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Volume 100, Issue 10

November 15 2002

In this Issue

INSIDE BLOOD
FOCUS ON HEMATOLOGY
PLENARY PAPERS
REVIEW ARTICLES
HOW I TREAT
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
ERRATA
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Of mouse, not of man? a surprise at the α-globin locus

John M. Cunningham,Stephen M. Jane

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Phages that display P-selectin antagonism

Paul S. Frenette

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FOCUS ON HEMATOLOGY

Introduction: congenital methemoglobinemia revisited

Quentin Gibson

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Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase

Melanie J. Percy,Matthew J. S. Gillespie,Geraldine Savage,Anne E. Hughes,Mary Frances McMullin,Terry R. J. Lappin

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PLENARY PAPERS

Deletion of the mouse α-globin regulatory element (HS −26) has an unexpectedly mild phenotype

Eduardo Anguita,Jacqueline A. Sharpe,Jacqueline A. Sloane-Stanley,Cristina Tufarelli,Douglas R. Higgs,William G. Wood

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REVIEW ARTICLES

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
Clinical Trials & Observations

David J. Kuter,C. Glenn Begley

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HOW I TREAT

How we manage venous thromboembolism during pregnancy
Clinical Trials & Observations

Shannon M. Bates,Jeffrey S. Ginsberg

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation
Clinical Trials & Observations

Joseph H. Antin,Daniel Weisdorf,Donna Neuberg,Roberta Nicklow,Shawn Clouthier,Stephanie J. Lee,Edwin Alyea,Carol McGarigle,Bruce R. Blazar,Stephen Sonis,Robert J. Soiffer,James L.M. Ferrara

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Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
Clinical Trials & Observations

Paolo Prandoni,Anthonie W. A. Lensing,Andrea Piccioli,Enrico Bernardi,Paolo Simioni,Bruno Girolami,Antonio Marchiori,Paola Sabbion,Martin H. Prins,Franco Noventa,Antonio Girolami

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ERRATA

Erratum for vol. 100, p. 718

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HEMATOPOIESIS

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children

Hans Verhoef,Clive E. West,Rob Kraaijenhagen,Silas M. Nzyuko,Rose King,Mary M. Mbandi,Susanne van Laatum,Roos Hogervorst,Carla Schep,Frans J. Kok

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Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice

Hédia Chagraoui,Emiko Komura,Micheline Tulliez,Stéphane Giraudier,William Vainchenker,Françoise Wendling

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B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment

Yoshiko Hashimoto,Encarnacion Montecino-Rodriguez,Hyosuk Leathers,Robert P. Stephan,Kenneth Dorshkind

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GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21^WAF1 and p27^Kip1 proteins

Sachiko Ezoe,Itaru Matsumura,Soichi Nakata,Karin Gale,Katsuhiko Ishihara,Naoko Minegishi,Takashi Machii,Toshio Kitamura,Masayuki Yamamoto,Tariq Enver,Yuzuru Kanakura

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Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation

Jiang F. Zhong,Yuxia Zhan,W. French Anderson,Yi Zhao

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Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells

Patricia E. Burger,Sandra Coetzee,Wallace L. McKeehan,Mikio Kan,Perry Cook,Yong Fan,Toshio Suda,Robert P. Hebbel,Nicolas Novitzky,William A. Muller,E. Lynette Wilson

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hnRNP-K and Purα act together to repress the transcriptional activity of the CD43 gene promoter

Nicolas Da Silva,Ajit Bharti,Carl S. Shelley

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In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients

P. Artur Plett,Stacy M. Frankovitz,Christie M. Orschell-Traycoff

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Supplemental data

Characterization of gene expression of CD34⁺ cells from normal and myelodysplastic bone marrow

Wolf-K. Hofmann,Sven de Vos,Martina Komor,Dieter Hoelzer,William Wachsman,H. Phillip Koeffler

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C

Andrew C. Pearce,Jonathan I. Wilde,Gina M. Doody,Denise Best,Osamu Inoue,Elena Vigorito,Victor L. J. Tybulewicz,Martin Turner,Steve P. Watson

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Specific inhibition of P-selectin–mediated cell adhesion by phage display–derived peptide antagonists

Tom J. M. Molenaar,Chantal C. M. Appeldoorn,Sonja A. M. de Haas,Ingrid N. Michon,Arnaud Bonnefoy,Marc F. Hoylaerts,Hans Pannekoek,Theo J. C. van Berkel,Johan Kuiper,Erik A. L. Biessen

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Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates

Marie-Hélène Laprise,Francine Grondin,Pauline Cayer,Patrick P. McDonald,Claire M. Dubois

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Identification of distal regulatory regions in the human αIIb gene locus necessary for consistent, high-level megakaryocyte expression

Michael A. Thornton,Chunyan Zhang,Maria A. Kowalska,Mortimer Poncz

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Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium

Wen-Hong Su,Hsiun-ing Chen,Chauying J. Jen

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Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow

Hideto Matsui,Mitsuhiko Sugimoto,Tomohiro Mizuno,Shizuko Tsuji,Shigeki Miyata,Michio Matsuda,Akira Yoshioka

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Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction

Andreas E. May,Roland Schmidt,Sandip M. Kanse,Triantafyllos Chavakis,Ross W. Stephens,Albert Schömig,Klaus T. Preissner,Franz-Josef Neumann

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Sialyltransferase specificity in selectin ligand formation

Lesley G. Ellies,Markus Sperandio,Gregory H. Underhill,James Yousif,Michael Smith,John J. Priatel,Geoffrey S. Kansas,Klaus Ley,Jamey D. Marth

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Cloning, expression, and functional characterization of the von Willebrand factor–cleaving protease (ADAMTS13)

Barbara Plaimauer,Klaus Zimmermann,Dirk Völkel,Gerhard Antoine,Randolf Kerschbaumer,Pegah Jenab,Miha Furlan,Helen Gerritsen,Bernhard Lämmle,Hans Peter Schwarz,Friedrich Scheiflinger

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IMMUNOBIOLOGY

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

Megan A. Cooper,Jennifer E. Bush,Todd A. Fehniger,Jeffrey B. VanDeusen,Ross E. Waite,Yang Liu,Hector L. Aguila,Michael A. Caligiuri

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Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression

James N. Kochenderfer,Sumiko Kobayashi,Eric D. Wieder,Chunliu Su,Jeffrey J. Molldrem

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Long-lived immature dendritic cells mediated by TRANCE-RANK interaction

Isabelle Cremer,Marie-Caroline Dieu-Nosjean,Sylvie Maréchal,Colette Dezutter-Dambuyant,Sarah Goddard,David Adams,Nathalie Winter,Christine Menetrier-Caux,Catherine Sautès-Fridman,Wolf H. Fridman,Chris G. F. Mueller

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Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences ofNf1 deficiency in T-cell development and function

David A. Ingram,Lei Zhang,Jennifer McCarthy,Mary Jo Wenning,Lucy Fisher,Feng-Chun Yang,D. Wade Clapp,Reuben Kapur

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Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31^hiLy-6C^neg bone marrow precursors in a mouse model of asthma

Leonie S. van Rijt,Jan-Bas Prins,Pieter J. M. Leenen,Kris Thielemans,Victor C. de Vries,Henk C. Hoogsteden,Bart N. Lambrecht

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Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow

Taku Kouro,Vinay Kumar,Paul W. Kincade

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Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice

Corinna La Rosa,Zhongde Wang,John C. Brewer,Simon F. Lacey,Maria C. Villacres,Rahul Sharan,Radhika Krishnan,Matthew Crooks,Susan Markel,Rebecca Maas,Don J. Diamond

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Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8⁺ T cells

Evren Özdemir,Lisa S. St. John,Geraldine Gillespie,Sarah Rowland-Jones,Richard E. Champlin,Jeffrey J. Molldrem,Krishna V. Komanduri

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Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)

David Voehringer,Marie Koschella,Hanspeter Pircher

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Interaction of human hematopoietic stem cells with bacterial pathogens

Annette Kolb-Mäurer,Martin Wilhelm,Florian Weissinger,Eva-Bettina Bröcker,Werner Goebel

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NEOPLASIA

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

Akihiko Yokoyama,Issay Kitabayashi,Paul M. Ayton,Michael L. Cleary,Misao Ohki

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Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells

Claudio Pisano,Peter Kollar,Maurizio Giannı́,Yesim Kalac,Vincenzo Giordano,Fabiana Fosca Ferrara,Richard Tancredi,Antonio Devoto,Alessandra Rinaldi,Alessandro Rambaldi,Sergio Penco,Mauro Marzi,Giampiero Moretti,Loredana Vesci,Ornella Tinti,Paolo Carminati,Mineko Terao,Enrico Garattini

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Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo

Xiaoyan Jiang,Eddy Ng,Calvin Yip,Wolfgang Eisterer,Yves Chalandon,Matthew Stuible,Allen Eaves,Connie J. Eaves

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Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ

Ingo Ringshausen,Folker Schneller,Christian Bogner,Susanne Hipp,Justus Duyster,Christian Peschel,Thomas Decker

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Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-κB/Rel–regulated inhibitors of apoptosis

Gerd Munzert,Dieter Kirchner,Heike Stobbe,Lothar Bergmann,Roland M. Schmid,Hartmut Döhner,Hermann Heimpel

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Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia

Kjeld Schmiegelow,Peter Garred,Birgitte Lausen,Bente Andreassen,Bodil Laub Petersen,Hans Ole Madsen

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The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia

Claire Seedhouse,Rowena Bainton,Michael Lewis,Alexander Harding,Nigel Russell,Emma Das-Gupta

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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin

Matthias Mayerhofer,Peter Valent,Wolfgang R. Sperr,James D. Griffin,Christian Sillaber

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RED CELLS

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

David A. Weinstein,Cindy N. Roy,Mark D. Fleming,Massimo F. Loda,Joseph I. Wolfsdorf,Nancy C. Andrews

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Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum

Silvia Deaglio,Andrea Capobianco,Angelita Calı̀,Francesca Bellora,Federica Alberti,Luisella Righi,Anna Sapino,Clara Camaschella,Fabio Malavasi

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Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin

Neil M. Matsui,Ajit Varki,Stephen H. Embury

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Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma

Mukul S. Goel,Scott L. Diamond

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A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells

Edward Melkun,Mylisa Pilione,Robert F. Paulson

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Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria

Tatsuyuki Kai,Tsutomu Shichishima,Hideyoshi Noji,Tetsuo Yamamoto,Masatoshi Okamoto,Kazuhiko Ikeda,Yukio Maruyama

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BRIEF REPORTS

Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance
Brief Report

Jonathan B. Pollett,Suzanne Trudel,Daniel Stern,Zhixiong H. Li,A. Keith Stewart

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Initial characterization of TREM-like transcript (TLT)–1: a putative inhibitory receptor within the TREM cluster
Brief Report

A. Valance Washington,Laura Quigley,Daniel W. McVicar

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Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants
Brief Report

Stella M. Davies,Loredana Ruggieri,Todd DeFor,John E. Wagner,Daniel J. Weisdorf,Jeffrey S. Miller,Andrea Velardi,Bruce R. Blazar

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Immortalization of yolk sac–derived precursor cells
Brief Report

Wen-Mei Yu,Teresa S. Hawley,Robert G. Hawley,Cheng-Kui Qu

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Polymorphism G₈₀A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
Brief Report

Caroline Laverdière,Sonia Chiasson,Irina Costea,Albert Moghrabi,Maja Krajinovic

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Two distinct HLA-A0201–presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
Brief Report

Ilaria Bellantuono,Liquan Gao,Suzanne Parry,Steve Marley,Francesco Dazzi,Jane Apperley,John M. Goldman,Hans J. Stauss

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CORRESPONDENCE

Chromosome 19 abnormalities are commonly seen in AML, M7

Stephen D. Nimer,Donal MacGrogan,Suresh Jhanwar,Sara Alvarez

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Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura

Han-Mou Tsai

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CMV infection following nonmyeloablative allogeneic stem cell transplantation using Campath

Rowena D. Bainton,Jennifer L. Byrne,Barbara J. Davy,Nigel H. Russell

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Issue Archive

Table of Contents

INSIDE BLOOD

Of mouse, not of man? a surprise at the α-globin locus Free

Phages that display P-selectin antagonism Free

FOCUS ON HEMATOLOGY

Introduction: congenital methemoglobinemia revisited Free

Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase Free

PLENARY PAPERS

Deletion of the mouse α-globin regulatory element (HS −26) has an unexpectedly mild phenotype Free

REVIEW ARTICLES

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies Free Clinical Trials & Observations

HOW I TREAT

How we manage venous thromboembolism during pregnancy Free Clinical Trials & Observations

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation Free Clinical Trials & Observations

Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis Free Clinical Trials & Observations

ERRATA

Erratum for vol. 100, p. 718 Free

HEMATOPOIESIS

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children Free

Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice Free

B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment Free

GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins Free

Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation Free

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells Free

hnRNP-K and Purα act together to repress the transcriptional activity of the CD43 gene promoter Free

In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients Free

Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C Free

Specific inhibition of P-selectin–mediated cell adhesion by phage display–derived peptide antagonists Free

Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates Free

Identification of distal regulatory regions in the human αIIb gene locus necessary for consistent, high-level megakaryocyte expression Free

Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium Free

Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow Free

Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction Free

Sialyltransferase specificity in selectin ligand formation Free

Cloning, expression, and functional characterization of the von Willebrand factor–cleaving protease (ADAMTS13) Free

IMMUNOBIOLOGY

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells Free

Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression Free

Long-lived immature dendritic cells mediated by TRANCE-RANK interaction Free

Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences ofNf1 deficiency in T-cell development and function Free

Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31hiLy-6Cneg bone marrow precursors in a mouse model of asthma Free

Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow Free

Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice Free

Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells Free

Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1) Free

Interaction of human hematopoietic stem cells with bacterial pathogens Free

NEOPLASIA

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties Free

Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells Free

Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo Free

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ Free

Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-κB/Rel–regulated inhibitors of apoptosis Free

Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia Free

The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia Free

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin Free

RED CELLS

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease Free

Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum Free

Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin Free

Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma Free

A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells Free

Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria Free

BRIEF REPORTS

Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance Free Brief Report

Initial characterization of TREM-like transcript (TLT)–1: a putative inhibitory receptor within the TREM cluster Free Brief Report

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants Free Brief Report

Immortalization of yolk sac–derived precursor cells Free Brief Report

Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia Free Brief Report

Two distinct HLA-A0201–presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL Free Brief Report

CORRESPONDENCE

Chromosome 19 abnormalities are commonly seen in AML, M7 Free

Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura Free

CMV infection following nonmyeloablative allogeneic stem cell transplantation using Campath Free

Email alerts

ASH Publications

American Society of Hematology

Of mouse, not of man? a surprise at the α-globin locus

Phages that display P-selectin antagonism

Introduction: congenital methemoglobinemia revisited

Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase

Deletion of the mouse α-globin regulatory element (HS −26) has an unexpectedly mild phenotype

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
Clinical Trials & Observations

How we manage venous thromboembolism during pregnancy
Clinical Trials & Observations

Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation
Clinical Trials & Observations

Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
Clinical Trials & Observations

Erratum for vol. 100, p. 718

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children

Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice

B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment

GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21^WAF1 and p27^Kip1 proteins

Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells

hnRNP-K and Purα act together to repress the transcriptional activity of the CD43 gene promoter

In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients

Characterization of gene expression of CD34⁺ cells from normal and myelodysplastic bone marrow

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C

Specific inhibition of P-selectin–mediated cell adhesion by phage display–derived peptide antagonists

Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates

Identification of distal regulatory regions in the human αIIb gene locus necessary for consistent, high-level megakaryocyte expression

Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium

Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow

Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction

Sialyltransferase specificity in selectin ligand formation

Cloning, expression, and functional characterization of the von Willebrand factor–cleaving protease (ADAMTS13)

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression

Long-lived immature dendritic cells mediated by TRANCE-RANK interaction

Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences ofNf1 deficiency in T-cell development and function

Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31^hiLy-6C^neg bone marrow precursors in a mouse model of asthma

Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow

Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice

Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8⁺ T cells

Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)

Interaction of human hematopoietic stem cells with bacterial pathogens

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells

Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ

Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-κB/Rel–regulated inhibitors of apoptosis

Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia

The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum

Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin

Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma

A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells

Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria

Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance
Brief Report

Initial characterization of TREM-like transcript (TLT)–1: a putative inhibitory receptor within the TREM cluster
Brief Report

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants
Brief Report

Immortalization of yolk sac–derived precursor cells
Brief Report

Polymorphism G₈₀A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
Brief Report

Two distinct HLA-A0201–presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
Brief Report

Chromosome 19 abnormalities are commonly seen in AML, M7

Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura

CMV infection following nonmyeloablative allogeneic stem cell transplantation using Campath