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Issue Archive

Volume 114, Issue 5
July 30 2009
Issue Cover

Table of Contents

INSIDE BLOOD

GENE THERAPY
Mutagenesis of hexon “FX” hepatic tropism
Eric J. Kremer
View Articletitled, Mutagenesis of hexon “<em>FX</em>” hepatic tropism
CLINICAL TRIALS
Avoiding “sticker” shock
David Green
View Articletitled, Avoiding “sticker” shock
INSIDE BLOOD
Bortezomib paradigm shift in myeloma
David J. McConkey
View Articletitled, Bortezomib paradigm shift in myeloma
PLATELETS & THROMBOPOIESIS
Granules and thrombus formation
Walter H. A. Kahr
View Articletitled, Granules and thrombus formation
THROMBOSIS & HEMOSTASIS
When 1 plus 1 equals 3 in VWD
Anne C. Goodeve
View Articletitled, When 1 plus 1 equals 3 in VWD
VASCULAR BIOLOGY
Functional redundancy of Ets1 and Ets2
Peter Oettgen
View Articletitled, Functional redundancy of Ets1 and Ets2

PERSPECTIVE

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
James W. Vardiman,Jüergen Thiele,Daniel A. Arber,Richard D. Brunning,Michael J. Borowitz,Anna Porwit,Nancy Lee Harris,Michelle M. Le Beau,Eva Hellström-Lindberg,Ayalew Tefferi,Clara D. Bloomfield
View Articletitled, The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

CLINICAL TRIALS AND OBSERVATIONS

Outcomes and predictors of very stable INR control during chronic anticoagulation therapy
Clinical Trials & Observations
Daniel M. Witt,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Thomas Delate,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Nathan P. Clark,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Chad Martell,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Thu Tran,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Mark A. Crowther,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,David A. Garcia,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Walter Ageno,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium,Elaine M. Hylek,on behalf of the Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium
View Articletitled, Outcomes and predictors of very stable INR control during chronic anticoagulation therapy
De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience
Clinical Trials & Observations
Constantine S. Tam,Tait D. Shanafelt,William G. Wierda,Lynne V. Abruzzo,Daniel L. Van Dyke,Susan O'Brien,Alessandra Ferrajoli,Susan A. Lerner,Alice Lynn,Neil E. Kay,Michael J. Keating
View Articletitled, De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience

GENE THERAPY

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer
Raul Alba,Angela C. Bradshaw,Alan L. Parker,David Bhella,Simon N. Waddington,Stuart A. Nicklin,Nico van Rooijen,Jerome Custers,Jaap Goudsmit,Dan H. Barouch,John H. McVey,Andrew H. Baker
View Articletitled, Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells
Génève Awong,Elaine Herer,Charles D. Surh,John E. Dick,Ross N. La Motte-Mohs,Juan Carlos Zúñiga-Pflücker
View Articletitled, Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells
Supplemental data
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate
Stella T. Chou,Eugene Khandros,L. Charles Bailey,Kim E. Nichols,Christopher R. Vakoc,Yu Yao,Zan Huang,John D. Crispino,Ross C. Hardison,Gerd A. Blobel,Mitchell J. Weiss
View Articletitled, Graded repression of <em>PU.1/Sfpi1</em> gene transcription by GATA factors regulates hematopoietic cell fate
Supplemental data
The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms
Sarah L. Siggins,Nhu-Y N. Nguyen,Matthew P. McCormack,Sumitha Vasudevan,Rehan Villani,Stephen M. Jane,Brandon J. Wainwright,David J. Curtis
View Articletitled, The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms
Supplemental data

IMMUNOBIOLOGY

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
Chongyun Fang,Xinhua Zhang,Takashi Miwa,Wen-Chao Song
View Articletitled, Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
HTLV-1–Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse
Mohamed Nejmeddine,Veera S. Negi,Sohini Mukherjee,Yuetsu Tanaka,Kim Orth,Graham P. Taylor,Charles R. M. Bangham
View Articletitled, HTLV-1–Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse
Supplemental data
Abundant c-Fas–associated death domain–like interleukin-1–converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death
Brief Report
Yu Yu,Cristina Iclozan,Tomohide Yamazaki,Xuexian Yang,Claudio Anasetti,Chen Dong,Xue-Zhong Yu
View Articletitled, Abundant c-Fas–associated death domain–like interleukin-1–converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death
Supplemental data

LYMPHOID NEOPLASIA

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406
Maite P. Quiroga,Kumudha Balakrishnan,Antonina V. Kurtova,Mariela Sivina,Michael J. Keating,William G. Wierda,Varsha Gandhi,Jan A. Burger
View Articletitled, B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406
Supplemental data
WT1 mutations in T-ALL
Valeria Tosello,Marc R. Mansour,Kelly Barnes,Maddalena Paganin,Maria Luisa Sulis,Sarah Jenkinson,Christopher G. Allen,Rosemary E. Gale,David C. Linch,Teresa Palomero,Pedro Real,Vundavalli Murty,Xiaopan Yao,Susan M. Richards,Anthony Goldstone,Jacob Rowe,Giuseppe Basso,Peter H. Wiernik,Elisabeth Paietta,Rob Pieters,Martin Horstmann,Jules P. P. Meijerink,Adolfo A. Ferrando
View Articletitled, <em>WT1</em> mutations in T-ALL
Supplemental data
Bortezomib induces canonical nuclear factor-κB activation in multiple myeloma cells
Teru Hideshima,Hiroshi Ikeda,Dharminder Chauhan,Yutaka Okawa,Noopur Raje,Klaus Podar,Constantine Mitsiades,Nikhil C. Munshi,Paul G. Richardson,Ruben D. Carrasco,Kenneth C. Anderson
View Articletitled, Bortezomib induces canonical nuclear factor-κB activation in multiple myeloma cells
Supplemental data
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response
Marc Remke,Stefan Pfister,Corinne Kox,Grischa Toedt,Natalia Becker,Axel Benner,Wiebke Werft,Stephen Breit,Shuangyou Liu,Felix Engel,Andrea Wittmann,Martin Zimmermann,Martin Stanulla,Martin Schrappe,Wolf-Dieter Ludwig,Claus R. Bartram,Bernhard Radlwimmer,Martina U. Muckenthaler,Peter Lichter,Andreas E. Kulozik
View Articletitled, High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response
Supplemental data

MYELOID NEOPLASIA

Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome
Ken I. Mills,Alexander Kohlmann,P. Mickey Williams,Lothar Wieczorek,Wei-min Liu,Rachel Li,Wen Wei,David T. Bowen,Helmut Loeffler,Jesus M. Hernandez,Wolf-Karsten Hofmann,Torsten Haferlach
View Articletitled, Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

β-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation
Raffaella Molteni,Carolina Lage Crespo,Sara Feigelson,Christian Moser,Monica Fabbri,Valentin Grabovsky,Fritz Krombach,Carlo Laudanna,Ronen Alon,Ruggero Pardi
View Articletitled, β-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation
Supplemental data

PLATELETS AND THROMBOPOIESIS

Endobrevin/VAMP-8–dependent dense granule release mediates thrombus formation in vivo
Gwenda J. Graham,Qiansheng Ren,James R. Dilks,Price Blair,Sidney W. Whiteheart,Robert Flaumenhaft
View Articletitled, Endobrevin/VAMP-8–dependent dense granule release mediates thrombus formation in vivo
Supplemental data

THROMBOSIS AND HEMOSTASIS

A novel deletion mutation is recurrent in von Willebrand disease types 1 and 3
Megan S. Sutherland,Anthony M. Cumming,Mackenzie Bowman,Paula H. B. Bolton-Maggs,Derrick J. Bowen,Peter W. Collins,Charles R. M. Hay,Andrew M. Will,Stephen Keeney
View Articletitled, A novel deletion mutation is recurrent in von Willebrand disease types 1 and 3

TRANSPLANTATION

TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
Holbrook E. Kohrt,Brit B. Turnbull,Kartoosh Heydari,Judith A. Shizuru,Ginna G. Laport,David B. Miklos,Laura J. Johnston,Sally Arai,Wen-Kai Weng,Richard T. Hoppe,Philip W. Lavori,Karl G. Blume,Robert S. Negrin,Samuel Strober,Robert Lowsky
View Articletitled, TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors
Supplemental data

VASCULAR BIOLOGY

An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis
Roland E. Kälin,Nadja E. Bänziger-Tobler,Michael Detmar,André W. Brändli
View Articletitled, An in vivo chemical library screen in <em>Xenopus</em> tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis
Supplemental data
Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis
Guo Wei,Ruchika Srinivasan,Carmen Z. Cantemir-Stone,Sudarshana M. Sharma,Ramasamy Santhanam,Michael Weinstein,Natarajan Muthusamy,Albert K. Man,Robert G. Oshima,Gustavo Leone,Michael C. Ostrowski
View Articletitled, <em>Ets1</em> and <em>Ets2</em> are required for endothelial cell survival during embryonic angiogenesis
Supplemental data

CORRESPONDENCE

SPRED1 disorder and predisposition to leukemia in children
Eric Pasmant,Paola Ballerini,Helene Lapillonne,Christine Perot,Dominique Vidaud,Guy Leverger,Judith Landman-Parker
View Articletitled, <em>SPRED1</em> disorder and predisposition to leukemia in children
All Issues

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