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Issue Archive

Volume 122, Issue 14
October 3 2013
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
Ikaros’ suspended flight in the thymus
Naomi Taylor,Valérie S. Zimmermann
View Articletitled, Ikaros’ suspended flight in the thymus
CLINICAL TRIALS & OBSERVATIONS
Panobinostat to revert bortezomib resistance
Clinical Trials & Observations
Philippe Moreau
View Articletitled, Panobinostat to revert bortezomib resistance
INSIDE BLOOD
SH2B3: a new leukemia predisposition gene
Cheryl L. Willman
View Articletitled, SH2B3: a new leukemia predisposition gene
MYELOID NEOPLASIA
STAT3 mutations and persistence of autoimmunity
Kirk R. Schultz
View Articletitled, STAT3 mutations and persistence of autoimmunity
THROMBOSIS & HEMOSTASIS
Kindlin ignites a new flame
Charles S. Abrams
View Articletitled, Kindlin ignites a new flame
TRANSPLANTATION
Doubling down on PKC benefits allogeneic BMT
Daniel H. Fowler
View Articletitled, Doubling down on PKC benefits allogeneic BMT
VASCULAR BIOLOGY
Leukocytes talking to VE-cadherin
Klaus Ley
View Articletitled, Leukocytes talking to VE-cadherin

BLOOD WORK

Lipogranulomatosis and hypersplenism induced by ruptured silicone breast implants
Amer M. Zeidan,Alison R. Moliterno
View Articletitled, Lipogranulomatosis and hypersplenism induced by ruptured silicone breast implants
Leptomeningeal metastases from primary plasma cell leukemia
Niels W.C.J. van de Donk,Henk M. Lokhorst
View Articletitled, Leptomeningeal metastases from primary plasma cell leukemia

BLOOD SPOTLIGHT

Pomalidomide
Martha Q. Lacy,Arleigh R. McCurdy
View Articletitled, Pomalidomide

REVIEW SERIES

Treatment of cancer-associated thrombosis
Agnes Y. Y. Lee,Erica A. Peterson
View Articletitled, Treatment of cancer-associated thrombosis

HOW I TREAT

How I treat CNS lymphomas
James L. Rubenstein,Neel K. Gupta,Gabriel N. Mannis,Amanda K. LaMarre,Patrick Treseler
View Articletitled, How I treat CNS lymphomas

CLINICAL TRIALS AND OBSERVATIONS

PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma
Clinical Trials & Observations
Paul G. Richardson,Robert L. Schlossman,Melissa Alsina,Donna M. Weber,Steven E. Coutre,Cristina Gasparetto,Sutapa Mukhopadhyay,Michael S. Ondovik,Mahmudul Khan,Carole S. Paley,Sagar Lonial
View Articletitled, PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma

HEMATOPOIESIS AND STEM CELLS

Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs
Sabrina Gordon-Keylock,Malgorzata Sobiesiak,Stanislav Rybtsov,Kate Moore,Alexander Medvinsky
View Articletitled, Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs
Supplemental data
Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B
Jau-Yi Li,Jonathan Adams,Laura M. Calvi,Timothy F. Lane,M. Neale Weitzmann,Roberto Pacifici
View Articletitled, Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B
Supplemental data
Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes
e-blood
Dominik Beck,Julie A. I. Thoms,Dilmi Perera,Judith Schütte,Ashwin Unnikrishnan,Kathy Knezevic,Sarah J. Kinston,Nicola K. Wilson,Tracey A. O’Brien,Berthold Göttgens,Jason W. H. Wong,John E. Pimanda
View Articletitled, Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes
Supplemental data
mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation
e-blood
Oren Levy,Weian Zhao,Luke J. Mortensen,Sarah LeBlanc,Kyle Tsang,Moyu Fu,Joseph A. Phillips,Vinay Sagar,Priya Anandakumaran,Jessica Ngai,Cheryl H. Cui,Peter Eimon,Matthew Angel,Charles P. Lin,Mehmet Fatih Yanik,Jeffrey M. Karp
View Articletitled, mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation
Supplemental data

IMMUNOBIOLOGY

Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus
Kevin W. Tinsley,Changwan Hong,Megan A. Luckey,Joo-Young Park,Grace Y. Kim,Hee-won Yoon,Hilary R. Keller,Andrew J. Sacks,Lionel Feigenbaum,Jung-Hyun Park
View Articletitled, Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus
Supplemental data
Requirement for Rictor in homeostasis and function of mature B lymphoid cells
Keunwook Lee,Lindsey Heffington,Julia Jellusova,Ki Taek Nam,Ariel Raybuck,Sung Hoon Cho,James W. Thomas,Robert C. Rickert,Mark Boothby
View Articletitled, Requirement for Rictor in homeostasis and function of mature B lymphoid cells
Supplemental data
Genetically coupled receptor–ligand pair NKp80-AICL enables autonomous control of human NK cell responses
Sascha N. Klimosch,Yvonne Bartel,Stefan Wiemann,Alexander Steinle
View Articletitled, Genetically coupled receptor–ligand pair NKp80-AICL enables autonomous control of human NK cell responses
Supplemental data
Partial IFN-γR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation
Marcela Moncada-Vélez,Rubén Martinez-Barricarte,Dusan Bogunovic,Xiao-Fei Kong,Lizbeth Blancas-Galicia,Cengiz Tirpan,Guzide Aksu,Quentin B. Vincent,Bertrand Boisson,Yuval Itan,Noé Ramírez-Alejo,Satoshi Okada,Alexandra Y. Kreins,Vanessa L. Bryant,Jose Luis Franco,Mélanie Migaud,Sara Espinosa-Padilla,Marco Yamazaki-Nakashimada,Francisco Espinosa-Rosales,Necil Kutukculer,Laurent Abel,Jacinta Bustamante,Guillaume Vogt,Jean-Laurent Casanova,Stéphanie Boisson-Dupuis
View Articletitled, Partial IFN-γR2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation
Supplemental data

LYMPHOID NEOPLASIA

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
Ophélie Meynet,Barbara Zunino,Lina Happo,Ludivine A. Pradelli,Johanna Chiche,Marie A. Jacquin,Laura Mondragón,Jean-François Tanti,Bruno Taillan,Georges Garnier,Julie Reverso-Meinietti,Nicolas Mounier,Jean-François Michiels,Ewa M. Michalak,Michel Carles,Clare L. Scott,Jean-Ehrland Ricci
View Articletitled, Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
Supplemental data
Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients
Betty Y. Chang,Michelle Francesco,Martin F. M. De Rooij,Padmaja Magadala,Susanne M. Steggerda,Min Mei Huang,Annemieke Kuil,Sarah E. M. Herman,Stella Chang,Steven T. Pals,Wyndham Wilson,Adrian Wiestner,Marcel Spaargaren,Joseph J. Buggy,Laurence Elias
View Articletitled, Egress of CD19<sup>+</sup>CD5<sup>+</sup> cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients
Supplemental data
Genetic loss of SH2B3 in acute lymphoblastic leukemia
Arianne Perez-Garcia,Alberto Ambesi-Impiombato,Michael Hadler,Isaura Rigo,Charles A. LeDuc,Kara Kelly,Chaim Jalas,Elisabeth Paietta,Janis Racevskis,Jacob M. Rowe,Martin S. Tallman,Maddalena Paganin,Giuseppe Basso,Wei Tong,Wendy K. Chung,Adolfo A. Ferrando
View Articletitled, Genetic loss of <em>SH2B3</em> in acute lymphoblastic leukemia

MYELOID NEOPLASIA

Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia
Christiane Katzerke,Vikas Madan,Dennis Gerloff,Daniela Bräuer-Hartmann,Jens-Uwe Hartmann,Alexander Arthur Wurm,Carsten Müller-Tidow,Susanne Schnittger,Daniel G. Tenen,Dietger Niederwieser,Gerhard Behre
View Articletitled, Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia
Supplemental data
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma
Isabel Ben-Batalla,Alexander Schultze,Mark Wroblewski,Robert Erdmann,Michael Heuser,Jonas S. Waizenegger,Kristoffer Riecken,Mascha Binder,Denis Schewe,Stefanie Sawall,Victoria Witzke,Miguel Cubas-Cordova,Melanie Janning,Jasmin Wellbrock,Boris Fehse,Christian Hagel,Jürgen Krauter,Arnold Ganser,James B. Lorens,Walter Fiedler,Peter Carmeliet,Klaus Pantel,Carsten Bokemeyer,Sonja Loges
View Articletitled, Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma
Supplemental data
STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients
Andres Jerez,Michael J. Clemente,Hideki Makishima,Hanna Rajala,Ines Gómez-Seguí,Thomas Olson,Kathy McGraw,Bartlomiej Przychodzen,Austin Kulasekararaj,Manuel Afable,Holleh D. Husseinzadeh,Naoko Hosono,Francis LeBlanc,Sonja Lagström,Dan Zhang,Pekka Ellonen,André Tichelli,Catherine Nissen,Alan E. Lichtin,Aleksandra Wodnar-Filipowicz,Ghulam J. Mufti,Alan F. List,Satu Mustjoki,Thomas P. Loughran, Jr,Jaroslaw P. Maciejewski
View Articletitled, STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients
Supplemental data
Comprehensive mutational profiling in advanced systemic mastocytosis
Juliana Schwaab,Susanne Schnittger,Karl Sotlar,Christoph Walz,Alice Fabarius,Markus Pfirrmann,Alexander Kohlmann,Vera Grossmann,Manja Meggendorfer,Hans-Peter Horny,Peter Valent,Mohamad Jawhar,Martina Teichmann,Georgia Metzgeroth,Philipp Erben,Thomas Ernst,Andreas Hochhaus,Torsten Haferlach,Wolf-Karsten Hofmann,Nicholas C. P. Cross,Andreas Reiter
View Articletitled, Comprehensive mutational profiling in advanced systemic mastocytosis
Supplemental data
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
Maria Lyngaas Torgersen,Nikolai Engedal,Stig-Ove Bøe,Peter Hokland,Anne Simonsen
View Articletitled, Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
Supplemental data
Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes
e-blood
Sébastien Malinge,Tim Chlon,Louis C. Doré,Rhett P. Ketterling,Martin S. Tallman,Elisabeth Paietta,Alan S. Gamis,Jeffrey W. Taub,Stella T. Chou,Mitchell J. Weiss,John D. Crispino,Maria E. Figueroa
View Articletitled, Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes
Supplemental data

PLATELETS AND THROMBOPOIESIS

Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia
Sylvain Audia,Maxime Samson,Matthieu Mahévas,Christophe Ferrand,Malika Trad,Marion Ciudad,Alexandrine Gautheron,Famky Seaphanh,Vanessa Leguy,Sabine Berthier,Bruno Salles,Laurent Martin,Bernard Lorcerie,Pablo Ortega-Deballon,Olivier Facy,Denis Caillot,Agnès Soudry-Faure,Marc Michel,Bertrand Godeau,Nicolas Larmonier,Philippe Saas,Nona Janikashvili,Bernard Bonnotte
View Articletitled, Preferential splenic CD8<sup>+</sup> T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q− syndrome
Brief Report
Adrianna Vlachos,Jason E. Farrar,Eva Atsidaftos,Ellen Muir,Anupama Narla,Thomas C. Markello,Sharon A. Singh,Michael Landowski,Hanna T. Gazda,Lionel Blanc,Johnson M. Liu,Steven R. Ellis,Robert J. Arceci,Benjamin L. Ebert,David M. Bodine,Jeffrey M. Lipton
View Articletitled, Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q− syndrome

THROMBOSIS AND HEMOSTASIS

Kindlin-2 regulates hemostasis by controlling endothelial cell–surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism
Elzbieta Pluskota,Yi Ma,Kamila M. Bledzka,Katarzyna Bialkowska,Dmitry A. Soloviev,Dorota Szpak,Eugene A. Podrez,Paul L. Fox,Stanley L. Hazen,James J. Dowling,Yan-Qing Ma,Edward F. Plow
View Articletitled, Kindlin-2 regulates hemostasis by controlling endothelial cell–surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism
Supplemental data

TRANSPLANTATION

Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice
Kelley M. K. Haarberg,Jun Li,Jessica Heinrichs,Dapeng Wang,Chen Liu,Crystina C. Bronk,Kane Kaosaard,Alexander M. Owyang,Sacha Holland,Esteban Masuda,Kin Tso,Bruce R. Blazar,Claudio Anasetti,Amer A. Beg,Xue-Zhong Yu
View Articletitled, Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice
Supplemental data

VASCULAR BIOLOGY

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin
Matthias Vockel,Dietmar Vestweber
View Articletitled, How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin

ERRATA

Falini B, Fizzotti M, Pucciarini A, et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood. 2000;95(6):2084-2092.
View Articletitled, Falini B, Fizzotti M, Pucciarini A, et al. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. <em>Blood</em>. 2000;95(6):<span class="related-article">2084-2092</span>.
Cortes JE, Kantarjian HM, Brümmendorf TH, et al. Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood. 2011;118(17):4567-4576
View Articletitled, Cortes JE, Kantarjian HM, Brümmendorf TH, et al. Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. <em>Blood</em>. 2011;118(17):<span class="related-article">4567-4576</span>
McClain KL. Are all mutant SNARES equal? Blood. 2012;119(25):5944-5945.
View Articletitled, McClain KL. Are all mutant SNARES equal? <em>Blood</em>. 2012;119(25):<span class="related-article">5944-5945</span>.
Bélanger S, Tu MM, Rahim MM, et al. Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice. Blood. 2012;120(3):592-602.
View Articletitled, Bélanger S, Tu MM, Rahim MM, et al. Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice. <em>Blood</em>. 2012;120(3):<span class="related-article">592-602</span>.
Morgan AS, Yang DT. Neutrophil alphabet. Blood. 2013;121(18):3546.
View Articletitled, Morgan AS, Yang DT. Neutrophil alphabet. <em>Blood</em>. 2013;121(18):<span class="related-article">3546</span>.
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