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Reinhild Brinker
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Journal Articles

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53 -deficient B-cell malignancies

Elena Izquierdo, Daniela Vorholt, Stuart Blakemore, Benedict Sackey, Janica L. Nolte, Verena Barbarino, Jan Schmitz, Nadine Nickel, Daniel Bachurski, Liudmila Lobastova, Milos Nikolic, Michael Michalik, Reinhild Brinker, Olaf Merkel, Marek Franitza, Theodoros Georgomanolis, René Neuhaus, Maximilian Koch, Niklas Nasada, Gero Knittel, Björn Chapuy, Nicole Ludwig, Eckart Meese, Lukas Frenzel, Hans Christian Reinhardt, Martin Peifer, Rocio Rebollido-Rios, Heiko Bruns, Marcus Krüger, Michael Hallek, Christian P. Pallasch
Journal: Blood
Blood (2022) 139 (25): 3617–3629.
https://doi.org/10.1182/blood.2021014007
Published: 2022
Includes: Supplemental data
Journal Articles

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

Janine Schwamb, MD, Valeska Feldhaus, M.Sc., Michael Baumann, MD, Michaela Patz, PhD, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2012) 120 (21): 3905.
https://doi.org/10.1182/blood.V120.21.3905.3905
Published: 2012
Journal Articles

B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides

Janine Schwamb, Valeska Feldhaus, Michael Baumann, Michaela Patz, Susanne Brodesser, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, Michael Hallek, Clemens-Martin Wendtner, Lukas P. Frenzel
Journal: Blood
Blood (2012) 120 (19): 3978–3985.
https://doi.org/10.1182/blood-2012-05-431783
Published: 2012
Includes: Supplemental data
Journal Articles

B Cell Receptor Stimulation of CLL Cells Leads to Upregulation of IRF4 Proteinexpression Influenced by SNP Expression,

Michaela Patz, PhD, Nina-Felizitas Linde, Lukas P. Frenzel, MD, Christian P. Pallasch, MD, Reinhild Brinker, Julia Claasen, Michael Hallek, MD, Clemens Wendtner, MD
Journal: Blood
Blood (2011) 118 (21): 3886.
https://doi.org/10.1182/blood.V118.21.3886.3886
Published: 2011
Journal Articles

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Valeska Feldhaus, Marion Rusch, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens-Martin Wendtner, MD
Journal: Blood
Blood (2011) 118 (21): 2829.
https://doi.org/10.1182/blood.V118.21.2829.2829
Published: 2011
Journal Articles

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Janine Schwamb, MD, Valeska Feldhaus, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Martin Wendtner, MD, Lukas P. Frenzel, MD
Journal: Blood
Blood (2011) 118 (21): 1766.
https://doi.org/10.1182/blood.V118.21.1766.1766
Published: 2011
Journal Articles

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Lukas P. Frenzel, MD, Malte Huelsemann, Julia Claasen, Reinhild Brinker, Sebastian Theurich, MD, Hans Jiro Becker, Michael S. von Bergwelt-Baildon, MD, PhD, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Wendtner, MD
Journal: Blood
Blood (2011) 118 (21): 1767.
https://doi.org/10.1182/blood.V118.21.1767.1767
Published: 2011
Journal Articles

Sustained NF-Kappa B Activity In Chronic Lymphocytic Leukemia Is Independent of Genetic and Epigenetic Modifications of the Tumor Suppressor Genes CYLD and A20

Lukas P. Frenzel, MD, Janine Schwamb, MD, Rainer Claus, MD, Julia Claasen, Reinhild Brinker, Christian P. Pallasch, MD, Christoph Plass, PhD, Clemens-Martin Wendtner, MD
Journal: Blood
Blood (2010) 116 (21): 3597.
https://doi.org/10.1182/blood.V116.21.3597.3597
Published: 2010
Journal Articles

Novel X-Linked Inhibitor of Apoptosis (XIAP) Inhibiting Compound as Sensitizer for TRAIL-Mediated Apoptosis In Chronic Lymphocytic Leukemia with Poor Prognosis

Lukas P. Frenzel, MD, Michaela Patz, PhD, Christian P. Pallasch, MD, Reinhild Brinker, Julia Claasen, Alexandra Schulz, Michael Hallek, MD, Hamid Kashkar, PhD, Clemens-Martin Wendtner, MD
Journal: Blood
Blood (2010) 116 (21): 1375.
https://doi.org/10.1182/blood.V116.21.1375.1375
Published: 2010
Journal Articles

Disruption of T Cell Suppression in Chronic Lymphocytic Leukemia by CD200 Blockade.

Christian P Pallasch, MD, Susanne Ulbrich, MD, Reinhild Brinker, Robert A Uger, PhD, Michael Hallek, MD, Clemens- Martin Wendtner, MD
Journal: Blood
Blood (2008) 112 (11): 2072.
https://doi.org/10.1182/blood.V112.11.2072.2072
Published: 2008