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Journal Articles

Idarucizumab, a Specific Reversal Agent for Dabigatran: Immediate, Complete and Sustained Reversal of Dabigatran-Induced Anticoagulation in Japanese Healthy Male Volunteers

Joanne van Ryn, PhD, Masahiro Yasaka, MD PhD, Ippei Ikushima, MD PhD, Akiko Harada, PhD, Atsushi Taniguchi, MSc, Susumu Imazu, PhD, Stephen Norris, PhD, Dietmar Gansser, PhD, Joachim Stangier, PhD

Blood (2016) 128 (22): 2627.

https://doi.org/10.1182/blood.V128.22.2627.2627

Published: 2016

Journal Articles

Mechanistic Differences of Prothrombin Complex Concentrate and Idarucizumab in a Trauma Model Under Dabigatran Anticoagulation

Markus Honickel, MD, Joanne van Ryn, PhD, Oliver Grottke, MDPhD

Blood (2015) 126 (23): 1128.

https://doi.org/10.1182/blood.V126.23.1128.1128

Published: 2015

Journal Articles

Idarucizumab Fully Restores Dabigatran-Induced Alterations on Platelet and Fibrin Deposition on Damaged Vessels: Studies in Vitro with Circulating Human Blood

Eduardo Arellano-Rodrigo, MD PhD, Irene Lopez-Vilchez, PhD, Patricia Molina, Marcos Pino, Maribel Diaz-Ricart, PhD, Joanne van Ryn, PhD, Gines Escolar, MD PhD

Blood (2014) 124 (21): 2878.

https://doi.org/10.1182/blood.V124.21.2878.2878

Published: 2014

Journal Articles

Reversal of Trauma-Induced Bleeding and Anticoagulation with a Dabigatran-Specific Antidote (idarucizumab) As Assessed By Shed and Washed Blood Tests in a Pig Model of Supratherapeutic Anticoagulation and Trauma

Oliver Grottke, MD PhD, Markus Honickel, MD, Johanna Schurer, Joanne van Ryn, PhD

Blood (2014) 124 (21): 4268.

https://doi.org/10.1182/blood.V124.21.4268.4268

Published: 2014

Journal Articles

Prothrombin Complex Concentrate in Combination with Fibrinogen Plus Tranexamic Acid Is More Effective Than Mono-Therapy with Prothrombin Complex Concentrate in a Dabigatran Anticoagulation Experimental Polytrauma Model

Oliver Grottke, MD PhD, Markus Honickel, MD, Henri M.H. Spronk, PhD, Hugo ten Cate, Joanne van Ryn, PhD, Rolf Rossaint, MD

Blood (2014) 124 (21): 346.

https://doi.org/10.1182/blood.V124.21.346.346

Published: 2014

Journal Articles

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Erica M. Sparkenbaugh, Pichika Chantrathammachart, Jacqueline Mickelson, Joanne van Ryn, Robert P. Hebbel, Dougald M. Monroe, Nigel Mackman, Nigel S. Key, Rafal Pawlinski

Blood (2014) 123 (11): 1747–1756.

https://doi.org/10.1182/blood-2013-08-523936

Published: 2014

Includes: Supplemental data

Journal Articles

Ex Vivo Prothrombin Complex Concentrates and a Specific Antidote Are Effective In Reversing Dabigatran-Induced Coagulopathy In Pigs

Joanne van Ryn, PhD, Henri M.H. Spronk, PhD, Rolf Rossaint, MD, Oliver Grottke, MD, PhD

Blood (2013) 122 (21): 2387.

https://doi.org/10.1182/blood.V122.21.2387.2387

Published: 2013

Journal Articles

Resuscitation With Different Volume Expanders Does Not Influence Coagulation After Antidoting Dabigatran With Its Specific Fab In a Pig Model Of Hemorrhagic Shock

Henri M.H. Spronk, PhD, Joanne van Ryn, PhD, Christian Zentai, Hugo ten Cate, MD, PhD, Rolf Rossaint, MD, Oliver Grottke, MD, PhD

Blood (2013) 122 (21): 3649.

https://doi.org/10.1182/blood.V122.21.3649.3649

Published: 2013

Journal Articles

A specific antidote for dabigatran: functional and structural characterization

Felix Schiele, Joanne van Ryn, Keith Canada, Corey Newsome, Eliud Sepulveda, John Park, Herbert Nar, Tobias Litzenburger

Blood (2013) 121 (18): 3554–3562.

https://doi.org/10.1182/blood-2012-11-468207

Published: 2013

Includes: Supplemental data

Journal Articles

Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

Henri M.H. Spronk, PhD, Julian I Borissoff, Oliver Soehnlein, Rory Koenen, Rene van Oerle, Sylvia Heeneman, Mat J.A.P. Daemen, Charles T Esmon, PhD, Jay L. Degen, PhD, Hartmut Weiler, PhD, Joanne van Ryn, MSc, PhD, Hugo Ten Cate, MD, PhD

Blood (2012) 120 (21): 103.

https://doi.org/10.1182/blood.V120.21.103.103

Published: 2012

Journal Articles

Reversal of Dabigatran's Anticoagulant Activity in the Monkey by a Specific Antidote and Pharmacokinetic and Pharmacodynamic Modeling

Joshuaine Toth, MS, Guanfa Gan, PhD, Joanne van Ryn, PhD, Holly Dursema, MS, Jennifer Isler, PhD, Kelly Coble, BS, John Burke, PhD, Bojan Lalovic, PhD, Stephen Olson, PhD

Blood (2012) 120 (21): 22.

https://doi.org/10.1182/blood.V120.21.22.22

Published: 2012

Journal Articles

In Vitro Characterization, Pharmacokinetics and Reversal of Supratherapeutic Doses of Dabigatran-Induced Bleeding in Rats by a Specific Antibody Fragment Antidote to Dabigatran

Joanne van Ryn, PhD, Tobias Litzenburger, PhD, Guanfa Gan, PhD, Kelly Coble, BS, Johanna Schurer

Blood (2012) 120 (21): 3418.

https://doi.org/10.1182/blood.V120.21.3418.3418

Published: 2012

Journal Articles

Acceleration of Dabigatran Elimination by Activated Charcoal Perfusion and Hemodialysis in a Pig Model.

Jessica Lange, MD, Christian Thiel, MD, Karolin Thiel, MD, Wilfried Klingert, Kathrin Klingert, Alfred Königsrainer, MD, Stephan Formella, MD, Andreas Clemens, MD, Joanne van Ryn, PhD, Martin Schenk, PhD

Blood (2012) 120 (21): 2272.

https://doi.org/10.1182/blood.V120.21.2272.2272

Published: 2012

Journal Articles

Assessment of Cross-Reactivity in Three Different Fecal Occult Blood Test Systems with Dabigatran and Dabigatran Etexilate: Identification of Useful Test Methods

Ashley M Goss, PhD, Joanne van Ryn, PhD, Johanna Schurer, Andreas Clemens, MD

Blood (2012) 120 (21): 4360.

https://doi.org/10.1182/blood.V120.21.4360.4360

Published: 2012

Journal Articles

The Successful Reversal of Dabigatran-Induced Bleeding by Coagulation Factor Concentrates in a Rat Tail Bleeding Model Do Not Correlate with Ex Vivo Markers of Anticoagulation

Joanne van Ryn, PhD, Johanna Schurer, Monika Kink-Eiband, Andreas Clemens, MD

Blood (2011) 118 (21): 2316.

https://doi.org/10.1182/blood.V118.21.2316.2316

Published: 2011

Journal Articles

Adsorption of Dabigatran Etexilate in Water or Dabigatran in Pooled Human Plasma by Activated Charcoal in Vitro.

Joanne van Ryn, PhD, Peter Sieger, PhD, Monika Kink-Eiband, Dietmar Gansser, PhD, Andreas Clemens, MD

Blood (2009) 114 (22): 1065.

https://doi.org/10.1182/blood.V114.22.1065.1065

Published: 2009

Journal Articles

Effects of Dabigatran, a Direct Thrombin Inhibitor, as Compared to the Direct Factor Xa Inhibitors, Rivaroxaban and Apixaban, on Tissue Factor-Induced Human Platelet Aggregation in Platelet Rich Plasma.

Joanne van Ryn, PhD, Monika Kink-Eiband, Norbert Hauel, PhD, Henning Priepke, PhD, Wolfgang Wienen, PhD

Blood (2007) 110 (11): 1884.

https://doi.org/10.1182/blood.V110.11.1884.1884

Published: 2007

Journal Articles

Dabigatran Inhibits Both Clot-Bound and Fluid Phase Thrombin In Vitro: Effects Compared to Heparin and Hirudin.

Joanne van Ryn, PhD, Norbert Hauel, PhD, Lisa Waldmann, Wolfgang Wienen, PhD

Blood (2007) 110 (11): 3998.

https://doi.org/10.1182/blood.V110.11.3998.3998

Published: 2007

Journal Articles

Comparison of the Antithrombotic Effectiveness of the Direct Thrombin Inhibitor, Dabigatran Etexilate, and Two Factor Xa Inhibitors in an A-V Shunt Model of Thrombosis in Rabbits.

Joanne van Ryn, PhD, Norbert Hauel, PhD, Henning Priepke, PhD, Kai Gerlach, PhD, Annette Schuler-Metz, PhD, Wolfgang Wienen, PhD

Blood (2007) 110 (11): 3154.

https://doi.org/10.1182/blood.V110.11.3154.3154

Published: 2007

Journal Articles

Dabigatran Inhibits Arterial Thrombosis in a Porcine Model of Cyclic Flow Reduction.

Joanne van Ryn, PhD, Henning Priepke, PhD, Uwe J. Ries, PhD, Norbert Hauel, PhD, Jean-Marie Stassen, PhD, Wolfgang Wienen, PhD

Blood (2006) 108 (11): 906.

https://doi.org/10.1182/blood.V108.11.906.906

Published: 2006

NARROW

Idarucizumab, a Specific Reversal Agent for Dabigatran: Immediate, Complete and Sustained Reversal of Dabigatran-Induced Anticoagulation in Japanese Healthy Male Volunteers

Mechanistic Differences of Prothrombin Complex Concentrate and Idarucizumab in a Trauma Model Under Dabigatran Anticoagulation

Idarucizumab Fully Restores Dabigatran-Induced Alterations on Platelet and Fibrin Deposition on Damaged Vessels: Studies in Vitro with Circulating Human Blood

Reversal of Trauma-Induced Bleeding and Anticoagulation with a Dabigatran-Specific Antidote (idarucizumab) As Assessed By Shed and Washed Blood Tests in a Pig Model of Supratherapeutic Anticoagulation and Trauma

Prothrombin Complex Concentrate in Combination with Fibrinogen Plus Tranexamic Acid Is More Effective Than Mono-Therapy with Prothrombin Complex Concentrate in a Dabigatran Anticoagulation Experimental Polytrauma Model

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Ex Vivo Prothrombin Complex Concentrates and a Specific Antidote Are Effective In Reversing Dabigatran-Induced Coagulopathy In Pigs

Resuscitation With Different Volume Expanders Does Not Influence Coagulation After Antidoting Dabigatran With Its Specific Fab In a Pig Model Of Hemorrhagic Shock

A specific antidote for dabigatran: functional and structural characterization

Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

Reversal of Dabigatran's Anticoagulant Activity in the Monkey by a Specific Antidote and Pharmacokinetic and Pharmacodynamic Modeling

In Vitro Characterization, Pharmacokinetics and Reversal of Supratherapeutic Doses of Dabigatran-Induced Bleeding in Rats by a Specific Antibody Fragment Antidote to Dabigatran

Acceleration of Dabigatran Elimination by Activated Charcoal Perfusion and Hemodialysis in a Pig Model.

Assessment of Cross-Reactivity in Three Different Fecal Occult Blood Test Systems with Dabigatran and Dabigatran Etexilate: Identification of Useful Test Methods

The Successful Reversal of Dabigatran-Induced Bleeding by Coagulation Factor Concentrates in a Rat Tail Bleeding Model Do Not Correlate with Ex Vivo Markers of Anticoagulation

Adsorption of Dabigatran Etexilate in Water or Dabigatran in Pooled Human Plasma by Activated Charcoal in Vitro.

Effects of Dabigatran, a Direct Thrombin Inhibitor, as Compared to the Direct Factor Xa Inhibitors, Rivaroxaban and Apixaban, on Tissue Factor-Induced Human Platelet Aggregation in Platelet Rich Plasma.

Dabigatran Inhibits Both Clot-Bound and Fluid Phase Thrombin In Vitro: Effects Compared to Heparin and Hirudin.

Comparison of the Antithrombotic Effectiveness of the Direct Thrombin Inhibitor, Dabigatran Etexilate, and Two Factor Xa Inhibitors in an A-V Shunt Model of Thrombosis in Rabbits.

Dabigatran Inhibits Arterial Thrombosis in a Porcine Model of Cyclic Flow Reduction.

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American Society of Hematology

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American Society of Hematology

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