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Journal Articles

The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine

Hyun Hyung An, Alyssa L. Gagne, Jean Ann Maguire, Giulia Pavani, Osheiza Abdulmalik, Paul Gadue, Deborah L. French, Connie M. Westhoff, Stella T. Chou

Blood (2022) 140 (15): 1723–1734.

https://doi.org/10.1182/blood.2022015883

Published: 2022

Includes: Supplemental data

Journal Articles

Detection of Rh Antibodies in Patient Plasma Using Genome Engineered Induced Pluripotent Stem Cell-Derived Red Cells

Hyun Hyung An, Jean Ann Maguire, Alyssa Gagne, Paul Gadue, Deborah L French, Connie M. Westhoff, Stella T. Chou

Blood (2021) 138 (Supplement 1): 350.

https://doi.org/10.1182/blood-2021-151202

Published: 2021

Journal Articles

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael Gonzalez, James Garifallou, Hakon Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy Speck, Deborah L. French, Paul Gadue, Mortimer Poncz

Blood (2021) 137 (19): 2662–2675.

https://doi.org/10.1182/blood.2020006389

Published: 2021

Includes: Supplemental data

Journal Articles

Tropomyosin 1 Genetically Constrains in Vitro Megakaryopoiesis

Christopher Thom, MD PhD, Chintan Jobaliya, Kimberly Lorenz, PhD, Jean Ann Maguire, PhD, Alyssa Gagne, Paul Gadue, PhD, Deborah L French, PhD, Benjamin F Voight, PhD

Blood (2019) 134 (Supplement_1): 3612.

https://doi.org/10.1182/blood-2019-121538

Published: 2019

Journal Articles

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

Brian Estevez, PhD, Sara Borst, BS, Danuta Jadwiga Jarocha, PhD, Varun Sudunagunta, Michael Gonzalez, PhD, Peng Gao, Kai Tan, Deborah L French, PhD, Paul Gadue, PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 220.

https://doi.org/10.1182/blood-2019-124851

Published: 2019

Journal Articles

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis

John Tkaczynski, BS, Randolph Lyde, PhD, Hyunsook Ahn, MSc, Francis Ayombil, PhD, Sara Borst, BS, Paul Gadue, PhD, Deborah L French, PhD, Denise Sabatino, PhD, Rodney M. Camire, PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 1102.

https://doi.org/10.1182/blood-2019-124788

Published: 2019

Journal Articles

Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis

Danuta Jadwiga Jarocha, PhD, Paul Gadue, PhD, Wei Tong, PhD, Robert C Newton, PhD, Mortimer Poncz, MD

Blood (2018) 132 (Supplement 1): 2559.

https://doi.org/10.1182/blood-2018-99-115407

Published: 2018

Journal Articles

Customized Induced Pluripotent Stem Cell-Derived Red Cell Reagents

David Posocco, Hyun H An, Jean Ann Maguire, Judith Aeschlimann, Deborah L French, PhD, Paul Gadue, PhD, Connie M. Westhoff, PhD, Stella T Chou, MD

Blood (2017) 130 (Supplement 1): 3.

https://doi.org/10.1182/blood.V130.Suppl_1.3.3

Published: 2017

Journal Articles

Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake

Xiuli Sim, Danuta Jarocha, Vincent Hayes, Hayley A. Hanby, Michael S. Marks, Rodney M. Camire, Deborah L. French, Mortimer Poncz, Paul Gadue

Blood (2017) 130 (2): 192–204.

https://doi.org/10.1182/blood-2017-01-761049

Published: 2017

Includes: Supplemental data

Journal Articles

Understanding platelet generation from megakaryocytes: implications for in vitro–derived platelets

Xiuli Sim, Mortimer Poncz, Paul Gadue, Deborah L. French

Blood (2016) 127 (10): 1227–1233.

https://doi.org/10.1182/blood-2015-08-607929

Published: 2016

Journal Articles

Temporally Distinct Developmental Waves of Erythropoiesis from Human Pluripotent Stem Cells

Orna Steinberg Shemer, MD MSc, Marta Byrska-Bishop, PhD, Jacob C Ulirsch, Osheiza Abdulmalik, DVM, MS, Yu Yao, MD, Ah Ram Kim, PhD, Paul Gadue, PhD, Paul D. Kingsley, PhD, Deborah French, PhD, Ross C. Hardison, PhD, James Palis, MD, Vijay G Sankaran, MD PhD, Mitchell J Weiss, MD PhD

Blood (2015) 126 (23): 1170.

https://doi.org/10.1182/blood.V126.23.1170.1170

Published: 2015

Journal Articles

Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale

Yuhuan Wang, Vincent Hayes, Danuta Jarocha, Xiuli Sim, Dawn C. Harper, Rudy Fuentes, Spencer K. Sullivan, Paul Gadue, Stella T. Chou, Beverly J. Torok-Storb, Michael S. Marks, Deborah L. French, Mortimer Poncz

Blood (2015) 125 (23): 3627–3636.

https://doi.org/10.1182/blood-2014-08-593053

Published: 2015

Includes: Supplemental data

Journal Articles

Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells

Ji-Yoon Noh, PhD, Shilpa Gandre-Babbe, PhD, Yuhuan Wang, PhD, Vincent Hayes, BS, Yu Yao, Paul Gadue, PhD, Spencer Sullivan, MD, Stella T. Chou, MD, Vikram R Paralkar, MD, Kellie R Machlus, PhD, Joseph E. Italiano, PhD, Michael Kyba, PhD, Deborah L. French, PhD, Mortimer Poncz, MD, Mitchell J. Weiss, MD PhD

Blood (2014) 124 (21): 3846.

https://doi.org/10.1182/blood.V124.21.3846.3846

Published: 2014

Journal Articles

High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Spencer K. Sullivan, Jason A. Mills, Sevasti B. Koukouritaki, Karen K. Vo, Randolph B. Lyde, Prasuna Paluru, Guoha Zhao, Li Zhai, Lisa M. Sullivan, Yuhuan Wang, Siddharth Kishore, Eyad Z. Gharaibeh, Michele P. Lambert, David A. Wilcox, Deborah L. French, Mortimer Poncz, Paul Gadue

Blood (2014) 123 (5): 753–757.

https://doi.org/10.1182/blood-2013-10-530725

Published: 2014

Includes: Supplemental data

Journal Articles

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines

Blood (2013) 122 (12): 2047–2051.

https://doi.org/10.1182/blood-2013-02-484444

Published: 2013

Includes: Supplemental data

Journal Articles

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients

Loïc Garçon, Jingping Ge, Shwetha H. Manjunath, Jason A. Mills, Marisa Apicella, Shefali Parikh, Lisa M. Sullivan, Gregory M. Podsakoff, Paul Gadue, Deborah L. French, Philip J. Mason, Monica Bessler, Mitchell J. Weiss

Blood (2013) 122 (6): 912–921.

https://doi.org/10.1182/blood-2013-01-478321

Published: 2013

Includes: Supplemental data

Journal Articles

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

Blood (2013) 122 (3): 376–385.

https://doi.org/10.1182/blood-2012-11-466722

Published: 2013

Includes: Supplemental data

Journal Articles

The Aryl Hydrocarbon Receptor (AhR) Regulates the Production of Bipotential Hematopoietic Progenitor Cells

Brenden W Smith, Sarah S Rozelle, Paul Gadue, PhD, Deborah L. French, PhD, David H.K. Chui, MD, Martin H. Steinberg, MD, David H. Sherr, Ph.D, George J. Murphy, Ph.D

Blood (2012) 120 (21): 766.

https://doi.org/10.1182/blood.V120.21.766.766

Published: 2012

Journal Articles

Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT)

Spencer K. Sullivan, MD, Jason A. Mills, PhD, Li Zhai, MD, Prasuna Paluru, MS, Karen Vo, Michele Lambert, MD, Sevasti B. Koukouritaki, PhD, Juan Fang, MD, David A. Wilcox, PhD, Deborah L. French, PhD, Mortimer Poncz, MD, Paul Gadue, PhD

Blood (2012) 120 (21): 387.

https://doi.org/10.1182/blood.V120.21.387.387

Published: 2012

Journal Articles

Targeted Gene Correction of Glanzmann Thrombasthenia Induced Pluripotent Stem Cells Restores Surface Expression and Fibrinogen Binding of Integrin αIIbβ3,

Spencer Sullivan, MD, Jason A. Mills, PhD, Li Zhai, MD, Prasuna Paluru, MS, Guohua Zhao, PhD, Lin Lu, PhD, Michele Lambert, MD, Deborah L. French, PhD, Mortimer Poncz, MD, Paul Gadue, PhD

Blood (2011) 118 (21): 4173.

https://doi.org/10.1182/blood.V118.21.4173.4173

Published: 2011

NARROW

The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine

Detection of Rh Antibodies in Patient Plasma Using Genome Engineered Induced Pluripotent Stem Cell-Derived Red Cells

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Tropomyosin 1 Genetically Constrains in Vitro Megakaryopoiesis

The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakaryocyte-Biased Hematopoietic Progenitor Cells: Mechanistic Studies and Drug Correction

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis

Janus Kinase (Jak) 1 Inhibition Affects Both Megakaryopoiesis and Thrombopoiesis

Customized Induced Pluripotent Stem Cell-Derived Red Cell Reagents

Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake

Understanding platelet generation from megakaryocytes: implications for in vitro–derived platelets

Temporally Distinct Developmental Waves of Erythropoiesis from Human Pluripotent Stem Cells

Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale

Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells

High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

The Aryl Hydrocarbon Receptor (AhR) Regulates the Production of Bipotential Hematopoietic Progenitor Cells

Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT)

Targeted Gene Correction of Glanzmann Thrombasthenia Induced Pluripotent Stem Cells Restores Surface Expression and Fibrinogen Binding of Integrin αIIbβ3,

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American Society of Hematology

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ASH Publications

American Society of Hematology

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