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Issue Archive

Volume 124, Issue 1
July 3 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
A new prognostic score for CLL
Clinical Trials & Observations
Constantine S. Tam,John F. Seymour
View Articletitled, A new prognostic score for CLL
INSIDE BLOOD COMMENTARY
miR in CLL: more than mere markers of prognosis?
Arnon P. Kater,Eric Eldering
View Articletitled, <em>miR</em> in CLL: <em>more</em> than <em>mere</em> markers of prognosis?
INSIDE BLOOD COMMENTARY
IL-7 and TSLP receptors: twisted sisters
Scott K. Durum
View Articletitled, IL-7 and TSLP receptors: twisted sisters
INSIDE BLOOD COMMENTARY
CDK6, a new target in MLL-driven leukemia
Iléana Antony-Debré,Ulrich Steidl
View Articletitled, CDK6, a new target in MLL-driven leukemia
INSIDE BLOOD COMMENTARY
Epigenetic therapy reprograms hereditary disease
José M. Bautista
View Articletitled, Epigenetic therapy reprograms hereditary disease
INSIDE BLOOD COMMENTARY
Zinc fingers poke zebrafish, cause thrombosis!
Pudur Jagadeeswaran
View Articletitled, Zinc fingers poke zebrafish, cause thrombosis!

BLOOD WORK

Langerhans cell histiocytosis with atypical histiocytic marrow infiltration
Jorge Galvez Silva,Michael Rytting
View Articletitled, Langerhans cell histiocytosis with atypical histiocytic marrow infiltration
Doublet spherocytes
Kalyan Mantripragada,Peter J. Quesenberry
View Articletitled, Doublet spherocytes

PLENARY PAPER

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
Theresa Placke,Katrin Faber,Atsushi Nonami,Sarah L. Putwain,Helmut R. Salih,Florian H. Heidel,Alwin Krämer,David E. Root,David A. Barbie,Andrei V. Krivtsov,Scott A. Armstrong,William C. Hahn,Brian J. Huntly,Stephen M. Sykes,Michael D. Milsom,Claudia Scholl,Stefan Fröhling
View Articletitled, Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
Supplemental data

PLENARY PAPER

Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families
Lisa Mirabello,Elizabeth R. Macari,Lea Jessop,Steven R. Ellis,Timothy Myers,Neelam Giri,Alison M. Taylor,Katherine E. McGrath,Jessica M. Humphries,Bari J. Ballew,Meredith Yeager,Joseph F. Boland,Ji He,Belynda D. Hicks,Laurie Burdett,Blanche P. Alter,Leonard Zon,Sharon A. Savage
View Articletitled, Whole-exome sequencing and functional studies identify <em>RPS29</em> as a novel gene mutated in multicase Diamond-Blackfan anemia families
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Erythropoietin therapy after allogeneic hematopoietic cell transplantation: a prospective, randomized trial
Clinical Trials & Observations
Aurélie Jaspers,Frédéric Baron,Évelyne Willems,Laurence Seidel,Kaoutar Hafraoui,Gaetan Vanstraelen,Christophe Bonnet,Yves Beguin
View Articletitled, Erythropoietin therapy after allogeneic hematopoietic cell transplantation: a prospective, randomized trial
Supplemental data
Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia
Clinical Trials & Observations
Rainer Claus,David M. Lucas,Amy S. Ruppert,Katie E. Williams,Daniel Weng,Kara Patterson,Manuela Zucknick,Christopher C. Oakes,Laura Z. Rassenti,Andrew W. Greaves,Susan Geyer,William G. Wierda,Jennifer R. Brown,John G. Gribben,Jacqueline C. Barrientos,Kanti R. Rai,Neil E. Kay,Thomas J. Kipps,Peter Shields,Weiqiang Zhao,Michael R. Grever,Christoph Plass,John C. Byrd
View Articletitled, Validation of <em>ZAP-70</em> methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia
Supplemental data
Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia
Clinical Trials & Observations
Natali Pflug,Jasmin Bahlo,Tait D. Shanafelt,Barbara F. Eichhorst,Manuela A. Bergmann,Thomas Elter,Kathrin Bauer,Gebhart Malchau,Kari G. Rabe,Stephan Stilgenbauer,Hartmut Döhner,Ulrich Jäger,Michael J. Eckart,Georg Hopfinger,Raymonde Busch,Anna-Maria Fink,Clemens-Martin Wendtner,Kirsten Fischer,Neil E. Kay,Michael Hallek
View Articletitled, Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia
Supplemental data
Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study
Clinical Trials & Observations
Sara Bringhen,Maria Teresa Petrucci,Alessandra Larocca,Concetta Conticello,Davide Rossi,Valeria Magarotto,Pellegrino Musto,Luana Boccadifuoco,Massimo Offidani,Paola Omedé,Fabiana Gentilini,Giovannino Ciccone,Giulia Benevolo,Mariella Genuardi,Vittorio Montefusco,Stefania Oliva,Tommaso Caravita,Paola Tacchetti,Mario Boccadoro,Pieter Sonneveld,Antonio Palumbo
View Articletitled, Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study
Supplemental data

HEMATOPOIESIS AND STEM CELLS

CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish
Erica Bresciani,Blake Carrington,Stephen Wincovitch,MaryPat Jones,Aniket V. Gore,Brant M. Weinstein,Raman Sood,P. Paul Liu
View Articletitled, CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish
Supplemental data
In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells
Brief Report
Narges M. Rashidi,Mark K. Scott,Nico Scherf,Axel Krinner,Jens S. Kalchschmidt,Kleoniki Gounaris,Murray E. Selkirk,Ingo Roeder,Cristina Lo Celso
View Articletitled, In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells
Supplemental data

LYMPHOID NEOPLASIA

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1
Marek Mraz,Liguang Chen,Laura Z. Rassenti,Emanuela M. Ghia,Hongying Li,Kristen Jepsen,Erin N. Smith,Karen Messer,Kelly A. Frazer,Thomas J. Kipps
View Articletitled, miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1
Supplemental data
Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology
Bella Patel,Aditi Dey,Anna Z. Castleton,Claire Schwab,Edward Samuel,Janani Sivakumaran,Brendan Beaton,Nahid Zareian,Christie Yu Zhang,Lena Rai,Tariq Enver,Anthony V. Moorman,Adele K. Fielding
View Articletitled, Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology
Supplemental data
Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia
Brief Report
Chen Shochat,Noa Tal,Vitalina Gryshkova,Yehudit Birger,Obul R. Bandapalli,Giovanni Cazzaniga,Nava Gershman,Andreas E. Kulozik,Andrea Biondi,Marc R. Mansour,Jean-Claude Twizere,Martina U. Muckenthaler,Nir Ben-Tal,Stefan N. Constantinescu,Dani Bercovich,Shai Izraeli
View Articletitled, Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection
Rosine Saleh,Ghaith Wedeh,Harald Herrmann,Siham Bibi,Sabine Cerny-Reiterer,Irina Sadovnik,Katharina Blatt,Emir Hadzijusufovic,Sylvie Jeanningros,Catherine Blanc,Magali Legarff-Tavernier,Elise Chapiro,Florence Nguyen-Khac,Frédéric Subra,Patrick Bonnemye,Patrice Dubreuil,Vanessa Desplat,Hélène Merle-Béral,Michael Willmann,Thomas Rülicke,Peter Valent,Michel Arock
View Articletitled, A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by <em>KIT</em> D816V transfection
Supplemental data
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
Daniel Sasca,Patricia S. Hähnel,Jakub Szybinski,Kaml Khawaja,Oliver Kriege,Saskia V. Pante,Lars Bullinger,Susanne Strand,Dennis Strand,Matthias Theobald,Thomas Kindler
View Articletitled, SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells
Kalliopi Makarona,Valentina S. Caputo,Joana R. Costa,Binbin Liu,David O’Connor,Deena Iskander,David Roper,Lynn Robertson,Neha Bhatnagar,Evangelos Terpos,Elisabeth Georgiou,Maria Papaioannou,D. Mark Layton,Lucio Luzzatto,Irene Roberts,Anastasios Karadimitris
View Articletitled, Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells
Supplemental data

THROMBOSIS AND HEMOSTASIS

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function
Yang Liu,Colin A. Kretz,Morgan L. Maeder,Catherine E. Richter,Philip Tsao,Andy H. Vo,Michael C. Huarng,Thomas Rode,Zhilian Hu,Rohit Mehra,Steven T. Olson,J. Keith Joung,Jordan A. Shavit
View Articletitled, Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function
Supplemental data

CORRESPONDENCE

Lysine-specific demethylase 1 (LSD1) in hematopoietic and lymphoid neoplasms
Dennis Niebel,Jutta Kirfel,Viktor Janzen,Tobias Höller,Michael Majores,Ines Gütgemann
View Articletitled, Lysine-specific demethylase 1 (LSD1) in hematopoietic and lymphoid neoplasms
Many BCR-ABL1 compound mutations reported in chronic myeloid leukemia patients may actually be artifacts due to PCR-mediated recombination
Wendy T. Parker,Stuart R. Phillis,David T. O. Yeung,Timothy P. Hughes,Hamish S. Scott,Susan Branford
View Articletitled, Many <em>BCR-ABL1</em> compound mutations reported in chronic myeloid leukemia patients may actually be artifacts due to PCR-mediated recombination
The effect of low-molecular-weight heparin in cancer patients: the mirror image of survival?
Sandro Barni,Erminio Bonizzoni,Melina Verso,Gualberto Gussoni,Fausto Petrelli,Tania Perrone,Giancarlo Agnelli
View Articletitled, The effect of low-molecular-weight heparin in cancer patients: the mirror image of survival?
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