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Todd A. Fehniger
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Journal Articles

WUN101-01: First in Human Human (FIH) Phase 1 Study of WU-NK-101 (W-NK1) in Patients with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)

Amanda F. Cashen, MHD Monzr M. Al Malki, Don A. Stevens, Lori Muffly, Natasha Edwin, Edward Abadir, Peter Tan, Sandrine Niyongere, Ashish Bajel, Laura Arthur, Nitin Mahajan, Ben Capoccia, Tom Leedom, Basia Muz, Kristann Magee, Ouiam Bakkacha, Justo L. Gonzalez, Deborah Masters, Stephen Moran, Eileen McNulty, Angela Pannunzio, Jayakumar Vadakekolathu, Tony Wu, Maria del Rosario, Preeta Dasgupta, Michael Munroe, Laura Simpson, Melissa M Berrien-Elliott, John Muth, Sergio Rutella, Jan K Davidson-Moncada, Todd A Fehniger
Journal: Blood
Blood (2024) 144 (Supplement 1): 4257.
https://doi.org/10.1182/blood-2024-201520
Published: 2024
Journal Articles

NK Cell Immunotherapy to Reduce Relapse after Haploidentical Transplant for High-Risk Pediatric and Young Adult AML

Thomas Pfeiffer, Stephanie Hyde, Amanda F. Cashen, Jeffrey J. Bednarski, Todd A Fehniger
Journal: Blood
Blood (2024) 144 (Supplement 1): 2088.1.
https://doi.org/10.1182/blood-2024-198030
Published: 2024
Journal Articles

W-NK1 Choreographs Innate and Adaptive Immune Responses to Provide a Robust and Durable Anti-AML Response

Tom Leedom, Basia Muz, Kristann Magee, Jayakumar Vadakekolathu, Laura Arthur, Melissa Tran, Lena Luukkonen, Nitin Mahajan, Alexander Hamil, John Muth, Melissa M Berrien-Elliott, Todd A Fehniger, Sergio Rutella, Jan K Davidson-Moncada
Journal: Blood
Blood (2024) 144 (Supplement 1): 916.
https://doi.org/10.1182/blood-2024-201812
Published: 2024
Journal Articles

Comprehensive Characterization and Validation of the Tumor Microenvironment in Patients with Relapsed/Refractory Large B-Cell Lymphoma Identifies Subgroups with Greatest Benefit from CD19 CAR T-Cell Therapy

Xubin Li, Kartik Singhal, Qing Deng, Dai Chihara, David A Russler-Germain, Usama Hussein, Jennifer Ann Foltz, Jared Henderson, Ashley Wilson, Evelyn Schmidt, Imran A. Nizamuddin, Tommy Dinh, Ryan Sun, Akhil Kesaraju, Laura K. Hilton, David W. Scott, Francisco Vega, Christopher R. Flowers, Obi Griffith, Todd A Fehniger, Malachi Griffith, Michael R. Green
Journal: Blood
Blood (2024) 144 (Supplement 1): 643.
https://doi.org/10.1182/blood-2024-204166
Published: 2024
Journal Articles

Clearance of Leukemia Associated Mutations (LAMs) after Induction Therapy Is Associated with Favorable Outcomes in Intermediate Risk Acute Myeloid Leukemia: Interim Results of a Multicenter, Prospective Phase II Trial

Meagan Jacoby, David H Spencer, Geoffrey L. Uy, Feng Gao, Tasha Burton, Sharon E Heath, Feiyu Du, Shelly O'Laughlin, Robert Fulton, Zeina A. Al-Mansour, Christopher R. Cogle, Eric J Huselton, John F. DiPersio, Peter Westervelt, Mark A. Schroeder, Armin Ghobadi, Iskra Pusic, Keith Stockerl-Goldstein, Brad S. Kahl, Amanda F. Cashen, Matt Christopher, Nathan Singh, Ravi Vij, Zachary D. Crees, Ryan B. Day, Todd A Fehniger, Karolyn Oetjen, Dilan A. Patel, Miriam Y Kim, Michael Slade, Daniel C. Link, Matthew J. Walter, Camille N. Abboud, Ramzi Abboud, Timothy J Ley
Journal: Blood
Blood (2024) 144 (Supplement 1): 224.
https://doi.org/10.1182/blood-2024-201694
Published: 2024
Journal Articles

Mosunetuzumab Plus Polatuzumab Vedotin Induces Early Complete Responses in Previously Untreated High Tumor Burden Follicular Lymphoma

David A Russler-Germain, Fei Wan, Emily R. King, Chaz Moreno, Michelle Becker-Hapak, Patrick Pence, Joseph Rueve, Sushanth A Pureti, Dilan A. Patel, Brad S. Kahl, Neha Mehta-Shah, Todd A Fehniger, Nancy L. Bartlett
Journal: Blood
Blood (2024) 144 (Supplement 1): 4414.
https://doi.org/10.1182/blood-2024-202085
Published: 2024
Journal Articles

Duvelisib for Cytokine Release Syndrome Prophylaxis during CD19-Targeted CAR T Cell Therapy

Michael Slade, Michael P. Rettig, Zachary David Crees, Neha Mehta-Shah, Todd A Fehniger, Amanda F Cashen, Iskra Pusic, Geoffrey L Uy, Peter Westervelt, John DiPersio, Armin Ghobadi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3470.
https://doi.org/10.1182/blood-2023-172439
Published: 2023
Journal Articles

WU-NK-101 (W-NK), a Memory-like (ML) NK Cell, Naturally Overcomes Tumor Microenvironment (TME) Metabolic Challenges, Retaining Anti-Tumor Potency

Nupur Bhatnagar, Vincent Petit, Jayakumar Vadakekolathu, Christian Pinset, Nitin Mahajan, John Dean, Christine Spingola, Laura Arthur, David Boocock, Clare Coveney, John Muth, Jan Baughman, Melissa M Berrien-Elliott, Marc Sitbon, Matthew L. Cooper, Jan Davidson-Moncada, Todd A Fehniger, Sergio Rutella
Journal: Blood
Blood (2023) 142 (Supplement 1): 4834.
https://doi.org/10.1182/blood-2023-178868
Published: 2023
Journal Articles

Adoptively Infused Memory-like Natural Killer Cells Impact Adaptive Immune Responses in Patients with Acute Myeloid Leukemia

Sergio Rutella, Jayakumar Vadakekolathu, Amanda F Cashen, Nitin Mahajan, Yanira Ruiz-Heredia, Alejandro Martín-Muñoz, Santiago Barrio, Melissa M Berrien-Elliott, Jan Davidson-Moncada, Todd A Fehniger
Journal: Blood
Blood (2023) 142 (Supplement 1): 4813.
https://doi.org/10.1182/blood-2023-184986
Published: 2023
Journal Articles

WU-NK-101 (W-NK), a Memory-like (ML) NK Cell, Intrinsically Overcomes Factors Restricting Adoptive Cell Therapy (ACT) in Acute Myeloid Leukemia (AML)

Sergio Rutella, John Muth, Jayakumar Vadakekolathu, Tom Leedom, Alex Hamil, Laura Arthur, Nitin Mahajan, Elizabeth Schramm, Renaud Warin, Amber M Foust, David Boocock, Clare Coveney, Jan Baughman, Vincent Petit, Nupur Bhatnagar, Kristann Magee, Melissa M Berrien-Elliott, Matthew L. Cooper, Jan Davidson-Moncada, Todd A Fehniger
Journal: Blood
Blood (2023) 142 (Supplement 1): 466.
https://doi.org/10.1182/blood-2023-184923
Published: 2023
Journal Articles

Mechanisms of Cytokine-Induced NK Cell Therapy: IL-12/15/18 Induce a Unique Transcriptional, Epigenetic, and Functional Human NK Cell Memory Program

Jennifer Tran, Jennifer Ann Foltz, Pamela Wong, Changxu Fan, Michelle Becker-Hapak, Nancy D Marin, Celia C Cubitt, David A Russler-Germain, Mark Foster, Timothy Schappe, Lynne Marsala, Joseph Rueve, Kimberly Hwang, Ting Wang, Melissa M Berrien-Elliott, Amanda F Cashen, Jeffrey J. Bednarski, Obi Griffith, Malachi Griffith, Allegra Petti, Todd A Fehniger
Journal: Blood
Blood (2023) 142 (Supplement 1): 2067.
https://doi.org/10.1182/blood-2023-182435
Published: 2023
Journal Articles

Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction

Mehmet Emrah Selli, Jack H. Landmann, Marina Terekhova, John Lattin, Amanda Heard, Yu-Sung Hsu, Tien-Ching Chang, Jufang Chang, John Warrington, Helen Ha, Natalie Kingston, Graham Hogg, Michael Slade, Melissa M. Berrien-Elliott, Mark Foster, Samantha Kersting-Schadek, Agata Gruszczynska, David DeNardo, Todd A. Fehniger, Maxim Artyomov, Nathan Singh
Journal: Blood
Blood (2023) 141 (26): 3153–3165.
https://doi.org/10.1182/blood.2023020100
Published: 2023
Includes: Supplemental data
Journal Articles

Allogeneic natural killer cell therapy

Melissa M. Berrien-Elliott, Miriam T. Jacobs, Todd A. Fehniger
Journal: Blood
Blood (2023) 141 (8): 856–868.
https://doi.org/10.1182/blood.2022016200
Published: 2023
Journal Articles

Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes in Newly Diagnosed Patients (Alliance 151303)

David A. Russler-Germain, Kilannin Krysiak, Cody Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary Skidmore, Lee Trani, Feng Gao, Susan M. Geyer, Amanda F. Cashen, Neha Mehta-Shah, Brad S. Kahl, Nancy L. Bartlett, Izidore S. Lossos, Eric D. Hsi, Peter Martin, John P. Leonard, Malachi Griffith, Obi L. Griffith, Todd A. Fehniger
Journal: Blood
Blood (2022) 140 (Supplement 1): 3543–3545.
https://doi.org/10.1182/blood-2022-157051
Published: 2022
Journal Articles

Costimulatory Domains Direct Distinct Fates of CAR T Cell Dysfunction

Mehmet Emrah Selli, Jack Landmann, John Lattin, Amanda Heard, John Warrington, Helen Ha, Jufang Chang, Natalie Kingston, Graham Hogg, Mark Foster, Samantha Kersting-Schadek, Marina Terekhova, David DeNardo, Todd A. Fehniger, Maxim Artyomov, Nathan Singh
Journal: Blood
Blood (2022) 140 (Supplement 1): 2354–2355.
https://doi.org/10.1182/blood-2022-159687
Published: 2022
Journal Articles

Putative Predictors of Response to WU-NK-101, an Allogeneic, Enhanced Memory (ML) Natural Killer (NK) Cell Therapy Product, for Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Sergio Rutella, Amanda F. Cashen, John Muth, Mary Elizabeth Mathyer, Alun James Carter, Brunda Tumala, Laura Arthur, Kristann Magee, Paula Comune Pennacchi, Julian Gorrochategui, Vincent Petit, Daniel Primo, Dominique Blanchard, Michael Kiebish, Nupur Bhatnagar, David Boocock, Jayakumar Vadakekolathu, Matthew L Cooper, Melissa M. Berrien-Elliott, Jan K Davidson-Moncada, Todd A. Fehniger
Journal: Blood
Blood (2022) 140 (Supplement 1): 7400–7401.
https://doi.org/10.1182/blood-2022-157199
Published: 2022
Journal Articles

Phase I Study of Baricitinib Gvhd Prophylaxis in HLA-Matched, Peripheral Blood Allogeneic Hematopoietic Cell Transplant

Mark A. Schroeder, Jaebok Choi, Himachandana Atluri, Jordan Atkins, Melinda Harding, Jeremy Eisele, Feng Gao, Ramzi Abboud, Camille Abboud, Sr., Amanda F. Cashen, Matthew Christopher, Todd A. Fehniger, Francesca Ferraro, Armin Ghobadi, Meagan A. Jacoby, Iskra Pusic, Keith E Stockerl-Goldstein, Geoffrey L. Uy, Ravi Vij, Matthew J Walter, Peter Westervelt, John F. DiPersio
Journal: Blood
Blood (2022) 140 (Supplement 1): 1875–1876.
https://doi.org/10.1182/blood-2022-157214
Published: 2022
Journal Articles

Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma

Clinical Trials & Observations
Jeffrey P. Ward, Melissa M. Berrien-Elliott, Felicia Gomez, Jingqin Luo, Michelle Becker-Hapak, Amanda F. Cashen, Nina D. Wagner-Johnston, Kami Maddocks, Matthew Mosior, Mark Foster, Kilannin Krysiak, Alina Schmidt, Zachary L. Skidmore, Sweta Desai, Marcus P. Watkins, Anne Fischer, Malachi Griffith, Obi L. Griffith, Todd A. Fehniger, Nancy L. Bartlett
Journal: Blood
Blood (2022) 139 (13): 1999–2010.
https://doi.org/10.1182/blood.2021011894
Published: 2022
Includes: Supplemental data
Journal Articles

Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant

Clinical Trials & Observations
Jeffrey J. Bednarski, Clare Zimmerman, Melissa M. Berrien-Elliott, Jennifer A. Foltz, Michelle Becker-Hapak, Carly C. Neal, Mark Foster, Timothy Schappe, Ethan McClain, Patrick P. Pence, Sweta Desai, Samantha Kersting-Schadek, Pamela Wong, David A. Russler-Germain, Bryan Fisk, Wen-Rong Lie, Jeremy Eisele, Stephanie Hyde, Sima T. Bhatt, Obi L. Griffith, Malachi Griffith, Allegra A. Petti, Amanda F. Cashen, Todd A. Fehniger
Journal: Blood
Blood (2022) 139 (11): 1670–1683.
https://doi.org/10.1182/blood.2021013972
Published: 2022
Includes: Supplemental data
Journal Articles

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

Clinical Trials & Observations Brief Report
Melissa M. Berrien-Elliott, Michelle Becker-Hapak, Amanda F. Cashen, Miriam Jacobs, Pamela Wong, Mark Foster, Ethan McClain, Sweta Desai, Patrick Pence, Sarah Cooley, Claudio Brunstein, Feng Gao, Camille N. Abboud, Geoffrey L. Uy, Peter Westervelt, Meagan A. Jacoby, Iskra Pusic, Keith E. Stockerl-Goldstein, Mark A. Schroeder, John F. DiPersio, Patrick Soon-Shiong, Jeffrey S. Miller, Todd A. Fehniger
Journal: Blood
Blood (2022) 139 (8): 1177–1183.
https://doi.org/10.1182/blood.2021011532
Published: 2022
Includes: Supplemental data