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Mirjam H.M. Heemskerk
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Journal Articles

T-Cell Monitoring for the Recently Expanded Repertoire of HLA Class I-Restricted Minor Histocompatibility Antigens Using Barcoded Peptide-MHC Multimers

Kyra J. Fuchs, Marcus Göransson, Michel G.D. Kester, Natasja W. Ettienne, Marian van de Meent, Rob C.M. de Jong, Eva A.S. Koster, Constantijn J.M. Halkes, Ferenc A. Scheeren, Mirjam H.M. Heemskerk, Peter Van Balen, J.H. Frederik Falkenburg, Sine R. Hadrup, Marieke Griffioen
Journal: Blood
Blood (2024) 144 (Supplement 1): 691.
https://doi.org/10.1182/blood-2024-197955
Published: 2024
Journal Articles

T Cell Receptor-Based Targeting of Immunoglobulin Constant Domains for Treatment of Multiple Myeloma

Miranda H. Meeuwsen, Anne K. Wouters, Tassilo L.A. Wachsmann, Renate S. Hagedoorn, Dennis F.G. Remst, Michel G.D. Kester, Dirk M. van der Steen, Arnoud H. de Ru, Peter A. van Veelen, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Blood
Blood (2022) 140 (Supplement 1): 10292–10293.
https://doi.org/10.1182/blood-2022-170314
Published: 2022
Journal Articles

Immunotherapy Targeting Mutant Nucleophosmin-1 on Acute Myeloid Leukemia

Georgia Koutsoumpli, Dyantha I. van der Lee, Nina C. Groenland, M. Willy Honders, Rob C.M. de Jong, Renate S. Hagedoorn, Hendrik Veelken, Peter A. van Veelen, Dominik Lock, Mirjam H.M. Heemskerk, J.H.Frederik Falkenburg, Ian Johnston, Marieke Griffioen
Journal: Blood
Blood (2022) 140 (Supplement 1): 10243–10244.
https://doi.org/10.1182/blood-2022-158195
Published: 2022
Journal Articles

Broadly Applicable TCR Based Therapy for Multiple Myeloma Targeting the Jchain

Miranda H. Meeuwsen, Anne K. Wouters, Tassilo L.A. Wachsmann, Renate S. Hagedoorn, Michel G.D. Kester, Dennis F.G. Remst, Dirk M. van der Steen, Arnoud H. de Ru, Els P. van Hees, Marieke Griffioen, Peter A. van Veelen, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Blood
Blood (2022) 140 (Supplement 1): 4498–4499.
https://doi.org/10.1182/blood-2022-156923
Published: 2022
Journal Articles

High-Dimensional Mass Cytometric Analysis of the Bone Marrow Compartment Identifies a Disease-Specific Immune Cell Network in Aplastic Anemia

Emma S. Pool, Yvonne Kooy-Winkelaar, Vincent van Unen, J.H.Frederik Falkenburg, Frits Koning, Mirjam H.M. Heemskerk, Jennifer M.L. Tjon
Journal: Blood
Blood (2022) 140 (Supplement 1): 477–478.
https://doi.org/10.1182/blood-2022-162187
Published: 2022
Journal Articles

Special Anatomical Subtypes of Diffuse Large B-Cell Lymphoma Have Distinct Tumor Microenvironments

Troy Noordenbos, Fleur A De Groot, Ruben A.L. De Groen, Lorraine M. De Haan, Ricki T. Krog, Aniko Sijs-Szabo, Marieke Griffioen, Rosa de Groot, Mirjam H.M. Heemskerk, Marieke E. Ijsselsteijn, Valeska Terpstra, Marcel Nijland, Pim Mutseaers, Martine E.D. Chamuleau, Marie Jose Kersten, Arjan Diepstra, Judith Bovée, Patty M. Jansen, Noel F.C.C. De Miranda, Joost S.P. Vermaat
Journal: Blood
Blood (2022) 140 (Supplement 1): 164–165.
https://doi.org/10.1182/blood-2022-156103
Published: 2022
Journal Articles

Sickle Cell Disease Patients Mount Adequate Humoral but Reduced Cellular Responses to COVID-19 Vaccination

Cilia R. Pothast, Quincy Hofsink, Sabine Haggenburg, Michel Bhoekhan, Nienke J.E. Haverkate, Romy C. Dijkland, Kayleigh van Dijk, Frederik J.H. Falkenburg, Annoek E.C. Broers, Jaap van Doesum, Robert S. van Binnendijk, Gerco den Hartog, Judith A. Burger, Joey H. Bouhuijs, Birgit I. Lissenberg-Witte, Gaby P. Smits, Dorine Wouters, Ester M.M. van Leeuwen, Hetty J. Bontkes, Neeltje A. Kootstra, Sonja Zweegman, Arnon P. Kater, Kaz Groen, Tom van Meerten, Pim G.N.J. Mutsaers, Tim Beaumont, Marit J. van Gils, Abraham Goorhuis, Mette D. Hazenberg, Inger S. Nijhof, Mirjam H.M. Heemskerk, Caroline E. Rutten
Journal: Blood
Blood (2022) 140 (Supplement 1): 1957–1959.
https://doi.org/10.1182/blood-2022-169164
Published: 2022
Journal Articles

Sars-Cov-2-Specific CD4 + and CD8 + T Cell Responses Can Originate from Cross-Reactive CMV-Specific T Cells

Cilia R. Pothast, Romy C. Dijkland, Melissa Thaler, Renate S. Hagedoorn, Michel G.D. Kester, Anne K. Wouters, Pieter S. Hiemstra, Martijn J. van Hemert, Stephanie Gras, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Blood
Blood (2022) 140 (Supplement 1): 2631–2632.
https://doi.org/10.1182/blood-2022-156715
Published: 2022
Journal Articles

Immunotherapy By Targeting CD45 in Mismatched HLA-DP to Treat Patients after Allogeneic Stem Cell Transplantation

Nadine E. Struckman, Sebastian Klobuch, Michel G.D. Kester, Wendy de Klerk, Arnoud H. de Ru, Mirjam H.M. Heemskerk, Peter A. van Veelen, Peter van Balen, J.H.Frederik Falkenburg, Marieke Griffioen
Journal: Blood
Blood (2022) 140 (Supplement 1): 4545–4546.
https://doi.org/10.1182/blood-2022-166282
Published: 2022
Journal Articles

Discordant Cellular and Humoral Responses to a 3-Dose COVID-19 mRNA Vaccination Schedule in Patients with Hematologic Malignancies

Cilia R. Pothast, Quincy Hofsink, Sabine Haggenburg, Bhoekhan S. Michel, Nienke J.E. Haverkate, Romy C. Dijkland, Kayleigh Van Dijk, Frederik J.H. Falkenburg, Annoek E.C. Broers, Jaap van Doesum, Robert S. Van Binnendijk, Gerco Den Hartog, Judith A. Burger, Joey H. Bouhuijs, Birgit I. Lissenberg-Witte, Gaby P. Smits, Dorine Wouters, Ester M.M. van Leeuwen, Hetty J. Bontkes, Neeltje A. Kootstra, Sonja Zweegman, Arnon P. Kater, Kaz Groen, Tom van Meerten, Pim G.N.J. Mutsaers, Tim Beaumont, Marit J. Van Gils, Abraham Goorhuis, Mette D. Hazenberg, Inger S. Nijhof, Mirjam H.M. Heemskerk, Caroline E. Rutten
Journal: Blood
Blood (2022) 140 (Supplement 1): 8347–8349.
https://doi.org/10.1182/blood-2022-168991
Published: 2022
Journal Articles

Mutated NPM1 As Target for Immunotherapy of Acute Myeloid Leukemia

Dyantha I. Van Der Lee, BSc., Helena M. Bijen, MSc, Renate S. Hagedoorn, ing., Willy M. Honders, ing., Michel G.D. Kester, ing., Dirk M. van der Steen, ing., Arnoud H. de Ru, ing., Inge Jedema, PhD, Hendrik Veelken, MD PhD, Mirjam H.M. Heemskerk, PhD, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Marieke Griffioen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 168.
https://doi.org/10.1182/blood.V130.Suppl_1.168.168
Published: 2017
Journal Articles

Induction of Antigen-Specific T-Cell Responses through Dendritic Cell Vaccination in AML: Results of a Phase I/II Trial and Ex Vivo Enhancement By Checkpoint Blockade

Felix S. Lichtenegger, MD, Katrin Deiser, PhD, Maurine Rothe, Frauke M. Schnorfeil, PhD, Christina Krupka, PhD, Christian Augsberger, Thomas Köhnke, MD, Veit L. Bücklein, MD, Torben Altmann, MD, Andreas Moosmann, Monika Brüggemann, MD PhD, Mirjam H.M. Heemskerk, PhD, Georg Wittmann, MD, Beate Wagner, MD, Wolfgang Hiddemann, MD, Iris Bigalke, PhD, Gunnar Kvalheim, MD PhD, Marion Subklewe, MD
Journal: Blood
Blood (2016) 128 (22): 764.
https://doi.org/10.1182/blood.V128.22.764.764
Published: 2016
Journal Articles

Inducible MyD88/CD40 (iMC) Enhances Proliferation and Survival of Tumor-Specific TCR-Modified T Cells and Improves Anti-Tumor Efficacy in Myeloma

Tsvetelina Pentcheva-Hoang, PhD, David Torres, Tania Rodriguez, PhD, Ana Korngold, PhD, An Lu, Jeannette Crisostomo, Annemarie Moseley, MD PhD, Lorenz Jahn, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD, Aaron E Foster, PhD
Journal: Blood
Blood (2016) 128 (22): 4550.
https://doi.org/10.1182/blood.V128.22.4550.4550
Published: 2016
Journal Articles

Endogenous Immunoglobulin-Derived Neoepitopes Are Processed and Form a Sizeable Fraction of the HLA Class I Ligandome of Human Lymphoma Cells

Cornelis A.M. van Bergen, PhD, Dirk M. van der Steen, Michel G.D. Kester, Marvyn T. Koning, BSc, Peter A. van Veelen, PhD, Marieke Griffioen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD, Hendrik Veelken, MD PhD, Marcelo A Navarrete, MD PhD
Journal: Blood
Blood (2016) 128 (22): 914.
https://doi.org/10.1182/blood.V128.22.914.914
Published: 2016
Journal Articles

T Cell Receptor Gene Therapy Targeting the Intracellular Transcription Factor Bob1 for the Treatment of Multiple Myeloma and Other B Cell Malignancies

Lorenz Jahn, Renate S. Hagedoorn, Pleun Hombrink, PhD, Michel G.D. Kester, Dirk M. van der Steen, Chopie Hassan, Marjolein P. Schoonakker, Erwin van der Pijl, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD
Journal: Blood
Blood (2015) 126 (23): 3002.
https://doi.org/10.1182/blood.V126.23.3002.3002
Published: 2015
Journal Articles

Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma

Tsvetalina Hoang, PhD, Aaron Foster, PhD, Jeannette Crisostomo, An Lu, Annemarie Moseley, MDPhD, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD
Journal: Blood
Blood (2015) 126 (23): 1886.
https://doi.org/10.1182/blood.V126.23.1886.1886
Published: 2015
Journal Articles

Functional Evaluation of T-Cells Generated from WT1-TCR Transduced Human Hematopoietic Stem Cells Using the OP9-DL1 Coculture System

Sarah Bonte, Master in Biomedical MDcine, Sylvia Snauwaert, MD PhD, Jasper Van Heuverswyn, Glenn Goetgeluk, Mirjam H.M. Heemskerk, PhD, Hans Stauss, MD PhD, Renata Stripecke, PhD, Bart Vandekerckhove, MD PhD, Tessa Kerre, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2152.
https://doi.org/10.1182/blood.V124.21.2152.2152
Published: 2014
Journal Articles

T Cell Receptors Specific for the Intracellular Transcription Factor Bob1 Allow Efficient Targeting of Human B Cell Leukemia and Multiple Myeloma

Lorenz Jahn, Pleun Hombrink, Michel G.D. Kester, Dirk M. van der Steen, Renate S. Hagedoorn, Chopie Hassan, Marjolein P. Schoonakker, Erwin van der Pijl, Peter A. van Veelen, PhD, J.H. Frederik Falkenburg, MD PhD, Mirjam H.M. Heemskerk, PhD
Journal: Blood
Blood (2014) 124 (21): 3832.
https://doi.org/10.1182/blood.V124.21.3832.3832
Published: 2014
Journal Articles

High-Affinity CD20-Specific T-Cell Receptors Suitable for Adoptive Immunotherapy in the Treatment of CD20 low B-Cell Malignancies

Lorenz Jahn, Pleun Hombrink, Chopie Hassan, Michel G.D. Kester, Renate S. Hagedoorn, Dirk M. van der Steen, Marjolein P. Schoonakker, J.H. Frederik Falkenburg, MD PhD, Peter A. van Veelen, PhD, Mirjam H.M. Heemskerk, PhD
Journal: Blood
Blood (2014) 124 (21): 3837.
https://doi.org/10.1182/blood.V124.21.3837.3837
Published: 2014
Journal Articles

Imprint Of Early CMV Reactivation On The Reconstituting T-Lymphocyte Compartment One and Two Year After Hematopoietic Stem Cell Transplantation

Gertjan Lugthart, MD, Monique M. van Ostaijen-Ten Dam, Cornelia M. Jol-van der Zijde, Tessa C. van Holten, Michel G.D. Kester, Mirjam H.M. Heemskerk, PhD, Robbert G.M. Bredius, MD, PhD, Maarten J.D. van Tol, PhD, Arjan C. Lankester, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3295.
https://doi.org/10.1182/blood.V122.21.3295.3295
Published: 2013