Abstract
Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells. Thereby they control cell fate decisions and survival. We recently demonstrated that Notch has a pathogenetic role in multiple myeloma (MM), where tight interactions between neoplastic plasma cells and their microenvironment are essential for tumor cell growth (
Blood.
2004
; 103
:3511
–3515Author notes
Corresponding author
2005, The American Society of Hematology
2004
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