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Issue Archive

Volume 129, Issue 24
June 15 2017
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Restoring leukemia cell function from the inside out
Clinical Trials & Observations
John G. Gribben
View Articletitled, Restoring leukemia cell function from the inside out
INSIDE BLOOD COMMENTARY
Barcodes show family trees in ALL
Jonas Larsson
View Articletitled, Barcodes show family trees in ALL
INSIDE BLOOD COMMENTARY
Novel oncogenic noncoding mutations in T-ALL
Steven Goossens,Pieter Van Vlierberghe
View Articletitled, Novel oncogenic noncoding mutations in T-ALL
INSIDE BLOOD COMMENTARY
Pre-PMF emerging as important subgroup of MPN
Heinz Gisslinger
View Articletitled, Pre-PMF emerging as important subgroup of MPN
INSIDE BLOOD COMMENTARY
From tumor suppressor to thrombus resolver
Eric F. Grabowski
View Articletitled, From tumor suppressor to thrombus resolver

PERSPECTIVE

Biological considerations of plasma-derived and recombinant factor VIII immunogenicity
Jesse Lai,Christine Hough,Julie Tarrant,David Lillicrap
View Articletitled, Biological considerations of plasma-derived and recombinant factor VIII immunogenicity

REVIEW ARTICLE

Targeting the interleukin-1 pathway in patients with hematological disorders
Charlotte E. M. de Mooij,Mihai G. Netea,Walter J. F. M. van der Velden,Nicole M. A. Blijlevens
View Articletitled, Targeting the interleukin-1 pathway in patients with hematological disorders

CLINICAL TRIALS AND OBSERVATIONS

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia
Clinical Trials & Observations
Ramiro Garzon,Michael Savona,Rachid Baz,Michael Andreeff,Nashat Gabrail,Martin Gutierrez,Lynn Savoie,Paul Morten Mau-Sorensen,Nina Wagner-Johnston,Karen Yee,Thaddeus J. Unger,Jean-Richard Saint-Martin,Robert Carlson,Tami Rashal,Trinayan Kashyap,Boris Klebanov,Sharon Shacham,Michael Kauffman,Richard Stone
View Articletitled, A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia
Supplemental data
Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma
Clinical Trials & Observations
John Kuruvilla,Michael Savona,Rachid Baz,Paul Morten Mau-Sorensen,Nashat Gabrail,Ramiro Garzon,Richard Stone,Michael Wang,Lynn Savoie,Peter Martin,Ian Flinn,Meagan Jacoby,Thaddeus J. Unger,Jean-Richard Saint-Martin,Tami Rashal,Sharon Friedlander,Robert Carlson,Michael Kauffman,Sharon Shacham,Martin Gutierrez
View Articletitled, Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma
Supplemental data

GENE THERAPY

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells
Geoffrey L. Rogers,Jamie L. Shirley,Irene Zolotukhin,Sandeep R. P. Kumar,Alexandra Sherman,George Q. Perrin,Brad E. Hoffman,Arun Srivastava,Etiena Basner-Tschakarjan,Mark A. Wallet,Cox Terhorst,Moanaro Biswas,Roland W. Herzog
View Articletitled, Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8<sup>+</sup> T cells
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Osteoblasts support megakaryopoiesis through production of interleukin-9
Min Xiao,Yongkui Wang,Chen Tao,Zhenyu Wang,Jun Yang,Zhenguo Chen,Zhipeng Zou,Mangmang Li,Anling Liu,Chunhong Jia,Bin Huang,Bo Yan,Pinglin Lai,Changhai Ding,Daozhang Cai,Guozhi Xiao,Yu Jiang,Xiaochun Bai
View Articletitled, Osteoblasts support megakaryopoiesis through production of interleukin-9
Supplemental data

LYMPHOID NEOPLASIA

Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding
Mirjam E. Belderbos,Taco Koster,Bertien Ausema,Sabrina Jacobs,Sharlaine Sowdagar,Erik Zwart,Eveline de Bont,Gerald de Haan,Leonid V. Bystrykh
View Articletitled, Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding
Supplemental data
Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report
Sunniyat Rahman,Michael Magnussen,Theresa E. León,Nadine Farah,Zhaodong Li,Brian J. Abraham,Krisztina Z. Alapi,Rachel J. Mitchell,Tom Naughton,Adele K. Fielding,Arnold Pizzey,Sophia Bustraan,Christopher Allen,Teodora Popa,Karin Pike-Overzet,Laura Garcia-Perez,Rosemary E. Gale,David C. Linch,Frank J. T. Staal,Richard A. Young,A. Thomas Look,Marc R. Mansour
View Articletitled, Activation of the <em>LMO2</em> oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis
CME
Paola Guglielmelli,Annalisa Pacilli,Giada Rotunno,Elisa Rumi,Vittorio Rosti,Federica Delaini,Margherita Maffioli,Tiziana Fanelli,Alessandro Pancrazzi,Daniela Pietra,Silvia Salmoiraghi,Carmela Mannarelli,Annalisa Franci,Chiara Paoli,Alessandro Rambaldi,Francesco Passamonti,Giovanni Barosi,Tiziano Barbui,Mario Cazzola,Alessandro M. Vannucchi,on behalf of the AGIMM Group
View Articletitled, Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Lysis of human neutrophils by community-associated methicillin-resistant Staphylococcus aureus
Mallary C. Greenlee-Wacker,Silvie Kremserová,William M. Nauseef
View Articletitled, Lysis of human neutrophils by community-associated methicillin-resistant <em>Staphylococcus aureus</em>
Supplemental data

THROMBOSIS AND HEMOSTASIS

Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice
Subhradip Mukhopadhyay,Toni M. Antalis,Khanh P. Nguyen,Mark H. Hoofnagle,Rajabrata Sarkar
View Articletitled, Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice
Supplemental data

TRANSPLANTATION

Phase 1 multicenter trial of brentuximab vedotin for steroid-refractory acute graft-versus-host disease
Clinical Trials & Observations
Yi-Bin Chen,Miguel-Angel Perales,Shuli Li,Maria Kempner,Carol Reynolds,Jami Brown,Yvonne A. Efebera,Steven M. Devine,Areej El-Jawahri,Steven L. McAfee,Thomas R. Spitzer,Robert J. Soiffer,Jerome Ritz,Corey Cutler
View Articletitled, Phase 1 multicenter trial of brentuximab vedotin for steroid-refractory acute graft-versus-host disease

LETTERS TO BLOOD

Coxiella burnetii antibody seropositivity is not a risk factor for AIDS-related non-Hodgkin lymphoma
Halie K. Miller,Loredana Santo,M. Constanza Camargo,Cheryl A. Winkler,James J. Goedert,Gilbert J. Kersh,Charles S. Rabkin
View Articletitled, <em>Coxiella burnetii</em> antibody seropositivity is not a risk factor for AIDS-related non-Hodgkin lymphoma
Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations
Shaoyan Hu,Maoxiang Qian,Hui Zhang,Yu Guo,Jin Yang,Xujie Zhao,Hailong He,Jun Lu,Jian Pan,Meimei Chang,Guoqing Du,Ting-Nien Lin,Shirley Kow-Yin Kham,Thuan Chong Quah,Hany Ariffin,Ah-Moy Tan,Yong Cheng,Chunliang Li,Allen Eng-Juh Yeoh,Ching-Hon Pui,Anders Jacobsen Skanderup,Jun J. Yang
View Articletitled, Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations
Supplemental data

BLOOD WORK

Erdheim-Chester disease presenting as bradycardia in an elderly man
M. Mansour Ceesay,Robin Dowse
View Articletitled, Erdheim-Chester disease presenting as bradycardia in an elderly man
Coarse basophilic stippling in lead poisoning
Nelson C. N. Chan,K. P. Chan
View Articletitled, Coarse basophilic stippling in lead poisoning

ERRATA

Cicalese MP, Ferrua F, Castagnaro L, et al. Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency. Blood. 2016;128(1):45-54.
View Articletitled, Cicalese MP, Ferrua F, Castagnaro L, et al. Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency. <em>Blood.</em> 2016;128(1):45-54.
Marini O, Costa S, Bevilacqua D, et al. Mature CD10+ and immature CD10− neutrophils present in G-CSF–treated donors display opposite effects on T cells. Blood. 2017;129(10):1343-1356.
View Articletitled, Marini O, Costa S, Bevilacqua D, et al. Mature CD10<sup>+</sup> and immature CD10<sup>−</sup> neutrophils present in G-CSF–treated donors display opposite effects on T cells. <em>Blood.</em> 2017;129(10):1343-1356.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Prefibrotic/early vs overt PMF
CME
View Articletitled, Prefibrotic/early vs overt PMF
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