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Volume 107, Issue 2

January 15 2006

In this Issue

INSIDE BLOOD
PLENARY PAPERS
PERSPECTIVES
REVIEW ARTICLES
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

INSIDE BLOOD

NEOPLASIA

A new twist in myeloma treatment

Paul W. Sanders

View Articletitled, A new twist in myeloma treatment

HEMOSTASIS

No kidding! Hemoglobin makes NO

Jon O. Lundberg

View Articletitled, No kidding! Hemoglobin makes NO

CLINICAL OBSERVATIONS

Transplantation for cutaneous disease

Morie A. Gertz

View Articletitled, Transplantation for cutaneous disease

HEMOSTASIS

Platelet-collagen interaction: a new modulator

Alastair W. Poole

View Articletitled, Platelet-collagen interaction: a new modulator

GENE THERAPY

Sleeping Beauty awakens!

Bruce A. Bunnell

View Articletitled, Sleeping Beauty awakens!

HEMATOPOIESIS

Is a little hypoxia good for you?

Josef T. Prchal,Victor R. Gordeuk

View Articletitled, Is a little hypoxia good for you?

HEMATOPOIESIS

Closing the TRAIL to the DISC

Robert T. Means, Jr

View Articletitled, Closing the TRAIL to the DISC

HEMOSTASIS

EC does it with HIF

Gregg L. Semenza

View Articletitled, EC does it with HIF

IMMUNOBIOLOGY

Knock-outs and inhibitors: one and the same?

Zachary A. Knight,Kevan M. Shokat

View Articletitled, Knock-outs and inhibitors: one and the same?

NEOPLASIA

Bcl-rambo: a maverick of apoptotic genes

James Feusner

View Articletitled, Bcl-rambo: a maverick of apoptotic genes

PLENARY PAPERS

C1qTNF–related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen

Gerald Lasser,Prasenjit Guchhait,Jeff L. Ellsworth,Paul Sheppard,Ken Lewis,Paul Bishop,Miguel A. Cruz,Jose A. Lopez,Joachim Fruebis

View Articletitled, C1qTNF–related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen

Supplemental data

PERSPECTIVES

The paradox of response and survival in cancer therapeutics
Clinical Trials & Observations

Carol Ann Huff,William Matsui,B. Douglas Smith,Richard J. Jones

View Articletitled, The paradox of response and survival in cancer therapeutics

REVIEW ARTICLES

Regulation of human fetal hemoglobin: new players, new complexities

Arthur Bank

View Articletitled, Regulation of human fetal hemoglobin: new players, new complexities

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

The leukotriene B₄ lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans

Sabina A. Islam,Seddon Y. Thomas,Christoph Hess,Benjamin D. Medoff,Terry K. Means,Christian Brander,Craig M. Lilly,Andrew M. Tager,Andrew D. Luster

View Articletitled, The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans

Role of dendritic cell–derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma

William Vermi,Fabio Facchetti,Elena Riboldi,Holger Heine,Sara Scutera,Sarah Stornello,Daniela Ravarino,Paola Cappello,Mirella Giovarelli,Raffaele Badolato,Mario Zucca,Francesca Gentili,Marco Chilosi,Claudio Doglioni,Alessandro Negro Ponzi,Silvano Sozzani,Tiziana Musso

View Articletitled, Role of dendritic cell–derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation
Clinical Trials & Observations

Michele L. Donato,Adrienne M. Feasel,Donna M. Weber,Victor G. Prieto,Sergio A. Giralt,Richard E. Champlin,Madeleine Duvic

View Articletitled, Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation

Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci
Clinical Trials & Observations

Manuel F. Rosado,Gerald E. Byrne, Jr,Feying Ding,Kenneth A. Fields,Phillip Ruiz,Sander R. Dubovy,Gale R. Walker,Arnold Markoe,Izidore S. Lossos

View Articletitled, Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci

Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol
Clinical Trials & Observations

Antonella Vitale,Anna Guarini,Cristina Ariola,Marco Mancini,Cristina Mecucci,Antonio Cuneo,Fabrizio Pane,Giuseppe Saglio,Giuseppe Cimino,Agostino Tafuri,Giovanna Meloni,Francesco Fabbiano,Anna Recchia,Maria Grazia Kropp,Mauro Krampera,Nicola Cascavilla,Felicetto Ferrara,Antonio Romano,Patrizio Mazza,Claudio Fozza,Francesca Paoloni,Marco Vignetti,Robin Foà

View Articletitled, Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol

Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate
Clinical Trials & Observations

Elias Jabbour,Hagop Kantarjian,Susan O'Brien,Mary Beth Rios,Lynne Abruzzo,Srdan Verstovsek,Guillermo Garcia-Manero,Jorge Cortes

View Articletitled, Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate

GENE THERAPY

Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

Xin Huang,Andrew C. Wilber,Lei Bao,Dong Tuong,Jakub Tolar,Paul J. Orchard,Bruce L. Levine,Carl H. June,R. Scott McIvor,Bruce R. Blazar,Xianzheng Zhou

View Articletitled, Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

HEMATOPOIESIS

Von Hippel-Lindau–dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster
Clinical Trials & Observations

Silverio Perrotta,Bruno Nobili,Marcella Ferraro,Carmela Migliaccio,Adriana Borriello,Valeria Cucciolla,Vincenzo Martinelli,Francesca Rossi,Francesca Punzo,Paola Cirillo,Giuseppe Parisi,Vincenzo Zappia,Bruno Rotoli,Fulvio Della Ragione

View Articletitled, Von Hippel-Lindau–dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster

Differential effects of GATA-1 on proliferation and differentiation of erythroid lineage cells

Jie Zheng,Kenji Kitajima,Eiko Sakai,Tohru Kimura,Naoko Minegishi,Masayuki Yamamoto,Toru Nakano

View Articletitled, Differential effects of GATA-1 on proliferation and differentiation of erythroid lineage cells

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Severe secondary deficiency of von Willebrand factor–cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure
Clinical Trials & Observations

Tomoko Ono,Jun Mimuro,Seiji Madoiwa,Kenji Soejima,Yuji Kashiwakura,Akira Ishiwata,Katsuhiro Takano,Tsukasa Ohmori,Yoichi Sakata

View Articletitled, Severe secondary deficiency of von Willebrand factor–cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure

Platelet PECAM-1 inhibits thrombus formation in vivo

Shahrokh Falati,Sonali Patil,Peter L. Gross,Michelle Stapleton,Glenn Merrill-Skoloff,Natasha E. Barrett,Katherine L. Pixton,Harmut Weiler,Brian Cooley,Debra K. Newman,Peter J. Newman,Barbara C. Furie,Bruce Furie,Jonathan M. Gibbins

View Articletitled, Platelet PECAM-1 inhibits thrombus formation in vivo

Supplemental data

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

Katsue Suzuki-Inoue,Gemma L. J. Fuller,Ángel García,Johannes A. Eble,Stefan Pöhlmann,Osamu Inoue,T. Kent Gartner,Sascha C. Hughan,Andrew C. Pearce,Gavin D. Laing,R. David G. Theakston,Edina Schweighoffer,Nicole Zitzmann,Takashi Morita,Victor L. J. Tybulewicz,Yukio Ozaki,Steve P. Watson

View Articletitled, A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice

Ajay K. Malik,Megan E. Baldwin,Franklin Peale,Germaine Fuh,Wei-Ching Liang,Henry Lowman,Gloria Meng,Napoleone Ferrara,Hans-Peter Gerber

View Articletitled, Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice

Supplemental data

The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states

Jian-Guo Wang,Shawn A. Mahmud,Jacob A. Thompson,Jian-Guo Geng,Nigel S. Key,Arne Slungaard

View Articletitled, The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation

Jack H. Crawford,T. Scott Isbell,Zhi Huang,Sruti Shiva,Balu K. Chacko,Alan N. Schechter,Victor M. Darley-Usmar,Jeffrey D. Kerby,John D. Lang, Jr,David Kraus,Chien Ho,Mark T. Gladwin,Rakesh P. Patel

View Articletitled, Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation

Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets

Dharmendra Pandey,Pankaj Goyal,James R. Bamburg,Wolfgang Siess

View Articletitled, Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development

Alexander H. Licht,Felix Müller-Holtkamp,Ingo Flamme,Georg Breier

View Articletitled, Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
Brief Report

Atul F. Kamath,Anil K. Chauhan,Janka Kisucka,Vandana S. Dole,Joseph Loscalzo,Diane E. Handy,Denisa D. Wagner

View Articletitled, Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

Supplemental data

IMMUNOBIOLOGY

TACI-BLyS signaling via B-cell–dendritic cell cooperation is required for naive CD8⁺ T-cell priming in vivo

Yaiza Diaz-de-Durana,George T. Mantchev,Richard J. Bram,Alessandra Franco

View Articletitled, TACI-BLyS signaling via B-cell–dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo

Skewed T-cell differentiation in patients with indolent non-Hodgkin lymphoma reversed by ex vivo T-cell culture with γc cytokines

Andrea Anichini,Roberta Mortarini,Luca Romagnoli,Paola Baldassari,Antonello Cabras,Carmelo Carlo-Stella,Alessandro M. Gianni,Massimo Di Nicola

View Articletitled, Skewed T-cell differentiation in patients with indolent non-Hodgkin lymphoma reversed by ex vivo T-cell culture with γc cytokines

Supplemental data

FcϵR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells

Huihong Qiao,Marcus V. Andrade,Felipe A. Lisboa,Katrina Morgan,Michael A. Beaven

View Articletitled, FcϵR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells

Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44

Mihail Firan,Sohita Dhillon,Pila Estess,Mark H. Siegelman

View Articletitled, Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

Gang Zhou,Charles G. Drake,Hyam I. Levitsky

View Articletitled, Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo

Rukhsana Aslam,Edwin R. Speck,Michael Kim,Andrew R. Crow,K. W. Annie Bang,Frederick P. Nestel,Heyu Ni,Alan H. Lazarus,John Freedman,John W. Semple

View Articletitled, Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo

Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells

Antonio Bilancio,Klaus Okkenhaug,Montserrat Camps,Juliet L. Emery,Thomas Ruckle,Christian Rommel,Bart Vanhaesebroeck

View Articletitled, Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells

Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway
Brief Report

Keith Thompson,Javier Rojas-Navea,Michael J. Rogers

View Articletitled, Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway

Supplemental data

NEOPLASIA

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model

Eline Menu,Helena Jernberg-Wiklund,Thomas Stromberg,Hendrik De Raeve,Leonard Girnita,Olle Larsson,Magnus Axelson,Kewal Asosingh,Kenneth Nilsson,Ben Van Camp,Karin Vanderkerken

View Articletitled, Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model

Potential protective action of pituitary adenylate cyclase-activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury

Akira Arimura,Min Li,Vecihi Batuman

View Articletitled, Potential protective action of pituitary adenylate cyclase-activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G₂/M-phase accumulation and apoptosis in multiple myeloma cells

Thomas Strömberg,Simon Ekman,Leonard Girnita,Lina Y. Dimberg,Olle Larsson,Magnus Axelson,Johan Lennartsson,Ulf Hellman,Kristina Carlson,Anders Österborg,Karin Vanderkerken,Kenneth Nilsson,Helena Jernberg-Wiklund

View Articletitled, IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells

Supplemental data

Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells

Hiroo Hasegawa,Yasuaki Yamada,Kanki Komiyama,Masahiko Hayashi,Masami Ishibashi,Tatsushi Yoshida,Toshiyuki Sakai,Takashi Koyano,Toh-Seok Kam,Ken Murata,Kazuyuki Sugahara,Kazuto Tsuruda,Norihiko Akamatsu,Kunihiro Tsukasaki,Masato Masuda,Nobuyuki Takasu,Shimeru Kamihira

View Articletitled, Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells

Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas

Roberto Piva,Roberto Chiarle,Andrea D. Manazza,Riccardo Taulli,William Simmons,Chiara Ambrogio,Valentina D'Escamard,Elisa Pellegrino,Carola Ponzetto,Giorgio Palestro,Giorgio Inghirami

View Articletitled, Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas

Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia

Wei Liu,Meng Guo,Ya-Bei Xu,Dao Li,Zhao-Nian Zhou,Ying-Li Wu,Zhu Chen,Scott C. Kogan,Guo-Qiang Chen

View Articletitled, Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia

Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier

Michal Stark,Yehuda G. Assaraf

View Articletitled, Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier

Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir

M. Zahidunnabi Dewan,Jun-nosuke Uchihara,Kazuo Terashima,Mitsuo Honda,Tetsutaro Sata,Mamoru Ito,Nobutaka Fujii,Kimiharu Uozumi,Kunihiro Tsukasaki,Masao Tomonaga,Yoko Kubuki,Akihiko Okayama,Masakazu Toi,Naoki Mori,Naoki Yamamoto

View Articletitled, Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir

KSHV viral cyclin inactivates p27^KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas

Grzegorz Sarek,Annika Järviluoma,Päivi M. Ojala

View Articletitled, KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas

Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR

Kathryn E. Boyd,Ying-Yi Xiao,Kai Fan,Amanda Poholek,Neal G. Copeland,Nancy A. Jenkins,Archibald S. Perkins

View Articletitled, Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR

Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia
Clinical Trials & Observations

Christine Mayr,Michael R. Speicher,David M. Kofler,Raymund Buhmann,John Strehl,Raymonde Busch,Michael Hallek,Clemens-Martin Wendtner

View Articletitled, Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia

PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

Karoline V. Gleixner,Matthias Mayerhofer,Karl J. Aichberger,Sophia Derdak,Karoline Sonneck,Alexandra Böhm,Alexander Gruze,Puchit Samorapoompichit,Paul W. Manley,Doriano Fabbro,Winfried F. Pickl,Christian Sillaber,Peter Valent

View Articletitled, PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma

Esther P. M. Tjin,Richard W. J. Groen,Irma Vogelzang,Patrick W. B. Derksen,Melanie D. Klok,Helen P. Meijer,Susanne van Eeden,Steven T. Pals,Marcel Spaargaren

View Articletitled, Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma

The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
Clinical Trials & Observations

Amy Holleman,Monique L. den Boer,Renée X. de Menezes,Meyling H. Cheok,Cheng Cheng,Karin M. Kazemier,Gritta E. Janka-Schaub,Ulrich Göbel,Ulrike B. Graubner,William E. Evans,Rob Pieters

View Articletitled, The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia

Supplemental data

A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair
Brief Report

David M. Weinstock,Beth Elliott,Maria Jasin

View Articletitled, A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair

Supplemental data

Activating Notch1 mutations in mouse models of T-ALL
Brief Report

Jennifer O'Neil,Jennifer Calvo,Keith McKenna,Veena Krishnamoorthy,Jon C. Aster,Craig H. Bassing,Frederick W. Alt,Michelle Kelliher,A. Thomas Look

View Articletitled, Activating Notch1 mutations in mouse models of T-ALL

Supplemental data

PHAGOCYTES

Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain

Sayan Nandi,Mohammed P. Akhter,Mark F. Seifert,Xu-Ming Dai,E. Richard Stanley

View Articletitled, Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain

Supplemental data

The intracellular domain of CD44 promotes the fusion of macrophages

Weiguo Cui,Juan Zhang Ke,Qing Zhang,Hua-Zhu Ke,Cécile Chalouni,Agnès Vignery

View Articletitled, The intracellular domain of CD44 promotes the fusion of macrophages

How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes

Eric Hatterer,Nathalie Davoust,Marianne Didier-Bazes,Carine Vuaillat,Christophe Malcus,Marie-Françoise Belin,Serge Nataf

View Articletitled, How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes

Supplemental data

The inositol phosphatase SHIP-2 down-regulates FcγR-mediated phagocytosis in murine macrophages independently of SHIP-1

Jing Ai,Amita Maturu,Wesley Johnson,Yijie Wang,Clay B. Marsh,Susheela Tridandapani

View Articletitled, The inositol phosphatase SHIP-2 down-regulates FcγR-mediated phagocytosis in murine macrophages independently of SHIP-1

RED CELLS

Deletion of the core region of 5′ HS2 of the mouse β-globin locus control region reveals a distinct effect in comparison with human β-globin transgenes

Xiao Hu,Michael Bulger,M. A. Bender,Jennifer Fields,Mark Groudine,Steven Fiering

View Articletitled, Deletion of the core region of 5′ HS2 of the mouse β-globin locus control region reveals a distinct effect in comparison with human β-globin transgenes

TRANSPLANTATION

NF-κB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145

Sanja Vodanovic-Jankovic,Parameswaran Hari,Paulette Jacobs,Richard Komorowski,William R. Drobyski

View Articletitled, NF-κB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145

β-Glucan enhances complement-mediated hematopoietic recovery after bone marrow injury

Daniel E. Cramer,Daniel J. Allendorf,Jarek T. Baran,Richard Hansen,Jose Marroquin,Bing Li,Janina Ratajczak,Mariusz Z. Ratajczak,Jun Yan

View Articletitled, β-Glucan enhances complement-mediated hematopoietic recovery after bone marrow injury

CORRESPONDENCE

Interleukin-3 (IL-3) is overexpressed by T lymphocytes in multiple myeloma patients

Nicola Giuliani,Francesca Morandi,Sara Tagliaferri,Simona Colla,Sabrina Bonomini,Gabriella Sammarelli,Vittorio Rizzoli

View Articletitled, Interleukin-3 (IL-3) is overexpressed by T lymphocytes in multiple myeloma patients

Expression of ABH antigens on platelets

Brian R. Curtis,Richard H. Aster

View Articletitled, Expression of ABH antigens on platelets

Thiopurine methyltransferase in acute lymphoblastic leukemia

Mary V. Relling,Ching-Hon Pui,Cheng Cheng,William E. Evans

View Articletitled, Thiopurine methyltransferase in acute lymphoblastic leukemia

Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma

Hidenobu Takahashi,Friedrich Feuerhake,Stefano Monti,Jeffery L. Kutok,Jon C. Aster,Margaret A. Shipp

View Articletitled, Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma

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Enhanced α2-3 linked sialylation determines the extended half-life of CHO-rVWF

Considerations on the Dose and Schedule of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia: Does Dose Matter?

Prognostic Biomarkers in MCL: Insights from the SHINE Trial on the impact of MCL35 score and TP53 Mutation Status

STAT1-driven interferon signatures are associated with JAK inhibitor sensitivity in T-ALL

Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

PERSPECTIVES

The paradox of response and survival in cancer therapeutics Clinical Trials & Observations

REVIEW ARTICLES

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation Clinical Trials & Observations

Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci Clinical Trials & Observations

Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol Clinical Trials & Observations

Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

Von Hippel-Lindau–dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster Clinical Trials & Observations

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Severe secondary deficiency of von Willebrand factor–cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure Clinical Trials & Observations

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice Brief Report

IMMUNOBIOLOGY

Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway Brief Report

NEOPLASIA

Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia Clinical Trials & Observations

The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia Clinical Trials & Observations

A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair Brief Report

Activating Notch1 mutations in mouse models of T-ALL Brief Report

PHAGOCYTES

RED CELLS

TRANSPLANTATION

CORRESPONDENCE

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The paradox of response and survival in cancer therapeutics
Clinical Trials & Observations

Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation
Clinical Trials & Observations

Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci
Clinical Trials & Observations

Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol
Clinical Trials & Observations

Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate
Clinical Trials & Observations

Von Hippel-Lindau–dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster
Clinical Trials & Observations

Severe secondary deficiency of von Willebrand factor–cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure
Clinical Trials & Observations

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
Brief Report

Alkylamines cause Vγ9Vδ2 T-cell activation and proliferation by inhibiting the mevalonate pathway
Brief Report

Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia
Clinical Trials & Observations

The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
Clinical Trials & Observations

A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair
Brief Report

Activating Notch1 mutations in mouse models of T-ALL
Brief Report