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Issue Archive

Volume 120, Issue 5
August 2 2012
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
Darwinian evolution and tiding clones in multiple myeloma
Nizar J. Bahlis
View Articletitled, Darwinian evolution and tiding clones in multiple myeloma
CLINICAL TRIALS
Iron out for nontransfused thalassemia
Peter W. Marks
View Articletitled, Iron out for nontransfused thalassemia
PLATELETS & THROMBOPOIESIS
HIT-antibodies promote their own antigen
Andreas Greinacher,Krystin Krauel,Inga Jensch
View Articletitled, HIT-antibodies promote their own antigen

Blood Work

Lymphoma-associated hemophagocytic lymphohistiocytosis
Omar S. Aljitawi,Jamie M. Boone
View Articletitled, Lymphoma-associated hemophagocytic lymphohistiocytosis

Perspectives

Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrum
Kirsten van Langevelde,Linda E. Flinterman,Astrid van Hylckama Vlieg,Frits R. Rosendaal,Suzanne C. Cannegieter
View Articletitled, Broadening the factor V Leiden paradox: pulmonary embolism and deep-vein thrombosis as 2 sides of the spectrum
Supplemental data

Review Article

Proteasome inhibitors in multiple myeloma: 10 years later
Philippe Moreau,Paul G. Richardson,Michele Cavo,Robert Z. Orlowski,Jesús F. San Miguel,Antonio Palumbo,Jean-Luc Harousseau
View Articletitled, Proteasome inhibitors in multiple myeloma: 10 years later

How I Treat

How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment
Waleed Ghanima,Bertrand Godeau,Douglas B. Cines,James B. Bussel
View Articletitled, How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment

Clinical Trials and Observations

Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study
Clinical Trials & Observations
Ali T. Taher,John Porter,Vip Viprakasit,Antonis Kattamis,Suporn Chuncharunee,Pranee Sutcharitchan,Noppadol Siritanaratkul,Renzo Galanello,Zeynep Karakas,Tomasz Lawniczek,Jacqueline Ros,Yiyun Zhang,Dany Habr,Maria Domenica Cappellini
View Articletitled, Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study
Supplemental data

Immunobiology

Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine
Suresh Pallikkuth,Anita Parmigiani,Sandra Y. Silva,Varghese K. George,Margaret Fischl,Rajendra Pahwa,Savita Pahwa
View Articletitled, Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine
Supplemental data
Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway
Siok-Keen Tey,Rajiv Khanna
View Articletitled, Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway
Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications
Veronica Marrella,Pietro L. Poliani,Elena Fontana,Anna Casati,Virginia Maina,Barbara Cassani,Francesca Ficara,Manuela Cominelli,Francesca Schena,Marianna Paulis,Elisabetta Traggiai,Paolo Vezzoni,Fabio Grassi,Anna Villa
View Articletitled, Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: therapeutic implications
Supplemental data
Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands
Won Ho Yang,Claudia Nussbaum,Prabhjit K. Grewal,Jamey D. Marth,Markus Sperandio
View Articletitled, Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands
Supplemental data

Lymphoid Neoplasia

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice
Crystina L. Kriss,Javier A. Pinilla-Ibarz,Adam W. Mailloux,John J. Powers,Chih-Hang Anthony Tang,Chang Won Kang,Nicola Zanesi,Pearlie K. Epling-Burnette,Eduardo M. Sotomayor,Carlo M. Croce,Juan R. Del Valle,Chih-Chi Andrew Hu
View Articletitled, Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice
Supplemental data
ASK1 promotes apoptosis of normal and malignant plasma cells
Fan-Ru Lin,Shang-Yi Huang,Kuo-Hsuan Hung,Shin-Tang Su,Cheng-Han Chung,Atsushi Matsuzawa,Michael Hsiao,Hidenori Ichijo,Kuo-I Lin
View Articletitled, ASK1 promotes apoptosis of normal and malignant plasma cells
Supplemental data
Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma
Sarah H. Beachy,Masahiro Onozawa,Yang Jo Chung,Chris Slape,Sven Bilke,Princy Francis,Marbin Pineda,Robert L. Walker,Paul Meltzer,Peter D. Aplan
View Articletitled, Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma
Supplemental data
Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides
Jan B. Egan,Chang-Xin Shi,Waibhav Tembe,Alexis Christoforides,Ahmet Kurdoglu,Shripad Sinari,Sumit Middha,Yan Asmann,Jessica Schmidt,Esteban Braggio,Jonathan J. Keats,Rafael Fonseca,P. Leif Bergsagel,David W. Craig,John D. Carpten,A. Keith Stewart
View Articletitled, Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides
Supplemental data
Clonal competition with alternating dominance in multiple myeloma
Jonathan J. Keats,Marta Chesi,Jan B. Egan,Victoria M. Garbitt,Stephen E. Palmer,Esteban Braggio,Scott Van Wier,Patrick R. Blackburn,Angela S. Baker,Angela Dispenzieri,Shaji Kumar,S. Vincent Rajkumar,John D. Carpten,Michael Barrett,Rafael Fonseca,A. Keith Stewart,P. Leif Bergsagel
View Articletitled, Clonal competition with alternating dominance in multiple myeloma
Supplemental data
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma
Brian A. Walker,Christopher P. Wardell,Lorenzo Melchor,Sanna Hulkki,Nicola E. Potter,David C. Johnson,Kerry Fenwick,Iwanka Kozarewa,David Gonzalez,Christopher J. Lord,Alan Ashworth,Faith E. Davies,Gareth J. Morgan
View Articletitled, Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma
Supplemental data
Clinical and prognostic role of annexin A2 in multiple myeloma
Anja Seckinger,Tobias Meiβner,Jérôme Moreaux,Daniela Depeweg,Jens Hillengass,Katja Hose,Thierry Rème,Angela Rösen-Wolff,Anna Jauch,Reinhard Schnettler,Volker Ewerbeck,Hartmut Goldschmidt,Bernard Klein,Dirk Hose
View Articletitled, Clinical and prognostic role of annexin A2 in multiple myeloma
Supplemental data
Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4
Xiangao Huang,Maurizio Di Liberto,David Jayabalan,Jun Liang,Scott Ely,Jamieson Bretz,Arthur L. Shaffer, III,Tracey Louie,Isan Chen,Sophia Randolph,William C. Hahn,Louis M. Staudt,Ruben Niesvizky,Malcolm A. S. Moore,Selina Chen-Kiang
View Articletitled, Prolonged early G<sub>1</sub> arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4
Supplemental data

Myeloid Neoplasia

Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004
Clinical Trials & Observations
Henrik Hasle,Jonas Abrahamsson,Erik Forestier,Shau-Yin Ha,Jesper Heldrup,Kirsi Jahnukainen,Ólafur Gísli Jónsson,Birgitte Lausen,Josefine Palle,Bernward Zeller,on behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO)
View Articletitled, Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004
Supplemental data
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
Satomi Tanaka,Satoru Miyagi,Goro Sashida,Tetsuhiro Chiba,Jin Yuan,Makiko Mochizuki-Kashio,Yutaka Suzuki,Sumio Sugano,Chiaki Nakaseko,Koutaro Yokote,Haruhiko Koseki,Atsushi Iwama
View Articletitled, Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
Supplemental data
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells
Yue Zhang,Xiaomei Yan,Goro Sashida,Xinghui Zhao,Yalan Rao,Susumu Goyama,Susan P. Whitman,Nicholas Zorko,Kelsie Bernot,Rajeana M. Conway,David Witte,Qian-fei Wang,Daniel G. Tenen,Zhijian Xiao,Guido Marcucci,James C. Mulloy,H. Leighton Grimes,Michael A. Caligiuri,Gang Huang
View Articletitled, Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells
Supplemental data
Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias
Nicholas A. Zorko,Kelsie M. Bernot,Susan P. Whitman,Ronald F. Siebenaler,Elshafa H. Ahmed,Gabriele G. Marcucci,Daniel A. Yanes,Kathleen K. McConnell,Charlene Mao,Chidimma Kalu,Xiaoli Zhang,David Jarjoura,Adrienne M. Dorrance,Nyla A. Heerema,Benjamin H. Lee,Gang Huang,Guido Marcucci,Michael A. Caligiuri
View Articletitled, <em>Mll</em> partial tandem duplication and <em>Flt3</em> internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Platelets and Thrombopoiesis

Dynamic antibody-binding properties in the pathogenesis of HIT
Bruce S. Sachais,Rustem I. Litvinov,Serge V. Yarovoi,Lubica Rauova,Jillian L. Hinds,Ann H. Rux,Gowthami M. Arepally,Mortimer Poncz,Adam Cuker,John W. Weisel,Douglas B. Cines
View Articletitled, Dynamic antibody-binding properties in the pathogenesis of HIT
Supplemental data

Thrombosis and Hemostasis

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1–dependent manner
Jing Huang,Sandra L. Haberichter,J. Evan Sadler
View Articletitled, The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1–dependent manner
All Issues

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