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Journal Articles

RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development

Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Xinghui Zhao, PhD, Aili Chen, PhD, Yue Zhang, MD, Fuhong He, Yunzhu Dong, Yalan Rao, PhD, Bo Li, Rajeana Conway, Alba Maiques-Díaz, Nuomin Huang, Shannon E Elf, Johannes Zuber, MD, Zhijian Xiao, MD, William Tse, Daniel G. Tenen, MD, Qianfei Wang, Wei Chen, James C. Mulloy, PhD, Stephen D Nimer, MD, Gang Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 2187.
https://doi.org/10.1182/blood.V124.21.2187.2187
Published: 2014
Journal Articles

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Xinghui Zhao, Aili Chen, Xiaomei Yan, Yue Zhang, Fuhong He, Yoshihiro Hayashi, Yunzhu Dong, Yalan Rao, Bo Li, Rajeana M. Conway, Alba Maiques-Diaz, Shannon E. Elf, Nuomin Huang, Johannes Zuber, Zhijian Xiao, William Tse, Daniel G. Tenen, Qianfei Wang, Wei Chen, James C. Mulloy, Stephen D. Nimer, Gang Huang
Journal: Blood
Blood (2014) 123 (11): 1729–1738.
https://doi.org/10.1182/blood-2013-03-489575
Published: 2014
Includes: Supplemental data
Journal Articles

Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells

Yue Zhang, MD, Xiaomei Yan, Goro Sashida, MD, Xinghui Zhao, PhD, Yalan Rao, PhD, Susumu Goyama, MD, PhD, Susan Whitman, PhD, Nicholas Zorko, Kelsie M. Bernot, PhD, Rajeana M. Conway, David Witte, Qianfei Wang, Daniel G Tenen, MD, Zhijian Xiao, MD, Guido Marcucci, MD, James C. Mulloy, PhD, H. Leighton Grimes, PhD, Michael A. Caligiuri, M.D., Gang Huang
Journal: Blood
Blood (2012) 120 (21): 3501.
https://doi.org/10.1182/blood.V120.21.3501.3501
Published: 2012
Journal Articles

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan P. Whitman, Nicholas Zorko, Kelsie Bernot, Rajeana M. Conway, David Witte, Qian-fei Wang, Daniel G. Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, H. Leighton Grimes, Michael A. Caligiuri, Gang Huang
Journal: Blood
Blood (2012) 120 (5): 1118–1129.
https://doi.org/10.1182/blood-2012-02-412379
Published: 2012
Includes: Supplemental data
Journal Articles

MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion

Yue Zhang, Xiaomei Yan, Goro Sashida, MD, Xinghui Zhao, Yalan Rao, PhD, Susumu Goyama, MD, PhD, Susan P. Whitman, PhD, Nicholas Zorko, Kelsie M. Bernot, PhD, David Witte, MD, Qian-fei Wang, MD, Daniel G. Tenen, Zhijian Xiao, MD, Guido Marcucci, MD, James C. Mulloy, PhD, Michael A Caligiuri, MD, Gang Huang
Journal: Blood
Blood (2011) 118 (21): 2801.
https://doi.org/10.1182/blood.V118.21.2801.2801
Published: 2011
Journal Articles

Pro-Survival Role of RUNX1 in Acute Myeloid Leukemia with Common Fusion Proteins

Susumu Goyama, MD, PhD, Janet Schibler, Yalan Rao, PhD, Mark Wunderlich, MS, Kevin A. Link, PhD, Gang Huang, James C. Mulloy, PhD
Journal: Blood
Blood (2011) 118 (21): 870.
https://doi.org/10.1182/blood.V118.21.870.870
Published: 2011
Journal Articles

Differential MLL Interaction and H3K4me3 Mark Maintenance at PU.1 Regulatory Region by AML Translocations-Associated Oncoproteins AML1-ETO and CBFβ-SMMHC.

Gang Huang, Xiaomei Yan, Xinghui Zhao, Yalan Rao, Goro Sashida, Rajeana Bowie
Journal: Blood
Blood (2009) 114 (22): 674.
https://doi.org/10.1182/blood.V114.22.674.674
Published: 2009