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Journal Articles

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53 -deficient B-cell malignancies

Blood (2022) 139 (25): 3617–3629.

https://doi.org/10.1182/blood.2021014007

Published: 2022

Includes: Supplemental data

Journal Articles

Cell cycle control in Richter transformation

Christian P. Pallasch

Blood (2021) 138 (12): 1005–1007.

https://doi.org/10.1182/blood.2021011648

Published: 2021

Journal Articles

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

Blood (2021) 137 (5): 646–660.

https://doi.org/10.1182/blood.2020005734

Published: 2021

Includes: Supplemental data

Journal Articles

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL

Valeska Berg, Marion Rusch, Nachiket Vartak, Christian Jüngst, Astrid Schauss, Herbert Waldmann, Christian Hedberg, Christian P. Pallasch, Philippe I. H. Bastiaens, Michael Hallek, Clemens-Martin Wendtner, Lukas P. Frenzel

Blood (2015) 125 (19): 2948–2957.

https://doi.org/10.1182/blood-2014-07-586511

Published: 2015

Includes: Supplemental data

Journal Articles

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Malte F Huelsemann, Michaela Patz, PhD, Laura Beckmann, Kerstin Brinkmann, Teresa Otto, Joachim Fandrey, MD, Hans Jiro Becker, Sebastian Theurich, MD, Michael S. von Bergwelt-Baildon, MD PhD, Christian P. Pallasch, MD, Réne P. Zahedi, Hamid Kashkar, PhD, Christian Reinhardt, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2014) 124 (21): 1947.

https://doi.org/10.1182/blood.V124.21.1947.1947

Published: 2014

Journal Articles

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Valeska Berg, Marion Rusch, PhD, Nachiket Vartak, PhD, Christian Juengst, Astrid Schauss, Herbert Waldmann, PhD, Christian Hedberg, PhD, Christian P. Pallasch, MD, Philippe Bastiaens, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2014) 124 (21): 1953.

https://doi.org/10.1182/blood.V124.21.1953.1953

Published: 2014

Journal Articles

Phagocytic Function of Macrophages Is Impaired By Chronic Lymphocytic Leukemia and high–grade Lymphoma Progression and Can be Highly Effectively Restored for Chemo-Immunotherapy

Janine Schwamb, MD, Nina Reinart, Daniela Vorholt, Thomas Ulas, PhD, Vangica Ristovska, MD, Christian J Braun, MD, Michael T Hemann, PhD, Joachim Schultze, MD, Michael Hallek, MD, Christian P. Pallasch, MD

Blood (2014) 124 (21): 2727.

https://doi.org/10.1182/blood.V124.21.2727.2727

Published: 2014

Journal Articles

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Valeska Berg, Nachiket Vartak, PhD, Rainer Claus, MD, Julia Claasen, Marion Rusch, PhD, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Christopher Plass, PhD, Philippe Bastiaens, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens Wendtner, MD, Lukas P. Frenzel, MD

Blood (2013) 122 (21): 4148.

https://doi.org/10.1182/blood.V122.21.4148.4148

Published: 2013

Journal Articles

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Christian P. Pallasch, MD, Leskov Ilya, MD, PhD, Yadira M Soto, Christian J. Braun, MD, Nadine Kutsch, MD, Adam Drake, PhD, Lukas P. Frenzel, MD, Bettina Iliopoulou, PhD, Nico van Rooijen, PhD, Clemens Wendtner, MD, Michael Hallek, MD, Jianzhu Chen, PhD, Michael T Hemann, PhD

Blood (2012) 120 (21): 1335.

https://doi.org/10.1182/blood.V120.21.1335.1335

Published: 2012

Journal Articles

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

Malte Huelsemann, Lukas P. Frenzel, MD, Dunja Baatout, M.Sc., Julia Claasen, Sebastian Theurich, MD, Laurent Kintzelé, Hans Jiro Becker, Michaela Patz, PhD, Christian P. Pallasch, MD, Michael S. von Bergwelt-Baildon, MD, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2012) 120 (21): 3918.

https://doi.org/10.1182/blood.V120.21.3918.3918

Published: 2012

Journal Articles

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Alexandra Schulz, PhD, Yoon Jung Park, Ph.D., Rainer Claus, MD, Hamid Kashkar, PhD, Jens Seeger, PhD, Julia Claasen, Christian P. Pallasch, MD, Christoph Plass, PhD, Michael Hallek, MD, Clemens Wendtner, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3898.

https://doi.org/10.1182/blood.V120.21.3898.3898

Published: 2012

Journal Articles

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

Janine Schwamb, MD, Valeska Feldhaus, M.Sc., Michael Baumann, MD, Michaela Patz, PhD, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3905.

https://doi.org/10.1182/blood.V120.21.3905.3905

Published: 2012

Journal Articles

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides

Janine Schwamb, Valeska Feldhaus, Michael Baumann, Michaela Patz, Susanne Brodesser, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, Michael Hallek, Clemens-Martin Wendtner, Lukas P. Frenzel

Blood (2012) 120 (19): 3978–3985.

https://doi.org/10.1182/blood-2012-05-431783

Published: 2012

Includes: Supplemental data

Journal Articles

TOSO-Deficient B Cells Show An Impaired NF-κB and Migration Signaling In Vivo

Alexandra Schulz, Christian P. Pallasch, MD, Michael Hallek, MD, Lukas P. Frenzel, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 1779.

https://doi.org/10.1182/blood.V118.21.1779.1779

Published: 2011

Journal Articles

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Janine Schwamb, MD, Valeska Feldhaus, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2011) 118 (21): 1766.

https://doi.org/10.1182/blood.V118.21.1766.1766

Published: 2011

Journal Articles

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Lukas P. Frenzel, MD, Malte Huelsemann, Julia Claasen, Reinhild Brinker, Sebastian Theurich, MD, Hans Jiro Becker, Michael S. von Bergwelt-Baildon, MD, PhD, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 1767.

https://doi.org/10.1182/blood.V118.21.1767.1767

Published: 2011

Journal Articles

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Valeska Feldhaus, Marion Rusch, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens-Martin Wendtner, MD

Blood (2011) 118 (21): 2829.

https://doi.org/10.1182/blood.V118.21.2829.2829

Published: 2011

Journal Articles

B Cell Receptor Stimulation of CLL Cells Leads to Upregulation of IRF4 Proteinexpression Influenced by SNP Expression,

Michaela Patz, PhD, Nina-Felizitas Linde, Lukas P. Frenzel, MD, Christian P. Pallasch, MD, Reinhild Brinker, Julia Claasen, Michael Hallek, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 3886.

https://doi.org/10.1182/blood.V118.21.3886.3886

Published: 2011

Journal Articles

Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells

N. Deepa Pantulu, Christian P. Pallasch, Anna Kordelia Kurz, Ahmad Kassem, Lukas Frenzel, Sebastian Sodenkamp, Hans Michael Kvasnicka, Clemens M. Wendtner, Axel zur Hausen

Blood (2010) 116 (24): 5280–5284.

https://doi.org/10.1182/blood-2010-02-269829

Published: 2010

Journal Articles

Microenvironment Influences Expression of TOSO – a Novel NF-Kappa B Target Gene In Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Alexandra Schulz, Christian P. Pallasch, MD, Rainer Claus, MD, Sabine Ponader, PhD, Jan A. Burger, MD, PhD, Michael Hallek, MD, Christoph Plass, PhD, Clemens-Martin Wendtner, MD

Blood (2010) 116 (21): 695.

https://doi.org/10.1182/blood.V116.21.695.695

Published: 2010

NARROW

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53 -deficient B-cell malignancies

Cell cycle control in Richter transformation

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Phagocytic Function of Macrophages Is Impaired By Chronic Lymphocytic Leukemia and high–grade Lymphoma Progression and Can be Highly Effectively Restored for Chemo-Immunotherapy

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides

TOSO-Deficient B Cells Show An Impaired NF-κB and Migration Signaling In Vivo

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

B Cell Receptor Stimulation of CLL Cells Leads to Upregulation of IRF4 Proteinexpression Influenced by SNP Expression,

Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells

Microenvironment Influences Expression of TOSO – a Novel NF-Kappa B Target Gene In Chronic Lymphocytic Leukemia

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American Society of Hematology

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American Society of Hematology

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