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Volume 94, Issue 8

October 15 1999

In this Issue

INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
PLENARY PAPERS
PERSPECTIVE
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS

INTRODUCTION: FOCUS ON HEMATOLOGY

CD34⁺ or CD34⁻: Does it Really Matter?

Margaret A. Goodell

View Articletitled, CD34+ or CD34−: Does it Really Matter?

FOCUS ON HEMATOLOGY

Reversible Expression of CD34 by Murine Hematopoietic Stem Cells

Takashi Sato,Joseph H. Laver,Makio Ogawa

View Articletitled, Reversible Expression of CD34 by Murine Hematopoietic Stem Cells

PLENARY PAPERS

Posttranslational Processing of the Thrombopoietin Receptor Is Impaired in Polycythemia Vera

Alison R. Moliterno,Jerry L. Spivak

View Articletitled, Posttranslational Processing of the Thrombopoietin Receptor Is Impaired in Polycythemia Vera

A Bispecific Diabody That Mediates Natural Killer Cell Cytotoxicity Against Xenotransplantated Human Hodgkin’s Tumors

Michaela A.E. Arndt,Jürgen Krauss,Sergey M. Kipriyanov,Michael Pfreundschuh,Melvyn Little

View Articletitled, A Bispecific Diabody That Mediates Natural Killer Cell Cytotoxicity Against Xenotransplantated Human Hodgkin’s Tumors

PERSPECTIVE

Uremic Bleeding: Closing the Circle After 30 Years of Controversies?

Marina Noris,Giuseppe Remuzzi

View Articletitled, Uremic Bleeding: Closing the Circle After 30 Years of Controversies?

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Lymphoproliferative Syndrome With Autoimmunity: A Possible Genetic Basis for Dominant Expression of the Clinical Manifestations

Frédéric Rieux-Laucat,Séverine Blachère,Sylvia Danielan,Jean Pierre De Villartay,Mathias Oleastro,Eric Solary,Brigitte Bader-Meunier,Peter Arkwright,Corinne Pondaré,Françoise Bernaudin,Helen Chapel,Susan Nielsen,Mohamed Berrah,Alain Fischer,Françoise Le Deist

View Articletitled, Lymphoproliferative Syndrome With Autoimmunity: A Possible Genetic Basis for Dominant Expression of the Clinical Manifestations

Monosomy 13 Is Associated With the Transition of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

Hervé Avet-Loiseau,Jian-Yong Li,Nadine Morineau,Thierry Facon,Christophe Brigaudeau,Jean-Luc Harousseau,Bernard Grosbois,Régis Bataille,on behalf of the Intergroupe Francophone du Myélome

View Articletitled, Monosomy 13 Is Associated With the Transition of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

Gene-Gene and Gene-Environment Interactions Determine Risk of Thrombosis in Families With Inherited Antithrombin Deficiency

H.H. van Boven,J.P. Vandenbroucke,E. Briët,F.R. Rosendaal

View Articletitled, Gene-Gene and Gene-Environment Interactions Determine Risk of Thrombosis in Families With Inherited Antithrombin Deficiency

HEMATOPOIESIS

Symmetry of Initial Cell Divisions Among Primitive Hematopoietic Progenitors Is Independent of Ontogenic Age and Regulatory Molecules

Shiang Huang,Ping Law,Karl Francis,Bernhard O. Palsson,Anthony D. Ho

View Articletitled, Symmetry of Initial Cell Divisions Among Primitive Hematopoietic Progenitors Is Independent of Ontogenic Age and Regulatory Molecules

Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size

Unnur Thorsteinsdottir,Guy Sauvageau,R. Keith Humphries

View Articletitled, Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size

Increased Fetal and Extramedullary Hematopoiesis in Fas-Deficient C57BL/6-lpr/lpr Mice

Elke Schneider,Géraldine Moreau,Anne Arnould,Florence Vasseur,Naushad Khodabaccus,Michel Dy,Sophie Ezine

View Articletitled, Increased Fetal and Extramedullary Hematopoiesis in Fas-Deficient C57BL/6-lpr/lpr Mice

Gene Duplication of Zebrafish JAK2 Homologs Is Accompanied by Divergent Embryonic Expression Patterns: Only jak2a Is Expressed During Erythropoiesis

Andrew C. Oates,Alison Brownlie,Stephen J. Pratt,Danielle V. Irvine,Eric C. Liao,Barry H. Paw,Kristen J. Dorian,Stephen L. Johnson,John H. Postlethwait,Leonard I. Zon,Andrew F. Wilks

View Articletitled, Gene Duplication of Zebrafish JAK2 Homologs Is Accompanied by Divergent Embryonic Expression Patterns: Only jak2a Is Expressed During Erythropoiesis

Genetic Modification of Human B-Cell Development: B-Cell Development Is Inhibited by the Dominant Negative Helix Loop Helix Factor Id3

Ana C. Jaleco,Alexander P.A. Stegmann,Mirjam H.M. Heemskerk,Franka Couwenberg,Arjen Q. Bakker,Kees Weijer,Hergen Spits

View Articletitled, Genetic Modification of Human B-Cell Development: B-Cell Development Is Inhibited by the Dominant Negative Helix Loop Helix Factor Id3

Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus

Pieter C.M. Res,Franka Couwenberg,Florry A. Vyth-Dreese,Hergen Spits

View Articletitled, Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus

The W^sh, W⁵⁷, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of Kit

Georgina Berrozpe,Inna Timokhina,Steven Yukl,Youichi Tajima,Masao Ono,Andrew D. Zelenetz,Peter Besmer

View Articletitled, The Wsh, W57, and Ph Kit Expression Mutations Define Tissue-Specific Control Elements Located Between −23 and −154 kb Upstream of Kit

Activation of the Erythropoietin Receptor Is Not Required for Internalization of Bound Erythropoietin

Diana L. Beckman,Lilie L. Lin,Mary E. Quinones,Gregory D. Longmore

View Articletitled, Activation of the Erythropoietin Receptor Is Not Required for Internalization of Bound Erythropoietin

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells

Marion Dorsch,Nika N. Danial,Paul B. Rothman,Stephen P. Goff

View Articletitled, A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells

Unique Differentiation Programs of Human Fetal Liver Stem Cells Shown Both In Vitro and In Vivo in NOD/SCID Mice

Franck E. Nicolini,Tessa L. Holyoake,Johanne D. Cashman,Pat P.Y. Chu,Karen Lambie,Connie J. Eaves

View Articletitled, Unique Differentiation Programs of Human Fetal Liver Stem Cells Shown Both In Vitro and In Vivo in NOD/SCID Mice

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Targeting of a Heterologous Protein to a Regulated Secretion Pathway in Cultured Endothelial Cells

Yvonne H. Datta,Hagop Youssoufian,Peter W. Marks,Bruce M. Ewenstein

View Articletitled, Targeting of a Heterologous Protein to a Regulated Secretion Pathway in Cultured Endothelial Cells

Influence of Fibrillar Collagen Structure on the Mechanisms of Platelet Thrombus Formation Under Flow

Brian Savage,Mark H. Ginsberg,Zaverio M. Ruggeri

View Articletitled, Influence of Fibrillar Collagen Structure on the Mechanisms of Platelet Thrombus Formation Under Flow

Neutrophil Adhesion on Polyurethanes Preadsorbed With High Molecular Weight Kininogen

Lin-Yue L. Yung,Robert W. Colman,Stuart L. Cooper

View Articletitled, Neutrophil Adhesion on Polyurethanes Preadsorbed With High Molecular Weight Kininogen

Circulating Activated Platelets Assist THP-1 Monocytoid/Endothelial Cell Interaction Under Shear Stress

Gregor Theilmeier,Tim Lenaerts,Claude Remacle,Désiré Collen,Jos Vermylen,Marc F. Hoylaerts

View Articletitled, Circulating Activated Platelets Assist THP-1 Monocytoid/Endothelial Cell Interaction Under Shear Stress

A Novel Approach to Arterial Thrombolysis

Petr Klement,Peng Liao,Laszlo Bajzar

View Articletitled, A Novel Approach to Arterial Thrombolysis

IMMUNOBIOLOGY

β₂-Microglobulin Identified as an Apoptosis-Inducing Factor and Its Characterization

Masaki Mori,Yasuhito Terui,Masayuki Ikeda,Hiroshi Tomizuka,Masaya Uwai,Tadashi Kasahara,Nobuyuki Kubota,Takehito Itoh,Yuji Mishima,Miyuki Douzono-Tanaka,Muneo Yamada,Seiichi Shimamura,Jiro Kikuchi,Yusuke Furukawa,Yukihito Ishizaka,Kazuma Ikeda,Hiroyuki Mano,Keiya Ozawa,Kiyohiko Hatake

View Articletitled, β2-Microglobulin Identified as an Apoptosis-Inducing Factor and Its Characterization

Fibronectin Upregulates Gelatinase B (MMP-9) and Induces Coordinated Expression of Gelatinase A (MMP-2) and Its Activator MT1-MMP (MMP-14) by Human T Lymphocyte Cell Lines. A Process Repressed Through RAS/MAP Kinase Signaling Pathways

Jordi Esparza,Carme Vilardell,Javier Calvo,Manel Juan,Jordi Vives,Alvaro Urbano-Márquez,Jordi Yagüe,Maria C. Cid

View Articletitled, Fibronectin Upregulates Gelatinase B (MMP-9) and Induces Coordinated Expression of Gelatinase A (MMP-2) and Its Activator MT1-MMP (MMP-14) by Human T Lymphocyte Cell Lines. A Process Repressed Through RAS/MAP Kinase Signaling Pathways

Signaling Through CD43 Induces Natural Killer Cell Activation, Chemokine Release, and PYK-2 Activation

Marta Nieto,José Luis Rodrı́guez-Fernández,Francisco Navarro,David Sancho,José M.R. Frade,Mario Mellado,Carlos Martı́nez-A,Carlos Cabañas,Francisco Sánchez-Madrid

View Articletitled, Signaling Through CD43 Induces Natural Killer Cell Activation, Chemokine Release, and PYK-2 Activation

An Inositolphosphate-Binding Immunophilin, IPBP12

Earlene Brown Cunningham

View Articletitled, An Inositolphosphate-Binding Immunophilin, IPBP12

Analysis of T Cells in Paroxysmal Nocturnal Hemoglobinuria Provides Direct Evidence That Thymic T-Cell Production Declines With Age

Stephen J. Richards,Gareth J. Morgan,Peter Hillmen

View Articletitled, Analysis of T Cells in Paroxysmal Nocturnal Hemoglobinuria Provides Direct Evidence That Thymic T-Cell Production Declines With Age

Monocytoid B Cells Are Distinct From Splenic Marginal Zone Cells and Commonly Derive From Unmutated Naive B Cells and Less Frequently From Postgerminal Center B Cells by Polyclonal Transformation

Karoline Stein,Michael Hummel,Petra Korbjuhn,Hans-Dieter Foss,Ioannis Anagnostopoulos,Theresa Marafioti,Harald Stein

View Articletitled, Monocytoid B Cells Are Distinct From Splenic Marginal Zone Cells and Commonly Derive From Unmutated Naive B Cells and Less Frequently From Postgerminal Center B Cells by Polyclonal Transformation

Human Immunodeficiency Virus nef Gene Expression Affects Generation and Function of Human T Cells, But Not Dendritic Cells

Bruno Verhasselt,Evelien Naessens,Chris Verhofstede,Magda De Smedt,Sigrid Schollen,Tessa Kerre,Dominique Vanhecke,Jean Plum

View Articletitled, Human Immunodeficiency Virus nef Gene Expression Affects Generation and Function of Human T Cells, But Not Dendritic Cells

Early Maturation of T-Cell Progenitors in the Absence of Glucocorticoids

Rosa Sacedón,Angeles Vicente,Alberto Varas,Eva Jiménez,Juan José Muñoz,Agustı́n G. Zapata

View Articletitled, Early Maturation of T-Cell Progenitors in the Absence of Glucocorticoids

Resting and Cytokine-Stimulated Human Small Airway Epithelial Cells Recognize and Engulf Apoptotic Eosinophils

Garry M. Walsh,Darren W. Sexton,Morgan G. Blaylock,Catherine M. Convery

View Articletitled, Resting and Cytokine-Stimulated Human Small Airway Epithelial Cells Recognize and Engulf Apoptotic Eosinophils

NEOPLASIA

In Vitro Evaluation of Fludarabine in Combination With Cyclophosphamide and/or Mitoxantrone in B-Cell Chronic Lymphocytic Leukemia

Beatriz Bellosillo,Neus Villamor,Dolors Colomer,Gabriel Pons,Emili Montserrat,Joan Gil

View Articletitled, In Vitro Evaluation of Fludarabine in Combination With Cyclophosphamide and/or Mitoxantrone in B-Cell Chronic Lymphocytic Leukemia

Phenylarsine Oxide Blocks Interleukin-1β–Induced Activation of the Nuclear Transcription Factor NF-κB, Inhibits Proliferation, and Induces Apoptosis of Acute Myelogenous Leukemia Cells

Zeev Estrov,Sunil K. Manna,David Harris,Quin Van,Elihu H. Estey,Hagop M. Kantarjian,Moshe Talpaz,Bharat B. Aggarwal

View Articletitled, Phenylarsine Oxide Blocks Interleukin-1β–Induced Activation of the Nuclear Transcription Factor NF-κB, Inhibits Proliferation, and Induces Apoptosis of Acute Myelogenous Leukemia Cells

A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma

William P. Schiemann,Walther M. Pfeifer,Edi Levi,Marshall E. Kadin,Harvey F. Lodish

View Articletitled, A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma

Expression of Human Inducible Nitric Oxide Synthase Gene in T-Cell Lines Infected With Human T-Cell Leukemia Virus Type-I and Primary Adult T-Cell Leukemia Cells

Naoki Mori,Youichi Nunokawa,Yasuaki Yamada,Shuichi Ikeda,Masao Tomonaga,Naoki Yamamoto

View Articletitled, Expression of Human Inducible Nitric Oxide Synthase Gene in T-Cell Lines Infected With Human T-Cell Leukemia Virus Type-I and Primary Adult T-Cell Leukemia Cells

Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous Growth of Kaposi’s Sarcoma Herpesvirus-Associated Infected Primary Effusion Lymphoma Cells

Karen D. Jones,Yoshiyasu Aoki,Yuan Chang,Patrick S. Moore,Robert Yarchoan,Giovanna Tosato

View Articletitled, Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous Growth of Kaposi’s Sarcoma Herpesvirus-Associated Infected Primary Effusion Lymphoma Cells

PHAGOCYTES

Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation

Marco A. Cassatella,Sara Gasperini,Chiara Bovolenta,Federica Calzetti,Marieke Vollebregt,Patrizia Scapini,Martina Marchi,Ritsu Suzuki,Asuka Suzuki,Akihiko Yoshimura

View Articletitled, Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation

RED CELLS

The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

Ernest Beutler,Terri Gelbart,Takahito Kondo,Alison T. Matsunaga

View Articletitled, The Molecular Basis of a Case of γ-Glutamylcysteine Synthetase Deficiency

TRANSPLANTATION

ABO Blood Group Antigens on Human Plasma von Willebrand Factor After ABO-Mismatched Bone Marrow Transplantation

Taei Matsui,Taketo Shimoyama,Masanori Matsumoto,Yoshihiro Fujimura,Yoshinobu Takemoto,Masahiro Sako,Jiharu Hamako,Koiti Titani

View Articletitled, ABO Blood Group Antigens on Human Plasma von Willebrand Factor After ABO-Mismatched Bone Marrow Transplantation

Shiga-Like Toxin-1 Receptor on Human Breast Cancer, Lymphoma, and Myeloma and Absence From CD34⁺ Hematopoietic Stem Cells: Implications for Ex Vivo Tumor Purging and Autologous Stem Cell Transplantation

E.C. LaCasse,M.R. Bray,B. Patterson,W.-M. Lim,S. Perampalam,L. G. Radvanyi,A. Keating,A.K. Stewart,R. Buckstein,J.S. Sandhu,N. Miller,D. Banerjee,D. Singh,A.R. Belch,L.M. Pilarski,J. Gariépy

View Articletitled, Shiga-Like Toxin-1 Receptor on Human Breast Cancer, Lymphoma, and Myeloma and Absence From CD34+ Hematopoietic Stem Cells: Implications for Ex Vivo Tumor Purging and Autologous Stem Cell Transplantation

Correlation Between Disparity for the Minor Histocompatibility Antigen HA-1 and the Development of Acute Graft-Versus-Host Disease After Allogeneic Marrow Transplantation

Li-Hui Tseng,Ming-Tseh Lin,John A. Hansen,Ted Gooley,Ji Pei,Anajane G. Smith,Emily G. Martin,Effie W. Petersdorf,Paul J. Martin

View Articletitled, Correlation Between Disparity for the Minor Histocompatibility Antigen HA-1 and the Development of Acute Graft-Versus-Host Disease After Allogeneic Marrow Transplantation

Viral Hyperinfection of the Central Nervous System and High Mortality After Hematopoietic Stem Cell Transplantation for Treatment of Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinating Disease

Richard K. Burt,Josette Padilla,Mauro C. Dal Canto,Stephen D. Miller

View Articletitled, Viral Hyperinfection of the Central Nervous System and High Mortality After Hematopoietic Stem Cell Transplantation for Treatment of Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinating Disease

Long-Term Chimerism and B-Cell Function After Bone Marrow Transplantation in Patients With Severe Combined Immunodeficiency With B Cells: A Single-Center Study of 22 Patients

Elie Haddad,Françoise Le Deist,Pierre Aucouturier,Marina Cavazzana-Calvo,Stephane Blanche,Geneviève De Saint Basile,Alain Fischer

View Articletitled, Long-Term Chimerism and B-Cell Function After Bone Marrow Transplantation in Patients With Severe Combined Immunodeficiency With B Cells: A Single-Center Study of 22 Patients

BRIEF REPORTS

Expression of Cell-Homologous Genes of Human Herpesvirus-8 in Human Immunodeficiency Virus-Negative Lymphoproliferative Diseases

Mario Luppi,Patrizia Barozzi,Antonio Maiorana,Raffaella Trovato,Roberto Marasca,Monica Morselli,Katia Cagossi,Giuseppe Torelli

View Articletitled, Expression of Cell-Homologous Genes of Human Herpesvirus-8 in Human Immunodeficiency Virus-Negative Lymphoproliferative Diseases

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Cardiac complete response in AL amyloidosis has similar survival to matched general population

Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma

Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.

NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS