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A novel conditioning regimen improves outcomes in β-thalassemia major patients using unrelated donor peripheral blood stem cell transplantation
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study
A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia
Use of 111-Indium–labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects
Issue Archive
November 8 2012
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Red Cells, Iron, and Erythropoiesis
A novel conditioning regimen improves outcomes in β-thalassemia major patients using unrelated donor peripheral blood stem cell transplantation
Clinical Trials & Observations
Chunfu Li,Xuedong Wu,Xiaoqing Feng,Yuelin He,Huaying Liu,Fuyu Pei,Jianyu Liao,Lan He,Lei Shi,Na Li,Qiujun Liu,Shiting Liu,Geyu Chen,Qingxia Su,Yuqiong Ren,Yanhua Wang,Wanxia Tan
Review Article
Clinical Trials and Observations
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study
Clinical Trials & Observations
Zijun Y. Xu-Monette,Lin Wu,Carlo Visco,Yu Chuan Tai,Alexander Tzankov,Wei-min Liu,Santiago Montes-Moreno,Karen Dybkær,April Chiu,Attilio Orazi,Youli Zu,Govind Bhagat,Kristy L. Richards,Eric D. Hsi,X. Frank Zhao,William W. L. Choi,Xiaoying Zhao,J. Han van Krieken,Qin Huang,Jooryung Huh,Weiyun Ai,Maurilio Ponzoni,Andrés J. M. Ferreri,Fan Zhou,Brad S. Kahl,Jane N. Winter,Wei Xu,Jianyong Li,Ronald S. Go,Yong Li,Miguel A. Piris,Michael B. Møller,Roberto N. Miranda,Lynne V. Abruzzo,L. Jeffrey Medeiros,Ken H. Young
Gene Therapy
Immunobiology
Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques
Luca Micci,Barbara Cervasi,Zachary S. Ende,Robin I. Iriele,Elane Reyes-Aviles,Carol Vinton,James Else,Guido Silvestri,Aftab A. Ansari,Francois Villinger,Savita Pahwa,Jacob D. Estes,Jason M. Brenchley,Mirko Paiardini
Lymphoid Neoplasia
t(X;14)(p11;q32) in MALT lymphoma involving GPR34 reveals a role for GPR34 in tumor cell growth
Stephen M. Ansell,Takashi Akasaka,Ellen McPhail,Michelle Manske,Esteban Braggio,Tammy Price-Troska,Steven Ziesmer,Frank Secreto,Rafael Fonseca,Mamta Gupta,Mark Law,Thomas E. Witzig,Martin J. S. Dyer,Ahmet Dogan,James R. Cerhan,Anne J. Novak
Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma
Wilfried Valleron,Loic Ysebaert,Laure Berquet,Virginie Fataccioli,Cathy Quelen,Antoine Martin,Marie Parrens,Laurence Lamant,Laurence de Leval,Christian Gisselbrecht,Philippe Gaulard,Pierre Brousset
Myeloid Neoplasia
A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia
Clinical Trials & Observations
Jerald P. Radich,Kenneth J. Kopecky,Frederick R. Appelbaum,Suzanne Kamel-Reid,Wendy Stock,Greg Malnassy,Elisabeth Paietta,Martha Wadleigh,Richard A. Larson,Peter Emanuel,Martin Tallman,Jeff Lipton,A. Robert Turner,Michael Deininger,Brian J. Druker
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice
Cyrus Khandanpour,Joseph Krongold,Judith Schütte,Frederique Bouwman,Lothar Vassen,Marie-Claude Gaudreau,Riyan Chen,Fernando J. Calero-Nieto,Evangelia Diamanti,Rebecca Hannah,Sara E. Meyer,H. Leighton Grimes,Bert A. van der Reijden,Joop H. Jansen,Chandrashekhar V. Patel,Justine K. Peeters,Bob Löwenberg,Ulrich Dührsen,Bertie Göttgens,Tarik Möröy
Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome
Shinobu Matsuura,Yukiko Komeno,Kristen E. Stevenson,Joseph R. Biggs,Kentson Lam,Tingdong Tang,Miao-Chia Lo,Xiuli Cong,Ming Yan,Donna S. Neuberg,Dong-Er Zhang
Phagocytes, Granulocytes, and Myelopoiesis
Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis
Takuro Kuriyama,Katsuto Takenaka,Kentaro Kohno,Takuji Yamauchi,Shinya Daitoku,Goichi Yoshimoto,Yoshikane Kikushige,Junji Kishimoto,Yasunobu Abe,Naoki Harada,Toshihiro Miyamoto,Hiromi Iwasaki,Takanori Teshima,Koichi Akashi
Use of 111-Indium–labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects
Brief Report
Neda Farahi,Nanak R. Singh,Sarah Heard,Chrystalla Loutsios,Charlotte Summers,Chandra K. Solanki,Kishor Solanki,Kottekkattu K. Balan,Prina Ruparelia,A. Michael Peters,Alison M. Condliffe,Edwin R. Chilvers
Platelets and Thrombopoiesis
Thrombosis and Hemostasis
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
Friederike Langhauser,Eva Göb,Peter Kraft,Christian Geis,Joachim Schmitt,Marc Brede,Kerstin Göbel,Xavier Helluy,Mirko Pham,Martin Bendszus,Peter Jakob,Guido Stoll,Sven G. Meuth,Bernhard Nieswandt,Keith R. McCrae,Christoph Kleinschnitz
Transplantation
Vascular Biology
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Cover Image
Cover Image
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Mutations in RUNX1 induce myelodysplastic changes in mouse bone marrow. A trinucleated neutrophilic metamyelocyte was observed in a Wright-Giemsa-stained cytospin of bone marrow from a mouse that received a transplant of RUNX1(41-214) -expressing cells. RUNX1(41-214) is a truncated protein corresponding to the runt homology domain of human RUNX1. See the article by Matsuura et al on page 4028.
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