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Guoying Zhang
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Journal Articles

Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis

Yan Zhang, Guoying Zhang, Cui Jian, Congqing Wu, PhD, Nigel Mackman, PhD, Susan Smyth, MD PhD, Yinan Wei, Zhenyu Li, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3644.
https://doi.org/10.1182/blood-2019-130439
Published: 2019
Journal Articles

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis

Madhu M. Ouseph, Yunjie Huang, Meenakshi Banerjee, Smita Joshi, Laura MacDonald, Yu Zhong, Huijuan Liu, Xianting Li, Binggang Xiang, Guoying Zhang, Masaaki Komatsu, Zhenyu Yue, Zhenyu Li, Brian Storrie, Sidney W. Whiteheart, Qing Jun Wang
Journal: Blood
Blood (2015) 126 (10): 1224–1233.
https://doi.org/10.1182/blood-2014-09-598722
Published: 2015
Includes: Supplemental data
Journal Articles

VPS33B, a Member of the Sec1/Munc18 Protein Family, Binds to Integrin Beta Subunits and Is Required for α IIb β 3 Outside-in Signaling

Binggang Xiang, PhD, Guoying Zhang, MD, Shaojing Ye, MD PhD, Cai Huang, PhD, Jun Liu, MD PhD, Changgeng Ruan, Susan S. Smyth, MD PhD, Sidney W. Whiteheart, PhD, Zhenyu Li, MD PhD
Journal: Blood
Blood (2014) 124 (21): 340.
https://doi.org/10.1182/blood.V124.21.340.340
Published: 2014
Journal Articles

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

Jingyan Han, Guoying Zhang, Emily J. Welch, Ying Liang, Jian Fu, Stephen M. Vogel, Clifford A. Lowell, Xiaoping Du, David A. Cheresh, Asrar B. Malik, Zhenyu Li
Journal: Blood
Blood (2013) 122 (25): 4140–4149.
https://doi.org/10.1182/blood-2013-03-491423
Published: 2013
Includes: Supplemental data
Journal Articles

Platelets Protect From Lipopolysaccharide-Induced Lethal Endotoxemia by Inhibiting Macrophage-Dependent Inflammation Via the Cyclooxygenase 1 (COX1) Signaling Pathway

Binggang Xiang, PhD, Guoying Zhang, MD, Xiang-An Li, Ph.D, Andrew J. Morris, PhD, Alan Daugherty, Ph.D, Sidney W. Whiteheart, PhD, Susan S. Smyth, MD, PhD, Zhenyu Li, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 93.
https://doi.org/10.1182/blood.V120.21.93.93
Published: 2012
Journal Articles

Src Family Kinases Contribute to G I and G q -Mediated Platelet Activation

Binggang Xiang, PhD, Guoying Zhang, Zhenyu Li, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 5263.
https://doi.org/10.1182/blood.V118.21.5263.5263
Published: 2011
Journal Articles

DISTINCT ROLES for Rap1b In PLATELET SECRETION and INTEGRIN a IIB b 3 OUTSIDE-In SIGNALING

Guoying Zhang, Binggang Xiang, PhD, Ye Shaojing, Magdalena Chrzanowska-Wodnicka, Andrew J. Morris, PhD, T. Kent Gartner, PhD, Sidney W. Whiteheart, PhD, Gilbert C. White, II II, MD, Susan S. Smyth, MD, PhD, Zhenyu Li, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2200.
https://doi.org/10.1182/blood.V118.21.2200.2200
Published: 2011
Journal Articles

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

Guoying Zhang, Binggang Xiang, Anping Dong, Radek C. Skoda, Alan Daugherty, Susan S. Smyth, Xiaoping Du, Zhenyu Li
Journal: Blood
Blood (2011) 118 (13): 3670–3679.
https://doi.org/10.1182/blood-2011-03-341107
Published: 2011
Includes: Supplemental data
Journal Articles

A novel P2Y 12 -Independent Signaling Pathway Mediating Akt Phosphorylation In Response to Thrombin Receptors

Binggang Xiang, PhD, Guoying Zhang, Junling Liu, Andrew J. Morris, PhD, Susan S. Smyth, MD, PhD, T. Kent Gartner, PhD, Zhenyu Li, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3191.
https://doi.org/10.1182/blood.V116.21.3191.3191
Published: 2010
Journal Articles

Biphasic Roles for the Soluble Guanylyl Cyclase (sGC) In Platelet Activation In Mice

Guoying Zhang, Binggang Xiang, PhD, Radek C. Skoda, MD, Susan S. Smyth, MD, PhD, Xiaoping Du, MD, PhD, Zhenyu Li, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 486.
https://doi.org/10.1182/blood.V116.21.486.486
Published: 2010
Journal Articles

Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK–dependent integrin outside-in retractile signaling pathway

Panagiotis Flevaris, Zhenyu Li, Guoying Zhang, Yi Zheng, Junling Liu, Xiaoping Du
Journal: Blood
Blood (2009) 113 (4): 893–901.
https://doi.org/10.1182/blood-2008-05-155978
Published: 2009
Journal Articles

LPS Stimulates Platelet Secretion and Promotes Platelet Aggregation Via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway.

Guoying Zhang, MD, Emily Welch, BS, Asrar B. Malik, PhD, Xiaoping Du, MD, PhD, Zhenyu Li, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 3658.
https://doi.org/10.1182/blood.V110.11.3658.3658
Published: 2007
Journal Articles

Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin α IIb β 3

Zhenyu Li, Guoying Zhang, Robert Feil, Jiahuai Han, Xiaoping Du
Journal: Blood
Blood (2006) 107 (3): 965–972.
https://doi.org/10.1182/blood-2005-03-1308
Published: 2006
Journal Articles

The Role of the cGMP-Dependent Protein Kinase II in Platelet Activation and In Vivo Thrombosis.

Zhenyu Li, MD, PhD, Guoying Zhang, MD, Hong Yin, MD, Robert Feil, PhD, Franz Hofmann, PhD, Xiaoping Du, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 653.
https://doi.org/10.1182/blood.V106.11.653.653
Published: 2005