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David Witte
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Journal Articles

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Swarnava Roy, PhD, Parul Rai, MD, Marthe-Sandrine Eiymo Mwa Mpollo, PhD, Kyung-Hee Chang, PhD, Tilat Rizvi, Loberg Anastacia, Bruce J. Aronow, PhD, Tadashi Inagami, PhD, David Witte, MD, Jose A Cancelas, MD PhD, Punam Malik, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 440.
https://doi.org/10.1182/blood.V130.Suppl_1.440.440
Published: 2017
Journal Articles

Increased Oxidative Stress In Sickle Cell Disease Activates The Renin-Angiotensin-TGF-β Pathway To Mediate Sickle Nephropathy

Swarnava Roy, PhD, Diamantis G. Konstantinidis, PhD, Tilat Rizvi, PhD, Kyung-Hee Chang, PhD, Nambirajan Sundaram, Michael Wourms, M.Sc., Loberg Anastacia, Lanxi Song, Katie Burke, Tadashi Inagami, PhD, Nancy Ratner, PhD, David Witte, MD, Theodosia A. Kalfa, M.D., Ph.D., Jose A Cancelas, MD, PhD, Shiva Kumar Shanmukhappa, PhD, Punam Malik, MD
Journal: Blood
Blood (2013) 122 (21): 2211.
https://doi.org/10.1182/blood.V122.21.2211.2211
Published: 2013
Journal Articles

Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels

Paritha Arumugam, PhD, Eric S. Mullins, MD, Maureen A Shaw, MS, Kumar Shanmukhappa, BVSc., PhD, Anastacia Loberg, Tilat Rizvi, PhD, Janaka Wansapura, PhD, David Witte, MD, Punam Malik, MD, Jay L. Degen, PhD
Journal: Blood
Blood (2013) 122 (21): 729.
https://doi.org/10.1182/blood.V122.21.729.729
Published: 2013
Journal Articles

Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells

Yue Zhang, MD, Xiaomei Yan, Goro Sashida, MD, Xinghui Zhao, PhD, Yalan Rao, PhD, Susumu Goyama, MD, PhD, Susan Whitman, PhD, Nicholas Zorko, Kelsie M. Bernot, PhD, Rajeana M. Conway, David Witte, Qianfei Wang, Daniel G Tenen, MD, Zhijian Xiao, MD, Guido Marcucci, MD, James C. Mulloy, PhD, H. Leighton Grimes, PhD, Michael A. Caligiuri, M.D., Gang Huang
Journal: Blood
Blood (2012) 120 (21): 3501.
https://doi.org/10.1182/blood.V120.21.3501.3501
Published: 2012
Journal Articles

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

Yue Zhang, Xiaomei Yan, Goro Sashida, Xinghui Zhao, Yalan Rao, Susumu Goyama, Susan P. Whitman, Nicholas Zorko, Kelsie Bernot, Rajeana M. Conway, David Witte, Qian-fei Wang, Daniel G. Tenen, Zhijian Xiao, Guido Marcucci, James C. Mulloy, H. Leighton Grimes, Michael A. Caligiuri, Gang Huang
Journal: Blood
Blood (2012) 120 (5): 1118–1129.
https://doi.org/10.1182/blood-2012-02-412379
Published: 2012
Includes: Supplemental data
Journal Articles

MLL-PTD Causes Hypomorph Condition of CBF Complex (RUNX1/CBFβ) and Predisposes the Abnormal Hematopoietic Stem and Progenitor Cells (HSPCs) to Clonal Expansion

Yue Zhang, Xiaomei Yan, Goro Sashida, MD, Xinghui Zhao, Yalan Rao, PhD, Susumu Goyama, MD, PhD, Susan P. Whitman, PhD, Nicholas Zorko, Kelsie M. Bernot, PhD, David Witte, MD, Qian-fei Wang, MD, Daniel G. Tenen, Zhijian Xiao, MD, Guido Marcucci, MD, James C. Mulloy, PhD, Michael A Caligiuri, MD, Gang Huang
Journal: Blood
Blood (2011) 118 (21): 2801.
https://doi.org/10.1182/blood.V118.21.2801.2801
Published: 2011
Journal Articles

Fibrinogen Supports Colitis-Associated Adenoma Progression through a Mechanism Coupled to Engagement of the Leukocyte Integrin α M β 2 .

Netanel Horowitz, MD, Kris A. Steinbrecher, Ph.D, Maureen A. Shaw, Kelley A. Barney, Matthew Flick, PhD, Eleana Harmel-Laws, David Witte, M.D., Elizabeth A. Blevins, Joseph S. Palumbo, MD
Journal: Blood
Blood (2009) 114 (22): 334.
https://doi.org/10.1182/blood.V114.22.334.334
Published: 2009
Journal Articles

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

Ajay Perumbeti, Tomoyasu Higashimoto, Fabrizia Urbinati, Robert Franco, Herbert J. Meiselman, David Witte, Punam Malik
Journal: Blood
Blood (2009) 114 (6): 1174–1185.
https://doi.org/10.1182/blood-2009-01-201863
Published: 2009
Includes: Supplemental data
Journal Articles

Correction of Sickle Cell Anemia with γ-Globin Gene Delivered by Lentivirus Vector in the Setting of Myeloablative or Reduced Intensity Conditioning, and Establishing Critical Determinants for Successful Gene Therapy for Sickle Cell Disease.

Ajay Perumbeti, M.D., Tomoyasu Higashimoto, Phd., Fabrizia Urbinati, Phd., Kristy Lauderback, B.S., Anastacia Loberg, B.S., Gabriel Estevez-Pagani, Herbert Meiselman, M.D., Robert Franco, Phd., David Witte, M.D., Clinton H. Joiner, MD, PhD, Punam Malik
Journal: Blood
Blood (2008) 112 (11): 2354.
https://doi.org/10.1182/blood.V112.11.2354.2354
Published: 2008
Journal Articles

Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells

Gabriel Ghiaur, Michael J. Ferkowicz, Michael D. Milsom, Jeff Bailey, David Witte, Jose A. Cancelas, Mervin C. Yoder, David A. Williams
Journal: Blood
Blood (2008) 111 (7): 3313–3321.
https://doi.org/10.1182/blood-2007-08-110114
Published: 2008
Includes: Supplemental data