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Journal Articles

Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale

Yuhuan Wang, Vincent Hayes, Danuta Jarocha, Xiuli Sim, Dawn C. Harper, Rudy Fuentes, Spencer K. Sullivan, Paul Gadue, Stella T. Chou, Beverly J. Torok-Storb, Michael S. Marks, Deborah L. French, Mortimer Poncz

Blood (2015) 125 (23): 3627–3636.

https://doi.org/10.1182/blood-2014-08-593053

Published: 2015

Includes: Supplemental data

Journal Articles

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Ronghua Meng, Jie Wu, Dawn C. Harper, Yuhuan Wang, M. Anna Kowalska, Charles S. Abrams, Lawrence F. Brass, Mortimer Poncz, Timothy J. Stalker, Michael S. Marks

Blood (2015) 125 (10): 1623–1632.

https://doi.org/10.1182/blood-2014-07-586727

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

Comparative Analysis of Infused “Static”, Ex Vivo-Generated Platelets Vs. Infused Megakaryocytes-Generated Platelets: A Cautionary Tale

Yuhuan Wang, PhD, Vincent Hayes, Danuta Jarocha, PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 2881.

https://doi.org/10.1182/blood.V124.21.2881.2881

Published: 2014

Journal Articles

Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells

Ji-Yoon Noh, PhD, Shilpa Gandre-Babbe, PhD, Yuhuan Wang, PhD, Vincent Hayes, BS, Yu Yao, Paul Gadue, PhD, Spencer Sullivan, MD, Stella T. Chou, MD, Vikram R Paralkar, MD, Kellie R Machlus, PhD, Joseph E. Italiano, PhD, Michael Kyba, PhD, Deborah L. French, PhD, Mortimer Poncz, MD, Mitchell J. Weiss, MD PhD

Blood (2014) 124 (21): 3846.

https://doi.org/10.1182/blood.V124.21.3846.3846

Published: 2014

Journal Articles

High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Spencer K. Sullivan, Jason A. Mills, Sevasti B. Koukouritaki, Karen K. Vo, Randolph B. Lyde, Prasuna Paluru, Guoha Zhao, Li Zhai, Lisa M. Sullivan, Yuhuan Wang, Siddharth Kishore, Eyad Z. Gharaibeh, Michele P. Lambert, David A. Wilcox, Deborah L. French, Mortimer Poncz, Paul Gadue

Blood (2014) 123 (5): 753–757.

https://doi.org/10.1182/blood-2013-10-530725

Published: 2014

Includes: Supplemental data

Journal Articles

Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis

Aae Suzuki, Liang Zhao, Ph.D., Yuhuan Wang, PhD, Lurong Lian, Sang H. Min, MD, Mortimer Poncz, MD, Charles S. Abrams, MD

Blood (2013) 122 (21): 2313.

https://doi.org/10.1182/blood.V122.21.2313.2313

Published: 2013

Journal Articles

Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice

Yuhuan Wang, PhD, Vincent M. Hayes, Prasuna Paluru, Stella T. Chou, MD, Deborah L. French, Mortimer Poncz, MD

Blood (2013) 122 (21): 1165.

https://doi.org/10.1182/blood.V122.21.1165.1165

Published: 2013

Journal Articles

Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs)

Yuhuan Wang, PhD, Vincent M. Hayes, Lin Lu, Ph.D, Xiaoji Chen, Rudy Fuentes, PhD, Qiang Jeremy Wen, MD, PhD, Stella T Chou, MD, John Crispino, PhD, Patrick Paddison, PhD, Deborah L. French, PhD, Beverly Torok-Storb, PhD, Mortimer Poncz, MD

Blood (2012) 120 (21): 3450.

https://doi.org/10.1182/blood.V120.21.3450.3450

Published: 2012

Journal Articles

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation

Aae Suzuki, Jae-Won Shin, Ph.D., Yuhuan Wang, PhD, Mortimer Poncz, MD, John K. Choi, MD, PhD, Dennis E Discher, Ph.D., Christopher L. Carpenter, MD, PhD, Lurong Lian, Liang Zhao, Ph.D., Yanfeng Wang, Charles S. Abrams, MD

Blood (2012) 120 (21): 385.

https://doi.org/10.1182/blood.V120.21.385.385

Published: 2012

Journal Articles

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Rudy Fuentes, PhD, Hyun Sook Ahn, Vincent M. Hayes, Valerie Tutwiler, Yuhuan Wang, PhD, Daniel W. Bougie, PhD, M. Anna Kowalska, PhD, Lubica Rauova, M.D., Ph.D., Richard H. Aster, MD, Douglas B. Cines, MD, Vladimir R Muzykantov, MD PhD, Mortimer Poncz, MD, Sergei Zaitsev, PhD

Blood (2012) 120 (21): 1171.

https://doi.org/10.1182/blood.V120.21.1171.1171

Published: 2012

Journal Articles

Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf

Yukako Ono, Yuhuan Wang, Hidenori Suzuki, Shinichiro Okamoto, Yasuo Ikeda, Mitsuru Murata, Mortimer Poncz, Yumiko Matsubara

Blood (2012) 120 (18): 3812–3821.

https://doi.org/10.1182/blood-2012-02-413617

Published: 2012

Includes: Supplemental data

Journal Articles

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models

Ronghua Meng, Yuhuan Wang, Yu Yao, Zhe Zhang, Dawn C. Harper, Harry F. G. Heijnen, Anand Sitaram, Wei Li, Graça Raposo, Mitchell J. Weiss, Mortimer Poncz, Michael S. Marks

Blood (2012) 120 (2): 404–414.

https://doi.org/10.1182/blood-2011-11-389551

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction

Yuhuan Wang, Ronghua Meng, Vincent Hayes, Rudy Fuentes, Xiang Yu, Charles S. Abrams, Harry F. G. Heijnen, Gerd A. Blobel, Michael S. Marks, Mortimer Poncz

Blood (2011) 118 (23): 6183–6191.

https://doi.org/10.1182/blood-2011-06-363580

Published: 2011

Includes: Supplemental data

Journal Articles

Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf

Yuhuan Wang, PhD, Yukako Ono, MD, Yasuo Ikeda, MD, Shinichiro Okamoto, MD, PhD, Mitsuru Murata, MD, Mortimer Poncz, MD, Yumiko Matsubara, PhD

Blood (2011) 118 (21): 908.

https://doi.org/10.1182/blood.V118.21.908.908

Published: 2011

Journal Articles

Expansion of Platelets for Transfusion

Rudy Fuentes, Yuhuan Wang, Mortimer Poncz, MD

Blood (2010) 116 (21): SCI-47.

https://doi.org/10.1182/blood.V116.21.SCI-47.SCI-47

Published: 2010

Journal Articles

Defective Production, Turnover, and Secretion of the Platelet α-Granule Protein P-Selectin In Mice with Disrupted FOG1-NuRD Interaction

Yuhuan Wang, PhD, Ronghua Meng, PhD, Gerd Blobel, MD, PhD, Michael S. Marks, PhD, Mortimer Poncz, MD

Blood (2010) 116 (21): 547.

https://doi.org/10.1182/blood.V116.21.547.547

Published: 2010

Journal Articles

Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia

Aae Suzuki, Lurong Lian, Liang Zhao, Sang H. Min, MD, Yuhuan Wang, Mortimer Poncz, MD, John K Choi, Christopher L. Carpenter, MD, PhD, Charles S. Abrams, MD

Blood (2010) 116 (21): 549.

https://doi.org/10.1182/blood.V116.21.549.549

Published: 2010

Journal Articles

FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment

Gregory D. Gregory, Annarita Miccio, Alexey Bersenev, Yuhuan Wang, Wei Hong, Zhe Zhang, Mortimer Poncz, Wei Tong, Gerd A. Blobel

Blood (2010) 115 (11): 2156–2166.

https://doi.org/10.1182/blood-2009-10-251280

Published: 2010

Includes: Supplemental data

Journal Articles

FOG-1 Requires NuRD to Promote Hematopoiesis and Maintain Lineage Fidelity within the Megakaryocytic–Erythroid Compartment.

Gregory D Gregory, PhD, Annarita Miccio, PhD, Alexey Bersenev, MD, Yuhuan Wang, PhD, Wei Hong, MD, Zhe Zhang, Mortimer Poncz, MD, Wei Tong, PhD, Gerd A Blobel, MD, PhD

Blood (2009) 114 (22): 702.

https://doi.org/10.1182/blood.V114.22.702.702

Published: 2009

Journal Articles

Infusing Mature Megakaryocytes Into Mice Yields Functional Platelets: Biological and Clinical Implications.

Rudy Fuentes, BS, Yuhuan Wang, PhD, Jessica Hirsh, BS, Mortimer Poncz, MD

Blood (2009) 114 (22): 225.

https://doi.org/10.1182/blood.V114.22.225.225

Published: 2009

NARROW

Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Comparative Analysis of Infused “Static”, Ex Vivo-Generated Platelets Vs. Infused Megakaryocytes-Generated Platelets: A Cautionary Tale

Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells

High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Loss Of Phosphatidylinositol Transfer Proteins (PITPs) Causes Thrombocytopenia Due To a Defect In Thrombopoiesis

Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice

Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs)

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models

Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction

Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf

Expansion of Platelets for Transfusion

Defective Production, Turnover, and Secretion of the Platelet α-Granule Protein P-Selectin In Mice with Disrupted FOG1-NuRD Interaction

Mice That Lack RhoA In Their Platelets Have Normal Actin Dynamics, but Have Macrothrombocytopenia

FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment

FOG-1 Requires NuRD to Promote Hematopoiesis and Maintain Lineage Fidelity within the Megakaryocytic–Erythroid Compartment.

Infusing Mature Megakaryocytes Into Mice Yields Functional Platelets: Biological and Clinical Implications.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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