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Issue Archive

Volume 122, Issue 11
September 12 2013
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Microbiomarkers with big impact in CLL
Thomas D. Schmittgen
View Articletitled, Microbiomarkers with big impact in CLL
PLATELETS & THROMBOPOIESIS
Better late than never?
Keith R. McCrae
View Articletitled, Better late than never?
RED CELLS, IRON, & ERYTHROPOIESIS
GLEE-ful for sickle cell pain?
Abdullah Kutlar
View Articletitled, GLEE-ful for sickle cell pain?
TRANSPLANTATION
Attack of the T-cell clones
Karl S. Peggs
View Articletitled, Attack of the T-cell clones
TRANSPLANTATION
From nuclear to a global family: more donors for MDS
Nicolaus Kröger
View Articletitled, From nuclear to a global family: more donors for MDS

BLOOD WORK

Killers on the road: Klebsiella and Pseudomonas bacteremia detected on peripheral blood smear
Irina Yoko Takihi,Alex Freire Sandes
View Articletitled, Killers on the road: <em>Klebsiella</em> and <em>Pseudomonas</em> bacteremia detected on peripheral blood smear
CNS involvement in DLBCL
Muhammad Kashif
View Articletitled, CNS involvement in DLBCL

PLENARY PAPER

Mast cell activation contributes to sickle cell pathobiology and pain in mice
Lucile Vincent,Derek Vang,Julia Nguyen,Mihir Gupta,Kathryn Luk,Marna E. Ericson,Donald A. Simone,Kalpna Gupta
View Articletitled, Mast cell activation contributes to sickle cell pathobiology and pain in mice
Supplemental data

REVIEW ARTICLE

The major histocompatibility complex: a model for understanding graft-versus-host disease
Effie W. Petersdorf
View Articletitled, The major histocompatibility complex: a model for understanding graft-versus-host disease

REVIEW SERIES

Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients
Julia E. Geddings,Nigel Mackman
View Articletitled, Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients

CLINICAL TRIALS AND OBSERVATIONS

Evaluation of WHO criteria for diagnosis of polycythemia vera: a prospective analysis
Clinical Trials & Observations
Richard T. Silver,William Chow,Attilio Orazi,Stephen P. Arles,Stanley J. Goldsmith
View Articletitled, Evaluation of WHO criteria for diagnosis of polycythemia vera: a prospective analysis

IMMUNOBIOLOGY

Altered natural killer cell subset homeostasis and defective chemotactic responses in paroxysmal nocturnal hemoglobinuria
Brief Report
Yasser M. El-Sherbiny,Richard J. Kelly,Anita Hill,Gina M. Doody,Peter Hillmen,Graham P. Cook
View Articletitled, Altered natural killer cell subset homeostasis and defective chemotactic responses in paroxysmal nocturnal hemoglobinuria
Supplemental data

LYMPHOID NEOPLASIA

Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia
Alessandra Ferrajoli,Tait D. Shanafelt,Cristina Ivan,Masayoshi Shimizu,Kari G. Rabe,Nazila Nouraee,Mariko Ikuo,Asish K. Ghosh,Susan Lerner,Laura Z. Rassenti,Lianchun Xiao,Jianhua Hu,James M. Reuben,Steliana Calin,M. James You,John T. Manning,William G. Wierda,Zeev Estrov,Susan O’Brien,Thomas J. Kipps,Michael J. Keating,Neil E. Kay,George A. Calin
View Articletitled, Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia
Supplemental data

MYELOID NEOPLASIA

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents
Cedric Dos Santos,Tinisha McDonald,Yin Wei Ho,Hongjun Liu,Allen Lin,Stephen J. Forman,Ya-Huei Kuo,Ravi Bhatia
View Articletitled, The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents
Supplemental data
MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction
Andrew G. Muntean,Wei Chen,Morgan Jones,Eric M. Granowicz,Ivan Maillard,Jay L. Hess
View Articletitled, MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction
Supplemental data
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies
Joshua J. Oaks,Ramasamy Santhanam,Christopher J. Walker,Steve Roof,Jason G. Harb,Greg Ferenchak,Ann-Kathrin Eisfeld,James R. Van Brocklyn,Roger Briesewitz,Sahar A. Saddoughi,Kyosuke Nagata,Robert Bittman,Michael A. Caligiuri,Omar Abdel-Wahab,Ross Levine,Ralph B. Arlinghaus,Alfonso Quintas-Cardama,John M. Goldman,Jane Apperley,Alistair Reid,Dragana Milojkovic,Mark T. Ziolo,Guido Marcucci,Besim Ogretmen,Paolo Neviani,Danilo Perrotti
View Articletitled, Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses
Heather B. Cohen,Katharine T. Briggs,John P. Marino,Katya Ravid,Simon C. Robson,David M. Mosser
View Articletitled, TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses
Supplemental data

PLATELETS AND THROMBOPOIESIS

The effect of rituximab on vaccine responses in patients with immune thrombocytopenia
Ishac Nazi,John G. Kelton,Mark Larché,Denis P. Snider,Nancy M. Heddle,Mark A. Crowther,Richard J. Cook,Alan T. Tinmouth,Joy Mangel,Donald M. Arnold
View Articletitled, The effect of rituximab on vaccine responses in patients with immune thrombocytopenia

THROMBOSIS AND HEMOSTASIS

Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia A
Corien L. Eckhardt,Alice S. van Velzen,Marjolein Peters,Jan Astermark,Paul P. Brons,Giancarlo Castaman,Marjon H. Cnossen,Natasja Dors,Carmen Escuriola-Ettingshausen,Karly Hamulyak,Daniel P. Hart,Charles R. M. Hay,Saturnino Haya,Waander L. van Heerde,Cedric Hermans,Margareta Holmström,Victor Jimenez-Yuste,Russell D. Keenan,Robert Klamroth,Britta A. P. Laros-van Gorkom,Frank W. G. Leebeek,Ri Liesner,Anne Mäkipernaa,Christoph Male,Evelien Mauser-Bunschoten,Maria G. Mazzucconi,Simon McRae,Karina Meijer,Michael Mitchell,Massimo Morfini,Marten Nijziel,Johannes Oldenburg,Kathelijne Peerlinck,Pia Petrini,Helena Platokouki,Sylvia E. Reitter-Pfoertner,Elena Santagostino,Piercarla Schinco,Frans J. Smiers,Berthold Siegmund,Annarita Tagliaferri,Thynn T. Yee,Pieter Willem Kamphuisen,Johanna G. van der Bom,Karin Fijnvandraat,for the INSIGHT Study Group
View Articletitled, Factor VIII gene (<em>F8</em>) mutation and risk of inhibitor development in nonsevere hemophilia A
Supplemental data

TRANSPLANTATION

HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion
Sanja Stevanović,Cornelis A. M. van Bergen,Simone A. P. van Luxemburg-Heijs,Boris van der Zouwen,Ekaterina S. Jordanova,Alwine B. Kruisselbrink,Marian van de Meent,Jessica C. Harskamp,Frans H. J. Claas,Erik W. A. Marijt,Jaap Jan Zwaginga,Constantijn J. M. Halkes,Inge Jedema,Marieke Griffioen,J. H. Frederik Falkenburg
View Articletitled, HLA class II upregulation during viral infection leads to HLA-DP–directed graft-versus-host disease after CD4+ donor lymphocyte infusion
Supplemental data
Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)
Wael Saber,Corey S. Cutler,Ryotaro Nakamura,Mei-Jie Zhang,Ehab Atallah,J. Douglas Rizzo,Richard T. Maziarz,Jorge Cortes,Matt E. Kalaycio,Mary M. Horowitz
View Articletitled, Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)
Supplemental data

CORRESPONDENCE

In vivo evidence insufficient to conclude that “KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission”
Carolyn E. Behrendt,John A. Zaia
View Articletitled, In vivo evidence insufficient to conclude that “KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission”
Response: KIR/HLA incompatibility in HIV-1 transmission and importance of the ‘missing self’ model
Wim Jennes,Sonja Verheyden,Julie W. Mertens,Makhtar Camara,Moussa Seydi,Tandakha N. Dieye,Souleymane Mboup,Christian Demanet,Luc Kestens
View Articletitled, Response: KIR/HLA incompatibility in HIV-1 transmission and importance of the ‘missing self’ model
Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens
Neus Masqué-Soler,Monika Szczepanowski,Christian W. Kohler,Rainer Spang,Wolfram Klapper
View Articletitled, Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens
Supplemental data
ANKRD26-related thrombocytopenia and myeloid malignancies
Patrizia Noris,Remi Favier,Marie-Christine Alessi,Amy E. Geddis,Shinji Kunishima,Paula G. Heller,Paola Giordano,Karen Y. Niederhoffer,James B. Bussel,Gian Marco Podda,Nicola Vianelli,Rogier Kersseboom,Alessandro Pecci,Chiara Gnan,Caterina Marconi,Anne Auvrignon,William Cohen,Jennifer C. Yu,Akihiro Iguchi,Allison Miller Imahiyerobo,Francoise Boehlen,Dorsaf Ghalloussi,Daniela De Rocco,Pamela Magini,Elisa Civaschi,Ginevra Biino,Marco Seri,Anna Savoia,Carlo L. Balduini
View Articletitled, <em>ANKRD26</em>-related thrombocytopenia and myeloid malignancies
Plasma hepcidin of Ethiopian highlanders with steady-state hypoxia
Erika L. Lundgrin,Allison J. Janocha,Carl D. Koch,Amha Gebremedhin,Anna Di Rienzo,Gorka Alkorta-Aranburu,Gary M. Brittenham,Serpil C. Erzurum,Cynthia M. Beall
View Articletitled, Plasma hepcidin of Ethiopian highlanders with steady-state hypoxia
Supplemental data
Fcγ receptor IIB gene polymorphism in adult Japanese patients with primary immune thrombocytopenia
Takashi Satoh,Koji Miyazaki,Asako Shimohira,Naoki Amano,Yuka Okazaki,Tetsuya Nishimoto,Tohru Akahoshi,Shinichi Munekata,Yuhsaku Kanoh,Yasuo Ikeda,Masaaki Higashihara,Shinichiro Takahashi,Masataka Kuwana
View Articletitled, <em>Fcγ receptor IIB</em> gene polymorphism in adult Japanese patients with primary immune thrombocytopenia
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Multicolor immunofluorescent staining for CD3 (clone PS1, IgG2a + IgG2a ALEXA 546) (red), CD8 (clone 4B11, IgG2b + IgGb ALEXA 647) (blue), and HLA class II (clone CR3/43, IgG1 + IgG1 ALEXA 488) (green) was performed on colonic biopsy from patient-2 obtained at the time of GVHD diagnosis after CD4+ DLI. Double CD3+CD8+ cells (purple) were defined as CD8+ T-cells, whereas CD3+CD8- expressing cells (red) were defined as CD4+ T-cells. Images were captured with a confocal laser scanning microscope (LSM510, Zeiss, Sliedrecht, The Netherlands) (×200 magnification) (supplemental Methods). See the article by Stevanović et al on page 1963.

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NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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