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Issue Archive

Volume 120, Issue 9
August 30 2012
Issue Cover

Table of Contents

Inside Blood

IMMUNOBIOLOGY
HIV infection, lymphoid fibrosis, and disease
Steven G. Deeks
View Articletitled, HIV infection, lymphoid fibrosis, and disease
CLINICAL TRIALS
Treating myeloma: the future is already here!
Ola Landgren,Neha Korde
View Articletitled, Treating myeloma: the future is already here!
GENE THERAPY
Suicidal T cells: a jump-start for the thymus
Rupert Handgretinger
View Articletitled, Suicidal T cells: a jump-start for the thymus
INSIDE BLOOD
BTK inhibition in myeloma: targeting the seed and the soil
Claire M. Edwards
View Articletitled, BTK inhibition in myeloma: targeting the seed and the soil
MYELOID NEOPLASIA
A drug that stops traffic at the nuclear border
Lucy A. Godley
View Articletitled, A drug that stops traffic at the nuclear border
RED CELLS & IRON
Why not the liver instead of the kidney?
Joachim Fandrey
View Articletitled, Why not the liver instead of the kidney?
THROMBOSIS & HEMOSTASIS
Factors VIII and V swap fatty feet
Koen Mertens,Alexander B. Meijer
View Articletitled, Factors VIII and V swap fatty feet

Blood Work

Cryoglobulin deposits on a blood smear
Jean-Francois Lesesve
View Articletitled, Cryoglobulin deposits on a blood smear

Plenary Paper

MYELOID NEOPLASIA
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia
Parvathi Ranganathan,Xueyan Yu,Caroline Na,Ramasamy Santhanam,Sharon Shacham,Michael Kauffman,Alison Walker,Rebecca Klisovic,William Blum,Michael Caligiuri,Carlo M. Croce,Guido Marcucci,Ramiro Garzon
View Articletitled, Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

Perspectives

Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection
Nikolaos Papadantonakis,Shinobu Matsuura,Katya Ravid
View Articletitled, Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection

Review Article

The role of miRNAs in the pathogenesis and diagnosis of B-cell lymphomas
Lorena Di Lisio,Nerea Martinez,Santiago Montes-Moreno,Miguel Piris-Villaespesa,Margarita Sanchez-Beato,Miguel A. Piris
View Articletitled, The role of miRNAs in the pathogenesis and diagnosis of B-cell lymphomas

How I Treat

How I manage pulmonary nodular lesions and nodular infiltrates in patients with hematologic malignancies or undergoing hematopoietic cell transplantation
John R. Wingard,John W. Hiemenz,Michael A. Jantz
View Articletitled, How I manage pulmonary nodular lesions and nodular infiltrates in patients with hematologic malignancies or undergoing hematopoietic cell transplantation

Clinical Trials and Observations

A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
Clinical Trials & Observations
Andrzej J. Jakubowiak,Dominik Dytfeld,Kent A. Griffith,Daniel Lebovic,David H. Vesole,Sundar Jagannath,Ammar Al-Zoubi,Tara Anderson,Brian Nordgren,Kristen Detweiler-Short,Keith Stockerl-Goldstein,Asra Ahmed,Terri Jobkar,Diane E. Durecki,Kathryn McDonnell,Melissa Mietzel,Daniel Couriel,Mark Kaminski,Ravi Vij
View Articletitled, A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
Supplemental data
Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome
Clinical Trials & Observations
Takashi Taga,Akiko Moriya Saito,Kazuko Kudo,Daisuke Tomizawa,Kiminori Terui,Hiroshi Moritake,Akitoshi Kinoshita,Shotaro Iwamoto,Hideki Nakayama,Hiroyuki Takahashi,Akio Tawa,Akira Shimada,Tomohiko Taki,Hisato Kigasawa,Katsuyoshi Koh,Souichi Adachi
View Articletitled, Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome
Supplemental data

Gene Therapy

T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation
Luca Vago,Giacomo Oliveira,Attilio Bondanza,Maddalena Noviello,Corrado Soldati,Domenico Ghio,Immacolata Brigida,Raffaella Greco,Maria Teresa Lupo Stanghellini,Jacopo Peccatori,Sergio Fracchia,Matteo Del Fiacco,Catia Traversari,Alessandro Aiuti,Alessandro Del Maschio,Claudio Bordignon,Fabio Ciceri,Chiara Bonini
View Articletitled, T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation
Supplemental data

Hematopoiesis and Stem Cells

FGF signaling facilitates postinjury recovery of mouse hematopoietic system
Meng Zhao,Jason T. Ross,Tomer Itkin,John M. Perry,Aparna Venkatraman,Jeffrey S. Haug,Mark J. Hembree,Chu-Xia Deng,Tsvee Lapidot,Xi C. He,Linheng Li
View Articletitled, FGF signaling facilitates postinjury recovery of mouse hematopoietic system
Supplemental data
FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation
Tomer Itkin,Aya Ludin,Ben Gradus,Shiri Gur-Cohen,Alexander Kalinkovich,Amir Schajnovitz,Yossi Ovadya,Orit Kollet,Jonathan Canaani,Elias Shezen,Douglas J. Coffin,Grigori N. Enikolopov,Thorsten Berg,Wanda Piacibello,Eran Hornstein,Tsvee Lapidot
View Articletitled, FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation
Supplemental data

Immunobiology

Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution
Ming Zeng,Mirko Paiardini,Jessica C. Engram,Greg J. Beilman,Jeffrey G. Chipman,Timothy W. Schacker,Guido Silvestri,Ashley T. Haase
View Articletitled, Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution

Lymphoid Neoplasia

Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma
Brief Report
Charles B. Simone, II,John C. Morris,Donn M. Stewart,Nicole E. Urquhart,John E. Janik,Robert J. Kreitman,Elena Lita,Kevin Conlon,Gilian Wharfe,Thomas A. Waldmann,Aradhana Kaushal
View Articletitled, Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma
Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies
Clinical Trials & Observations
Nicola Gökbuget,Michael Kneba,Thorsten Raff,Heiko Trautmann,Claus-Rainer Bartram,Renate Arnold,Rainer Fietkau,Mathias Freund,Arnold Ganser,Wolf-Dieter Ludwig,Georg Maschmeyer,Harald Rieder,Stefan Schwartz,Hubert Serve,Eckhard Thiel,Monika Brüggemann,Dieter Hoelzer,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia
View Articletitled, Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies
Supplemental data
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma
Yu-Tzu Tai,Betty Y. Chang,Sun-Young Kong,Mariateresa Fulciniti,Guang Yang,Yolanda Calle,Yiguo Hu,Jianhong Lin,Jian-Jun Zhao,Antonia Cagnetta,Michele Cea,Michael A. Sellitto,Mike Y. Zhong,Qiuju Wang,Chirag Acharya,Daniel R. Carrasco,Joseph J. Buggy,Laurence Elias,Steven P. Treon,William Matsui,Paul Richardson,Nikhil C. Munshi,Kenneth C. Anderson
View Articletitled, Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma
Supplemental data

Myeloid Neoplasia

Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice
Dongqing Yan,Robert E. Hutchison,Golam Mohi
View Articletitled, Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice
Supplemental data

Platelets and Thrombopoiesis

VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis
Wilko Thiele,Jaya Krishnan,Melanie Rothley,Debra Weih,Diana Plaumann,Vanessa Kuch,Luca Quagliata,Herbert A. Weich,Jonathan P. Sleeman
View Articletitled, VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis
Supplemental data

Red Cells, Iron, and Erythropoiesis

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
Ryan Zarychanski,Vincent P. Schulz,Brett L. Houston,Yelena Maksimova,Donald S. Houston,Brian Smith,Jesse Rinehart,Patrick G. Gallagher
View Articletitled, Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
Supplemental data
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
William Querbes,Roman L. Bogorad,Javid Moslehi,Jamie Wong,Amy Y. Chan,Elena Bulgakova,Satya Kuchimanchi,Akin Akinc,Kevin Fitzgerald,Victor Koteliansky,William G. Kaelin, Jr
View Articletitled, Treatment of erythropoietin deficiency in mice with systemically administered siRNA
Supplemental data

Thrombosis and Hemostasis

Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity
Gary E. Gilbert,Valerie A. Novakovic,Randal J. Kaufman,Hongzhi Miao,Steven W. Pipe
View Articletitled, Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity
Supplemental data

Transplantation

Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms
Satoru Otsuru,Patricia L. Gordon,Kengo Shimono,Reena Jethva,Roberta Marino,Charlotte L. Phillips,Ted J. Hofmann,Elena Veronesi,Massimo Dominici,Masahiro Iwamoto,Edwin M. Horwitz
View Articletitled, Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms
Supplemental data

Vascular Biology

ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration
Guoquan Liu,Aaron T. Place,Zhenlong Chen,Viktor M. Brovkovych,Stephen M. Vogel,William A. Muller,Randal A. Skidgel,Asrar B. Malik,Richard D. Minshall
View Articletitled, ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration
Supplemental data

Correspondence

Malignancies are the major cause of death in patients with adult onset common variable immunodeficiency
Isabella Quinti,Carlo Agostini,Stefano Tabolli,Grazia Brunetti,Francesco Cinetto,Antonio Pecoraro,Giuseppe Spadaro
View Articletitled, Malignancies are the major cause of death in patients with adult onset common variable immunodeficiency
Seasonal and pandemic (A/H1N1 2009) MF-59–adjuvanted influenza vaccines in complete remission non-Hodgkin lymphoma patients previously treated with rituximab containing regimens
Davide Bedognetti,Filippo Ansaldi,Elisa Zanardi,Paolo Durando,Mario Roberto Sertoli,Carlotta Massucco,Enrico Balleari,Omar Racchi,Gabriele Zoppoli,Andrea Orsi,Cristiano Alicino,Giancarlo Icardi,Francesco M. Marincola,Simonetta Zupo,Manlio Ferrarini,Andrea De Maria
View Articletitled, Seasonal and pandemic (A/H1N1 2009) MF-59–adjuvanted influenza vaccines in complete remission non-Hodgkin lymphoma patients previously treated with rituximab containing regimens
Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl
Fabien Touzot,Liliane Dal-Cortivo,Virginie Verkarre,Annick Lim,Anne Crucis-Armengaud,Despina Moshous,Sébastien Héritier,Pierre Frange,Sophie Kaltenbach,Stéphane Blanche,Capucine Picard,Salima Hacein-Bey-Abina,Marina Cavazzana-Calvo,Alain Fischer
View Articletitled, Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl
Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response
Laurence Legros,Philippe Rousselot,Stéphane Giraudier,Michel Tulliez,Françoise Huguet,Franck-Emmanuel Nicolini,Francois-Xavier Mahon
View Articletitled, Second attempt to discontinue imatinib in CP-CML patients with a second sustained complete molecular response
Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans
Harold T. Bae,Clinton T. Baldwin,Paola Sebastiani,Marilyn J. Telen,Allison Ashley-Koch,Melanie Garrett,W. Craig Hooper,Christopher J. Bean,Michael R. DeBaun,Dan E. Arking,Pallav Bhatnagar,James F. Casella,Jeffrey Renn Keefer,Emily Barron-Casella,Victor Gordeuk,Gregory J. Kato,Caterina Minniti,James Taylor,Andrew Campbell,Lori Luchtman-Jones,Carolyn Hoppe,Mark T. Gladwin,Yingze Zhang,Martin H. Steinberg
View Articletitled, Meta-analysis of 2040 sickle cell anemia patients: <em>BCL11A</em> and <em>HBS1L-MYB</em> are the major modifiers of HbF in African Americans

Errata

Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011;118(16):4384–4393.
View Articletitled, Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. <em>Blood</em>. 2011;118(16):<span class="related-article">4384–4393</span>.
San-Miguel JF. Consolidation therapy in myeloma: a consolidated approach? Blood. 2012;120(1):2–3.
View Articletitled, San-Miguel JF. Consolidation therapy in myeloma: a consolidated approach? <em>Blood</em>. 2012;120(1):<span class="related-article">2–3</span>.
  • Cover Image

    Cover Image

    issue cover

    Wright-stained peripheral blood smear demonstrating eccentrocytes (cells with eccentric hemoglobin puddling), stomatocytes, and reticulocytes. This morphology is typical of hereditary xerocytosis, an inherited disorder of erythrocyte dehydration. Mutations in the FAM38A gene, which encodes the membrane-associated mechanotransduction protein, PIEZO1, have been identified in patients with hereditary xerocytosis. See the article by Zarychanski et al on page 1908.

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