Page 1 | Search Results | Blood | American Society of Hematology

1-12 of 12

Sort by

Sort Order Select

Journal Articles

ALX148 Is a High Affinity Sirpα Fusion Protein That Blocks CD47, Enhances the Activity of Anti-Cancer Antibodies and Checkpoint Inhibitors, and Has a Favorable Safety Profile in Preclinical Models

Steven E Kauder, PhD, Tracy C Kuo, PhD, Amy Chen, Ons Harrabi, Sony S Rocha, Laura Doyle, Sangeetha Bollini, Bora Han, PhD, Emma Ruth B Sangalang, Janet Sim, PhD, Sophia Randolph, MDPhD, Jaume Pons, PhD, Hong I Wan, PhD

Blood (2017) 130 (Supplement 1): 112.

https://doi.org/10.1182/blood.V130.Suppl_1.112.112

Published: 2017

Journal Articles

Synergistic Loss of IRF4 and Induction of IRF7 Sensitizes Primary Myeloma Cells to IMiD Killing by IFNβ in Prolonged Early G1 Arrest Induced by CDK4/CDK6 Inhibition

Xiangao Huang, PhD, David Jayabalan, B.S.M.S, Maurizio Di Liberto, Ph.D., Jackson D Harvey, B.S., Anna C. Schinzel, PhD, Tomer M Mark, MD, MSc, Mohamad Hussein, MD, Sophia Randolph, MD, PhD, William C. Hahn, MD, PhD, Ruben Niesvizky, MD, Selina Chen-Kiang, PhD

Blood (2012) 120 (21): 572.

https://doi.org/10.1182/blood.V120.21.572.572

Published: 2012

Journal Articles

Prolonged early G 1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4

Xiangao Huang, Maurizio Di Liberto, David Jayabalan, Jun Liang, Scott Ely, Jamieson Bretz, Arthur L. Shaffer, III, Tracey Louie, Isan Chen, Sophia Randolph, William C. Hahn, Louis M. Staudt, Ruben Niesvizky, Malcolm A. S. Moore, Selina Chen-Kiang

Blood (2012) 120 (5): 1095–1106.

https://doi.org/10.1182/blood-2012-03-415984

Published: 2012

Includes: Supplemental data

Journal Articles

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

Blood (2012) 119 (20): 4597–4607.

https://doi.org/10.1182/blood-2011-10-388298

Published: 2012

Includes: Supplemental data

Journal Articles

Preliminary Results of a Phase 2 Study of PD 0332991 in Combination with Bortezomib and Dexamethasone in Patients with Relapsed and Refractory Multiple Myeloma

Ruben Niesvizky, MD, Luciano J Costa, MD, PhD, Nisreen A. Haideri, MD, Georg Hess, Seema Singhal, MD, Ivan Spicka, MD, PhD, Edward A. Stadtmauer, MD, Ashraf Z. Badros, MD, Marc S Raab, John L Jakubczak, PhD, Sindy T. Kim, BS, Sophia Randolph, MD, PhD, Scott A Ely, M.D., Selina Chen-Kiang, PhD

Blood (2011) 118 (21): 2940.

https://doi.org/10.1182/blood.V118.21.2940.2940

Published: 2011

Journal Articles

A Phase I Study of PD 0332991: Complete CDK4/6 Inhibition and Tumor Response In Sequential Combination with Bortezomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma

Ruben Niesvizky, MD, Suzanne Lentzsch, MD, PhD, Ashraf Z. Badros, MD, Asher A. Chanan-Khan, MD, Seema B. Singhal, MD, Jeffrey A. Zonder, MD, Ravi Vij, MBBS, MD, Xiangao Huang, PhD, Maurizio DiLiberto, PhD, Rachel Courtney, PhD, M. Naveed Shaik, PhD, Sindy T. Kim, BS, Sophia Randolph, MD, PhD, Scott A Ely, MD, MPH, Selina Chen-Kiang, PhD

Blood (2010) 116 (21): 860.

https://doi.org/10.1182/blood.V116.21.860.860

Published: 2010

Journal Articles

Lenalidomide Targets Myeloma Cells Preferentially During Prolonged Early G1 Arrest but Not Synchronization Into S Phase by Selective and Reversible Inhibition of CDK4/CDK6 through Loss of IRF-4

Xiangao Huang, Ph.D., Maurizio Di Liberto, Ph.D., David Jayabalan, B.S.M.S, Mohamad Hussein, M.D., Sophia Randolph, M.D., Ph.D., Ruben Niesvizky, M.D., Selina Chen-Kiang, Ph.D.

Blood (2010) 116 (21): 449.

https://doi.org/10.1182/blood.V116.21.449.449

Published: 2010

Journal Articles

Induction of Metabolic Impairment In Prolonged Early G1 Arrest Induced by CDK4/CDK6 Inhibition Sensitizes Myeloma Cells for Proteasome Inhibitor Killing During Subsequent S Phase Synchronization

Maurizio Di Liberto, Ph.D., Xiangao Huang, Ph.D., Jamieson Bretz, Ph.D., Scott A Ely, M.D., Rediet Zewdu, B.S., David Jayabalan, B.S.M.S, Suzhen Chen, B.S., Christopher J Kirk, Ph.D., Sophia Randolph, M.D., Ph.D., Ruben Niesvizky, M.D., Ph.D., Selina Chen-Kiang, Ph.D.

Blood (2010) 116 (21): 2989.

https://doi.org/10.1182/blood.V116.21.2989.2989

Published: 2010

Journal Articles

Identification of Informative Gene Expression Signatures Indicative of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Exposure and Clinical Efficacy in Patients with Advanced Cutaneous T-Cell Lymphoma.

Andrey Loboda, PhD, Valeria Fantin, PhD, Sophia Randolph, MD, PhD, Justin L. Ricker, MD, PhD, James S. Hardwick, PhD, Victoria M. Richon, PhD, Stanley R. Frankel, MD

Blood (2006) 108 (11): 4686.

https://doi.org/10.1182/blood.V108.11.4686.4686

Published: 2006

Journal Articles

High Expression and Persistent Activation of STAT1, 3 and 5 Predicts Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Resistance in Cutaneous T-Cell Lymphoma Cells.

Valeria R. Fantin, PhD, Andrey Loboda, PhD, Jennifer A. Roth, Cloud Paweletz, PhD, Sophia Randolph, MD, PhD, Jacqueline W. Pierce, PhD, Elizabeth A. Harrington, PhD, Ronald C. Hendrickson, PhD, John F. Reilly, PhD, Christopher Ware, Marshall E. Kadin, MD, Madeleine Duvic, MD, Stanley R. Frankel, MD, Victoria M. Richon, PhD

Blood (2006) 108 (11): 4679.

https://doi.org/10.1182/blood.V108.11.4679.4679

Published: 2006

Journal Articles

Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Provides Prolonged Clinical Benefit to Advanced Cutaneous T-Cell Lymphoma Patients: Updated Results of the Phase IIb Multicenter Clinical Trial.

Madeleine Duvic, MD, Youn H. Kim, MD, Timothy M. Kuzel, MD, Theresa R. Pacheco, MD, Francine M. Foss, MD, Sareeta Parker, MD, Stanley R. Frankel, MD, Cong Chen, PhD, Justin L. Ricker, MD, PhD, Jean Marie Arduino, PhD, Sophia Randolph, MD, PhD, Victoria M. Richon, PhD, Elise A. Olsen, MD

Blood (2006) 108 (11): 399.

https://doi.org/10.1182/blood.V108.11.399.399

Published: 2006

Journal Articles

Clinical Responses to Oral Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Are Associated with Specific Gene Expression Signatures in Patients with Advanced Leukemias: Results of a Phase I Trial.

Andrey Loboda, PhD, Valeria R. Fantin, PhD, Carlos E. Bueso-Ramos, MD, PhD, Sophia Randolph, MD, PhD, James S. Hardwick, PhD, Justin L. Ricker, MD, PhD, Victoria M. Richon, PhD, Jean-Pierre Issa, MD, Hagop M. Kantarjian, MD, Stanley R. Frankel, MD, Guillermo Garcia-Manero, MD

Blood (2006) 108 (11): 2320.

https://doi.org/10.1182/blood.V108.11.2320.2320

Published: 2006

NARROW

ALX148 Is a High Affinity Sirpα Fusion Protein That Blocks CD47, Enhances the Activity of Anti-Cancer Antibodies and Checkpoint Inhibitors, and Has a Favorable Safety Profile in Preclinical Models

Synergistic Loss of IRF4 and Induction of IRF7 Sensitizes Primary Myeloma Cells to IMiD Killing by IFNβ in Prolonged Early G1 Arrest Induced by CDK4/CDK6 Inhibition

Prolonged early G 1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

Preliminary Results of a Phase 2 Study of PD 0332991 in Combination with Bortezomib and Dexamethasone in Patients with Relapsed and Refractory Multiple Myeloma

A Phase I Study of PD 0332991: Complete CDK4/6 Inhibition and Tumor Response In Sequential Combination with Bortezomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma

Lenalidomide Targets Myeloma Cells Preferentially During Prolonged Early G1 Arrest but Not Synchronization Into S Phase by Selective and Reversible Inhibition of CDK4/CDK6 through Loss of IRF-4

Induction of Metabolic Impairment In Prolonged Early G1 Arrest Induced by CDK4/CDK6 Inhibition Sensitizes Myeloma Cells for Proteasome Inhibitor Killing During Subsequent S Phase Synchronization

Identification of Informative Gene Expression Signatures Indicative of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Exposure and Clinical Efficacy in Patients with Advanced Cutaneous T-Cell Lymphoma.

High Expression and Persistent Activation of STAT1, 3 and 5 Predicts Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Resistance in Cutaneous T-Cell Lymphoma Cells.

Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Provides Prolonged Clinical Benefit to Advanced Cutaneous T-Cell Lymphoma Patients: Updated Results of the Phase IIb Multicenter Clinical Trial.

Clinical Responses to Oral Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Are Associated with Specific Gene Expression Signatures in Patients with Advanced Leukemias: Results of a Phase I Trial.

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only