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Journal Articles

Efficacy of a novel BCL-xL degrader, DT2216, in preclinical models of JAK2 -mutated post-MPN AML

Open Access
Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P. Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J. Mead, Raajit K. Rampal, Jeffrey W. Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2025) 146 (3): 341–355.
https://doi.org/10.1182/blood.2024027117
Published: 2025
Includes: Supplemental data
Journal Articles

Redefining risk stratification in pLCH

Free
Jithma P. Abeykoon, W. Oliver Tobin
Journal: Blood
Blood (2025) 146 (2): 136–138.
https://doi.org/10.1182/blood.2025029134
Published: 2025
Journal Articles

BRAF V600E -positive mononuclear cells in blood at diagnosis portend treatment failure and neurodegeneration in pediatric LCH

Available to Purchase
Howard Lin, Akanksha Batajoo, Erin Peckham-Gregory, Daniel Zinn, Olive S. Eckstein, Nader Kim El-Mallawany, Nitya Gulati, Zachary D. Prudowsky, Brooks Scull, Jessica Velazquez, Harshal Abhyankar, Stephen J. Simko, Daria Vakula, Ryan Fleischmann, Vivekanudeep Karri, M. John Hicks, Kevin E. Fisher, Choladda V. Curry, Angshumoy Roy, Deborah Schiff, Kenneth M. Heym, Michael E. Scheurer, D. Williams Parsons, Miriam Merad, Tsz-Kwong Man, Kenneth L. McClain, Jennifer Picarsic, Carl E. Allen
Journal: Blood
Blood (2025) 146 (2): 206–218.
https://doi.org/10.1182/blood.2024026671
Published: 2025
Includes: Supplemental data
Journal Articles

Cell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2 -mutant MDS stem/progenitor cells

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Brief Report
Kouhei Takashima, Malgorzata Olszewska, Vrinda Jethalia, Maria Sirenko, Lewis Silverman, Lewis E. Tomalin, Saul Carcamo, Dan Hasson, Eirini P. Papapetrou
Journal: Blood
Blood (2025) 146 (1): 115–122.
https://doi.org/10.1182/blood.2024025670
Published: 2025
Includes: Supplemental data
Journal Articles

DNMT3A mutations are unlikely to affect interferon alfa treatment outcomes in patients with polycythemia vera

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Clinical Trials & Observations
Ghaith Abu-Zeinah, Katie Erdos, Neville Lee, Yara Ganom, Christoph Klade, Kurt Krejcy, Heinz Gisslinger, Richard T. Silver, Joseph M. Scandura
Journal: Blood
Blood (2025) 146 (1): 123–126.
https://doi.org/10.1182/blood.2024027528
Published: 2025
Includes: Supplemental data
Journal Articles

Therapy-related juvenile myelomonocytic leukemia

Free
Ahmed Mohamed, Aida I. Richardson
Journal: Blood
Blood (2025) 146 (1): 127.
https://doi.org/10.1182/blood.2025028952
Published: 2025
Journal Articles

Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia

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Bing Z Carter, Po Yee Mak, Edward Ayoub, Xiaogang Wu, Baozhen Ke, Yuki Nishida, Andrew Futreal, Lauren B Ostermann, Andrea D Bedoy, Steffen Boettcher, Courtney D. DiNardo, Anna Puzio-Kuter, Masha V Poyurovsky, Arnold J. Levine, Michael Andreeff
Journal: Blood
Blood blood.2025028935.
https://doi.org/10.1182/blood.2025028935
Published: 2025
Includes: Supplemental data
Journal Articles

Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis

Open Access
Juan Carlos Hernández-Boluda, Adrián Mosquera-Orgueira, Luuk Gras, Linda Koster, Joe Tuffnell, Nicolaus Kröger, Massimiliano Gambella, Thomas Schroeder, Marie Robin, Katja Sockel, Jakob Passweg, Igor Wolfgang Blau, Ibrahim Yakoub-Agha, Ruben Van Dijck, Mattias Stelljes, Henrik Sengeloev, Jan Vydra, Uwe Platzbecker, Moniek de Witte, Frédéric Baron, Kristina Carlson, Javier Rojas, Carlos Pérez Míguez, Davide Crucitti, Kavita Raj, Joanna Drozd-Sokolowska, Giorgia Battipaglia, Nicola Polverelli, Tomasz Czerw, Donal P. McLornan
Journal: Blood
Blood (2025) 145 (26): 3139–3152.
https://doi.org/10.1182/blood.2024027287
Published: 2025
Includes: Supplemental data
Journal Articles

Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML

Open Access
Aristi Damaskou, Rachael Wilson, Malgorzata Gozdecka, George Giotopoulos, Ryan Asby, Maria Eleftheriou, Muxin Gu, Christian Récher, Véronique Mansat- De Mas, Francois Vergez, Ambrine Sahal, Binje Vick, Evangelia K Papachristou, Ashley Sawle, Eliza Yankova, Monika Dudek, Xiaoxuan Liu, James Russell, Justyna Rak, Christine Hilcenko, Clive S D'Santos, Irmela Jeremias, Jean-Emmanuel Sarry, Konstantinos Tzelepis, Brian JP Huntly, Alan J Warren, Omid Tavana, George S Vassiliou
Journal: Blood
Blood blood.2024026113.
https://doi.org/10.1182/blood.2024026113
Published: 2025
Includes: Supplemental data
Journal Articles

Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer

Open Access
Bernd Zeisig, Chiou-Tsun Tsai, Clemence Virely, Tsz Kan Kan Fung, Ali Tugrul Akin, Estelle Troadec, Bo Jiao, Richard Thompson, Priscilla Nga Ieng Lau, Nanjun Li, Andriani Charalambous, Larissa Bomfim, Jennifer Lynch, Athina Georgiou, Robbert Hoogeboom, Claire Lynn, Si Yi Zhang, Piers EM Patten, Cynthia Fisher, Anna Schuh, Seishi Ogawa, Ghulam J Mufti, Professor, Mohammad M. Karimi, Chi Wai Eric So
Journal: Blood
Blood blood.2025028560.
https://doi.org/10.1182/blood.2025028560
Published: 2025
Includes: Supplemental data
Journal Articles

IPSS-M risk and specific sex-associated somatic mutations predict response to ESA therapy in LR-MDS: building a new score

Available to Purchase
Marco Gabriele Raddi, Sophie Park, Michaela Fontenay, Olivier Kosmider, María Díez-Campelo, Juan Carlos Caballero Berrocal, Marie Sébert, Lionel Adès, Uwe Platzbecker, Matteo G Della Porta, Giorgio Mattiuz, Sven Julien Maria De Pourcq, Lorenzo Tofani, Giulia Maggioni, Elena Tofacchi, Angela Consagra, Luca Rigodanza, Gloria Andreossi, Cristina Amato, Mathieu Meunier, Célia Orlando, Emmanuelle Clappier, Nicolas Chapuis, Pierre Walczak, Katharina Zoldan, Anne Sophie Kubasch, Valeria Santini
Journal: Blood
Blood blood.2024027540.
https://doi.org/10.1182/blood.2024027540
Published: 2025
Includes: Supplemental data
Journal Articles

Loss of BAP1 defines a unique subtype of TP53-mutated de novo AML and confers sensitivity to BCL-xL inhibitors

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Jaclyn Andricovich, Coen Johannes Lap, Alexandros Tzatsos
Journal: Blood
Blood blood.2024026417.
https://doi.org/10.1182/blood.2024026417
Published: 2025
Includes: Supplemental data
Journal Articles

PI3Kγ in leukemia: class IB PI3 kinase reemerges as a cancer-intrinsic target

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Qingyu Luo, Amanda L. Fortune, Andrew A. Lane
Journal: Blood
Blood (2025) 145 (25): 2945–2953.
https://doi.org/10.1182/blood.2024027376
Published: 2025
Journal Articles

Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes

Open Access
Patrick K. Reville, Bofei Wang, Jennifer Marvin-Peek, Bin Yuan, Yu-An Kuo, Araceli Garza, Jessica Root, Wei Qiao, Andrea Arruda, Ivo Veletic, Yiwei Liu, Nicholas J. Short, Courtney D. DiNardo, Tapan M. Kadia, Naval G. Daver, Philip L. Lorenzi, Koji Sasaki, Steven Kornblau, Mark D. Minden, Farhad Ravandi, Hagop M. Kantarjian, Hussein A. Abbas
Journal: Blood
Blood (2025) 145 (25): 3015–3029.
https://doi.org/10.1182/blood.2024027244
Published: 2025
Includes: Supplemental data
Journal Articles

Social determinants of health and access to allogeneic hematopoietic cell transplantation for acute myeloid leukemia

Free
CME Clinical Trials & Observations
Natalie Wuliji, Salene M. W. Jones, Ted Gooley, Aaron T. Gerds, Bruno C. Medeiros, Paul J. Shami, John Galvin, Kehinde Adekola, Selina Luger, Maria R. Baer, David Rizzieri, Tanya M. Wildes, Eunice S. Wang, Mikkael A. Sekeres, Sudipto Mukherjee, Julie Smith, Mitchell Garrison, Kiarash Kojouri, Jacob Appelbaum, Mary-Elizabeth Percival, Brenda M. Sandmaier, Stephanie Lee, Frederick R. Appelbaum, Rayne Rouce, Mohamed L. Sorror
Journal: Blood
Blood (2025) 145 (25): 3041–3051.
https://doi.org/10.1182/blood.2024027543
Published: 2025
Includes: Supplemental data
Journal Articles

TP53 -mutated acute myeloid leukemia: how can we improve outcomes?

Available to Purchase
Clinical Trials & Observations
David A. Sallman, Maximilian Stahl
Journal: Blood
Blood (2025) 145 (24): 2828–2833.
https://doi.org/10.1182/blood.2024024245
Published: 2025
Journal Articles

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in adults over 70 years old

Available to Purchase
Roland B. Walter, Victoria Potter, Charles Craddock
Journal: Blood
Blood (2025) 145 (24): 2847–2856.
https://doi.org/10.1182/blood.2024024247
Published: 2025
Journal Articles

Approaching a therapeutic inflection point for FLT3 -mutated AML

Available to Purchase
Clinical Trials & Observations
Alexander E. Perl
Journal: Blood
Blood (2025) 145 (24): 2834–2839.
https://doi.org/10.1182/blood.2024024248
Published: 2025
Journal Articles

The fit older adult with acute myeloid leukemia: clinical challenges to providing evidence-based frontline treatment

Available to Purchase
Sameem Abedin, Geoffrey L. Uy, Laura C. Michaelis
Journal: Blood
Blood (2025) 145 (24): 2840–2846.
https://doi.org/10.1182/blood.2024026004
Published: 2025
Journal Articles

Introduction to a Blood Spotlight series on acute myeloid leukemia

Free
Selina M. Luger
Journal: Blood
Blood (2025) 145 (24): 2801–2802.
https://doi.org/10.1182/blood.2025028384
Published: 2025