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Journal Articles

Novel NOTCH1 Effector NFIL3 Is a Therapeutic Target to Combat Drug Resistance and Improve Patient Outcomes in Newly Diagnosed and Relapsed-Refractory Multiple Myeloma

Wen-Hui Cheng, Daniela Simone Maichl, Julius Arthur Kirner, Stefanie Schmidt, Carsten Patrick Ade, Mengshi Yang, Malik Salman Haider, Robert Luxenhofer, Lyudmyla Taranets, Melanie Haffner-Luntzer, Verena Fischer, Anita Ignatius, Nikita Popova, Franziska Jundt

Blood (2024) 144 (Supplement 1): 3287.

https://doi.org/10.1182/blood-2024-205288

Published: 2024

Journal Articles

Mechanical Loading Shows Anti-Myeloma Effects While Rescuing Bone Loss with Net Bone Formation in a Myeloma Bone Disease Murine Model

Fani Ziouti, Maximilian Rummler, Andreas Brandl, PhD, Andreas Beilhack, MD, Maureen Lynch, PhD, Bettina Willie, PhD, Franziska Jundt, MD

Blood (2018) 132 (Supplement 1): 3164.

https://doi.org/10.1182/blood-2018-99-116796

Published: 2018

Journal Articles

Targeted Remodeling of the Tumor Microenvironment Via Mechanical Stimulation Defines a Novel Therapeutic Strategy in Myeloma Bone Disease

Fani Ziouti, Maximilian Rummler, Anne Seliger, Andreas Brandl, PhD, Andreas Beilhack, MD, Bjarne Bogen, MD PhD, Maureen Lynch, PhD, Franz Jakob, MD, Regina Ebert, PhD, Bettina Willie, PhD, Franziska Jundt, MD

Blood (2017) 130 (Supplement 1): 1778.

https://doi.org/10.1182/blood.V130.Suppl_1.1778.1778

Published: 2017

Journal Articles

The Notch Target Genes Hey1 and Hes7 Transcriptionally Suppress Gli1 Expression and Hedgehog Signaling in Hodgkin-Reed/Sternberg Cells of Classical Hodgkin Lymphoma: A Novel Mechanism of Drug Resistance

Rolf Schwarzer, PhD, Julia Godau, Hermann Einsele, MD, Franziska Jundt, MD

Blood (2014) 124 (21): 275.

https://doi.org/10.1182/blood.V124.21.275.275

Published: 2014

Journal Articles

Hematopoietic Cell Lines and Patient Samples Show a Correlation Between Upregulated MSI2 and BCR-ABL Expression

Jaspal S. Kaeda, PhD, Rolf Schwarzer, Robert K. Slany, PhD, Thomas Burmeister, MD, Elisabetta Vagge, Leila Amini, Frauke Ringel, PhD, Katarina Pardon, Michaela Schwarz, MD, Bernd Dörken, Franziska Jundt, MD, Philipp le Coutre, MD

Blood (2013) 122 (21): 2618.

https://doi.org/10.1182/blood.V122.21.2618.2618

Published: 2013

Journal Articles

Targeting Notch and Hedgehog Embryonic Signaling Pathways Has Potent Anti-Tumor Activity in Myeloma and Is Effective in Myeloma Bone Disease.

Rolf Schwarzer, Nicole Schünemann, David M Wong, Bjarne Bogen, Kurt Bommert, Bernd Dörken, MD, Rudolf Manz, Franziska Jundt, MD

Blood (2012) 120 (21): 2938.

https://doi.org/10.1182/blood.V120.21.2938.2938

Published: 2012

Journal Articles

High-Level Expression of Mastermind-Like 2 (MAML2) Contributes to Aberrant Activation of the NOTCH Signaling Pathway In Human Lymphomas

Karl Köchert, Stephan Kreher, Jon C Aster, MD, PhD, Motoo Kitagawa, Korinna Jöhrens, Ioannis Anagnostopoulos, Franziska Jundt, MD, PD, Harald Stein, MD, Martin Janz, MD, Bernd Dörken, MD, Stephan Mathas, MD

Blood (2010) 116 (21): 2685.

https://doi.org/10.1182/blood.V116.21.2685.2685

Published: 2010

Journal Articles

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts T reg cells via regulation of MIP-3α

Björn Lamprecht, Stephan Kreher, Ioannis Anagnostopoulos, Korinna Jöhrens, Giovanni Monteleone, Franziska Jundt, Harald Stein, Martin Janz, Bernd Dörken, Stephan Mathas

Blood (2008) 112 (8): 3339–3347.

https://doi.org/10.1182/blood-2008-01-134783

Published: 2008

Includes: Supplemental data

Journal Articles

A Novel Notch Pathway Inhibitor Blocks Osteoclast Activity and Synergistically Induces Apoptosis with the Proteasome Inhibitor Bortezomib in Multiple Myeloma Cells.

Franziska Jundt, MD, Rolf Schwarzer, Phd, Martin Kaiser, MD, Oezlem Acikgoez, MD, Ulrike Heider, MD, Stephan Mathas, MD, Robert Preissner, Phd, Orhan Sezer, MD, Bernd Dorken, MD

Blood (2007) 110 (11): 1522.

https://doi.org/10.1182/blood.V110.11.1522.1522

Published: 2007

Journal Articles

Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

Stephan Mathas, Korinna Jöhrens, Stefan Joos, Andreas Lietz, Franziska Hummel, Martin Janz, Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Peter Lichter, Harald Stein, Claus Scheidereit, Bernd Dörken

Blood (2005) 106 (13): 4287–4293.

https://doi.org/10.1182/blood-2004-09-3620

Published: 2005

Journal Articles

The Notch Ligand Jagged1 Causes a Myeloproliferative Disorder in Mice Lacking IκBα.

Franziska Jundt, MD, Rudolf A. Rupec, MD, Bernd Rebholz, PhD, Bernd Doerken, MD, Irmgard Foerster, PhD, Ralf Huss, MD, Klaus Pfeffer, MD

Blood (2005) 106 (11): 1226.

https://doi.org/10.1182/blood.V106.11.1226.1226

Published: 2005

Journal Articles

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and anaplastic large cell lymphomas

Franziska Jundt, Nina Raetzel, Christine Müller, Cornelis F. Calkhoven, Katharina Kley, Stephan Mathas, Andreas Lietz, Achim Leutz, Bernd Dörken

Blood (2005) 106 (5): 1801–1807.

https://doi.org/10.1182/blood-2004-11-4513

Published: 2005

Journal Articles

Manipulation of the Notch Pathway by γ-Secretase Inhibitors as a Novel Therapeutic Approach in Multiple Myeloma.

Franziska Jundt, MD, Oezlem Acikgoez, MD, Robert Preissner, PhD, Bernd Dorken, MD

Blood (2004) 104 (11): 645.

https://doi.org/10.1182/blood.V104.11.645.645

Published: 2004

Journal Articles

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

Franziska Jundt, Kristina Schulze Pröbsting, Ioannis Anagnostopoulos, Gwendolin Muehlinghaus, Manik Chatterjee, Stephan Mathas, Ralf C. Bargou, Rudolf Manz, Harald Stein, Bernd Dörken

Blood (2004) 103 (9): 3511–3515.

https://doi.org/10.1182/blood-2003-07-2254

Published: 2004

Journal Articles

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

Stephan Mathas, Andreas Lietz, Martin Janz, Michael Hinz, Franziska Jundt, Claus Scheidereit, Kurt Bommert, Bernd Dörken

Blood (2003) 102 (3): 1028–1034.

https://doi.org/10.1182/blood-2002-04-1154

Published: 2003

Journal Articles

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

Franziska Jundt, Ioannis Anagnostopoulos, Reinhold Förster, Stephan Mathas, Harald Stein, Bernd Dörken

Blood (2002) 99 (9): 3398–3403.

https://doi.org/10.1182/blood.V99.9.3398

Published: 2002

Journal Articles

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease

Franziska Jundt, Katharina Kley, Ioannis Anagnostopoulos, Kristina Schulze Pröbsting, Axel Greiner, Stephan Mathas, Claus Scheidereit, Thomas Wirth, Harald Stein, Bernd Dörken

Blood (2002) 99 (8): 3060–3062.

https://doi.org/10.1182/blood.V99.8.3060

Published: 2002

Journal Articles

Overexpression of I Kappa B Alpha Without Inhibition of NF-κB Activity and Mutations in the I Kappa B Alpha Gene in Reed-Sternberg Cells

Florian Emmerich, Martina Meiser, Michael Hummel, Gudrun Demel, Hans-Dieter Foss, Franziska Jundt, Stephan Mathas, Daniel Krappmann, Claus Scheidereit, Harald Stein, Bernd Dörken

Blood (1999) 94 (9): 3129–3134.

https://doi.org/10.1182/blood.V94.9.3129

Published: 1999

Journal Articles

Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils

Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Florian Emmerich, Gerd Müller, Hans-Dieter Foss, Hans-Dieter Royer, Harald Stein, Bernd Dörken

Blood (1999) 94 (6): 2065–2071.

https://doi.org/10.1182/blood.V94.6.2065

Published: 1999

NARROW

Novel NOTCH1 Effector NFIL3 Is a Therapeutic Target to Combat Drug Resistance and Improve Patient Outcomes in Newly Diagnosed and Relapsed-Refractory Multiple Myeloma

Mechanical Loading Shows Anti-Myeloma Effects While Rescuing Bone Loss with Net Bone Formation in a Myeloma Bone Disease Murine Model

Targeted Remodeling of the Tumor Microenvironment Via Mechanical Stimulation Defines a Novel Therapeutic Strategy in Myeloma Bone Disease

The Notch Target Genes Hey1 and Hes7 Transcriptionally Suppress Gli1 Expression and Hedgehog Signaling in Hodgkin-Reed/Sternberg Cells of Classical Hodgkin Lymphoma: A Novel Mechanism of Drug Resistance

Hematopoietic Cell Lines and Patient Samples Show a Correlation Between Upregulated MSI2 and BCR-ABL Expression

Targeting Notch and Hedgehog Embryonic Signaling Pathways Has Potent Anti-Tumor Activity in Myeloma and Is Effective in Myeloma Bone Disease.

High-Level Expression of Mastermind-Like 2 (MAML2) Contributes to Aberrant Activation of the NOTCH Signaling Pathway In Human Lymphomas

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts T reg cells via regulation of MIP-3α

A Novel Notch Pathway Inhibitor Blocks Osteoclast Activity and Synergistically Induces Apoptosis with the Proteasome Inhibitor Bortezomib in Multiple Myeloma Cells.

Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

The Notch Ligand Jagged1 Causes a Myeloproliferative Disorder in Mice Lacking IκBα.

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and anaplastic large cell lymphomas

Manipulation of the Notch Pathway by γ-Secretase Inhibitors as a Novel Therapeutic Approach in Multiple Myeloma.

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease

Overexpression of I Kappa B Alpha Without Inhibition of NF-κB Activity and Mutations in the I Kappa B Alpha Gene in Reed-Sternberg Cells

Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils

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American Society of Hematology

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American Society of Hematology

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