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Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation
Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3
Improved outcome with rituximab in patients with HIV-associated multicentric Castleman disease
Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997
Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease
A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax
Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency
Issue Archive
September 29 2011
Table of Contents
Inside Blood
Plenary Paper
Hematopoiesis and Stem Cells
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor
Peilin Ma,Raghuveer Singh Mali,Veerendra Munugalavadla,Subha Krishnan,Baskar Ramdas,Emily Sims,Holly Martin,Joydeep Ghosh,Shuo Li,Rebecca J. Chan,Gerald Krystal,Andrew W. Craig,Clifford Takemoto,Reuben Kapur
Review Article
How I Treat
Clinical Trials and Observations
Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
Clinical Trials & Observations
Xavier C. Badoux,Michael J. Keating,Sijin Wen,Bang-Ning Lee,Mariela Sivina,James Reuben,William G. Wierda,Susan M. O'Brien,Stefan Faderl,Steven M. Kornblau,Jan A. Burger,Alessandra Ferrajoli
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation
Clinical Trials & Observations
Nicola Gökbuget,Nadezda Basara,Herrad Baurmann,Joachim Beck,Monika Brüggemann,Helmut Diedrich,Björn Güldenzoph,Gernot Hartung,Heinz-August Horst,Andreas Hüttmann,Guido Kobbe,Ralph Naumann,Richard Ratei,Albrecht Reichle,Hubert Serve,Matthias Stelljes,Andreas Viardot,Mohammed Wattad,Dieter Hoelzer
Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3
Clinical Trials & Observations
John D. Shaughnessy, Jr,Pingping Qu,Saad Usmani,Christoph J. Heuck,Qing Zhang,Yiming Zhou,Erming Tian,Ichiro Hanamura,Frits van Rhee,Elias Anaissie,Joshua Epstein,Bijay Nair,Owen Stephens,Ryan Williams,Sarah Waheed,Yazan Alsayed,John Crowley,Bart Barlogie
Gene Therapy
Immunobiology
Improved outcome with rituximab in patients with HIV-associated multicentric Castleman disease
Clinical Trials & Observations
Christian Hoffmann,Holger Schmid,Markus Müller,Christian Teutsch,Jan van Lunzen,Stefan Esser,Timo Wolf,Christoph Wyen,Michael Sabranski,Heinz-August Horst,Stefan Reuter,Martin Vogel,Hans Jäger,Johannes Bogner,Keikawus Arasteh
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
Ellen J. Wehrens,Gerdien Mijnheer,Chantal L. Duurland,Mark Klein,Jenny Meerding,Jorg van Loosdregt,Wilco de Jager,Birgit Sawitzki,Paul J. Coffer,Bas Vastert,Berent J. Prakken,Femke van Wijk
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
Rita Shaknovich,Leandro Cerchietti,Lucas Tsikitas,Matthias Kormaksson,Subhajyoti De,Maria E. Figueroa,Gianna Ballon,Shao Ning Yang,Nils Weinhold,Mark Reimers,Thomas Clozel,Karin Luttrop,Tomas J. Ekstrom,Jared Frank,Aparna Vasanthakumar,Lucy A. Godley,Franziska Michor,Olivier Elemento,Ari Melnick
Lymphoid Neoplasia
Follicular lymphoma tumor–infiltrating T-helper (TH) cells have the same polyfunctional potential as normal nodal TH cells despite skewed differentiation
Shannon P. Hilchey,Alexander F. Rosenberg,Ollivier Hyrien,Shelley Secor-Socha,Matthew R. Cochran,Michael T. Brady,Jyh-Chiang E. Wang,Iñaki Sanz,W. Richard Burack,Sally A. Quataert,Steven H. Bernstein
The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
Julia Hoellenriegel,Sarah A. Meadows,Mariela Sivina,William G. Wierda,Hagop Kantarjian,Michael J. Keating,Neill Giese,Susan O'Brien,Albert Yu,Langdon L. Miller,Brian J. Lannutti,Jan A. Burger
Myeloid Neoplasia
Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997
Brief Report
Mitchell R. Smith,Donna Neuberg,Ian W. Flinn,Michael R. Grever,Hillard M. Lazarus,Jacob M. Rowe,Gordon Dewald,John M. Bennett,Elisabeth M. Paietta,John C. Byrd,Mohamad A. Hussein,Frederick R. Appelbaum,Richard A. Larson,Mark R. Litzow,Martin S. Tallman
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD–induced myeloproliferation
Shabnam Kharazi,Adam J. Mead,Anna Mansour,Anne Hultquist,Charlotta Böiers,Sidinh Luc,Natalija Buza-Vidas,Zhi Ma,Helen Ferry,Debbie Atkinson,Kristian Reckzeh,Kristina Masson,Jörg Cammenga,Lars Rönnstrand,Fumio Arai,Toshio Suda,Claus Nerlov,Ewa Sitnicka,Sten Eirik W. Jacobsen
SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome–positive cells derived from patients with chronic myeloid leukemia
Nicola Esposito,Irene Colavita,Concetta Quintarelli,Agostino Rodeo Sica,Anna Lucia Peluso,Luigia Luciano,Marco Picardi,Luigi Del Vecchio,Tonia Buonomo,Timothy P. Hughes,Deborah White,Jerald P. Radich,Domenico Russo,Susan Branford,Giuseppe Saglio,Junia V. Melo,Rosanna Martinelli,Margherita Ruoppolo,Thea Kalebic,Giovanni Martinelli,Fabrizio Pane
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
Iris H. I. M. Hollink,Marry M. van den Heuvel-Eibrink,Susan T. C. J. M. Arentsen-Peters,Marta Pratcorona,Saman Abbas,Jenny E. Kuipers,Janneke F. van Galen,H. Berna Beverloo,Edwin Sonneveld,Gert-Jan J. L. Kaspers,Jan Trka,Andre Baruchel,Martin Zimmermann,Ursula Creutzig,Dirk Reinhardt,Rob Pieters,Peter J. M. Valk,C. Michel Zwaan
Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease
Brief Report
Jean-Claude Chomel,Marie-Laure Bonnet,Nathalie Sorel,Angelina Bertrand,Marie-Claude Meunier,Serge Fichelson,Michael Melkus,Annelise Bennaceur-Griscelli,François Guilhot,Ali G. Turhan
Platelets and Thrombopoiesis
Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease
Alec A. Schmaier,Timothy J. Stalker,Jeffrey J. Runge,Dooyoung Lee,Chandrasekaran Nagaswami,Patricia Mericko,Mei Chen,Simon Cliché,Claude Gariépy,Lawrence F. Brass,Daniel A. Hammer,John W. Weisel,Karen Rosenthal,Mark L. Kahn
Red Cells, Iron, and Erythropoiesis
A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax
e-blood
Bruce Russell,Rossarin Suwanarusk,Céline Borlon,Fabio T. M. Costa,Cindy S. Chu,Marcus J. Rijken,Kanlaya Sriprawat,Lucile Warter,Esther G. L. Koh,Benoit Malleret,Yves Colin,Olivier Bertrand,John H. Adams,Umberto D'Alessandro,Georges Snounou,Francois Nosten,Laurent Rénia
Thrombosis and Hemostasis
Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model
Pauline M. van Helden,Sabine Unterthurner,Corinna Hermann,Maria Schuster,Rafi U. Ahmad,Alexandra N. Schiviz,Markus Weiller,Gerhard Antoine,Peter L. Turecek,Eva M. Muchitsch,Hans Peter Schwarz,Birgit M. Reipert
Transplantation
Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency
Clinical Trials & Observations
Jennifer Cuellar-Rodriguez,Juan Gea-Banacloche,Alexandra F. Freeman,Amy P. Hsu,Christa S. Zerbe,Katherine R. Calvo,Jennifer Wilder,Roger Kurlander,Kenneth N. Olivier,Steven M. Holland,Dennis D. Hickstein
Vascular Biology
Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer
Kristiina Aalto,Anu Autio,Elina A. Kiss,Kati Elima,Yvonne Nymalm,Tibor Z. Veres,Fumiko Marttila-Ichihara,Heli Elovaara,Tiina Saanijoki,Paul R. Crocker,Mikael Maksimow,Eva Bligt,Tiina A. Salminen,Marko Salmi,Anne Roivainen,Sirpa Jalkanen
Endothelial progenitor cell–dependent angiogenesis requires localization of the full-length form of uPAR in caveolae
Francesca Margheri,Anastasia Chillà,Anna Laurenzana,Simona Serratì,Benedetta Mazzanti,Riccardo Saccardi,Michela Santosuosso,Giovanna Danza,Niccolò Sturli,Fabiana Rosati,Lucia Magnelli,Laura Papucci,Lido Calorini,Francesca Bianchini,Mario Del Rosso,Gabriella Fibbi
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Cover Image
Cover Image
Colorized scanning electron micrograph of avian thrombocytes (red) adherent to collagen (turquoise blue) under flow. Thrombocytes have nuclei, are larger than platelets, and do not spread as well or form shear-resistant, occlusive aggregates. In contrast, mammalian platelets have evolved to favor more efficient hemostatic responses to trauma, but at the same time, predispose humans to myocardial infarction and stroke. Credit: Y. I. Veklich, C. Nagaswami, A. A. Schmaier, M. L. Kahn, J.W.Weisel. See the article by Schmaier et al, page 3661.
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