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Issue Archive

Volume 115, Issue 11
March 18 2010
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
Target recognition–induced NK-cell responses
Xiaoli Zhang,Jianhua Yu
View Articletitled, Target recognition–induced NK-cell responses
CLINICAL TRIALS
Cyclophosphamide in aplastic anemia?
Gerard Socié
View Articletitled, Cyclophosphamide in aplastic anemia?
INSIDE BLOOD
V(D)J recombination and staggered DNA breaks: guilty again
Francisco Vega,L. Jeffrey Medeiros
View Articletitled, V(D)J recombination and staggered DNA breaks: guilty again
PHAGOCYTES & GRANULOCYTES
Macrophages give Gas(6) to cancer
Antonio Sica
View Articletitled, Macrophages give Gas(6) to cancer
PLATELETS & THROMBOPOIESIS
If Virchow were to meet Newton
Michael H. Kroll
View Articletitled, If Virchow were to meet Newton
THROMBOSIS & HEMOSTASIS
A novel antiphospholipid antibody agent?
Beverley J. Hunt
View Articletitled, A novel antiphospholipid antibody agent?

REVIEW ARTICLES

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies
Patrick R. Hagner,Abraham Schneider,Ronald B. Gartenhaus
View Articletitled, Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

CLINICAL TRIALS AND OBSERVATIONS

High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up
Clinical Trials & Observations
Robert A. Brodsky,Allen R. Chen,Donna Dorr,Ephraim J. Fuchs,Carol Ann Huff,Leo Luznik,B. Douglas Smith,William H. Matsui,Steven N. Goodman,Richard F. Ambinder,Richard J. Jones
View Articletitled, High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up
Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study
Brief Report
Alix E. Seif,Catherine S. Manno,Cecilia Sheen,Stephan A. Grupp,David T. Teachey
View Articletitled, Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study
Supplemental data

GENE THERAPY

B cell–specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia
Hannah M. Kerns,Byoung Y. Ryu,Brigid V. Stirling,Blythe D. Sather,Alexander Astrakhan,Stephanie Humblet-Baron,Denny Liggitt,David J. Rawlings
View Articletitled, B cell–specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia
Supplemental data

HEMATOPOIESIS AND STEM CELLS

FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment
Gregory D. Gregory,Annarita Miccio,Alexey Bersenev,Yuhuan Wang,Wei Hong,Zhe Zhang,Mortimer Poncz,Wei Tong,Gerd A. Blobel
View Articletitled, FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment
Supplemental data

IMMUNOBIOLOGY

Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Cyril Fauriat,Eric O. Long,Hans-Gustaf Ljunggren,Yenan T. Bryceson
View Articletitled, Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Supplemental data
Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells
Renaud Colisson,Lucie Barblu,Christophe Gras,Françoise Raynaud,Reda Hadj-Slimane,Claudine Pique,Olivier Hermine,Yves Lepelletier,Jean-Philippe Herbeuval
View Articletitled, Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells
Supplemental data
Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
Gregory F. Sonnenberg,Paul R. Mangan,Natalie A. Bezman,Debora R. Sekiguchi,Eline T. Luning Prak,Jan Erikson,Jonathan S. Maltzman,Martha S. Jordan,Gary A. Koretzky
View Articletitled, Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
Irradiation and IL-15 promote loss of CD8 T-cell tolerance in response to lymphopenia
Thilo Oelert,Maria Papatriantafyllou,Georg Pougialis,Günter J. Hämmerling,Bernd Arnold,Thomas Schüler
View Articletitled, Irradiation and IL-15 promote loss of CD8 T-cell tolerance in response to lymphopenia
Supplemental data
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
Dalya R. Soond,Elisa Bjørgo,Kristine Moltu,Verity Q. Dale,Daniel T. Patton,Knut Martin Torgersen,Fiona Galleway,Breda Twomey,Jonathan Clark,J. S. Hill Gaston,Kjetil Taskén,Peter Bunyard,Klaus Okkenhaug
View Articletitled, PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

LYMPHOID NEOPLASIA

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma
Eva Maria Murga Penas,Evelyne Callet-Bauchu,Hongtao Ye,Sophie Gazzo,Françoise Berger,Georgia Schilling,Nadine Albert-Konetzny,Eik Vettorazzi,Gilles Salles,Iwona Wlodarska,Ming-Qing Du,Carsten Bokemeyer,Judith Dierlamm
View Articletitled, The t(14;18)(q32;q21)/<em>IGH-MALT1</em> translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma
Overexpression of caveolin-1 in adult T-cell leukemia
Shigeki Sawada,Chie Ishikawa,Hiroe Tanji,Sawako Nakachi,Masachika Senba,Taeko Okudaira,Jun-Nosuke Uchihara,Naoya Taira,Kazuiku Ohshiro,Yasuaki Yamada,Yuetsu Tanaka,Hiroshi Uezato,Koichi Ohshima,Ken Sasai,Boudewijn M. T. Burgering,Madeleine Duc Dodon,Masahiro Fujii,Hajime Sunakawa,Naoki Mori
View Articletitled, Overexpression of caveolin-1 in adult T-cell leukemia
Human CD34+ cells engineered to express membrane-bound tumor necrosis factor–related apoptosis-inducing ligand target both tumor cells and tumor vasculature
Cristiana Lavazza,Carmelo Carlo-Stella,Arianna Giacomini,Loredana Cleris,Marco Righi,Daniela Sia,Massimo Di Nicola,Michele Magni,Paolo Longoni,Marco Milanesi,Maura Francolini,Annunziata Gloghini,Antonino Carbone,Franca Formelli,Alessandro M. Gianni
View Articletitled, Human CD34<sup>+</sup> cells engineered to express membrane-bound tumor necrosis factor–related apoptosis-inducing ligand target both tumor cells and tumor vasculature
Supplemental data

MYELOID NEOPLASIA

Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells
Nicholas B. Heaney,Francesca Pellicano,Bin Zhang,Lisa Crawford,Su Chu,Syed M. A. Kazmi,Elaine K. Allan,Heather G. Jorgensen,Alexandra E. Irvine,Ravi Bhatia,Tessa L. Holyoake
View Articletitled, Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells
Supplemental data
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
G. Wei Xu,Mohsin Ali,Tabitha E. Wood,Derek Wong,Neil Maclean,Xiaoming Wang,Marcela Gronda,Marko Skrtic,Xiaoming Li,Rose Hurren,Xinliang Mao,Meenakshi Venkatesan,Reza Beheshti Zavareh,Troy Ketela,John C. Reed,David Rose,Jason Moffat,Robert A. Batey,Sirano Dhe-Paganon,Aaron D. Schimmer
View Articletitled, The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
Supplemental data
An upstream insulator regulates DLK1 imprinting in AML
Brief Report
Haytham Khoury,Fernando Suarez-Saiz,Samantha Wu,Mark D. Minden
View Articletitled, An upstream insulator regulates <em>DLK1</em> imprinting in AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
Sonja Loges,Thomas Schmidt,Marc Tjwa,Katie van Geyte,Dirk Lievens,Esther Lutgens,Davy Vanhoutte,Delphine Borgel,Stephane Plaisance,Marc Hoylaerts,Aernout Luttun,Mieke Dewerchin,Bart Jonckx,Peter Carmeliet
View Articletitled, Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
Supplemental data

PLATELETS AND THROMBOPOIESIS

Role for ADAP in shear flow–induced platelet mechanotransduction
Ana Kasirer-Friede,Zaverio M. Ruggeri,Sanford J. Shattil
View Articletitled, Role for ADAP in shear flow–induced platelet mechanotransduction
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement
Margaret A. Lindorfer,Andrew W. Pawluczkowycz,Elizabeth M. Peek,Kimberly Hickman,Ronald P. Taylor,Charles J. Parker
View Articletitled, A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement

THROMBOSIS AND HEMOSTASIS

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug
Jacob H. Rand,Xiao-Xuan Wu,Anthony S. Quinn,Anthony W. Ashton,Pojen P. Chen,James J. Hathcock,Harry A. M. Andree,Douglas J. Taatjes
View Articletitled, Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug
Amino acid residues Arg659, Arg660, and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor
Sheng-Yu Jin,Christopher G. Skipwith,X. Long Zheng
View Articletitled, Amino acid residues Arg<sup>659</sup>, Arg<sup>660</sup>, and Tyr<sup>661</sup> in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor

TRANSPLANTATION

Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation
David H. McDermott,Susan E. Conway,Tao Wang,Stacy M. Ricklefs,Manza A. Agovi,Stephen F. Porcella,Huong Thi Bich Tran,Edgar Milford,Stephen Spellman,Reza Abdi
View Articletitled, Donor and recipient chemokine receptor <em>CCR5</em> genotype is associated with survival after bone marrow transplantation
Supplemental data
Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors
Olga Ostrovsky,Avichai Shimoni,Avital Rand,Israel Vlodavsky,Arnon Nagler
View Articletitled, Genetic variations in the heparanase gene (<em>HPSE</em>) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors
Supplemental data

CORRESPONDENCE

Pandemic influenza A (H1N1) virus infections in children with sickle cell disease
Baba Inusa,Mark Zuckerman,Nimze Gadong,Michele Afif,Sarah Arnott,Paul Heath,Grant Marais,Paula Robertson,Helen Payne,Olu Wilkey,David C. Rees
View Articletitled, Pandemic influenza A (H1N1) virus infections in children with sickle cell disease
  • Cover Image

    Cover Image

    issue cover

    Deconvolution of representative 2D XY focal plane was treated to allow Z scaling of pixel intensity (analyzed by Metamorph and ImageJ softwares). This representation was used to enhance the observation of TRAIL localization in the cytoplasm or its relocalization to the membrane. Unstimulated pDC (top image), HTLV-1–stimulated pDC (middle image) treated with chloroquine (bottom image) restrictively expressed TRAIL (green) in the cytoplasm in contrast to HTLV-1–activated pDC that expressed TRAIL at cell surface. Inhibitor of endosomal acidification, chloroquine, allowed detection of HTLV-1 particles (red) in the cytoplasm in contrast to the cell-surface detection of HTLV-1 virions in HTLV-1–activated pDC. See the article by Colisson et al on page 2177.

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