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Journal Articles

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Nick van Gastel, PhD, Jessica B. Spinelli, PhD, Azeem Sharda, MS, Amir Schajnovitz, PhD, Ninib Baryawno, PhD, Catherine S Rhee, PhD, Toshihiko Oki, MD PhD, Eliane Grace, Heather J. Soled, Charles Vidoudez, PhD, Sunia A. Trauger, PhD, Marcia C. Haigis, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 3725.

https://doi.org/10.1182/blood-2019-124789

Published: 2019

Journal Articles

Untargeted Metabolomics Identifies Glutamine Metabolism As a Driver of Chemoresistance in Acute Myeloid Leukemia

Nick van Gastel, PhD, Amir Schajnovitz, PhD, Charles Vidoudez, PhD, Toshihiko Oki, MD PhD, Azeem Sharda, MS, Sunia A. Trauger, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2523.

https://doi.org/10.1182/blood.V130.Suppl_1.2523.2523

Published: 2017

Journal Articles

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

Jonathan Hoggatt, PhD, Pratibha Singh, PhD, Tiffany Tate, BS, Peter V. Kharchenko, PhD, Amir Schajnovitz, PhD, Ninib Barawnyo, PhD, Francois Mercier, MD, Dwight Morrow, PhD, David T. Scadden, MD, Louis M. Pelus, PhD

Blood (2016) 128 (22): 368.

https://doi.org/10.1182/blood.V128.22.368.368

Published: 2016

Journal Articles

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

David B. Sykes, MD PhD, Youmna Sami Kfoury, PhD, Francois Mercier, MD, Mathias Wawer, PhD, Amir Schajnovitz, PhD, Hanna Meyer, PhD, Kerry A Pierce, PhD, Detlef Stoeckigt, PhD, Clary B Clish, PhD, Paul A Clemons, PhD, Andreas Janzer, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 1656.

https://doi.org/10.1182/blood.V128.22.1656.1656

Published: 2016

Journal Articles

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Rahul Palchaudhuri, PhD, Borja Saez, PhD, Jonathan Hoggatt, PhD, Amir Schajnovitz, David B. Sykes, MD PhD, Michael K Mansour, MD PhD, David T. Scadden, MD

Blood (2015) 126 (23): 32.

https://doi.org/10.1182/blood.V126.23.32.32

Published: 2015

Journal Articles

Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells

Blood (2015) 126 (23): 664.

https://doi.org/10.1182/blood.V126.23.664.664

Published: 2015

Journal Articles

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

Blood (2014) 124 (19): 2937–2947.

https://doi.org/10.1182/blood-2014-08-593426

Published: 2014

Includes: Supplemental data

Journal Articles

Human and Murine β-Defensin-Derived Peptides Induce Rapid Mobilization Of Murine Hematopoietic Stem and Progenitor Cells Via Activation Of CXCR4 Signaling and CXCL12 Release

Amir Schajnovitz, PhD, Alexander Kalinkovich, MD, PhD, Kfir Lapid, PhD, Alexander Berchanski, PhD, Tomer Itkin, PhD, Aya Ludin, DMD, PhD, Shiri Gur-Cohen, MSc, Karin Golan, MSc, Borja Saez, PhD, Orit Kollet, PhD, Kerstin Ahrens, PhD, Ehrahrdt Proksch, MD, PhD, Aviva Lapidot, PhD, Matityahu Fridkin, PhD, David T. Scadden, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 890.

https://doi.org/10.1182/blood.V122.21.890.890

Published: 2013

Journal Articles

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation

Tomer Itkin, Aya Ludin, Ben Gradus, Shiri Gur-Cohen, Alexander Kalinkovich, Amir Schajnovitz, Yossi Ovadya, Orit Kollet, Jonathan Canaani, Elias Shezen, Douglas J. Coffin, Grigori N. Enikolopov, Thorsten Berg, Wanda Piacibello, Eran Hornstein, Tsvee Lapidot

Blood (2012) 120 (9): 1843–1855.

https://doi.org/10.1182/blood-2011-11-394692

Published: 2012

Includes: Supplemental data

Journal Articles

S1P promotes murine progenitor cell egress and mobilization via S1P 1 -mediated ROS signaling and SDF-1 release

Karin Golan, Yaron Vagima, Aya Ludin, Tomer Itkin, Shiri Cohen-Gur, Alexander Kalinkovich, Orit Kollet, Chihwa Kim, Amir Schajnovitz, Yossi Ovadya, Kfir Lapid, Shoham Shivtiel, Andrew J. Morris, Mariusz Z. Ratajczak, Tsvee Lapidot

Blood (2012) 119 (11): 2478–2488.

https://doi.org/10.1182/blood-2011-06-358614

Published: 2012

Includes: Supplemental data

Journal Articles

Enhanced c-Met activity promotes G-CSF–induced mobilization of hematopoietic progenitor cells via ROS signaling

Blood (2011) 117 (2): 419–428.

https://doi.org/10.1182/blood-2009-06-230359

Published: 2011

Includes: Supplemental data

Journal Articles

The Chemotactic Lipid S1P Regulates Hematopoietic Progenitor Cell Egress and Mobilization Via Its Major Receptor S1P 1 and by SDF-1 Inhibition In a p38/Akt/mTOR Dependent Manner

Karin Golan, MSc, Yaron Vagima, PhD, Aya Ludin, DMD, MSc, Tomer Itkin, PhD, Alexander Kalinkovich, MD, PhD, Shiri Cohen-Gur, MSc, Orit Kollet, PhD, Amir Schajnovitz, MSc, Shoham Shivtiel, PhD, Tsvee Lapidot, PhD

Blood (2010) 116 (21): 553.

https://doi.org/10.1182/blood.V116.21.553.553

Published: 2010

Journal Articles

Expansion of Normal and Leukemic Hematopoietic Progenitor Cells by PTH Requires bFGF Activation of c-Kit and Its Downstream JAK2/STAT5 Signaling.

Tomer Itkin, MSc, Aya Ludin, DMD, MSc, Amir Schajnovitz, MSc, Alexander Kalinkovich, MD, PhD, Orit Kollet, PhD, Douglas J Coffin, PhD, Thorsten Berg, PhD, Wanda Piacibello, MD, Tsvee Lapidot, PhD

Blood (2009) 114 (22): 2511.

https://doi.org/10.1182/blood.V114.22.2511.2511

Published: 2009

Journal Articles

Functional SDF-1 Secretion from BM Stromal Cells Is a Cell Contact-Dependent Event Mediated by Cx43 and Cx45 Gap-Junctions

Amir Schajnovitz, MSc, Tomer Itkin, MSc, Aya Ludin, DMD, MSc, Alexander Kalinkovich, MD, PhD, Kfir Lapid, MSc, Rony Seger, PhD, Tsvee Lapidot, PhD

Blood (2008) 112 (11): 319.

https://doi.org/10.1182/blood.V112.11.319.319

Published: 2008

Journal Articles

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

Eike C. Buss, MD, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, MSc, Orit Kollet, PhD, Ayelet Dar, PhD, Melania Tesio, PhD, Stefan Fruehauf, MD, Marc Hotfilder, PhD, Anthony D. Ho, MD, Leonard D. Shultz, Tsvee Lapidot, PhD

Blood (2008) 112 (11): 1920.

https://doi.org/10.1182/blood.V112.11.1920.1920

Published: 2008

Journal Articles

AMD3100 Signals Via the Nervous System, Inducing Release to the Circulation of Bone Marrow SDF-1, Which Is Crucial for Progenitor Cell Mobilization.

Ayelet Dar, Alexander Kalinkovich, Neta Netzer, Ms, Raanan Margalit, Amir Schajnovitz, M.Sc, Francoise Baleux, Melania Tesio, M.Sc, Isabelle Petit, Tsvee Lapidot

Blood (2006) 108 (11): 1315.

https://doi.org/10.1182/blood.V108.11.1315.1315

Published: 2006

Journal Articles

The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components.

Melania Tesio, MSc, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, Msc, Ayelet Dar, PhD, Orit Kollet, PhD, Polinna Goichberg, PhD, Isabelle Petit, PhD, Silvia Giordano, MD,PhD, Massimo Aglietta, MD, Wanda Piacibello, MD, Tsvee Lapidot, PhD

Blood (2006) 108 (11): 3376.

https://doi.org/10.1182/blood.V108.11.3376.3376

Published: 2006

NARROW

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Untargeted Metabolomics Identifies Glutamine Metabolism As a Driver of Chemoresistance in Acute Myeloid Leukemia

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

Human and Murine β-Defensin-Derived Peptides Induce Rapid Mobilization Of Murine Hematopoietic Stem and Progenitor Cells Via Activation Of CXCR4 Signaling and CXCL12 Release

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation

S1P promotes murine progenitor cell egress and mobilization via S1P 1 -mediated ROS signaling and SDF-1 release

Enhanced c-Met activity promotes G-CSF–induced mobilization of hematopoietic progenitor cells via ROS signaling

The Chemotactic Lipid S1P Regulates Hematopoietic Progenitor Cell Egress and Mobilization Via Its Major Receptor S1P 1 and by SDF-1 Inhibition In a p38/Akt/mTOR Dependent Manner

Expansion of Normal and Leukemic Hematopoietic Progenitor Cells by PTH Requires bFGF Activation of c-Kit and Its Downstream JAK2/STAT5 Signaling.

Functional SDF-1 Secretion from BM Stromal Cells Is a Cell Contact-Dependent Event Mediated by Cx43 and Cx45 Gap-Junctions

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

AMD3100 Signals Via the Nervous System, Inducing Release to the Circulation of Bone Marrow SDF-1, Which Is Crucial for Progenitor Cell Mobilization.

The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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