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Journal Articles

Chromatin-Based Cellular Dependency of HOXA9/MEIS1-Driven Acute Myeloid Leukemia

Federica Valigi, Fulya Mina Kücüktas, Ilya Fliamer, Zivojin Jevtic, Hughes-Etienne Chatel-Soulet, Amandine Bovay, Rathick Sivalingam, Andreja Baosic, Florian Grebien, Robert K. Slany, Alexandar Tzankov, Sabine Juge, Jonathan Seguin, Menghan Wang, Athimed El Taher, Luca Giorgetti, Juerg Schwaller
Journal: Blood
Blood (2024) 144 (Supplement 1): 2729.
https://doi.org/10.1182/blood-2024-207011
Published: 2024
Journal Articles

The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis

Katrin Hetzner, Maria-Paz Garcia-Cuellar, Christian Büttner, Robert K. Slany
Journal: Blood
Blood (2018) 131 (6): 662–673.
https://doi.org/10.1182/blood-2017-11-815035
Published: 2018
Includes: Supplemental data
Journal Articles

2% of Healthy Newborns Reveal ETV6-RUNX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)

Daniel Schaefer, MSc, Marianne Olsen, MD, Ulrik Lausten-Thomsen, MD PhD, Cyrill Schipp, MSc, Martin Stanulla, MD, Robert K. Slany, PhD, Kjeld Schmiegelow, MD DMSc, Arndt Borkhardt, MD, Ute Fischer, PhD
Journal: Blood
Blood (2016) 128 (22): 4082.
https://doi.org/10.1182/blood.V128.22.4082.4082
Published: 2016
Journal Articles

Gipfel – a Novel Method for Unbiased Molecular ETV6-RUNX1 Screening of Healthy Newborns

Ute Fischer, PhD, Daniel Schäfer, MSc, Elisa Füller, MSc, Katrine Ask, MSc, Pina Fanny Ida Krell, MSc, Martin Stanulla, MD, Marianne Olsen, MD, Kjeld Schmiegelow, Robert K. Slany, PhD, Arndt Borkhardt, MD
Journal: Blood
Blood (2014) 124 (21): 5340.
https://doi.org/10.1182/blood.V124.21.5340.5340
Published: 2014
Journal Articles

Hematopoietic Cell Lines and Patient Samples Show a Correlation Between Upregulated MSI2 and BCR-ABL Expression

Jaspal S. Kaeda, PhD, Rolf Schwarzer, Robert K. Slany, PhD, Thomas Burmeister, MD, Elisabetta Vagge, Leila Amini, Frauke Ringel, PhD, Katarina Pardon, Michaela Schwarz, MD, Bernd Dörken, Franziska Jundt, MD, Philipp le Coutre, MD
Journal: Blood
Blood (2013) 122 (21): 2618.
https://doi.org/10.1182/blood.V122.21.2618.2618
Published: 2013
Journal Articles

Blockade of Mir-150 Maturation by MLL -Fusion/MYC/Lin-28 Is Required for MLL -Associated Leukemia

Xi Jiang, PhD, Hao Huang, PhD, Zejuan Li, MD, PhD, Yuanyuan Li, Xiao Wang, Sandeep Gurbuxani, MBBS, PhD, Ping Chen, MD, Chunjiang He, PhD, Dewen You, PhD, Shuodan Zhang, Jinhua Wang, Stephen Arnovitz, Abdel Elkahloun, PhD, Colles Price, Gia-Ming Hong, PhD, Haomin Ren, Rejani B. Kunjamma, Mary Beth Neilly, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Robert K. Slany, PhD, Paul P. Liu, MD, PhD, Jun Lu, PhD, Jiwang Zhang, MD, PhD, Chuan He, PhD, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2012) 120 (21): 3499.
https://doi.org/10.1182/blood.V120.21.3499.3499
Published: 2012
Journal Articles

The homeodomain region controls the phenotype of HOX-induced murine leukemia

Constanze Breitinger, Emanuel Maethner, Maria-Paz Garcia-Cuellar, Robert K. Slany
Journal: Blood
Blood (2012) 120 (19): 4018–4027.
https://doi.org/10.1182/blood-2011-10-384685
Published: 2012
Includes: Supplemental data
Journal Articles

MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells

Emanuel Maethner, Constanze Breitinger, Maria-Paz Garcia-Cuellar, Ph.D., Jay L. Hess, MD, PhD, Robert K. Slany, PhD
Journal: Blood
Blood (2011) 118 (21): 2443.
https://doi.org/10.1182/blood.V118.21.2443.2443
Published: 2011
Journal Articles

Ectopic Expression of the Leukemogenic Protein E2A-PBX1 in Early Hematopoietic Progenitors Blocks B-Lymphoid Commitment

Mark Woodcroft, BS, Patrick Thompson, Robert K. Slany, PhD, David LeBrun, MD
Journal: Blood
Blood (2011) 118 (21): 1393.
https://doi.org/10.1182/blood.V118.21.1393.1393
Published: 2011
Journal Articles

Hox Genes Regulate Rac1 Activity Through Control of Vav2 expression

Constanze Breitinger, Emanuel Maethner, Maria-Paz Garcia-Cuellar, Ph.D., Alexandra Schambony, Ph.D., Kirsten Schilling, Ph.D., Klaus D Fischer, Ph.D., Robert K. Slany, PhD
Journal: Blood
Blood (2011) 118 (21): 60.
https://doi.org/10.1182/blood.V118.21.60.60
Published: 2011
Journal Articles

Leukemogenic transformation by HOXA cluster genes

Christian Bach, Sebastian Buhl, Dorothée Mueller, María-Paz García-Cuéllar, Emanuel Maethner, Robert K. Slany
Journal: Blood
Blood (2010) 115 (14): 2910–2918.
https://doi.org/10.1182/blood-2009-04-216606
Published: 2010
Includes: Supplemental data
Journal Articles

Leukemogenic Transformation by Anterior HOXA -Cluster Genes.

Sebastian Buhl, Emanuel Maethner, Robert K. Slany, PhD
Journal: Blood
Blood (2009) 114 (22): 2962.
https://doi.org/10.1182/blood.V114.22.2962.2962
Published: 2009
Journal Articles

Hypomethylation of Tumor Suppressor Genes in Acute Myeloid Leukemia: Characteristic of Cell Lines with MLL Abnormalities?.

Hilmar Quentmeier, Sonja Röhrs, Wilhelm G Dirks, Claus Meyer, Rolf Marschalek, Michaela Scherr, Robert K. Slany, PhD, Andrew Wallace, Hans G. Drexler
Journal: Blood
Blood (2009) 114 (22): 365.
https://doi.org/10.1182/blood.V114.22.365.365
Published: 2009
Journal Articles

Oncogenic RAS Enables DNA Damage- and p53-Dependent Differentiation of Acute Myeloid Leukemia Cells in Response to Chemotherapy.

Mona Meyer, Daniela Rübsamen, Robert K. Slany, Thomas Illmer, Kathleen Stabla, Petra Roth, Thorsten Stiewe, Martin Eilers, Andreas Neubauer
Journal: Blood
Blood (2009) 114 (22): 5040.
https://doi.org/10.1182/blood.V114.22.5040.5040
Published: 2009
Journal Articles

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C

Maike Schwieger, Andrea Schüler, Martin Forster, Afra Engelmann, Michael A. Arnold, Ruud Delwel, Peter J. Valk, Jürgen Löhler, Robert K. Slany, Eric N. Olson, Carol Stocking
Journal: Blood
Blood (2009) 114 (12): 2476–2488.
https://doi.org/10.1182/blood-2008-05-158196
Published: 2009
Journal Articles

Evidence for An Anti-Cancer Barrier in a Mixed Lineage Leukemia Mouse Model in Vivo .

Sylvia Takacova, Jiri Bartek, Lucie Piterkova, Robert K. Slany, Vladimir Divoky
Journal: Blood
Blood (2008) 112 (11): 3347.
https://doi.org/10.1182/blood.V112.11.3347.3347
Published: 2008
Journal Articles

HOX-Gene Expression and Inhibition of the Non-Canonical NF-KappaB Pathway in t(7;12) Leukemias

Sarah Wildenhain, Jr., Julia Hauer, II, Silija Roettgers, III, Hartmut Engelmann, IV, Astrid Novosel, V, Vera Binder, Robert K. Slany, PhD, Wolf-Dieter Ludwig, Jochen Harbott, Arndt Borkhardt, Sr., MD
Journal: Blood
Blood (2008) 112 (11): 3110.
https://doi.org/10.1182/blood.V112.11.3110.3110
Published: 2008
Journal Articles

Alterations of the CxxC Domain Preclude Oncogenic Activation of Mixed Lineage Leukemia 2 (MLL2).

Robert K. Slany, PhD, Christian Bach, Dorothee Mueller, Sebastian Buhl, Maria-Paz Garcia-Cuellar
Journal: Blood
Blood (2008) 112 (11): 1792.
https://doi.org/10.1182/blood.V112.11.1792.1792
Published: 2008
Journal Articles

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

Dorothee Mueller, Christian Bach, Deniz Zeisig, Maria-Paz Garcia-Cuellar, Sara Monroe, Arun Sreekumar, Rong Zhou, Alexey Nesvizhskii, Arul Chinnaiyan, Jay L. Hess, Robert K. Slany
Journal: Blood
Blood (2007) 110 (13): 4445–4454.
https://doi.org/10.1182/blood-2007-05-090514
Published: 2007
Journal Articles

Purification of an MLL Partner Associated Complex (MPAC) Suggests a Common Role for MLL Fusion Partners in Transcriptional Elongation.

Robert K. Slany, PhD, Dorothee Mueller, Christian Bach, Deniz Zeisig, Maria-Paz Garcia-Cuellar, Ph.D., Sara Monroe, Ph.D., Arun Sreekumar, Ph.D., Ron Zhao, Ph.D., Alexey Nesvizhskii, Ph.D., Arul Chinnaiyan, Ph.D., Jay L. Hess, M.D. Ph.D.
Journal: Blood
Blood (2006) 108 (11): 770.
https://doi.org/10.1182/blood.V108.11.770.770
Published: 2006