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Journal Articles

Obesity-Induced Platelet Mitofusin-1 Expression Causes Vascular Dysfunction

Gowtham K Annarapu, Stefanie Taiclet, Scott Hahn, Deirdre Nolfi-Donegan, Michael Jurczak, Adam C Straub, Sruti Shiva

Blood (2023) 142 (Supplement 1): 2571.

https://doi.org/10.1182/blood-2023-187693

Published: 2023

Journal Articles

The Role of TSP-1, TGF-B1 and Galectin-3 in the Pathogenesis of ACS in Sickle Cell Disease

Ali San, Gowtham K Annarapu, Lynda Little-Ihrig, Enrico M. Novelli, Sruti Shiva

Blood (2022) 140 (Supplement 1): 8233–8234.

https://doi.org/10.1182/blood-2022-165434

Published: 2022

Journal Articles

Impact of Arginine Therapy on Clinical Outcomes, Mitochondrial Function and Oxidative Stress in Children with Sickle Cell Disease Hospitalized with Vasoocclusive Pain Episodes: A Randomized Controlled Trial

Claudia R. Morris, Nitya Bakshi, Deborah Leake, Scott Gillespie, Lou Ann Scism Brown, Frank Harris, Kirshma Khemani, Alexus Locke, Christopher A Rees, Mark A Griffiths, Loretta Reyes, Polly Kumari, Sruti Shiva, Carlton D. Dampier

Blood (2022) 140 (Supplement 1): 16–18.

https://doi.org/10.1182/blood-2022-156577

Published: 2022

Journal Articles

SOD2 V16A amplifies vascular dysfunction in sickle cell patients by curtailing mitochondria complex IV activity

Atinuke Dosunmu-Ogunbi, Shuai Yuan, Michael Reynolds, Luca Giordano, Subramaniam Sanker, Mara Sullivan, Donna Beer Stolz, Brett A. Kaufman, Katherine C. Wood, Yingze Zhang, Sruti Shiva, Seyed Mehdi Nouraie, Adam C. Straub

Blood (2022) 139 (11): 1760–1765.

https://doi.org/10.1182/blood.2021013350

Published: 2022

Includes: Supplemental data

Journal Articles

Heme-Induced Platelet Mitochondrial Oxidant Production Regulates Platelet Granule Release

Gowtham K Annarapu, Deirdre Nolfi-Donegan, Michael Reynolds, Sruti Shiva

Blood (2021) 138 (Supplement 1): 4204.

https://doi.org/10.1182/blood-2021-154047

Published: 2021

Journal Articles

Xanthine Oxidase Has a Protective Role during Heme Crisis By Binding and Degrading Heme

Heidi M Schmidt, Scott Hahn, MS, Gowtham K Annarapu, PhD, Mara Carreño, Francisco Schopfer, Sruti Shiva, PhD, Dario A. Vitturi, PhD, Eric Kelley, PhD, Adam C Straub, PhD

Blood (2020) 136 (Supplement 1): 12.

https://doi.org/10.1182/blood-2020-137185

Published: 2020

Journal Articles

Heme Induced Platelet Mitochondrial Oxidant Production Regulates Thrombospondin-1 Release from Platelets

Gowtham K Annarapu, PhD, Deirdre Nolfi-Donegan, MD, Anuradha Bharara Singh, PhD, Michael Reynolds, Sruti Shiva, PhD

Blood (2020) 136 (Supplement 1): 30.

https://doi.org/10.1182/blood-2020-142640

Published: 2020

Journal Articles

HMGB1-Mediated Platelet Activation Is Independent of Platelet Mitochondrial Reactive Oxygen Species Generation

Deirdre Nolfi-Donegan, MD, Gowtham K Annarapu, PhD, Cheryl A Hillery, MD, Sruti Shiva, PhD

Blood (2020) 136 (Supplement 1): 6.

https://doi.org/10.1182/blood-2020-141160

Published: 2020

Journal Articles

Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain

Claudia R. Morris, Lou Ann S. Brown, Michael Reynolds, Carlton D. Dampier, Peter A. Lane, Amanda Watt, Polly Kumari, Frank Harris, Shaminy Manoranjithan, Reshika D. Mendis, Janet Figueroa, Sruti Shiva

Blood (2020) 136 (12): 1402–1406.

https://doi.org/10.1182/blood.2019003672

Published: 2020

Includes: Supplemental data

Journal Articles

The Mitochondrion: A Link Between Hemolysis and Platelet Activation

Sruti Shiva, PhD

Blood (2019) 134 (Supplement_1): SCI-39.

https://doi.org/10.1182/blood-2019-121112

Published: 2019

Journal Articles

Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes

Sruti Shiva, PhD, Lou Ann Brown, PhD, Y Wang, Carlton Dampier, MD, Amanda Watt, Vinita Tripathi, Amina Bhutta, MD, Polly Kumari, MD, Janet Figueroa, MPH, April Zmitrovich, MSW, MPH, Claudia R. Morris, MD

Blood (2018) 132 (Supplement 1): 508.

https://doi.org/10.1182/blood-2018-99-112666

Published: 2018

Journal Articles

HMGB1 As a Novel Platelet Agonist That Acts Synergistically with ADP to Activate Platelets in Sickle Cell Disease

Deirdre Nolfi-Donegan, MD, Sruti Shiva, PhD, Cheryl A Hillery, MD

Blood (2018) 132 (Supplement 1): 1073.

https://doi.org/10.1182/blood-2018-99-110269

Published: 2018

Journal Articles

Role of Iron-Responsive Mitochondrial Metabolism and ROS in Anemia

Chanté L Richardson, MS, PhD, Valerie M Schrott, MS, Claudette M St. Croix, PhD, Yinna Wang, MD PhD, Catherine G Corey, BS, Sruti Shiva, PhD, Grant C Bullock, MD PhD

Blood (2014) 124 (21): 216.

https://doi.org/10.1182/blood.V124.21.216.216

Published: 2014

Journal Articles

Mitochondrial Uncoupling Protein 2 Is Present in Human Platelets and Regulates Platelet Activation

Sruti Shiva, PhD, Enrico M Novelli, MD MS, Grant C Bullock, MD PhD, Elizabeth Kenny, Gabrielle Hill, Catherine G Corey, BS

Blood (2014) 124 (21): 4147.

https://doi.org/10.1182/blood.V124.21.4147.4147

Published: 2014

Journal Articles

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation

Nayra Cardenes, Catherine Corey, Lisa Geary, Shilpa Jain, Sergey Zharikov, Suchitra Barge, Enrico M. Novelli, Sruti Shiva

Blood (2014) 123 (18): 2864–2872.

https://doi.org/10.1182/blood-2013-09-529420

Published: 2014

Includes: Supplemental data

Journal Articles

Citrate Synthase Activity Is Increased In Children With Sickle Cell Disease (SCD) On Hydroxyurea (HU) Therapy

Claudia R. Morris, MD, Cornelia Latronica, MD, Frans A Kuypers, PhD, Howard Rosenfeld, MD, Sandra K Larkin, MS, Stephanie Doniger, MD, Elliott Vichinsky, MD, Sruti Shiva, PhD

Blood (2013) 122 (21): 4690.

https://doi.org/10.1182/blood.V122.21.4690.4690

Published: 2013

Journal Articles

Nitrite Oxidase Activities of Cytochrome P450 and Mitochondria

Erin Curtis, Lewis L Hsu, MD, PhD, Yuen Yi Hon, PharmD, Lisa Geary, PhD, Audrey C Noguchi, Sruti Shiva, PhD

Blood (2011) 118 (21): 5310.

https://doi.org/10.1182/blood.V118.21.5310.5310

Published: 2011

Journal Articles

Sickle Cell Mice with Hypoxia-Reoxygenation Have Oxidative and Inflammatory Liver Injury - toward a New Experimental Model for Vaso- Occlusive Injury

Lewis L. Hsu, MD, PhD, Sruti Shiva, PhD, Caroline Mendelsohn, Michael R Hsu, Audrey C Noguchi, Laurel Mendelsohn, Mark Gladwin, MD

Blood (2008) 112 (11): 121.

https://doi.org/10.1182/blood.V112.11.121.121

Published: 2008

Journal Articles

Depletion and Restoration of the Intravascular Nitrite (NO2-) Reserve Modulate Susceptibility to Liver Vaso-Occlusive Infarction in Sickle Cell Transgenic Mice.

Lewis L. Hsu, MD, PhD, Sruti Shiva, PhD, Audrey Noguchi, Erin Curtis, Peter MacArthur, Nicolaas J.H. Raat, PhD, Bhalchandra A. Diwan, PhD, Alan N. Schechter, MD, Constance Tom Noguchi, PhD, Mark T. Gladwin, MD

Blood (2007) 110 (11): 841.

https://doi.org/10.1182/blood.V110.11.841.841

Published: 2007

Journal Articles

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

José Villagra, Sruti Shiva, Lori A. Hunter, Roberto F. Machado, Mark T. Gladwin, Gregory J. Kato

Blood (2007) 110 (6): 2166–2172.

https://doi.org/10.1182/blood-2006-12-061697

Published: 2007

Includes: Supplemental data

NARROW

Obesity-Induced Platelet Mitofusin-1 Expression Causes Vascular Dysfunction

The Role of TSP-1, TGF-B1 and Galectin-3 in the Pathogenesis of ACS in Sickle Cell Disease

Impact of Arginine Therapy on Clinical Outcomes, Mitochondrial Function and Oxidative Stress in Children with Sickle Cell Disease Hospitalized with Vasoocclusive Pain Episodes: A Randomized Controlled Trial

SOD2 V16A amplifies vascular dysfunction in sickle cell patients by curtailing mitochondria complex IV activity

Heme-Induced Platelet Mitochondrial Oxidant Production Regulates Platelet Granule Release

Xanthine Oxidase Has a Protective Role during Heme Crisis By Binding and Degrading Heme

Heme Induced Platelet Mitochondrial Oxidant Production Regulates Thrombospondin-1 Release from Platelets

HMGB1-Mediated Platelet Activation Is Independent of Platelet Mitochondrial Reactive Oxygen Species Generation

Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain

The Mitochondrion: A Link Between Hemolysis and Platelet Activation

Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes

HMGB1 As a Novel Platelet Agonist That Acts Synergistically with ADP to Activate Platelets in Sickle Cell Disease

Role of Iron-Responsive Mitochondrial Metabolism and ROS in Anemia

Mitochondrial Uncoupling Protein 2 Is Present in Human Platelets and Regulates Platelet Activation

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation

Citrate Synthase Activity Is Increased In Children With Sickle Cell Disease (SCD) On Hydroxyurea (HU) Therapy

Nitrite Oxidase Activities of Cytochrome P450 and Mitochondria

Sickle Cell Mice with Hypoxia-Reoxygenation Have Oxidative and Inflammatory Liver Injury - toward a New Experimental Model for Vaso- Occlusive Injury

Depletion and Restoration of the Intravascular Nitrite (NO2-) Reserve Modulate Susceptibility to Liver Vaso-Occlusive Infarction in Sickle Cell Transgenic Mice.

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

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American Society of Hematology

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American Society of Hematology

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