–899.
https://doi.org/10.1182/blood-2011-11-393371
Published: 2012
Includes: Supplemental data
Journal Articles

Expression of the Light Chain of Coagulation Factor VIII in Insect Cells

Svetlana A Shestopal, PhD, James H Kurasawa, MS, Timothy K Lee, PhD, Andrey G Sarafanov, PhD
Journal: Blood
Blood (2011) 118 (21): 2269.
https://doi.org/10.1182/blood.V118.21.2269.2269
Published: 2011
Journal Articles

Development of a Continuous Thrombin Generation-Based Test to Measure Potency in Factor VIII Concentrates

Merek J Gourley, Svetlana A Shestopal, PhD, Timothy K Lee, PhD, Mikhail V Ovanesov, PhD
Journal: Blood
Blood (2011) 118 (21): 1206.
https://doi.org/10.1182/blood.V118.21.1206.1206
Published: 2011