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Journal Articles

Lisaftoclax (APG-2575) Demonstrates Activity and Safety When Given with Accelerated Ramp-up and then Combined with Acalabrutinib or Rituximab in Patients (pts) with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Including Those with Prior Exposure to Venetoclax

Matthew S. Davids, Sikander Ailawadhi, Asher A. Chanan-Khan, Boyd Mudenda, Larysa Nogaieva, Iryna Kryachok, Ganna Usenko, Vladimir Ivanov, Olena Kyselova, Tetiana Perekhrestenko, Ivan Muzhychuk, Alexander Myasnikov, Les Lukavetsky, Andrei Proydakov, Olga Uspenskaya, Elena Borisenkova, Paula Marlton, Tanya Siddiqi, Allison M. Winter, Tamila Lysa, Bulat Akhatovich Bakirov, Tommy Fu, Mingyu Li, Mohammad Ahmad, Zi Chen, Zhiyan Liang, Divya J. Mekala, Olena Karpenko, Iurii Osipov, Asit De, Hengbang Wang, Nashat Gabrail, Vinod Ganju, Tatiana Konstantinova, Olga Samoilova, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2024) 144 (Supplement 1): 4614.
https://doi.org/10.1182/blood-2024-207408
Published: 2024
Journal Articles

Lisaftoclax (APG-2575) Safety and Activity As Monotherapy or Combined with Acalabrutinib or Rituximab in Patients (pts) with Treatment-Naïve, Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (R/R CLL/SLL): Initial Data from a Phase 2 Global Study

Matthew S. Davids, Asher Chanan-Khan, Boyd Mudenda, Larysa Nogaieva, Iryna Kriachok, Hanna Usenko, Vladimir Ivanov, Olena Kyselova, Tetiana Perekhrestenko, Ivan Muzhychuk, Alexander Myasnikov, Zvenyslava Maslyak, Andrew Proidakov, Olga Uspenskaya, Elena Borisenkova, Paula Marlton, Tanya Siddiqi, Allison Winter, Tamila Lysa, Bulat Bakirov, Lei Fu, Zi Chen, Min Yu, Mingyu Li, Laura Glass, Mohammad Ahmad, Olena Karpenko, Iurii Osipov, Asit De, Ben Paudyal, Hengbang Wang, Robert Winkler, Nashat Gabrail, Vinod Ganju, Tatiana S. Konstantinova, Olga S. Samoylova, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2022) 140 (Supplement 1): 2326–2328.
https://doi.org/10.1182/blood-2022-160386
Published: 2022
Journal Articles

A Multi-Center, Phase 1b Study to Assess the Safety, Pharmacokinetics and Efficacy of Subcutaneous Isatuximab Plus Pomalidomide and Dexamethasone, in Patients with Relapsed/Refractory Multiple Myeloma

Philippe Moreau, Gurdeep Parmar, Miles Prince, Enrique Ocio, Chatchada Karanes, Sumit Madan, Albert Oriol, Pierre Bories, Michel Delforge, Nashat Gabrail, Dorothee Semiond, Nan Jia, Sandrine Macé, Florence Suzan, Helgi van de Velde, Hang Quach
Journal: Blood
Blood (2021) 138 (Supplement 1): 2744.
https://doi.org/10.1182/blood-2021-147136
Published: 2021
Journal Articles

Efficacy of Oral Decitabine/Cedazuridine (ASTX727) in the CMML Subgroup from the Ascertain Phase 3 Study

Michael R. Savona, James K McCloskey, Elizabeth A. Griffiths, Karen Yee, Amer M. Zeidan, Aref Al-Kali, H. Joachim Deeg, Prapti Patel, Mitchell Sabloff, Mary-Margaret Keating, Kim-Hien Dao, Nancy Zhu, Nashat Gabrail, Salman Fazal, Joseph Maly, Olatoyosi Odenike, Hagop Kantarjian, Amy E. DeZern, Casey L. O'Connell, Gail J. Roboz, Lambert Busque, Richard A. Wells, Harshad Amin, Jasleen K. Randhawa, Brian Leber, Yong Hao, Harold N. Keer, Mohammad Azab, Guillermo Garcia-Manero
Journal: Blood
Blood (2021) 138 (Supplement 1): 3682.
https://doi.org/10.1182/blood-2021-154179
Published: 2021
Journal Articles

Trial in Progress: Phase 1b Study of Lisaftoclax (APG-2575) As a Single Agent or Combined with Other Therapeutic Agents in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (R/R CLL/SLL)

Matthew S. Davids, Tanya Siddiqi, Asher Chanan-Khan, Alan Skarbnik, Allison M. Winter, John M. Pagel, Carrie Smith, Nashat Gabrail, Tetiana Perekhrestenko, Halyna Pylypenko, Olena Kyselova, Olena Karpenko, Tetiana Popovska, Iryna Kriachok, Hanna Usenko, Andrew Proidakov, Vladimir Ivanov, Tamila Lysa, Elena Borisenkova, Bulat Bakirov, Les Lukavetsky, Olga Uspenskaya, Tatiana S. Konstantinova, Olga S. Samoylova, Zi Chen, Bo Huang, Mingyu Li, Mohammad Ahmad, Boyd Mudenda, Dajun Yang, Yifan Zhai
Journal: Blood
Blood (2021) 138 (Supplement 1): 1554.
https://doi.org/10.1182/blood-2021-152811
Published: 2021
Journal Articles

Clinical Efficacy and Safety of Oral Decitabine/Cedazuridine in 133 Patients with Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)

Michael R. Savona, MD, James K. McCloskey, MD, Elizabeth A. Griffiths, MD, Karen W.L. Yee, MD, Aref Al-Kali, MD, Amer M. Zeidan, MBBS, MHS, H. Joachim Deeg, MD, Prapti A. Patel, MD, Mitchell Sabloff, MSc,MDFRCPC, Mary-Margaret Keating, MD FRCPC, Kim-Hien Dao, DO, PhD, Nancy Zhu, MD, Nashat Gabrail, MD, Salman Fazal, MD, Joseph Maly, MD, Olatoyosi Odenike, MD, Hagop M. Kantarjian, MD, Amy E. DeZern, MD, Casey L. O'Connell, MD, Gail J. Roboz, MD, Lambert Busque, MD, Richard A. Wells, MD DPhil, Harshad Amin, MD, Jasleen K. Randhawa, MD, Brian Leber, MD, Yong Hao, MD PhD, Harold N. Keer, MDPhD, Mohammad Azab, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-133855
Published: 2020
Journal Articles

A Randomized, Open-Label, Multicenter, Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of KRT-232 Compared with Ruxolitinib in Patients with Phlebotomy-Dependent Polycythemia Vera

Jason Gotlib, MD MS, Nashat Gabrail, MD, Casey L. O'Connell, MD, Regina Garcia-Delgado, MD, Timothy Sbardellati, Wayne M. Rothbaum, Jesse McGreivy, Claire N Harrison, Professor, Jean-Jacques Kiladjian, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4168.
https://doi.org/10.1182/blood-2019-123546
Published: 2019
Journal Articles

OP-106 Horizon — Melflufen Therapy for RRMM Patients Refractory to Daratumumab and/or Pomalidomide; Updated Results and First Report on PFS

Paul Richardson, Enrique Ocio, MD, Albert Oriol, MD, Alessandra Larocca, MD, Paula Rodriguez Otero, MD, Jan Moreb, MD, Joan Bladé, MD, Hani Hassoun, MD, Michele Cavo, MD, Adrián Alegre, MD, Amitabha Mazumder, MD, Christopher Maisel, MD, Agne Paner, MD, Nashat Gabrail, MD, Jeffrey A Zonder, MD, Dharminder Chauhan, PhD, Johan Harmenberg, MD, Sara Thuresson, MSc, Hanan Zubair, MSc, Maria-Victoria Mateos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 600.
https://doi.org/10.1182/blood-2018-99-113095
Published: 2018
Journal Articles

Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia

Clinical Trials & Observations
Christine Chen, David Siegel, Martin Gutierrez, Meagan Jacoby, Craig C. Hofmeister, Nashat Gabrail, Rachid Baz, Morten Mau-Sorensen, Jesus G. Berdeja, Michael Savona, Lynn Savoie, Suzanne Trudel, Nuchanan Areethamsirikul, T. J. Unger, Tami Rashal, Tim Hanke, Michael Kauffman, Sharon Shacham, Donna Reece
Journal: Blood
Blood (2018) 131 (8): 855–863.
https://doi.org/10.1182/blood-2017-08-797886
Published: 2018
Includes: Supplemental data
Journal Articles

Efficacy and Safety of Pomalidomide As a Replacement Therapy for Lenalidomide for Relapsed/Refractory Multiple Myeloma Patients Refractory to a Lenalidomide-Containing Combination Regimen

James R Berenson, MD, Alexa Cohen, Tanya M. Spektor, PhD, Ashkan Lashkari, MD, Roy Mackintosh, MD, Alberto Bessudo, MD, Haresh Jhangiani, Nashat Gabrail, MD, Ibrahim Nakhoul, MD, Samir Kubba, MD, Jeffrey D. Neidhart, MD BS, Maluso Tina, Regina Swift, Robert Vescio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3106.
https://doi.org/10.1182/blood.V130.Suppl_1.3106.3106
Published: 2017
Journal Articles

Melflufen Therapy for Relapsed Refractory Multiple Myeloma (RRMM) Patients Refractory to Daratumumab and/or Pomalidomide: A Report on Early Efficacy

Maria-Victoria Mateos, MD, Joan Bladé, MD PhD, Alessandra Larocca, Albert Oriol, MD, Paula Rodriguez, MD, Adrián Alegre, MD, Michele Cavo, MD, Jan S Moreb, MD, Agne Paner, MD, Nashat Gabrail, MD, Kathleen G. Halka, MD, Hani Hassoun, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Jeffrey A Zonder, MD, Enrique M Ocio, MD, Catriona Byrne, RN, Johan Harmenberg, MD PhD, Sara Thuresson, MSc, Eva Nordstrom, MSc, MBA, Jakob Lindberg, MD PhD, Paul G Richardson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1841.
https://doi.org/10.1182/blood.V130.Suppl_1.1841.1841
Published: 2017
Journal Articles

Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma

Clinical Trials & Observations
John Kuruvilla, Michael Savona, Rachid Baz, Paul Morten Mau-Sorensen, Nashat Gabrail, Ramiro Garzon, Richard Stone, Michael Wang, Lynn Savoie, Peter Martin, Ian Flinn, Meagan Jacoby, Thaddeus J. Unger, Jean-Richard Saint-Martin, Tami Rashal, Sharon Friedlander, Robert Carlson, Michael Kauffman, Sharon Shacham, Martin Gutierrez
Journal: Blood
Blood (2017) 129 (24): 3175–3183.
https://doi.org/10.1182/blood-2016-11-750174
Published: 2017
Includes: Supplemental data
Journal Articles

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia

Clinical Trials & Observations
Ramiro Garzon, Michael Savona, Rachid Baz, Michael Andreeff, Nashat Gabrail, Martin Gutierrez, Lynn Savoie, Paul Morten Mau-Sorensen, Nina Wagner-Johnston, Karen Yee, Thaddeus J. Unger, Jean-Richard Saint-Martin, Robert Carlson, Tami Rashal, Trinayan Kashyap, Boris Klebanov, Sharon Shacham, Michael Kauffman, Richard Stone
Journal: Blood
Blood (2017) 129 (24): 3165–3174.
https://doi.org/10.1182/blood-2016-11-750158
Published: 2017
Includes: Supplemental data
Journal Articles

Selinexor Demonstrates Marked Synergy with Dexamethasone (Sel-Dex) in Preclinical Models and in Patients with Heavily Pretreated Refractory Multiple Myeloma (MM)

Christine I. Chen, MD MD FRCPC, Martin Gutierrez, MD, David S. Siegel, MD PhD, Joshua R. Richter, MD, Nina Wagner-Johnston, Craig C Hofmeister, MD MPH, Jesus G. Berdeja, MD, Nashat Gabrail, MD, Rachid Baz, MD, Morten Mau-Sorensen, MD, Suzanne Trudel, MD MSC, FRCPC, Rodger E. Tiedemann, MD PhD, Vishal Kukreti, MD, Nuchanan Areethamsirikul, MD, Asfar Azmi, PhD, Trinayan Kashyap, MSc, Yosef Landesman, PhD, Tracey Marshall, John McCartney, PhD, Jean-Richard Saint-Martin, Sasha Norori, MSc, Michael R Savona, MD, Tami Rashal, MD, Robert Carlson, PhD, Mansoor R Mirza, MD, Sharon Shacham, PhDMBA, Michael Kauffman, MD PhD, Donna E Reece, MD FRCPC
Journal: Blood
Blood (2014) 124 (21): 4773.
https://doi.org/10.1182/blood.V124.21.4773.4773
Published: 2014
Journal Articles

Oprozomib and Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma: Initial Results from the Dose Escalation Portion of a Phase 1b/2, Multicenter, Open-Label Study

Parameswaran N. Hari, MD, Kenneth H. Shain, MD PhD, Peter M. Voorhees, MD, Nashat Gabrail, MD, Muneer H. Abidi, MD, Jeffrey Zonder, MD, Ralph V. Boccia, MD, Paul G. Richardson, Linda L. Neuman, MD MBA, Sandra J. Dixon, MS, Claudia Paba Prada, MD
Journal: Blood
Blood (2014) 124 (21): 3453.
https://doi.org/10.1182/blood.V124.21.3453.3453
Published: 2014
Journal Articles

The Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL)

John Kuruvilla, MD, John C. Byrd, MD, Joseph M Flynn, Ramiro Garzon, MD, Pierluigi Porcu, MD, Nina Wagner-Johnston, Mary Lynn Savoie, MD FRCPC, Richard M. Stone, MD, Eric D. Jacobsen, MD, Morten Mau-Sorensen, MD, Peter de Nully Brown, Rachid Baz, MD, Bijal Shal, MD, Ian Flinn, Nashat Gabrail, MD, Vishal Kukreti, MD, Rodger E. Tiedemann, MD PhD, Yosef Landesman, PhD, Boris Klebanov, M.A., MsC, Eran Shacham, PhD, Jean-Richard Saint-Martin, Tracey Marshall, John McCartney, PhD, Dilara McCauley, PhD, Robert Carlson, PhD, Sasha Norori, MSc, Michael R Savona, MD, Tami Rashal, MD, Mansoor R Mirza, MD, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA
Journal: Blood
Blood (2014) 124 (21): 396.
https://doi.org/10.1182/blood.V124.21.396.396
Published: 2014
Journal Articles

Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML)

Michael Savona, MD, Ramiro Garzon, MD, Peter de Nully Brown, MD, Karen Yee, MD, Jeffrey E. Lancet, MD, Martin Gutierrez, MD, Nashat Gabrail, MD, Morten Mau-Sorensen, MD, Rachid Baz, MD, John C. Byrd, MD, John Kuruvilla, MD, David S. Siegel, MD, PhD, Sharon Shacham, PhD, MBA, Tami Rashal, MD, Cindy YF Yau, MSc, CCRP, Dilara McCauley, PhD, Jean-Richard Saint-Martin, John McCartney, PhD, Yosef Landesman, PhD, Boris Klebanov, Greg Pond, PhD, Amit M. Oza, MBBS, MD, Michael Kauffman, MD, PhD, Mansoor R Mirza, MD, Richard M. Stone, MD
Journal: Blood
Blood (2013) 122 (21): 1440.
https://doi.org/10.1182/blood.V122.21.1440.1440
Published: 2013
Journal Articles

Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM)

Christine I. Chen, MD, Martin Gutierrez, MD, Peter de Nully Brown, Nashat Gabrail, MD, Rachid Baz, MD, Donna E. Reece, MD, Michael Savona, MD, Suzanne Trudel, MD, MSC, FRCPC, David S. Siegel, MD, PhD, Morten Mau-Sorensen, MD, John Kuruvilla, MD, FRCPC, John C. Byrd, MD, Sharon Shacham, PhD, MBA, Tami Rashal, MD, Cindy YF Yau, MSc, CCRP, Dilara McCauley, PhD, Jean-Richard Saint-Martin, John McCartney, PhD, Yosef Landesman, PhD, Boris Klebanov, Greg Pond, PhD, Amit M. Oza, MBBS, MD, Michael Kauffman, MD, PhD, Mansoor R Mirza, MD
Journal: Blood
Blood (2013) 122 (21): 1942.
https://doi.org/10.1182/blood.V122.21.1942.1942
Published: 2013
Journal Articles

Patient-Reported Quality of Life (QoL) in Elderly, Newly Diagnosed Multiple Myeloma (MM) Patients Receiving Bortezomib-Based Combinations: Results From All Randomized Patients in the Community-Based, Phase 3b UPFRONT Study

Ruben Niesvizky, MD, Ian W. Flinn, MD, PhD, Robert Rifkin, MD, Nashat Gabrail, MD, Veena Charu, MD, Billy Clowney, MD, Yousuf Gaffar, MD, Thomas A. Warr, MD, FACP, Rachel Neuwirth, MS, Hui Huang, PhD, MBA, Sanggyu Choi, PhD, Deyanira Corzo, MD
Journal: Blood
Blood (2011) 118 (21): 1864.
https://doi.org/10.1182/blood.V118.21.1864.1864
Published: 2011
Journal Articles

Efficacy and Safety of Three Bortezomib-Based Combinations in Elderly, Newly Diagnosed Multiple Myeloma Patients: Results From All Randomized Patients in the Community-Based, Phase 3b UPFRONT Study

Ruben Niesvizky, MD, Ian W. Flinn, MD, PhD, Robert Rifkin, MD, Nashat Gabrail, MD, Veena Charu, MD, Billy Clowney, MD, James Essell, MD, Yousuf Gaffar, MD, Thomas A. Warr, MD, FACP, Rachel Neuwirth, MS, Deyanira Corzo, MD, James Reeves, MD
Journal: Blood
Blood (2011) 118 (21): 478.
https://doi.org/10.1182/blood.V118.21.478.478
Published: 2011