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Journal Articles

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease

Junaid Ansari, Elena Y. Senchenkova, Shantel A. Vital, Zaki Al-Yafeai, Gaganpreet Kaur, Erica M. Sparkenbaugh, A. Wayne Orr, Rafal Pawlinski, Robert P. Hebbel, D. Neil Granger, Paul Kubes, Felicity N. E. Gavins

Blood (2021) 137 (11): 1538–1549.

https://doi.org/10.1182/blood.2020009166

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

Specific Correction of the Intron-22 Inverted Factor VIII Gene in Autologous Blood Outgrowth Endothelial Cells from Patients with Severe Hemophilia A

Long V. Dinh, PhD, Eli Fine, PhD, Afshin Ameri, MD, Bernadette W. Luu, B.S., M.T. (CLS), Satish Kumar, PhD, Vincent P. Diego, PhD, Joanne E. Curran, PhD, Juan M Peralta, M.S., Henry Mead, M.B.A., M.P.H., Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, John Blangero, PhD, Jerry S. Powell, MD, Timothy C. Nichols, MD, Robert P. Hebbel, MD, Tom E. Howard, MD, PhD

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-142679

Published: 2020

Journal Articles

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Erica M. Sparkenbaugh, Pichika Chantrathammachart, Jacqueline Mickelson, Joanne van Ryn, Robert P. Hebbel, Dougald M. Monroe, Nigel Mackman, Nigel S. Key, Rafal Pawlinski

Blood (2014) 123 (11): 1747–1756.

https://doi.org/10.1182/blood-2013-08-523936

Published: 2014

Includes: Supplemental data

Journal Articles

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

John D. Belcher, Chunsheng Chen, Julia Nguyen, Liming Milbauer, Fuad Abdulla, Abdu I. Alayash, Ann Smith, Karl A. Nath, Robert P. Hebbel, Gregory M. Vercellotti

Blood (2014) 123 (3): 377–390.

https://doi.org/10.1182/blood-2013-04-495887

Published: 2014

Includes: Supplemental data

Journal Articles

Interference With TNFα Using Long-Term Etanercept In S+S Antilles Sickle Transgenic Mice Ameliorates Abnormal Endothelial Activation, Vasoocclusion, and Pulmonary Hypertension Including Its Pulmonary Arterial Wall Remodeling

Anna Solovey, Arif Somani, Chunsheng Chen, James Kiley, Paul Marker, Fuad Abdulla, M Gerard O'Sullivan, Robert J Kelm, Jr., John D Belcher, Ph.D., Gregory M Vercellotti, Robert P Hebbel

Blood (2013) 122 (21): 728.

https://doi.org/10.1182/blood.V122.21.728.728

Published: 2013

Journal Articles

A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing

Apurva V. Shirodkar, Rosanne St. Bernard, Anna Gavryushova, Anna Kop, Britta J. Knight, Matthew Shu-Ching Yan, Hon-Sum Jeffrey Man, Maneesh Sud, Robert P. Hebbel, Peter Oettgen, William C. Aird, Philip A. Marsden

Blood (2013) 121 (17): 3531–3540.

https://doi.org/10.1182/blood-2013-01-479170

Published: 2013

Includes: Supplemental data

Journal Articles

Mast Cell Activation Contributes to Neurogenic Inflammation and Pain in Sickle Cell Disease

Lucile Vincent, PhD, Julia Nguyen, Derek Vang, Oludare B Taiwo, Kathryn Luk, Michael Ansonoff, Marna Ericson, Donald Simone, John E. Pintar, Robert P Hebbel, Kalpna Gupta

Blood (2012) 120 (21): 374.

https://doi.org/10.1182/blood.V120.21.374.374

Published: 2012

Journal Articles

H-Ferritin Ferroxidase Activity Induces Cytoprotective Pathways and Inhibits Microvascular Stasis in Transgenic Sickle Mice

Gregory M Vercellotti, MD, Chunsheng Chen, PhD, Carol M Bruzzone, MS, Heather A. Bechtel, MD, Julia Ngyuen, BS, Robert P Hebbel, MD, Clifford J Steer, MD, John D Belcher, PhD

Blood (2012) 120 (21): 378.

https://doi.org/10.1182/blood.V120.21.378.378

Published: 2012

Journal Articles

Morphine Stimulates Wound Healing Via Mu Opioid Receptor and Promotes Wound Closure in Sickle Mice

Derek Vang, Marna Ericson, PhD, Michael A Ansonoff, PhD, John E Pintar, PhD, Robert P Hebbel, MD, Kalpna Gupta, PhD

Blood (2011) 118 (21): 2118.

https://doi.org/10.1182/blood.V118.21.2118.2118

Published: 2011

Journal Articles

Association of Mu Opioid Receptor with Neurogenic Inflammation in Sickle Mic

Kathryn Luk, Julia Nguyen, Derek Vang, Oludare B Taiwo, Divyanshoo Kohli, MD, Marna Ericson, PhD, Michael A Ansonoff, PhD, John E Pintar, PhD, Robert P Hebbel, MD, Kalpna Gupta, PhD

Blood (2011) 118 (21): 895.

https://doi.org/10.1182/blood.V118.21.895.895

Published: 2011

Journal Articles

Plasma Hemoglobin and Heme Trigger Weibel Palade Body Exocytosis and Vaso-Occlusion in Transgenic Sickle Mice

John D Belcher, PhD, Julia Nguyen, Chunsheng Chen, PhD, Ann Smith, PhD, Abdu I Alayash, PhD, DSc, Sethu L Nair, PhD, Arif Somani, MD, Robert P Hebbel, MD, Gregory M Vercellotti, MD

Blood (2011) 118 (21): 896.

https://doi.org/10.1182/blood.V118.21.896.896

Published: 2011

Journal Articles

Carbon Monoxide Therapy Modulates Hematopoietic Stem Cell Development in Heme-Oxygenase-1 Knockout Mice

Joan Denise Beckman, PhD, Paul H Marker, MS, Julia Nguyen, John D Belcher, PhD, Anthony J. Croatt, Karl A. Nath, MD, MBChB, Robert P Hebbel, MD, Gregory M Vercellotti, MD

Blood (2011) 118 (21): 1318.

https://doi.org/10.1182/blood.V118.21.1318.1318

Published: 2011

Journal Articles

The Blood Monocyte - TNF - Endothelial Axis in Activation of Endothelial Tissue Factor in the Transgenic Sickle Mouse: Possible Relevance of Etanercept to Sickle Coagulopathy

Anna Solovey, M.D., Liming Milbauer Chang, Ph.D., Fuad Abdulla, Rahn Kollander, Paul H Marker, MS, Robert Kelm, Jr., Ph.D., Gregory M Vercellotti, MD, Robert P Hebbel, MD

Blood (2011) 118 (21): 1048.

https://doi.org/10.1182/blood.V118.21.1048.1048

Published: 2011

Journal Articles

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

Felicity N. E. Gavins, Janice Russell, Elena L. Senchenkova, Lidiana De Almeida Paula, Amílcar S. Damazo, Charles T. Esmon, Daniel Kirchhofer, Robert P. Hebbel, D. Neil Granger

Blood (2011) 117 (15): 4125–4133.

https://doi.org/10.1182/blood-2010-08-301366

Published: 2011

Journal Articles

Exhaled Carbon Monoxide as a Marker of Hemolysis In Transgenic Mouse Models of Sickle Cell Anemia.

John D Belcher, PhD, Julia Nguyen, Julie Furne, Julie Vineyard, Joan Denise Beckman, PhD, Paul H Marker, MS, Robert P Hebbel, MD, Michael D Levitt, MD, Gregory M Vercellotti, MD

Blood (2010) 116 (21): 1642.

https://doi.org/10.1182/blood.V116.21.1642.1642

Published: 2010

Journal Articles

Association of Non-Healing Wounds, Pain and Neurochemical Alterations In Sickle Cell Disease

Josephine Anuforo, Julia Nguyen, Kathryn Luk, Silas Wallen-Friedman, Divyanshoo Kohli, Derek Vang, Marna Ericson, Donald Simone, Robert P Hebbel, MD, Kalpna Gupta, PhD

Blood (2010) 116 (21): 842.

https://doi.org/10.1182/blood.V116.21.842.842

Published: 2010

Journal Articles

Carbon Monoxide Therapy Reduces Reactive Oxygen Species Production and the Short-Term Hematopoietic Stem Cell Population In Heme-Oxygenase-1 Knockout Mice

Joan D. Beckman, PhD, Paul H Marker, MS, Julia Nguyen, John D Belcher, Ph.D., Robert P Hebbel, MD, Anthony J. Croatt, Karl A. Nath, MD, Gregory M. Vercellotti, MD

Blood (2010) 116 (21): 4767.

https://doi.org/10.1182/blood.V116.21.4767.4767

Published: 2010

Journal Articles

Pulmonary hypertension and nitric oxide depletion in sickle cell disease

H. Franklin Bunn, David G. Nathan, George J. Dover, Robert P. Hebbel, Orah S. Platt, Wendell F. Rosse, Russell E. Ware

Blood (2010) 116 (5): 687–692.

https://doi.org/10.1182/blood-2010-02-268193

Published: 2010

Journal Articles

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Divyanshoo R. Kohli, Yunfang Li, Sergey G. Khasabov, Pankaj Gupta, Lois J. Kehl, Marna E. Ericson, Julia Nguyen, Vinita Gupta, Robert P. Hebbel, Donald A. Simone, Kalpna Gupta

Blood (2010) 116 (3): 456–465.

https://doi.org/10.1182/blood-2010-01-260372

Published: 2010

Includes: Supplemental data

Journal Articles

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

Robert P. Hebbel, Gregory M. Vercellotti, Betty S. Pace, Anna N. Solovey, Rahn Kollander, Chine F. Abanonu, Julia Nguyen, Julie V. Vineyard, John D. Belcher, Fuad Abdulla, Shadé Osifuye, John W. Eaton, Robert J. Kelm, Jr, Arne Slungaard

Blood (2010) 115 (12): 2483–2490.

https://doi.org/10.1182/blood-2009-02-204990

Published: 2010

NARROW

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease

Specific Correction of the Intron-22 Inverted Factor VIII Gene in Autologous Blood Outgrowth Endothelial Cells from Patients with Severe Hemophilia A

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Interference With TNFα Using Long-Term Etanercept In S+S Antilles Sickle Transgenic Mice Ameliorates Abnormal Endothelial Activation, Vasoocclusion, and Pulmonary Hypertension Including Its Pulmonary Arterial Wall Remodeling

A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing

Mast Cell Activation Contributes to Neurogenic Inflammation and Pain in Sickle Cell Disease

H-Ferritin Ferroxidase Activity Induces Cytoprotective Pathways and Inhibits Microvascular Stasis in Transgenic Sickle Mice

Morphine Stimulates Wound Healing Via Mu Opioid Receptor and Promotes Wound Closure in Sickle Mice

Association of Mu Opioid Receptor with Neurogenic Inflammation in Sickle Mic

Plasma Hemoglobin and Heme Trigger Weibel Palade Body Exocytosis and Vaso-Occlusion in Transgenic Sickle Mice

Carbon Monoxide Therapy Modulates Hematopoietic Stem Cell Development in Heme-Oxygenase-1 Knockout Mice

The Blood Monocyte - TNF - Endothelial Axis in Activation of Endothelial Tissue Factor in the Transgenic Sickle Mouse: Possible Relevance of Etanercept to Sickle Coagulopathy

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

Exhaled Carbon Monoxide as a Marker of Hemolysis In Transgenic Mouse Models of Sickle Cell Anemia.

Association of Non-Healing Wounds, Pain and Neurochemical Alterations In Sickle Cell Disease

Carbon Monoxide Therapy Reduces Reactive Oxygen Species Production and the Short-Term Hematopoietic Stem Cell Population In Heme-Oxygenase-1 Knockout Mice

Pulmonary hypertension and nitric oxide depletion in sickle cell disease

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

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American Society of Hematology

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American Society of Hematology

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