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Journal Articles

Trial in Progress - Alliance A051901 - Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (Nivo-MR2) Induction Followed By Lenalidomide and Nivolumab Maintenance in Primary Central Nervous System Lymphoma (PCNSL)

Alvaro J Alencar, Olivia Bobek, Neha Mehta-Shah, Narendranath Epperla, Christine Lu-Emerson, Sarah C. Rutherford, Adam J. Olszewski, Thomas Ollila, Samuel Singer, Travis Dockter, Susan M. Geyer, Lori Rosenstein, Macarena De La Fuente, Eric D. Hsi, Shira N. Dinner, James L. Rubenstein, Nancy L. Bartlett, John P. Leonard

Blood (2024) 144 (Supplement 1): 4502.4.

https://doi.org/10.1182/blood-2024-209238

Published: 2024

Journal Articles

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma

Michael P Randall, Huimin Geng, Lingjing Chen, Aishwarya Ballapuram, Chitoh Yung, Ming Lu, Gregory Chin, Michael Mish, Jamie Bates, James L. Rubenstein

Blood (2024) 144 (Supplement 1): 978.

https://doi.org/10.1182/blood-2024-212194

Published: 2024

Journal Articles

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models

Jun Ma, Michael P Randall, Ming Lu, Lingjing Chen, Huimin Geng, Aishwarya Kumar, Saloni Malla, Mark Noviski, Ryan Rountree, James L. Rubenstein

Blood (2024) 144 (Supplement 1): 2988.

https://doi.org/10.1182/blood-2024-211266

Published: 2024

Journal Articles

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma

Michael P Randall, Andreas Rauschecker, Liam Gima-Lange, Jenai Wilmoth, Lingjing Chen, Ming Lu, Huimin Geng, Haifaa Abdulhaq, James L. Rubenstein

Blood (2023) 142 (Supplement 1): 3104.

https://doi.org/10.1182/blood-2023-190698

Published: 2023

Journal Articles

Next-Generation Sequencing of Newly-Diagnosed Primary CNS Lymphoma Reveals Alterations in BTG1, ETV6, and 6p Are Associated with Chemoresistance and Inferior Progression-Free Survival

Shirley S. Mo, Huimin Geng, Miguel Cerejo, Kwun Wah Wen, David A. Solomon, James L. Rubenstein

Blood (2022) 140 (Supplement 1): 3516–3517.

https://doi.org/10.1182/blood-2022-170569

Published: 2022

Journal Articles

Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment

Hua-Xin Gao, Eleanor Fraser, Mario Merlini, Huimin Geng, Lingjing Chen, Ming Lu, Yasmin Moshfegh, Joseph Cleveland, Jae Ryu, Jigyasa Sharma, David A. Solomon, Katerina Akassoglou, Clifford Lowell, James L. Rubenstein

Blood (2021) 138 (Supplement 1): 448.

https://doi.org/10.1182/blood-2021-153839

Published: 2021

Journal Articles

EBV-Positive Primary CNS Lymphomas in Older Patients: Incidence, Characteristics, Tumor Pathology, and Outcomes across a Large Multicenter Cohort

Prashasti Agrawal, Kevin A. David, MD, Zhengming Chen, PhD MPH, MS, Suchitra Sundaram, MD, Seo-Hyun Kim, MD, Ryan Vaca, MD, Yong Lin, PhD, Samuel Singer, MD, Mary-Kate Malecek, MD, Jordan Carter, MD, Adam Zayac, MD, Myung Sun Kim, MD, Nishitha Reddy, MD, Alma Habib, MD, Christopher Strouse, MD, Jerome Graber, MD, Veronika Bachanova, MD PhD, Mazie Tsang, MD, Ajay Major, MDMBA, David A. Bond, MD, Angel Mier-Hicks, MD, Pallawi Torka, MD, Priya Rajakumar, MD, Parameswaran Venugopal, MD, Michael Glantz, MD PhD, Samuel Goldlust, MD, Rahul Matnani, MD, Pallavi Kumar, MD, Thomas A Ollila, MD, Johnny Cai, DO, Stephen E. Spurgeon, MD, Alex G Sieg, MD MS, Joseph Cleveland, MD, Narendranath Epperla, MDMS, Reem Karmali, MDMSc, Seema Naik, MD, Sonali M. Smith, MD, James L. Rubenstein, MD PhD, Brad S. Kahl, MD, Amy Chadburn, MD, Andrew M. Evens, DO,MMSc, Peter Martin, FRCPC, MD MS

Blood (2020) 136 (Supplement 1): 4–6.

https://doi.org/10.1182/blood-2020-138885

Published: 2020

Journal Articles

Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide

Mazie Tsang, MD, Joseph Cleveland, MD, Miguel Carlos Cerejo, DO, Huimin Geng, PhD, James L. Rubenstein, MD PhD

Blood (2020) 136 (Supplement 1): 21–22.

https://doi.org/10.1182/blood-2020-143070

Published: 2020

Journal Articles

Real World (RW) Outcomes and Prognostication of Older Patients with Primary Central Nervous System Lymphoma (PCNSL) in the Contemporary Era

Blood (2020) 136 (Supplement 1): 24–26.

https://doi.org/10.1182/blood-2020-136551

Published: 2020

Journal Articles

Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies

David A. Solomon, MD, PhD, Huimin Geng, PhD, Raymond A. Sobel, MD, Lakshmi Subbaraj, B.S., Mazie Tsang, MD, James L. Rubenstein, MD PhD

Blood (2019) 134 (Supplement_1): 1494.

https://doi.org/10.1182/blood-2019-131302

Published: 2019

Journal Articles

Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma

Huimin Geng, PhD, Huaxin Gao, PhD, Cigall Kadoch, PhD, Ming Lu, Lingjing Chen, PhD, Rana Anjum, PhD, Lisa Drew, PhD, Sebastien Degorce, PhD, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, PhD, Clifford A. Lowell, MD PhD, James L. Rubenstein, MD, PhD

Blood (2016) 128 (22): 777.

https://doi.org/10.1182/blood.V128.22.777.777

Published: 2016

Journal Articles

Expression of B and T Lymphocyte Attenuator (BTLA) Correlates with CNS Metastasis and Adverse Prognosis in Activated B-Cell Lymphoma and Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Zhengshan Chen, PhD, Shawn Anderson, Eleanor Fraser, PhD, Ming Lu, Chen Lingjing, PhD, Colin Collins, PhD, Muschen Markus, PhD, James L. Rubenstein, MD PhD

Blood (2015) 126 (23): 3900.

https://doi.org/10.1182/blood.V126.23.3900.3900

Published: 2015

Journal Articles

Frequency, Risk Factors and Mortality Effect of Venous Thromboembolism in Adult Patients with Central Nervous System Lymphoma

Anjlee Mahajan, MD, Son Ho, PharmD, Mimi Lo, PharmD, James L. Rubenstein, MD PhD, Richard Fong, PharmD

Blood (2015) 126 (23): 4458.

https://doi.org/10.1182/blood.V126.23.4458.4458

Published: 2015

Journal Articles

Interim Results of a Phase I Study of Lenalidomide (CC-5013) Plus Intraventricular/Intravenous Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma

James L. Rubenstein, MD, PhD, Paul Formaker, Xiaomin Wang, PhD, Nianhang Chen, PhD, Michael Seider, MD, Pamela Munster, MD, Bertil Damato, MD, PhD

Blood (2014) 124 (21): 4470.

https://doi.org/10.1182/blood.V124.21.4470.4470

Published: 2014

Journal Articles

High-Dose Methotrexate Is Effective, Safe, and Leads To Durable Responses In Patients With AIDS-Related Primary Central Nervous System Lymphoma Treated During The Era Of Combined Anti-Retroviral Therapy

Neel K. Gupta, MD, Jimmy Hwang, Ph.D., James L. Rubenstein, M.D., Ph.D.

Blood (2013) 122 (21): 1792.

https://doi.org/10.1182/blood.V122.21.1792.1792

Published: 2013

Journal Articles

Obesity and Hepatitis B Infection and Risk Of Primary CNS Lymphoma

Chia-Ching J. Wang, MD, Paige M Bracci, PhD, James L. Rubenstein, M.D., Ph.D.

Blood (2013) 122 (21): 4298.

https://doi.org/10.1182/blood.V122.21.4298.4298

Published: 2013

Journal Articles

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy

Hua-Xin Gao, Ph.D., Shawn Anderson, Cigall Kadoch, Ph.D., Mekhala Maiti, Ph.D., Lingjing Chen, Ph.D., Dong-Han Yao, Gerd Melkus, Ph.D., Maria Wang, Ph.D., Yan Ren, Ph.D., Michael Breider, Ph.D., Carla Heise, PhD, Clifford A. Lowell, MD, PhD, Colin Collins, Ph.D., James L. Rubenstein, M.D., Ph.D.

Blood (2013) 122 (21): 374.

https://doi.org/10.1182/blood.V122.21.374.374

Published: 2013

Journal Articles

How I treat CNS lymphomas

James L. Rubenstein, Neel K. Gupta, Gabriel N. Mannis, Amanda K. LaMarre, Patrick Treseler

Blood (2013) 122 (14): 2318–2330.

https://doi.org/10.1182/blood-2013-06-453084

Published: 2013

Journal Articles

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

James L. Rubenstein, Valerie S. Wong, Cigall Kadoch, Hua-Xin Gao, Ramon Barajas, Lingjing Chen, S. Andrew Josephson, Brian Scott, Vanja Douglas, Mekhala Maiti, Lawrence D. Kaplan, Patrick A. Treseler, Soonmee Cha, Jimmy H. Hwang, Paola Cinque, Jason G. Cyster, Clifford Lowell

Blood (2013) 121 (23): 4740–4748.

https://doi.org/10.1182/blood-2013-01-476333

Published: 2013

Includes: Supplemental data

Journal Articles

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma

James L. Rubenstein, Jing Li, Lingjing Chen, Ranjana Advani, Jan Drappatz, Elizabeth Gerstner, Tracy Batchelor, Hendrikus Krouwer, James Hwang, Glenna Auerback, Cigall Kadoch, Clifford Lowell, Pamela Munster, Soonmee Cha, Marc A. Shuman, Lloyd E. Damon

Blood (2013) 121 (5): 745–751.

https://doi.org/10.1182/blood-2012-07-440974

Published: 2013

Includes: Supplemental data

NARROW

Trial in Progress - Alliance A051901 - Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (Nivo-MR2) Induction Followed By Lenalidomide and Nivolumab Maintenance in Primary Central Nervous System Lymphoma (PCNSL)

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma

Next-Generation Sequencing of Newly-Diagnosed Primary CNS Lymphoma Reveals Alterations in BTG1, ETV6, and 6p Are Associated with Chemoresistance and Inferior Progression-Free Survival

Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment

EBV-Positive Primary CNS Lymphomas in Older Patients: Incidence, Characteristics, Tumor Pathology, and Outcomes across a Large Multicenter Cohort

Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide

Real World (RW) Outcomes and Prognostication of Older Patients with Primary Central Nervous System Lymphoma (PCNSL) in the Contemporary Era

Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies

Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma

Expression of B and T Lymphocyte Attenuator (BTLA) Correlates with CNS Metastasis and Adverse Prognosis in Activated B-Cell Lymphoma and Acute Lymphoblastic Leukemia

Frequency, Risk Factors and Mortality Effect of Venous Thromboembolism in Adult Patients with Central Nervous System Lymphoma

Interim Results of a Phase I Study of Lenalidomide (CC-5013) Plus Intraventricular/Intravenous Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma

High-Dose Methotrexate Is Effective, Safe, and Leads To Durable Responses In Patients With AIDS-Related Primary Central Nervous System Lymphoma Treated During The Era Of Combined Anti-Retroviral Therapy

Obesity and Hepatitis B Infection and Risk Of Primary CNS Lymphoma

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy

How I treat CNS lymphomas

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma

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American Society of Hematology

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