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Boris Klebanov
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Journal Articles

Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis

Kellie R. Machlus, Stephen K. Wu, Prakrith Vijey, Thomas S. Soussou, Zhi-Jian Liu, Eran Shacham, T. J. Unger, Trinayan Kashyap, Boris Klebanov, Martha Sola-Visner, Marsha Crochiere, Joseph E. Italiano, Jr, Yosef Landesman
Journal: Blood
Blood (2017) 130 (9): 1132–1143.
https://doi.org/10.1182/blood-2016-11-752840
Published: 2017
Includes: Supplemental data
Journal Articles

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia

Clinical Trials & Observations
Ramiro Garzon, Michael Savona, Rachid Baz, Michael Andreeff, Nashat Gabrail, Martin Gutierrez, Lynn Savoie, Paul Morten Mau-Sorensen, Nina Wagner-Johnston, Karen Yee, Thaddeus J. Unger, Jean-Richard Saint-Martin, Robert Carlson, Tami Rashal, Trinayan Kashyap, Boris Klebanov, Sharon Shacham, Michael Kauffman, Richard Stone
Journal: Blood
Blood (2017) 129 (24): 3165–3174.
https://doi.org/10.1182/blood-2016-11-750158
Published: 2017
Includes: Supplemental data
Journal Articles

Combination of Selective Inhibitor of Nuclear Export (SINE) Compounds, Selinexor and KPT-8602, with Venetoclax (ABT-199) Displays Enhanced Activity in Leukemia and Large Cell Lymphoma

Melissa A. Fischer, PhD, Sharon Friedlander, PhD, Leah Hogdal, PhD, Pia Arrate, Hua Chang, PhD, Trinayan Kashyap, MS, Christian Argueta, PhD, Boris Klebanov, MA, MS, William Senapedis, PhD, Erkan Baloglu, PhD MBA, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael R. Savona, MD
Journal: Blood
Blood (2016) 128 (22): 3949.
https://doi.org/10.1182/blood.V128.22.3949.3949
Published: 2016
Journal Articles

Efficacy of Selinexor Is Dependent on IκB-α Expression and NF-Kb Deactivation in Multiple Myeloma Cells

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Christian Argueta, PhD, Margaret S. Lee, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD PhD, Yosef Landesman, PhD, William Senapedis, PhD
Journal: Blood
Blood (2016) 128 (22): 5660.
https://doi.org/10.1182/blood.V128.22.5660.5660
Published: 2016
Journal Articles

Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T Cell Effector Function in Mice: Implications for Combination with Immunotherapy

Paul M Tyler, Mariah M Servos, Boris Klebanov, Trinayan Kashyap, MS, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Michael Dougan, Stephanie K Dougan
Journal: Blood
Blood (2016) 128 (22): 2525.
https://doi.org/10.1182/blood.V128.22.2525.2525
Published: 2016
Journal Articles

Combination of Selinexor and the Proteasome Inhibitor, Bortezomib Shows Synergistic Cytotoxicity in Diffuse Large B-Cells Lymphoma Cells In Vitro and In Vivo

Trinayan Kashyap, MS, Irfana Muqbil, Amro Aboukameel, Boris Klebanov, MA, MS, Ramzi Mohammad, PhD, Asfar Sohail Azmi, PhD, William Senapedis, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2016) 128 (22): 4131.
https://doi.org/10.1182/blood.V128.22.4131.4131
Published: 2016
Journal Articles

Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination with Fludarabine and Cytarabine in Pediatric Patients with Relapsed or Refractory AML

Jeffrey E Rubnitz, MD PhD, Ronda Kaufman, PhD, Raul C. Ribeiro, MD, Boris Klebanov, MA, MS, Joel Ellis, PhD, Yosef Landesman, PhD, Hagop Youssoufian, MD, Tami Rashal, MD, Sharon Shacham
Journal: Blood
Blood (2015) 126 (23): 1345.
https://doi.org/10.1182/blood.V126.23.1345.1345
Published: 2015
Journal Articles

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)

Trinayan Kashyap, MS, Boris Klebanov, MA, MS, Margaret S. Lee, PhD, Yosef Landesman, PhD
Journal: Blood
Blood (2015) 126 (23): 3683.
https://doi.org/10.1182/blood.V126.23.3683.3683
Published: 2015
Journal Articles

In Vitro and in Vivo Quantification of Exportin-1 (XPO1) Occupancy By the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor in Multiple Myeloma, Acute Myeloid Leukemia, and Healthy PBMCs

Marsha Crochiere, PhD, Boris Klebanov, M.A., MsC, Erkan Baloglu, PhD, Ori Kalid, PhD, Trinayan Kashyap, MSc, William Senapedis, PhD, Diego del Alamo, BS, Tami Rashal, MD, Sharon Tamir, PhD, Dilara McCauley, PhD, Robert Carlson, PhD, Michael Savona, MD, Michael Kauffman, MD PhD, Sharon Shacham, PhDMBA, Yosef Landesman, PhD
Journal: Blood
Blood (2014) 124 (21): 5196.
https://doi.org/10.1182/blood.V124.21.5196.5196
Published: 2014
Journal Articles

The Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL)

John Kuruvilla, MD, John C. Byrd, MD, Joseph M Flynn, Ramiro Garzon, MD, Pierluigi Porcu, MD, Nina Wagner-Johnston, Mary Lynn Savoie, MD FRCPC, Richard M. Stone, MD, Eric D. Jacobsen, MD, Morten Mau-Sorensen, MD, Peter de Nully Brown, Rachid Baz, MD, Bijal Shal, MD, Ian Flinn, Nashat Gabrail, MD, Vishal Kukreti, MD, Rodger E. Tiedemann, MD PhD, Yosef Landesman, PhD, Boris Klebanov, M.A., MsC, Eran Shacham, PhD, Jean-Richard Saint-Martin, Tracey Marshall, John McCartney, PhD, Dilara McCauley, PhD, Robert Carlson, PhD, Sasha Norori, MSc, Michael R Savona, MD, Tami Rashal, MD, Mansoor R Mirza, MD, Michael Kauffman, MD PhD, Sharon Shacham, PhD MBA
Journal: Blood
Blood (2014) 124 (21): 396.
https://doi.org/10.1182/blood.V124.21.396.396
Published: 2014
Journal Articles

Phase I Trial of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Advanced Acute Myelogenous Leukemia (AML)

Michael Savona, MD, Ramiro Garzon, MD, Peter de Nully Brown, MD, Karen Yee, MD, Jeffrey E. Lancet, MD, Martin Gutierrez, MD, Nashat Gabrail, MD, Morten Mau-Sorensen, MD, Rachid Baz, MD, John C. Byrd, MD, John Kuruvilla, MD, David S. Siegel, MD, PhD, Sharon Shacham, PhD, MBA, Tami Rashal, MD, Cindy YF Yau, MSc, CCRP, Dilara McCauley, PhD, Jean-Richard Saint-Martin, John McCartney, PhD, Yosef Landesman, PhD, Boris Klebanov, Greg Pond, PhD, Amit M. Oza, MBBS, MD, Michael Kauffman, MD, PhD, Mansoor R Mirza, MD, Richard M. Stone, MD
Journal: Blood
Blood (2013) 122 (21): 1440.
https://doi.org/10.1182/blood.V122.21.1440.1440
Published: 2013
Journal Articles

Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (MM) Or Waldenstrom’s Macroglobulinemia (WM)

Christine I. Chen, MD, Martin Gutierrez, MD, Peter de Nully Brown, Nashat Gabrail, MD, Rachid Baz, MD, Donna E. Reece, MD, Michael Savona, MD, Suzanne Trudel, MD, MSC, FRCPC, David S. Siegel, MD, PhD, Morten Mau-Sorensen, MD, John Kuruvilla, MD, FRCPC, John C. Byrd, MD, Sharon Shacham, PhD, MBA, Tami Rashal, MD, Cindy YF Yau, MSc, CCRP, Dilara McCauley, PhD, Jean-Richard Saint-Martin, John McCartney, PhD, Yosef Landesman, PhD, Boris Klebanov, Greg Pond, PhD, Amit M. Oza, MBBS, MD, Michael Kauffman, MD, PhD, Mansoor R Mirza, MD
Journal: Blood
Blood (2013) 122 (21): 1942.
https://doi.org/10.1182/blood.V122.21.1942.1942
Published: 2013
Journal Articles

Preliminary Evidence Of Anti Tumor Activity Of Selinexor (KPT-330) In a Phase I Trial Ofa First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) In Patients (pts) With Relapsed / Refractory Non Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

John Kuruvilla, MD, Martin Gutierrez, MD, Bijal D. Shah, MD, Nashat Y. Gabrail, MD, Peter de Nully Brown, Richard M. Stone, MD, Ramiro Garzon, MD, Michael Savona, MD, David S. Siegel, MD, PhD, Rachid Baz, MD, Morten Mau-Sorensen, MD, Matthew S. Davids, MD, John C. Byrd, MD, Sharon Shacham, PhD, MBA, Tami Rashal, MD, Cindy YF Yau, Dilara McCauley, PhD, Jean-Richard Saint-Martin, John McCartney, PhD, Yosef Landesman, PhD, Boris Klebanov, Greg Pond, PhD, Amit M. Oza, MBBS, MD, Michael Kauffman, MD, PhD, Mansoor R Mirza
Journal: Blood
Blood (2013) 122 (21): 90.
https://doi.org/10.1182/blood.V122.21.90.90
Published: 2013