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Issue Archive

Volume 125, Issue 13
March 26 2015
Issue Cover

Table of Contents

EDITORIAL

Introduction to a series of reviews on inherited bleeding disorders
Clinical Trials & Observations
David Lillicrap
View Articletitled, Introduction to a series of reviews on inherited bleeding disorders

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Life after ibrutinib? A new unmet need in CLL
Clinical Trials & Observations
Javier Pinilla-Ibarz,Julio C. Chavez
View Articletitled, Life after ibrutinib? A new unmet need in CLL
INSIDE BLOOD COMMENTARY
New prognostic tools for myeloma
Clinical Trials & Observations
Ulf-Henrik Mellqvist
View Articletitled, New prognostic tools for myeloma
INSIDE BLOOD COMMENTARY
When the brain tells the blood how to clot
Eric Boilard
View Articletitled, When the brain tells the blood how to clot
INSIDE BLOOD COMMENTARY
Long-term outcomes in MPS-IH: throwing stars
Michael A. Pulsipher
View Articletitled, Long-term outcomes in MPS-IH: throwing stars

REVIEW SERIES

von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends
Peter J. Lenting,Olivier D. Christophe,Cécile V. Denis
View Articletitled, von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends

REVIEW SERIES

Diagnostic approach to von Willebrand disease
Clinical Trials & Observations
Christopher Ng,David G. Motto,Jorge Di Paola
View Articletitled, Diagnostic approach to von Willebrand disease

REVIEW SERIES

Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens
Clinical Trials & Observations
Johannes Oldenburg
View Articletitled, Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens

REVIEW SERIES

FVIII inhibitors: pathogenesis and avoidance
Clinical Trials & Observations
Jan Astermark
View Articletitled, FVIII inhibitors: pathogenesis and avoidance

REVIEW SERIES

Rare bleeding disorders: diagnosis and treatment
Roberta Palla,Flora Peyvandi,Amy D. Shapiro
View Articletitled, Rare bleeding disorders: diagnosis and treatment

CLINICAL TRIALS AND OBSERVATIONS

Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib
Clinical Trials & Observations
Preetesh Jain,Michael Keating,William Wierda,Zeev Estrov,Alessandra Ferrajoli,Nitin Jain,Binsah George,Danelle James,Hagop Kantarjian,Jan Burger,Susan O’Brien
View Articletitled, Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib
Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report
Clinical Trials & Observations
Antonio Palumbo,Sara Bringhen,Maria-Victoria Mateos,Alessandra Larocca,Thierry Facon,Shaji K. Kumar,Massimo Offidani,Philip McCarthy,Andrea Evangelista,Sagar Lonial,Sonja Zweegman,Pellegrino Musto,Evangelos Terpos,Andrew Belch,Roman Hajek,Heinz Ludwig,A. Keith Stewart,Philippe Moreau,Kenneth Anderson,Hermann Einsele,Brian G. M. Durie,Meletios A. Dimopoulos,Ola Landgren,Jesus F. San Miguel,Paul Richardson,Pieter Sonneveld,S. Vincent Rajkumar
View Articletitled, Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report
Supplemental data

HEMATOPOIESIS AND STEM CELLS

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice
Brief Report
Morag H. Stewart,Mareike Albert,Patrycja Sroczynska,V. Adam Cruickshank,Yanping Guo,Derrick J. Rossi,Kristian Helin,Tariq Enver
View Articletitled, The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice
Supplemental data

IMMUNOBIOLOGY

Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma
Idit Sagiv-Barfi,Holbrook E. Kohrt,Laura Burckhardt,Debra K. Czerwinski,Ronald Levy
View Articletitled, Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma
Supplemental data
CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia
Christina Arieta Kuksin,Gabriela Gonzalez-Perez,Lisa M. Minter
View Articletitled, CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia
Supplemental data

LYMPHOID NEOPLASIA

Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience
Clinical Trials & Observations
Benjamin Hebraud,Florence Magrangeas,Alice Cleynen,Valerie Lauwers-Cances,Marie-Lorraine Chretien,Cyrille Hulin,Xavier Leleu,Edwige Yon,Gerald Marit,Lionel Karlin,Murielle Roussel,Anne-Marie Stoppa,Karim Belhadj,Laurent Voillat,Laurent Garderet,Margaret Macro,Denis Caillot,Mohamad Mohty,Thierry Facon,Philippe Moreau,Michel Attal,Nikhil Munshi,Jill Corre,Stephane Minvielle,Herve Avet-Loiseau
View Articletitled, Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience
LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates
Valérie Lajoie,Bruno Lemieux,Bassem Sawan,Daniel Lichtensztejn,Zelda Lichtensztejn,Raymund Wellinger,Sabine Mai,Hans Knecht
View Articletitled, LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates
Supplemental data
Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model
Damian J. Green,Mazyar Shadman,Jon C. Jones,Shani L. Frayo,Aimee L. Kenoyer,Mark D. Hylarides,Donald K. Hamlin,D. Scott Wilbur,Ethan R. Balkan,Yukang Lin,Brian W. Miller,Sofia H. L. Frost,Ajay K. Gopal,Johnnie J. Orozco,Theodore A. Gooley,Kelly L. Laird,Brian G. Till,Tom Bäck,Brenda M. Sandmaier,John M. Pagel,Oliver W. Press
View Articletitled, Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model
Supplemental data

MYELOID NEOPLASIA

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress
Shrivani Sriskanthadevan,Danny V. Jeyaraju,Timothy E. Chung,Swayam Prabha,Wei Xu,Marko Skrtic,Bozhena Jhas,Rose Hurren,Marcela Gronda,Xiaoming Wang,Yulia Jitkova,Mahadeo A. Sukhai,Feng-Hsu Lin,Neil Maclean,Rob Laister,Carolyn A. Goard,Peter J. Mullen,Stephanie Xie,Linda Z. Penn,Ian M. Rogers,John E. Dick,Mark D. Minden,Aaron D. Schimmer
View Articletitled, AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress
Supplemental data
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN
Jean Grisouard,Takafumi Shimizu,Adrian Duek,Lucia Kubovcakova,Hui Hao-Shen,Stephan Dirnhofer,Radek C. Skoda
View Articletitled, Deletion of <em>Stat3</em> in hematopoietic cells enhances thrombocytosis and shortens survival in a <em>JAK2</em>-V617F mouse model of MPN
Supplemental data

PLATELETS AND THROMBOPOIESIS

Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation
Benjamin Goldenson,Gina Kirsammer,Monika J. Stankiewicz,Qiang Jeremy Wen,John D. Crispino
View Articletitled, Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury
Ye Tian,Breia Salsbery,Min Wang,Hengjie Yuan,Jing Yang,Zilong Zhao,Xiaoping Wu,Yanjun Zhang,Barbara A. Konkle,Perumal Thiagarajan,Min Li,Jianning Zhang,Jing-fei Dong
View Articletitled, Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury
Supplemental data
Premature changes in trabecular and cortical microarchitecture result in decreased bone strength in hemophilia
Brief Report
Adrienne Lee,Steven K. Boyd,Gregory Kline,Man-Chiu Poon
View Articletitled, Premature changes in trabecular and cortical microarchitecture result in decreased bone strength in hemophilia

TRANSPLANTATION

Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study
Mieke Aldenhoven,Robert F. Wynn,Paul J. Orchard,Anne O’Meara,Paul Veys,Alain Fischer,Vassili Valayannopoulos,Benedicte Neven,Attilio Rovelli,Vinod K. Prasad,Jakub Tolar,Heather Allewelt,Simon A. Jones,Rossella Parini,Marleen Renard,Victoria Bordon,Nico M. Wulffraat,Tom J. de Koning,Elsa G. Shapiro,Joanne Kurtzberg,Jaap Jan Boelens
View Articletitled, Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study
Supplemental data

BLOOD WORK

Diagnosis of bacteremia on a blood smear
Delphine Manzoni,Pierre Sujobert
View Articletitled, Diagnosis of bacteremia on a blood smear

CORRESPONDENCE

Population-based study on the impact of the familial form of Waldenström macroglobulinemia on overall survival
Clinical Trials & Observations
Vilhjálmur Steingrímsson,Sigrún Helga Lund,Ingemar Turesson,Lynn R. Goldin,Magnus Björkholm,Ola Landgren,Sigurdur Y. Kristinsson
View Articletitled, Population-based study on the impact of the familial form of Waldenström macroglobulinemia on overall survival
A roadmap for discovery and translation in lymphoma
David M. Weinstock,Riccardo Dalla-Favera,Randy D. Gascoyne,John P. Leonard,Ronald Levy,Izidore S. Lossos,Ari M. Melnick,Grzegorz S. Nowakowski,Oliver W. Press,Kerry J. Savage,Margaret A. Shipp,Louis M. Staudt
View Articletitled, A roadmap for discovery and translation in lymphoma
All Issues

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