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Richard J. Kelly
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Journal Articles

Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition

Alexander Röth, Guangsheng He, Andres Brodsky, Chatree Chai-Adisaksopha, Narcisa Sonia Comia, Anna Gaya, Martin Höglund, Richard J. Kelly, Ahlam Naila Kori, Je-Hwan Lee, Naoshi Obara, Antonio M Risitano, Anita Appius, Leigh Beveridge, Brittany Gentile, Zilu Zhang, Bing Han, Sasha Sreckovic
Journal: Blood
Blood (2024) 144 (Supplement 1): 2687.
https://doi.org/10.1182/blood-2024-208072
Published: 2024
Journal Articles

Incremental Effectiveness of Iptacopan Compared with C5 Inhibitors in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria: Results from a Modelling Analysis

Shreyans Gandhi, Regis Peffault De Latour, Katharina Pannagl, Maria-Magdalena Balp, Anggie Wiyani, Cheryl Druchok, Paul Lebeau, Richard J. Kelly
Journal: Blood
Blood (2024) 144 (Supplement 1): 5012.
https://doi.org/10.1182/blood-2024-201424
Published: 2024
Journal Articles

A Single-Centre Experience of Methotrexate in the Management of Pure Red Cell Aplasia and Pure White Cell Aplasia

Laura Batey, Richard J. Kelly, Talha Munir, Petra Muus, Abraham Mullasseril Varghese, Louise M Arnold, Catherine Barnfield, Isla Storey, Nora Youngs, Jessica Molyneux, Morag Griffin
Journal: Blood
Blood (2024) 144 (Supplement 1): 5684.
https://doi.org/10.1182/blood-2024-203945
Published: 2024
Journal Articles

Monotherapy Treatment with Zaltenibart (OMS906), an Alternative Pathway Masp-3 Inhibitor, Improved Key Hematologic Parameters in Patients with PNH with a Suboptimal Response to Ravulizumab: Interim Results from a Phase 2 Proof-of-Concept Study

Morag Griffin, Richard J. Kelly, Mathilde Gavillet, Petra Muus, Britta Hoechsmann, W. Jason Cummings, John Efthimiou, William Pullman, Hubert Schrezenmeier, Jens Panse
Journal: Blood
Blood (2024) 144 (Supplement 1): 4072.
https://doi.org/10.1182/blood-2024-205866
Published: 2024
Journal Articles

Thrombosis and Encapsulated Bacterial Infection Rates in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Received Pegcetacoplan: Nearly 3 Years of Post-Marketing Experience

Gloria F. Gerber, Richard J. Kelly, Hisakazu Nishimori, Regina Horneff, Peter Hillmen, Uchendu O. Uchendu, Yiwei Zhang, Stacie Lallier, Jens Panse
Journal: Blood
Blood (2024) 144 (Supplement 1): 5698.
https://doi.org/10.1182/blood-2024-201443
Published: 2024
Journal Articles

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria

CME Clinical Trials & Observations
Richard J. Kelly, Matthew Holt, Jennifer Vidler, Louise M. Arnold, Joanna Large, Briony Forrest, Catherine Barnfield, Alexandra Pike, Morag Griffin, Talha Munir, Petra Muus, Sateesh K. Nagumantry, Abraham Varghese, John R. Davies, Roochi Trikha, Austin G. Kulasekararaj, Lindsay Mitchell, Shreyans Gandhi
Journal: Blood
Blood (2024) 143 (12): 1157–1166.
https://doi.org/10.1182/blood.2023021762
Published: 2024
Journal Articles

MRD Directed Treatment Intensification with Either FLAG-Ida or DA-Cladribine Improves Survival in Older AML Patients: Results from the NCRI AML18 Randomised Trial

Nigel H. Russell, Abin Thomas, Robert Hills, Ian Thomas, Amanda Gilkes, Nuria Almuina, Sarah Burns, Lucy Marsh, Georgia Andrew, Nicholas McCarthy, Jennifer Byrne, Rob Sellar, Richard J. Kelly, Paul Cahalin, Ulrik Malthe Overgaard, Priyanka Mehta, Mike Dennis, Steve Knapper, Sylvie D Freeman
Journal: Blood
Blood (2023) 142 (Supplement 1): 830.
https://doi.org/10.1182/blood-2023-185956
Published: 2023
Journal Articles

Paroxysmal Nocturnal Haemoglobinuria (PNH) Arising from Non-Canonical Mutations

Alexandra Pike, Stephen John Richards, Claire E McKinley, Louise M Arnold, Abraham Mullasseril Varghese, Talha Munir, Petra Muus, Peter Hillmen, Morag Griffin, Richard J Kelly, Darren Newton
Journal: Blood
Blood (2023) 142 (Supplement 1): 4097.
https://doi.org/10.1182/blood-2023-188755
Published: 2023
Journal Articles

Biomarker Analyses in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 Trial

Pontus Lundberg, Silvia de la Iglesia, Richard J Kelly, Austin Kulasekararaj, Jun-Ichi Nishimura, Antonio M Risitano, Alexander Roeth, Simon Buatois, Sammy Chebon, Himika Patel, Anna Kiialainen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4088.
https://doi.org/10.1182/blood-2023-178694
Published: 2023
Journal Articles

Efficacy and Safety Is Maintained in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Pegcetacoplan for up to 3 Years

Carlos M de Castro, Brian Mulherin, Christopher J. Patriquin, Veena Selvaratnam, Raymond SM Wong, Richard J. Kelly, Lisa Tan, Peter Hillmen, Dale Zhang, Jessica Savage, Regis Peffault De Latour
Journal: Blood
Blood (2023) 142 (Supplement 1): 574.
https://doi.org/10.1182/blood-2023-181054
Published: 2023
Journal Articles

Psychometric Evaluation of the PNH Symptom Questionnaire (PNH-SQ) Among Patients with Paroxysmal Nocturnal Hemoglobinuria from Three Phase 2 Clinical Trials with Pozelimab Monotherapy or in Combination with Cemdisiran

Chris Hartford, Paolo Eusebi, Richard J. Kelly, Thibaud Alin, Xinyu Yang, Antoine Regnault, Dimittri Delevry, Ching Lum, Diana Rofail
Journal: Blood
Blood (2023) 142 (Supplement 1): 3752.
https://doi.org/10.1182/blood-2023-181667
Published: 2023
Journal Articles

52-Week Open-Label Extension Data from a Phase 2 Study Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran Combination Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switched from Eculizumab

Richard J. Kelly, Nicola Houghton, Talha Munir, Petra Muus, Nora Youngs, Lisa Aurand, Kosalai Mohan, Brian Senk, Rodrigo Pavani, Lorah Perlee, Amal Souttou, Morag Griffin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2716.
https://doi.org/10.1182/blood-2023-188671
Published: 2023
Journal Articles

Sars-Cov-2 Antibody and T-Cell Responses in Patients with Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia after Four COVID-19 Vaccinations

Alexandra Pike, Natalie Fox, Claire E McKinley, Louise M Arnold, Mark Harland, Deborah Clarke, Briony Forrest, Nicola Houghton, Nora Youngs, Emily Charlton, Tapiwa Zhakata, Catherine Barnfield, Ruth Harvey, Mary Wu, Caitlin Kavanagh, Stephen John Richards, Daniel Payne, Abraham Mullasseril Varghese, Sateesh Nagumantry, Talha Munir, Petra Muus, Morag Griffin, Darren Newton, Peter Hillmen, Richard J Kelly
Journal: Blood
Blood (2023) 142 (Supplement 1): 2712.
https://doi.org/10.1182/blood-2023-190393
Published: 2023
Journal Articles

Monitoring Patient Reported Outcomes in PNH: Interim Results of a Market Research with florio ® PNH

Louise M Arnold, Holger Brondke, Katharina Steinitz, Richard J. Kelly
Journal: Blood
Blood (2023) 142 (Supplement 1): 7211.
https://doi.org/10.1182/blood-2023-185560
Published: 2023
Journal Articles

Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency

Yasser M. El-Sherbiny, Gina M. Doody, Richard J. Kelly, Anita Hill, Peter Hillmen, Graham P. Cook
Journal: Blood
Blood (2015) 125 (8): 1351–1352.
https://doi.org/10.1182/blood-2014-07-591255
Published: 2015
Includes: Supplemental data
Journal Articles

Eculizumab Treatment Improves Outcomes of Pregnancy in Patients with Paroxysmal Nocturnal Hemoglobinuria

Richard J Kelly, MBChB, PhD, Britta Höchsmann, MD, Austin Kulasekararaj, Sophie de Guibert, MD, Alexander Röth, MD, Ilene C Weitz, MD, Elina Armstrong, MD PhD, Anita Hill, MBChB, PhD, Antonio M. Risitano, MD PhD, Christopher J Patriquin, MDFRCPC, Louis Terriou, MD, Petra Muus, MD PhD, Michelle P Turner, MS in Biostatistics, Hubert Schrezenmeier, MD PhD, Jeffrey Szer, MB BS FRACP, Regis Peffault de Latour, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4393.
https://doi.org/10.1182/blood.V124.21.4393.4393
Published: 2014
Journal Articles

“Red Cell Complement Loading In PNH Patients On Eculizumab Is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts For Increased Extravascular Hemolysis and Provides a Rationale For C3 Inhibition.”

Praveen Kaudlay, MBBS, MRCP, Haiying Hua, MD, Guansheng He, MD, Darren J Newton, PhD, Abraham M Varghese, MB ChB, Talha Munir, MBBS, MRCP, FRCPath, Anita Hill, MBChB, PhD, Richard J Kelly, MBChB, Stephen John Richards, PhD, Peter Hillmen, MB ChB, PhD
Journal: Blood
Blood (2013) 122 (21): 2466.
https://doi.org/10.1182/blood.V122.21.2466.2466
Published: 2013
Journal Articles

Altered natural killer cell subset homeostasis and defective chemotactic responses in paroxysmal nocturnal hemoglobinuria

Brief Report
Yasser M. El-Sherbiny, Richard J. Kelly, Anita Hill, Gina M. Doody, Peter Hillmen, Graham P. Cook
Journal: Blood
Blood (2013) 122 (11): 1887–1890.
https://doi.org/10.1182/blood-2013-06-507574
Published: 2013
Includes: Supplemental data
Journal Articles

Thrombosis in paroxysmal nocturnal hemoglobinuria

CME
Anita Hill, Richard J. Kelly, Peter Hillmen
Journal: Blood
Blood (2013) 121 (25): 4985–4996.
https://doi.org/10.1182/blood-2012-09-311381
Published: 2013
Journal Articles

Eculizumab in Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report of All 153 Patients Treated in the UK

Anita Hill, MBChB, PhD, Richard J Kelly, MBChB, Austin G Kulasekararaj, MBBS, MD, Shreyans A Gandhi, MBBS, MD, Lindsay D Mitchell, MBChB, Modupe Elebute, MBChB, MD, Stephen John Richards, PhD, Matthew Cullen, MSc, Louise M Arnold, RN, BSc, Joanna Large, RN, BSc, Alexandra Wood, RN, BSc, Gemma L Brooksbank, RN, BSc, Tracy Downing, Claire McKinley, BSc, Dena Cohen, BSc, MSc, Walter M Gregory, PhD, Judith C. W. Marsh, MD, PhD, Ghulam J. Mufti, MD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2012) 120 (21): 3472.
https://doi.org/10.1182/blood.V120.21.3472.3472
Published: 2012