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Journal Articles

Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia

Blood (2025) 146 (Supplement 1): 2539.

https://doi.org/10.1182/blood-2025-2539

Published: 2025

Journal Articles

Stepwise leukemogenesis and therapeutic targets revealed in B-cell acute lymphoblastic leukemia driven by PAX5 mutations

Zhilian Jia, Zunsong Hu, Lu Yang, Anthony Chan, Xiaohua Huang, Allen Mao, Ibrahim Aldoss, Lucy Ghoda, Michelle Afkhami, Guido Marcucci, Zhenhua Chen, Jianjun Chen, Chun-Wei Chen, Shai Izraeli, Markus Müschen, Nora Heisterkamp, Zhaohui Gu

Blood (2025) 146 (Supplement 1): 139.

https://doi.org/10.1182/blood-2025-139

Published: 2025

Journal Articles

DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

Blood (2025) 146 (Supplement 1): 212.

https://doi.org/10.1182/blood-2025-212

Published: 2025

Journal Articles

Mitochondrial RNA pseudouridine reprograms metabolism and induces immunosuppression in myeloid leukemia

Blood (2025) 146 (Supplement 1): 211.

https://doi.org/10.1182/blood-2025-211

Published: 2025

Journal Articles

Microrna-142 improves IL1RAP CAR-T cell activity in Acute Myeloid Leukemia

Kaito Harada, Dandan Zhao, Miso Park, Fang Chen, Yongfang Xu, Yi Zhang, Yile Zhou, Bea Parcutela, Yead Jewel, Ashlie Munoz, Idoroenyi Amanam, Le Xuan Truong Nguyen, Jianjun Chen, Lucy Ghoda, Stephen Forman, John Williams, Bin Zhang, Guido Marcucci

Blood (2025) 146 (Supplement 1): 2340.

https://doi.org/10.1182/blood-2025-2340

Published: 2025

Journal Articles

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Blood (2024) 144 (Supplement 1): 625.

https://doi.org/10.1182/blood-2024-201916

Published: 2024

Journal Articles

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Zhangliang Cheng, Salim Oulghazi, Philipp Berning, David Fonseca-Arce, Kohei Kume, Jake Fontaine, Lai N Chan, Jaewoong Lee, Fang Yu, Zhijian Qian, Joo Y. Song, Wing Chung Chan, Jianjun Chen, Mark M Taketo, Hilde Schjerven, Markus Müschen

Blood (2024) 144 (Supplement 1): 4125.

https://doi.org/10.1182/blood-2024-208125

Published: 2024

Journal Articles

Modeling the Initiation and Progression of Human MLL -Rearranged Precursor B Cell Acute Lymphoblastic Leukemia in Mice

Blood (2024) 144 (Supplement 1): 2738.

https://doi.org/10.1182/blood-2024-199829

Published: 2024

Journal Articles

TET1 Drives Myelodysplastic Syndromes and Represents a Promising Therapeutic Target

Chao Shen, Tingting Tang, Kitty Wang, Zunsong Hu, Yuan Che, Meiling Chen, Keren Zhou, Zhenhua Chen, Ying Qing, Wei Li, Dong Wu, Keith Leung, Lillian Sau, Zhaoxu Xu, Lucy Y. Ghoda, Guido Marcucci, Xiaolan Deng, Jianjun Chen

Blood (2024) 144 (Supplement 1): 3192.

https://doi.org/10.1182/blood-2024-199714

Published: 2024

Journal Articles

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Ruifeng Sun, Jaewoong Lee, Mark E Robinson, Kohei Kume, Ning Ma, Kadriye Nehir Cosgun, Lai N Chan, Irina Antoshkina, Dhruv Khanduja, Etienne Leveille, Samuel G. Katz, Jianjun Chen, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2023) 142 (Supplement 1): 719.

https://doi.org/10.1182/blood-2023-189742

Published: 2023

Journal Articles

Targeting Sumoylation Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

Li Du, Jiamin Guo, Zhenhua Chen, Jianjun Chen, Guido Marcucci, Steven T. Rosen

Blood (2023) 142 (Supplement 1): 411.

https://doi.org/10.1182/blood-2023-178037

Published: 2023

Journal Articles

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Blood (2023) 142 (Supplement 1): 2818.

https://doi.org/10.1182/blood-2023-190522

Published: 2023

Journal Articles

Metformin Potentiates Gilteritinib Sensitivity Via Targeting PLK1 Signaling: A Strategy to Improve Outcomes and Reduce Costs in Treating FLT3-Mutated Acute Myeloid Leukemia

Meiling Chen, Chao Shen, Yi Chen, Keren Zhou, Wei Li, Zhenhua Chen, Chengwu Zeng, Ying Qing, Dong Wu, Kitty Wang, Xiaolan Deng, Jianda Hu, Yong Wu, Jianjun Chen

Blood (2023) 142 (Supplement 1): 1427.

https://doi.org/10.1182/blood-2023-187751

Published: 2023

Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Blood (2022) 140 (Supplement 1): 998–1000.

https://doi.org/10.1182/blood-2022-165469

Published: 2022

Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Blood (2022) 140 (Supplement 1): 2975–2977.

https://doi.org/10.1182/blood-2022-162619

Published: 2022

Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Blood (2022) 140 (Supplement 1): 4931–4933.

https://doi.org/10.1182/blood-2022-167366

Published: 2022

Journal Articles

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yuhui Wu, Yinghui Zhu, Hanying Wang, Wenfeng Huang, Yichun Lin, Lianjun Zhang, Dandan Zhao, Juan Du, Rui Su, Ya-Huei Kuo, Jianjun Chen, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li

Blood (2021) 138 (Supplement 1): 358.

https://doi.org/10.1182/blood-2021-151679

Published: 2021

Journal Articles

METTL3 Dysregulates RNA Splicing by Translational Control of Splicing Factors via m 6 A Modification in CLL

Yiming Wu, Meiling Jin, Mike Fernandez, Kevyn Hart, Aijun Liao, Stacey M. Fernandes, Tinisha McDonald, Lucy Ghoda, Daniel Roeth, Markus Kalkum, Raju Pillai, Jianjun Chen, Jennifer R Brown, Alexey V. Danilov, Steven T. Rosen, Tanya Siddiqi, Lili Wang

Blood (2021) 138 (Supplement 1): 499.

https://doi.org/10.1182/blood-2021-149691

Published: 2021

Journal Articles

RNA modifications in hematopoietic malignancies: a new research frontier

Ying Qing, Rui Su, Jianjun Chen

Blood (2021) 138 (8): 637–648.

https://doi.org/10.1182/blood.2019004263

Published: 2021

Journal Articles

YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m 6 A-dependent manner

Blood (2021) 138 (1): 71–85.

https://doi.org/10.1182/blood.2020009676

Published: 2021

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Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia

Stepwise leukemogenesis and therapeutic targets revealed in B-cell acute lymphoblastic leukemia driven by PAX5 mutations

DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

Mitochondrial RNA pseudouridine reprograms metabolism and induces immunosuppression in myeloid leukemia

Microrna-142 improves IL1RAP CAR-T cell activity in Acute Myeloid Leukemia

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Modeling the Initiation and Progression of Human MLL -Rearranged Precursor B Cell Acute Lymphoblastic Leukemia in Mice

TET1 Drives Myelodysplastic Syndromes and Represents a Promising Therapeutic Target

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Targeting Sumoylation Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Metformin Potentiates Gilteritinib Sensitivity Via Targeting PLK1 Signaling: A Strategy to Improve Outcomes and Reduce Costs in Treating FLT3-Mutated Acute Myeloid Leukemia

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Targeting PRMT9 Suppresses Acute Myeloid Leukemia Maintenance

METTL3 Dysregulates RNA Splicing by Translational Control of Splicing Factors via m 6 A Modification in CLL

RNA modifications in hematopoietic malignancies: a new research frontier

YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m 6 A-dependent manner

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