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Journal Articles

The Favorable Effect of Activating NOTCH1 Receptor Mutations On Long Term Outcome in T-ALL Is Treatment Related and Can Be Separated From NOTCH Pathway Activation by FBXW7 Loss of Function.

Corinne Kox, Martin Zimmermann, PhD, Martin Stanulla, MD, Martin Schrappe, MD, Wolf-Dieter Ludwig, Rolf Koehler, PhD, Svenja Leible, Gabriele Tolle, Obul Reddy Bandapalli, Stephen Breit, Martina Ulrike Muckenthaler, Andreas Kulozik, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 908.
https://doi.org/10.1182/blood.V114.22.908.908
Published: 2009
Journal Articles

The Second Signal in Antigen-Presenting Cells: Complementary JAK-1 Directs Pro- and Anti-Inflammatory Cytokine Production Induced by CD40L.

Michael Conzelmann, Andreas Wagner, Anke Hildebrandt, Elena Rodionova, Michael Hess, Annika Zota, Thomas Giese, Christine Falk, Stephen Breit, Markus Hecker, Anthony D. Ho, Peter Dreger, Thomas Luft
Journal: Blood
Blood (2009) 114 (22): 1348.
https://doi.org/10.1182/blood.V114.22.1348.1348
Published: 2009
Journal Articles

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

Marc Remke, Stefan Pfister, Corinne Kox, Grischa Toedt, Natalia Becker, Axel Benner, Wiebke Werft, Stephen Breit, Shuangyou Liu, Felix Engel, Andrea Wittmann, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Wolf-Dieter Ludwig, Claus R. Bartram, Bernhard Radlwimmer, Martina U. Muckenthaler, Peter Lichter, Andreas E. Kulozik
Journal: Blood
Blood (2009) 114 (5): 1053–1062.
https://doi.org/10.1182/blood-2008-10-186536
Published: 2009
Includes: Supplemental data
Journal Articles

The Second Signal in Antigen-Presenting Cells: Complementary JAK1/JAK2 and CD40 Signalling Mediate Pro-Inflammatory Activation.

Michael Conzelmann, Elena Rodionova, Michael Hess, Annika Zota, Thomas Giese, Andreas Wagner, Stephen Breit, Markus Hecker, Anthony D. Ho, Peter Dreger, Thomas Luft
Journal: Blood
Blood (2008) 112 (11): 1261.
https://doi.org/10.1182/blood.V112.11.1261.1261
Published: 2008
Journal Articles

Notch Pathway Activation by a Combination of Activating NOTCH1 -Receptor and Inactivating FBXW7 Mutations Robustly Predicts Excellent Early Treatment Response in Pediatric T-ALL.

Corinne Kox, Svenja Leible, Stephen Breit, Martin Stanulla, MD, Martin Schrappe, MD, Martina Ulrike Muckenthaler, Andreas Kulozik
Journal: Blood
Blood (2008) 112 (11): 1493.
https://doi.org/10.1182/blood.V112.11.1493.1493
Published: 2008
Journal Articles

The Early Treatment Response of the Clinically Challenging Group of Childhood T-ALL without NOTCH1 Mutations Is Signified by a Specific mRNA Gene Profile.

Andreas Kulozik, Stephen Breit, Stefan Pfister, Shangyou Liu, Martin Stanulla, Martin Schrappe, Wolf-Dieter Ludwig, Ulrike Köhl, Arndt Borkhardt, Renate Kirschner-Schwabe, Martina U. Muckenthaler
Journal: Blood
Blood (2007) 110 (11): 2789.
https://doi.org/10.1182/blood.V110.11.2789.2789
Published: 2007
Journal Articles

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia

Clinical Trials & Observations
Stephen Breit, Martin Stanulla, Thomas Flohr, Martin Schrappe, Wolf-Dieter Ludwig, Gabriele Tolle, Margit Happich, Martina U. Muckenthaler, Andreas E. Kulozik
Journal: Blood
Blood (2006) 108 (4): 1151–1157.
https://doi.org/10.1182/blood-2005-12-4956
Published: 2006
Includes: Supplemental data
Journal Articles

Activating NOTCH1 Mutations Are Associated with Good Treatment Response in Childhood T-Cell Acute Lymphoblastic Leukemia.

Stephen Breit, PhD, Martin Stanulla, MD, Thomas Flohr, PhD, Martin Schrappe, MD, Wolf-Dieter Ludwig, MD, Gabriele Tolle, Margit Happich, Martina M. Muckenthaler, PhD, Andreas E. Kulozik, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 1444.
https://doi.org/10.1182/blood.V106.11.1444.1444
Published: 2005