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Hélène Lapillonne
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Journal Articles

Progressive chromatin rewiring by ETO2::GLIS2 revealed in a human iPSC model of pediatric leukemia initiation

Fabien Boudia, Marie Baille, Loelia Babin, Zakia Aid, Elie Robert, Julie Riviere, Klaudia Galant, Verónica Alonso-Pérez, Laura Anselmi, Brahim Arkoun, Nassera Abermil, Christophe Marzac, Salvatore Nicola Bertuccio, Alexia Regnault de Premesnil, Cecile K. Lopez, Alexandre Eeckhoutte, Audrey Naimo, Betty Leite, Cyril Catelain, Christophe Metereau, Patrick Gonin, Nathalie Gaspar, Juerg Schwaller, Olivier A Bernard, Hana Raslova, Murielle Gaudry, Antonin Marchais, Hélène Lapillonne, Arnaud Petit, Francoise Pflumio, Marie-Laure Arcangeli, Erika Brunet, Thomas Mercher
Journal: Blood
Blood blood.2024024505.
https://doi.org/10.1182/blood.2024024505
Published: 2024
Includes: Supplemental data
Journal Articles

Flow MRD Monitoring Combining Laip/Dfn and CD34+CD38- LSCs Is a Strong Predictor of Outcome in Adult AML Independently of the ELN-2022 Risk: First Results from the Multicentric Acute Leukemia French Intergroup MRD Flow Network

Adriana Plesa, Stéphanie Mathis, Florent Dumezy, Anne-Catherine Lhoumeau, Veronique Saada, Isabelle Arnoux, Jennifer Osman, Nicolas Chapuis, Franck Geneviève, Mikael Roussel, Delphine Manzoni, Anne Roggy, Remi Letestu, Veronique Harrivel, Elsa Bera, Jean Feuillard, Hélène Lapillonne, Richard Veyrat-Masson, Tatiana Raskovalova, Bouchra Badaoui, Valerie Bardet, Caroline Mayeur-Rousse, Francois Vergez, Jean Philippe Vial, Valerie Goncalves Monteiro, Frédéric Feger, Dominique Penther, Isabelle Luquet, Eric Delabesse, Nicolas Duployez, Karine Celli-Lebras, Mathilde Hunault, Raphael Itzykson, Arnaud Pigneux, Christian Récher, Hervé Dombret, Claude Preudhomme, Christophe Roumier
Journal: Blood
Blood (2024) 144 (Supplement 1): 226.
https://doi.org/10.1182/blood-2024-205457
Published: 2024
Journal Articles

Favourable Outcomes in Newly Diagnosed Paediatric AML with Gemtuzumab Ozogamicin and Risk-Stratified Therapy: Results from the International Phase III Myechild 01 Trial

Brenda Gibson, Andre Baruchel, Andrew Moore, Shanna Maycock, Owen Smith, Geoff Shenton, Jean-Pierre Bourquin, Yves Bertrand, Nicholas Heaney, Anna Lawson, Persis Jal Amrolia, Gerard Michel, Jean-Hugues Dalle, Marc Ansari, Hélène Lapillonne, Richard Dillon, Jelena Jovanovic, Siobhan Cross, Paul Virgo, Lucy Wheeler, Christophe Roumier, Nicolas Duployez, Christine Harrison, Claire Schwab, Wendy Cuccuini, Marina Lafage-Pochitaloff, Claude Preudhomme, Paresh Vyas, Pierre Hirsch, Gareth Veal, David Gillis, Pam Kearns, Guy Leverger, Phil Ancliff, Aimee Jackson, Arnaud Petit
Journal: Blood
Blood (2024) 144 (Supplement 1): 968.
https://doi.org/10.1182/blood-2024-198419
Published: 2024
Journal Articles

Childhood Langerhans cell histiocytosis hematological involvement: severity associated with BRAFV600E loads

Julian Thalhammer, Eric Jeziorski, Perrrine Marec-Berard, Mohamed-Aziz Barkaoui, Anne Pagnier, Pierre-Simon Rohrlich, Aurore Chevallier, Liana Carausu, Nathalie Aladjidi, Charlotte Rigaud, Amaury Leruste, Saba Azarnoush, Thomas Lauvray, Solenne Le Louet, Virginie Gandemer, Pauline Treguier, Ludovic Mansuy, Marlène Pasquet, Laura Olivier, Angélique Rome, Paul Saultier, Florentina Isfan, Cecile Renard, Valérie Li Thiao Te, Alexandra Salmon, Laurence Blanc, Wadih Abou Chahla, Anne Lambilliotte, Jean-Louis Louis Stephan, Frederic Geissmann, Julien Lejeune, Coralie Mallebranche, Yves Reguerre, Audrey Grain, Caroline Thomas, Zofia Hélias-Rodzewicz, Despina Moshous, Odile Fenneteau, Aurore Coulomb-L'hermine, Hélène Lapillonne, Geneviève de Saint Basile, Jean-Francois Emile, Sébastien Héritier, Jean Donadieu
Journal: Blood
Blood blood.2024025625.
https://doi.org/10.1182/blood.2024025625
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes for Children with High Risk Acute Myeloid Leukemia on the Myechild 01 International Phase III Clinical Trial

Andrew Moore, Shanna Maycock, Guy Leverger, Owen Smith, Andre Baruchel, Yves Bertrand, Phil Ancliff, Nicholas Heaney, Geoff Shenton, Arnaud Petit, Jean-Pierre Bourquin, Aimee Jackson, Anna Lawson, Persis Amrolia, Gerard Michel, Jean-Hugues Dalle, Marc Ansari, Hélène Lapillonne, Richard Dillon, Jelena Jovanovic, Christophe Roumier, Nicolas Duployez, Christine Harrison, Claire Schwab, Wendy Cuccuini, Marina Lafage-Pochitaloff, Paresh Vyas, Pierre Hirsch, Gareth Veal, Pam Kearns, Brenda Gibson
Journal: Blood
Blood (2023) 142 (Supplement 1): 730.
https://doi.org/10.1182/blood-2023-181593
Published: 2023
Journal Articles

AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network

Adriana Plesa, Florent Dumezy, Stéphanie Mathis, Anne-Catherine Lhoumeau, Valerie Bardet, Véronique Saada, Isabelle Arnoux, Bouchra Badaoui, Edouard Cornet, Jennifer Osman, Estelle Guerin, Nicolas Chapuis, Franck Genevieve, Rémi Letestu, Delphine Manzoni, Anne Roggy, Mikael Roussel, Véronique Harrivel, Elsa Bera, Caroline Mayeur-Rousse, Hélène Lapillonne, Richard Veyrat-Masson, Lydia Campos, Magali Le Garff-Tavernier, Tatiana Raskovalova, Francois Vergez, Julien Guy, Agnes Charpentier, Claire Hemar, Valerie Goncalves Monteiro, Frederic Fegier, Karine Celli-Lebras, Raphael Itzykson, Herve Dombret, Claude Preudhomme, Christophe Roumier
Journal: Blood
Blood (2022) 140 (Supplement 1): 6279–6281.
https://doi.org/10.1182/blood-2022-169696
Published: 2022
Journal Articles

Oral SGLT2 Inhibitors in Glycogen Storage Disease Type Ib and G6PC3-Deficiency. Preliminary Results from an Off-Label Study of 21 Patients

Jean Donadieu, Aurelia Alimi, Anais Brassier, Blandine Beaupain, Camille Wicker, jean-Meidi Alili, Christine Bellanne-Chantelot, Amelie Chaussade, Martin Castelle, Mathlide Lamarque, Isabelle Plo, Lea Durix, Aude Pion, Sylvie Souquere, Caroline Marty, Pierre Simon Rohrlich, Karine Mention, Wadih Abouchahla, Marie Szymanowski, Myriam Dao, Felipe Suarez, Paola Parronchi, Boaz Palterer, Noemie Urvoy, Hélène Lapillonne, Fabrizio Andreelli, Emile Van Schaftingen, Philippe Labrune, Pascale De Lonlay, Maria Veiga Da Cunha
Journal: Blood
Blood (2022) 140 (Supplement 1): 8320–8322.
https://doi.org/10.1182/blood-2022-169243
Published: 2022
Journal Articles

Treatment Outcomes of Childhood Picalm:MLLT10 + Acute Leukemias: An International Retrospective Study

Catherine Mark, Edward A. Kolb, Bianca F. Goemans, Soheil Meshinchi, Brenda Gibson, Anke K. Bergmann, Christine J. Harrison, Cornelis Jan Pronk, Hélène Lapillonne, Guy Leverger, Evangelia Antoniou, Andishe Attarbaschi, Michael Dworzak, Jan Stary, Daisuke Tomizawa, Monika Lejman, Kjeld Schmiegelow, Henrik Hasle, Brooklyn Joyce, Markus Schneider, Oussama Abla
Journal: Blood
Blood (2022) 140 (Supplement 1): 3403–3404.
https://doi.org/10.1182/blood-2022-156731
Published: 2022
Journal Articles

Multiparametric Flow Cytometry Evaluation of CD200L/CD200R- LSC/NK Synapse Including Leukemia Stem Cell (LSC) Fraction As a Potential Therapeutic Target and Marker of NK Cell Exhaustion in Pediatric AML-Conect-AML French Collaborative Network

Adriana Plesa, Octavia Cadassou, Joris Gutrin, Marine Villard, Christophe Roumier, Meyling Cheok, Florent Dumezy, Claude Preudhomme, Hélène Lapillonne, Arnaud Petit, Guy Leverger, Carine Halfon-Domenech, Cecile Renard, Yves Bertrand, Charles Dumontet, Sebastien Viel, Veronique Maguer-Satta, Thierry Walzer
Journal: Blood
Blood (2021) 138 (Supplement 1): 2375.
https://doi.org/10.1182/blood-2021-154181
Published: 2021
Journal Articles

Impact of Allogeneic Hematopoietic Stem Cell Transplantation in First Complete Remission and Additional Cytogenetic Aberrations at Diagnosis on Prognosis in 1256 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, Christine J. Harrison, Hester A. De Groot-Kruseman, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael Dworzak, Sarah Elitzur, José M. Fernández Navarro, Marta Fiocco, Robert B. Gerbing, Bianca F. Goemans, Erin Guest, Shau-Yin Ha, Henrik Hasle, Kathy Jackson, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Daisuke Tomizawa, Femke Verwer, C. Michel Zwaan, Gertjan J.L. Kaspers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2360.
https://doi.org/10.1182/blood-2021-148041
Published: 2021
Journal Articles

Impact and Dynamics of TP53 Mutated Clones in Shwachman Diamond Syndrome in a Series of 80 Patients

Jean-Alain Martignoles, Pierre Hirsch, MD PhD, Blandine Beaupain, Thomas Longval, MD, Nawa Hachem, MsC, Mira El-Khoury, PhD, Sophie Kaltenbach, Jean Soulier, MDPhD, Thierry Leblanc, MD, Pierre Simon Rohrlich, MDPhD, Eric Jeziorski, MDPhD, Isabelle Meyts, Dalila Adjaoud, MD, Vincent Barlogis, MD, PhD, Marlène Pasquet, MD, PhD, Laetitia Largeaud, Flore Sicre de Fontbrune, Claire Fieschi, MD PhD, Virginie Gandemer, MD PhD, Nathalie Aladjidi, MD, Fanny Fouyssac, MD, Guy Leverger, MD, Wadih Abou Chahla, MD, Stephane Blanche, MD, Despina Moushous, MD PhD, Aline Moignet Autrel, MD, Yves Bertrand, MD, Cecile Renard, Pascale Flandrin-Gresta, MD, Jean Louis Stephan, MDPhD, Olivier Tournilhac, MD PhD, Liana Carausu, Frederic Millot, MD, Marielaure Couec, MD, Claude Preudhomme, MD PhD, Hélène Lapillonne, MD PhD, Vahid Asnafi, MD PhD, Patrick Revy, Christine Bellanne-Chantelot, PhD PharmD, Francois Delhommeau, MD PhD, Jean Donadieu, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-138540
Published: 2020
Journal Articles

Outcome of (Novel) Subgroups in 1257 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia (AML) and the Significance of Minimal Residual Disease (MRD) Status: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, MD, Bianca F. Goemans, MD PhD, Christian M. Zwaan, MD PhD, Hester A. De Groot-Kruseman, PhD, Jonas Abrahamsson, MD PhD, Nira Arad-Cohen, MD PhD, Emmanuelle Bart-Delabesse, PharmD, PhD, Barbara Buldini, MD PhD, Barbara De Moerloose, MD PhD, Michael Dworzak, MD PhD, Sarah Elitzur, MD, José M. Fernández Navarro, MD, Robert B. Gerbing, MA, Erin Guest, MD, Shau-Yin Ha, MD PhD, Christine J. Harrison, PhD FRCPath, Henrik Hasle, PhD, Kathy Jackson, MD PhD, Charikleia Kelaidi, MD, Hélène Lapillonne, MD PhD, Guy Leverger, MD PhD, Franco Locatelli, MD PhD, Takako Miyamura, MD PhD, Sophia Polychronopoulou, MD PhD, Mareike Rasche, MD, Jeffrey E. Rubnitz, MD, Jan Stary, MD PhD, Daisuke Tomizawa, MD PhD, Femke Verwer, Gertjan J.L. Kaspers, Prof. MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-136064
Published: 2020
Journal Articles

Congenital Neutropenia Is Also Associated with a High Cancer Risk: A Study from the French Severe Chronic Neutropenia Registry

Jean Donadieu, MDPhD, Fares bou Mitri, Blandine Beaupain, MsC, Yves Bertrand, MD, Pierre Simon Rohrlich, MDPhD, Nathalie Aladjidi, MD, Alexia Rouland, MD, Felipe Suarez, MDPhD, Andre Vanoli, Jean Fraisse, MD, Olivier Hermine, Philippe Descamps, Sylvie François, MD, Hélène Lapillonne, MD PhD, Marlène Pasquet, MD, PhD, Matthieu Patient, Ilona Okhremchuck, Didier Blaise, MD, Faezeh Legrand, MD, Claire Fieschi, MD PhD, Flore Sicre de Fontbrune, Sarah cohen Beaussant, didier Simon Kamioner, MD, Francoise Bachelerie, PhD, Claire Deback, MD PhD, Christine Bellanne-Chantelot, PhD PharmD, Jean-François Emile, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–16.
https://doi.org/10.1182/blood-2020-136053
Published: 2020
Journal Articles

How Many Patients Have Congenital Neutropenia? a Population-Based Estimation from the Nationwide French Severe Chronic Neutropenia Registry

Jean Donadieu, MDPhD, Blandine Beaupain, MsC, Hélène Lapillonne, MD PhD, Odile Fenneteau, PharmD, Flore Sicre de Fontbrune, Yves Bertrand, MD, Nathalie Aladjidi, MD, Vincent Barlogis, MD, PhD, Wadih Abou Chahla, MD, Thierry Lamy, PhD MD, Aline Moignet Autrel, MD, Claire Fieschi, MD PhD, Thierry Leblanc, MD, Despina Moshous, MD PhD, Jean Soulier, MDPhD, Sarah cohen Beaussant, Francois Delhommeau, MD PhD, Helene Cavé, PharmD, PhD, Catherine Paillard, MD PhD, Elodie Gouache, MD, Fares bou Mitri, Damien Bonnet, Laurence Olivier Faivre, Philippe Labrune, MD PhD, Marlène Pasquet, MD, PhD, Virginie Gandemer, MD PhD, Nizar Mahlaoui, MD, Karl Balabanian, Francoise Bachelerie, PhD, Christine Bellanne-Chantelot, PhD PharmD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-135912
Published: 2020
Journal Articles

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Piqué-Borràs, Cathy Ignacimouttou, Alexis Caulier, Cécile K. Lopez, Elie Robert, Benjamin Uzan, Véronique Gelsi-Boyer, Zakia Aid, Cécile Thirant, Ute Moll, Samantha Tauchmann, Amina Kurtovic-Kozaric, Jaroslaw Maciejewski, Christine Dierks, Orietta Spinelli, Silvia Salmoiraghi, Thomas Pabst, Kazuya Shimoda, Virginie Deleuze, Hélène Lapillonne, Connor Sweeney, Véronique De Mas, Betty Leite, Zahra Kadri, Sébastien Malinge, Stéphane de Botton, Jean-Baptiste Micol, Benjamin Kile, Catherine L. Carmichael, Ilaria Iacobucci, Charles G. Mullighan, Martin Carroll, Peter Valent, Olivier A. Bernard, Eric Delabesse, Paresh Vyas, Daniel Birnbaum, Eduardo Anguita, Loïc Garçon, Eric Soler, Juerg Schwaller, Thomas Mercher
Journal: Blood
Blood (2020) 136 (6): 698–714.
https://doi.org/10.1182/blood.2019003062
Published: 2020
Includes: Supplemental data
Journal Articles

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia

Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphael Itzykson, Richard Moriggl, Michael Heuser, Roland Meisel, Peter Valent, Veronika Sexl, Johannes Zuber, Florian Grebien
Journal: Blood
Blood (2020) 136 (4): 387–400.
https://doi.org/10.1182/blood.2019003267
Published: 2020
Includes: Supplemental data
Journal Articles

Molecular MRD Monitoring Is Feasible in the Majority of Children with AML and Is Highly Predictive of Outcome: Results from the International MyeChild01 Study

Jelena Jovanovic, PhD, Nicola Potter, PhD, Anju Kanda, MSc, Claire Schwab, PhD, Aimee E Jackson, MSc, Richard Dillon, MA, PhD MRCP, FRCPath, Anna Lawson, BSc, Manohursingh Runglall, MSc, Paresh Vyas, MD PhD, Paul Virgo, Geoff Shenton, Nicholas Heaney, Beki James, MD, Katharine Patrick, MD, Persis J Amrolia, FRCP, FRCPath, PhD, Jean-Hugues Dalle, MD PhD, Gerard Michel, MD, Andrew S. Moore, MBBS,FRACP,PhD, Hélène Lapillonne, MD PhD, Claude Preudhomme, PharmD, PhD, Guy Leverger, MD, Owen P Smith, MD, Andre Baruchel, MD, Yves Bertrand, MD, Arnaud Petit, MD PhD, Keith Wheatley, DPhil, Pamela R. Kearns, PhDFRCPC, Christine J. Harrison, PhD FRCPath, Brenda Gibson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1393.
https://doi.org/10.1182/blood-2019-125257
Published: 2019
Journal Articles

Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia

Raphael Itzykson, Nicolas Duployez, Annette Fasan, Gauthier Decool, Alice Marceau-Renaut, Manja Meggendorfer, Eric Jourdan, Arnaud Petit, Hélène Lapillonne, Jean-Baptiste Micol, Pascale Cornillet-Lefebvre, Norbert Ifrah, Guy Leverger, Hervé Dombret, Nicolas Boissel, Torsten Haferlach, Claude Preudhomme
Journal: Blood
Blood (2018) 132 (2): 187–196.
https://doi.org/10.1182/blood-2018-03-837781
Published: 2018
Includes: Supplemental data
Journal Articles

Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia

CME Clinical Trials & Observations
Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi
Journal: Blood
Blood (2018) 131 (3): 289–300.
https://doi.org/10.1182/blood-2017-04-778829
Published: 2018
Includes: Supplemental data
Journal Articles

Molecular Profiling Defines Distinct Prognostic Subgroups in Chilhood Acute Myeloid Leukemia: A Report from the French ELAM02 Study Group

Alice Marceau-Renaut, PharmD, Nicolas Duployez, PharmD, PhD, Benoit Ducourneau, PharmD, Myriam Labopin, MD, Arnaud Petit, MD PhD, Alexandra Rousseau, Sandrine Geffroy, PhD, Maxime Bucci, Wendy Cuccuini, Odile Fenneteau, MD, Brigitte Nelken, MD, Stéphane Ducassou, MD, Virginie Gandemer, MDPhD, Thierry Leblanc, MD, Gerard Michel, MD, Yves Bertrand, MD, Andre Baruchel, MD, Guy Leverger, MD PhD, Claude Preudhomme, PharmD, PhD, Hélène Lapillonne, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 403.
https://doi.org/10.1182/blood.V130.Suppl_1.403.403
Published: 2017