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Volume 94, Issue 6

September 15 1999

In this Issue

INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
PLENARY PAPER
REVIEW ARTICLES
CHEMOKINES
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
ERRATA

INTRODUCTION: FOCUS ON HEMATOLOGY

Mutational Status of Ig V_H Genes Provides Clinically Valuable Information in B-Cell Chronic Lymphocytic Leukemia

Mark Naylor,J. Donald Capra

View Articletitled, Mutational Status of Ig VH Genes Provides Clinically Valuable Information in B-Cell Chronic Lymphocytic Leukemia

FOCUS ON HEMATOLOGY

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia: Presented in part at the 40^th Annual Meeting of The American Society of Hematology, held in Miami Beach, FL, December 4-8, 1998.

Rajendra N. Damle,Tarun Wasil,Franco Fais,Fabio Ghiotto,Angelo Valetto,Steven L. Allen,Aby Buchbinder,Daniel Budman,Klaus Dittmar,Jonathan Kolitz,Stuart M. Lichtman,Philip Schulman,Vincent P. Vinciguerra,Kanti R. Rai,Manlio Ferrarini,Nicholas Chiorazzi

View Articletitled, Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia: Presented in part at the 40th Annual Meeting of The American Society of Hematology, held in Miami Beach, FL, December 4-8, 1998.

Unmutated Ig V_H Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

Terry J. Hamblin,Zadie Davis,Anne Gardiner,David G. Oscier,Freda K. Stevenson

View Articletitled, Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

PLENARY PAPER

Promoter Elements of vav Drive Transgene Expression In Vivo Throughout the Hematopoietic Compartment

Sarah Ogilvy,Donald Metcalf,Leonie Gibson,Mary L. Bath,Alan W. Harris,Jerry M. Adams

View Articletitled, Promoter Elements of vav Drive Transgene Expression In Vivo Throughout the Hematopoietic Compartment

REVIEW ARTICLES

Regulation of the Erythropoietin Gene

Benjamin L. Ebert,H. Franklin Bunn

View Articletitled, Regulation of the Erythropoietin Gene

CHEMOKINES

Nuclear Factor-κB–Dependent Induction of Interleukin-8 Gene Expression by Tumor Necrosis Factor : Evidence for an Antioxidant Sensitive Activating Pathway Distinct From Nuclear Translocation

Spiros Vlahopoulos,Istvan Boldogh,Antonella Casola,Allan R. Brasier

View Articletitled, Nuclear Factor-κB–Dependent Induction of Interleukin-8 Gene Expression by Tumor Necrosis Factor : Evidence for an Antioxidant Sensitive Activating Pathway Distinct From Nuclear Translocation

Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3⁺, CD4⁺, CD8^low Thymocytes

David Chantry,Paola Romagnani,Carol J. Raport,Christi L. Wood,Angela Epp,Sergio Romagnani,Patrick W. Gray

View Articletitled, Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3+, CD4+, CD8low Thymocytes

CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist

Cédric Blanpain,Isabelle Migeotte,Benhur Lee,Jalal Vakili,Benjamin J. Doranz,Cédric Govaerts,Gilbert Vassart,Robert W. Doms,Marc Parmentier

View Articletitled, CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist

HEMATOPOIESIS

Reconstitution of Early Lymphoid Proliferation and Immune Function in Jak3-Deficient Mice by Interleukin-3

Michael P. Brown,Tetsuya Nosaka,Ralph A. Tripp,James Brooks,Jan M.A. van Deursen,Malcolm K. Brenner,Peter C. Doherty,James N. Ihle

View Articletitled, Reconstitution of Early Lymphoid Proliferation and Immune Function in Jak3-Deficient Mice by Interleukin-3

The Presence of Novel Amino Acids in the Cytoplasmic Domain of Stem Cell Factor Results in Hematopoietic Defects inSteel^17H Mice

Reuben Kapur,Ryan Cooper,Xingli Xiao,Mitchell J. Weiss,Peter Donovan,David A. Williams

View Articletitled, The Presence of Novel Amino Acids in the Cytoplasmic Domain of Stem Cell Factor Results in Hematopoietic Defects inSteel17H Mice

Rapid Differentiation of a Rare Subset of Adult Human Lin⁻CD34⁻CD38⁻ Cells Stimulated by Multiple Growth Factors In Vitro

Tomoaki Fujisaki,Marc G. Berger,Stefan Rose-John,Connie J. Eaves

View Articletitled, Rapid Differentiation of a Rare Subset of Adult Human Lin−CD34−CD38− Cells Stimulated by Multiple Growth Factors In Vitro

Identification of a 14-3-3 Binding Sequence in the Common β Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF

F.C. Stomski,M. Dottore,W. Winnall,M.A. Guthridge,J. Woodcock,C.J. Bagley,D.T. Thomas,R.K. Andrews,M.C. Berndt,A.F. Lopez

View Articletitled, Identification of a 14-3-3 Binding Sequence in the Common β Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF

Simultaneous Antagonism of Interleukin-5, Granulocyte-Macrophage Colony-Stimulating Factor, and Interleukin-3 Stimulation of Human Eosinophils by Targetting the Common Cytokine Binding Site of Their Receptors

Q. Sun,K. Jones,B. McClure,B. Cambareri,B. Zacharakis,P.O. Iversen,F. Stomski,J.M. Woodcock,C.J. Bagley,R. D’Andrea,A.F. Lopez

View Articletitled, Simultaneous Antagonism of Interleukin-5, Granulocyte-Macrophage Colony-Stimulating Factor, and Interleukin-3 Stimulation of Human Eosinophils by Targetting the Common Cytokine Binding Site of Their Receptors

Production of Thrombopoietin by Human Carcinomas and Its Novel Isoforms

Yutaka Sasaki,Takayuki Takahashi,Hiroshi Miyazaki,Atsushi Matsumoto,Takashi Kato,Kishiko Nakamura,Sumiko Iho,Yoshiaki Okuno,Kazuwa Nakao

View Articletitled, Production of Thrombopoietin by Human Carcinomas and Its Novel Isoforms

Transforming Growth Factor-β1 (TGF-β1) Induces Thrombopoietin From Bone Marrow Stromal Cells, Which Stimulates the Expression of TGF-β Receptor on Megakaryocytes and, in Turn, Renders Them Susceptible to Suppression by TGF-β Itself With High Specificity

Sumio Sakamaki,Yasuo Hirayama,Takuya Matsunaga,Hiroyuki Kuroda,Toshiro Kusakabe,Takehide Akiyama,Yuichi Konuma,Katsunori Sasaki,Naoki Tsuji,Tetsuro Okamoto,Masayoshi Kobune,Katsuhisa Kogawa,Junji Kato,Rishu Takimoto,Ryuzo Koyama,Yoshiro Niitsu

View Articletitled, Transforming Growth Factor-β1 (TGF-β1) Induces Thrombopoietin From Bone Marrow Stromal Cells, Which Stimulates the Expression of TGF-β Receptor on Megakaryocytes and, in Turn, Renders Them Susceptible to Suppression by TGF-β Itself With High Specificity

Involvement of the Retinoblastoma Protein in Monocytic and Neutrophilic Lineage Commitment of Human Bone Marrow Progenitor Cells

Gösta Bergh,Mats Ehinger,Inge Olsson,Sten Eirik W. Jacobsen,Urban Gullberg

View Articletitled, Involvement of the Retinoblastoma Protein in Monocytic and Neutrophilic Lineage Commitment of Human Bone Marrow Progenitor Cells

Signaling via Src Family Kinases Is Required for Normal Internalization of the Receptor c-Kit

Virginia C. Broudy,Nancy L. Lin,W. Conrad Liles,Seth J. Corey,Bridget O’Laughlin,Sherry Mou,Diana Linnekin

View Articletitled, Signaling via Src Family Kinases Is Required for Normal Internalization of the Receptor c-Kit

Osteoclast-Derived Zinc Finger (OCZF) Protein With POZ Domain, a Possible Transcriptional Repressor, Is Involved in Osteoclastogenesis

Akiko Kukita,Toshio Kukita,Mamoru Ouchida,Hidefumi Maeda,Hitomi Yatsuki,Osamu Kohashi

View Articletitled, Osteoclast-Derived Zinc Finger (OCZF) Protein With POZ Domain, a Possible Transcriptional Repressor, Is Involved in Osteoclastogenesis

ATM Is Upregulated During the Mitogenic Response in Peripheral Blood Mononuclear Cells

Toshiyuki Fukao,Hideo Kaneko,Geoff Birrell,Magtouf Gatei,Hideaki Tashita,Toko Yoshida,Simone Cross,Padmini Kedar,Dianne Watters,Kum Kum Khana,Ihor Misko,Naomi Kondo,Martin F. Lavin

View Articletitled, ATM Is Upregulated During the Mitogenic Response in Peripheral Blood Mononuclear Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Defensin Promotes the Binding of Lipoprotein(a) to Vascular Matrix

Khalil Bdeir,William Cane,Gabriela Canziani,Irwin Chaiken,John Weisel,Marlys L. Koschinsky,Richard M. Lawn,Peter G. Bannerman,Bruce S. Sachais,Alice Kuo,Mark A. Hancock,John Tomaszewski,P.N. Raghunath,Tomas Ganz,Abd Al-Roof Higazi,Douglas B. Cines

View Articletitled, Defensin Promotes the Binding of Lipoprotein(a) to Vascular Matrix

Cultured Endothelial Cells From Human Arteriovenous Malformations Have Defective Growth Regulation

Marie-Paule Wautier,Bernadette Boval,Olivier Chappey,Odile Enjolras,Nicolas Wernert,Jean-Jacques Merland,Jean-Luc Wautier

View Articletitled, Cultured Endothelial Cells From Human Arteriovenous Malformations Have Defective Growth Regulation

Fibrin Fragment Induction of Plasminogen Activator Inhibitor Transcription Is Mediated by Activator Protein-1 Through a Highly Conserved Element

Mitchell A. Olman,James S. Hagood,Warren L. Simmons,Gerald M. Fuller,Charles Vinson,Kimberly E. White

View Articletitled, Fibrin Fragment Induction of Plasminogen Activator Inhibitor Transcription Is Mediated by Activator Protein-1 Through a Highly Conserved Element

The Human Platelet IIb Gene Is Not Closely Linked to Its Integrin Partner β3

M.A. Thornton,M. Poncz,M. Korostishevsky,E. Yakobson,S. Usher,U. Seligsohn,H. Peretz

View Articletitled, The Human Platelet IIb Gene Is Not Closely Linked to Its Integrin Partner β3

IMMUNOBIOLOGY

CD34⁺ Acute Myeloid and Lymphoid Leukemic Blasts Can Be Induced to Differentiate Into Dendritic Cells

A. Cignetti,E. Bryant,B. Allione,A. Vitale,R. Foa,M.A. Cheever

View Articletitled, CD34+ Acute Myeloid and Lymphoid Leukemic Blasts Can Be Induced to Differentiate Into Dendritic Cells

NEOPLASIA

Isolation of a Highly Quiescent Subpopulation of Primitive Leukemic Cells in Chronic Myeloid Leukemia

Tessa Holyoake,Xiaoyan Jiang,Connie Eaves,Allen Eaves

View Articletitled, Isolation of a Highly Quiescent Subpopulation of Primitive Leukemic Cells in Chronic Myeloid Leukemia

Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils

Franziska Jundt,Ioannis Anagnostopoulos,Kurt Bommert,Florian Emmerich,Gerd Müller,Hans-Dieter Foss,Hans-Dieter Royer,Harald Stein,Bernd Dörken

View Articletitled, Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils

The (4;11)(q21;p15) Translocation Fuses the NUP98 andRAP1GDS1 Genes and Is Recurrent in T-Cell Acute Lymphocytic Leukemia

Damian J. Hussey,Mario Nicola,Sarah Moore,Gregory B. Peters,Alexander Dobrovic

View Articletitled, The (4;11)(q21;p15) Translocation Fuses the NUP98 andRAP1GDS1 Genes and Is Recurrent in T-Cell Acute Lymphocytic Leukemia

Interleukin-6 Regulation of Matrix Metalloproteinase (MMP-2 and MMP-9) and Tissue Inhibitor of Metalloproteinase (TIMP-1) Expression in Malignant Non-Hodgkin’s Lymphomas

Anna E. Kossakowska,Dylan R. Edwards,Christopher Prusinkiewicz,Melissa C. Zhang,Dianlin Guo,Stefan J. Urbanski,Thomas Grogan,Leah A. Marquez,Anna Janowska-Wieczorek

View Articletitled, Interleukin-6 Regulation of Matrix Metalloproteinase (MMP-2 and MMP-9) and Tissue Inhibitor of Metalloproteinase (TIMP-1) Expression in Malignant Non-Hodgkin’s Lymphomas

A Novel Epstein-Barr Virus-Like Virus, HV_MNE, in aMacaca Nemestrina With Mycosis Fungoides

E.D. Rivadeneira,M.G. Ferrari,R.F. Jarrett,A.A. Armstrong,P. Markham,T. Birkebak,S. Takemoto,C. Johnson-Delaney,J. Pecon-Slattery,E.A. Clark,G. Franchini

View Articletitled, A Novel Epstein-Barr Virus-Like Virus, HVMNE, in aMacaca Nemestrina With Mycosis Fungoides

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

Yongkui Jing,Jie Dai,Ruth M.E. Chalmers-Redman,Willam G. Tatton,Samuel Waxman

View Articletitled, Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

PHAGOCYTES

Role of Src in the Modulation of Multiple Adaptor Proteins in FcRI Oxidant Signaling

Rae-Kil Park,Kayvon D. Izadi,Yashwant M. Deo,Donald L. Durden

View Articletitled, Role of Src in the Modulation of Multiple Adaptor Proteins in FcRI Oxidant Signaling

RED CELLS

CD36 Peptides That Block Cytoadherence Define the CD36 Binding Region for Plasmodium falciparum-Infected Erythrocytes

Dror I. Baruch,Xin C. Ma,Brittan Pasloske,Russell J. Howard,Louis H. Miller

View Articletitled, CD36 Peptides That Block Cytoadherence Define the CD36 Binding Region for Plasmodium falciparum-Infected Erythrocytes

The Cellular Labile Iron Pool and Intracellular Ferritin in K562 Cells

Abraham M. Konijn,Hava Glickstein,Boris Vaisman,Esther G. Meyron-Holtz,Itzchak N. Slotki,Z. Ioav Cabantchik

View Articletitled, The Cellular Labile Iron Pool and Intracellular Ferritin in K562 Cells

TRANSFUSION MEDICINE

Stealth Cells: Prevention of Major Histocompatibility Complex Class II-Mediated T-Cell Activation by Cell Surface Modification

Kari L. Murad,Edmund J. Gosselin,John W. Eaton,Mark D. Scott

View Articletitled, Stealth Cells: Prevention of Major Histocompatibility Complex Class II-Mediated T-Cell Activation by Cell Surface Modification

TRANSPLANTATION

Behavior and Therapeutic Efficacy of β-Glucuronidase–Positive Mononuclear Phagocytes in a Murine Model of Mucopolysaccharidosis Type VII

Brian J. Freeman,Marie S. Roberts,Carole A. Vogler,Andrew Nicholes,A. Alex Hofling,Mark S. Sands

View Articletitled, Behavior and Therapeutic Efficacy of β-Glucuronidase–Positive Mononuclear Phagocytes in a Murine Model of Mucopolysaccharidosis Type VII

In Vivo Selection of Wild-Type Hematopoietic Stem Cells in a Murine Model of Fanconi Anemia

Kevin P. Battaile,Raynard L. Bateman,Derik Mortimer,Jean Mulcahy,R. Keaney Rathbun,Grover Bagby,William H. Fleming,Markus Grompe

View Articletitled, In Vivo Selection of Wild-Type Hematopoietic Stem Cells in a Murine Model of Fanconi Anemia

ERRATA

Erratum for vol. 82, p. 1395

View Articletitled, Erratum for vol. 82, p. 1395

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