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Tomoyasu Higashimoto
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Journal Articles

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension

Free
Brief Report
Nambirajan Sundaram, Anitaben Tailor, Laurel Mendelsohn, Janaka Wansapura, Xunde Wang, Tomoyasu Higashimoto, Michael W. Pauciulo, William Gottliebson, Vijay K. Kalra, William C. Nichols, Gregory J. Kato, Punam Malik
Journal: Blood
Blood (2010) 116 (1): 109–112.
https://doi.org/10.1182/blood-2009-09-244830
Published: 2010
Includes: Supplemental data
Journal Articles

A Novel Combination of Chicken Hypersensitive Site-4 Insulator Elements Improves Titers and Restores Full Insulator Activity.

Free
Paritha Arumugam, Fabrizia Urbinati, Phd., Chinavenmeni S. Velu, PhD, Tomoyasu Higashimoto, Phd., H. Leighton Grimes, PhD, Punam Malik
Journal: Blood
Blood (2009) 114 (22): 3566.
https://doi.org/10.1182/blood.V114.22.3566.3566
Published: 2009
Journal Articles

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

Free
Ajay Perumbeti, Tomoyasu Higashimoto, Fabrizia Urbinati, Robert Franco, Herbert J. Meiselman, David Witte, Punam Malik
Journal: Blood
Blood (2009) 114 (6): 1174–1185.
https://doi.org/10.1182/blood-2009-01-201863
Published: 2009
Includes: Supplemental data
Journal Articles

Correction of Sickle Cell Anemia with γ-Globin Gene Delivered by Lentivirus Vector in the Setting of Myeloablative or Reduced Intensity Conditioning, and Establishing Critical Determinants for Successful Gene Therapy for Sickle Cell Disease.

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Ajay Perumbeti, M.D., Tomoyasu Higashimoto, Phd., Fabrizia Urbinati, Phd., Kristy Lauderback, B.S., Anastacia Loberg, B.S., Gabriel Estevez-Pagani, Herbert Meiselman, M.D., Robert Franco, Phd., David Witte, M.D., Clinton H. Joiner, MD, PhD, Punam Malik
Journal: Blood
Blood (2008) 112 (11): 2354.
https://doi.org/10.1182/blood.V112.11.2354.2354
Published: 2008
Journal Articles

Mechanism of Reduction in Titers from Lentivirus Vectors Carrying Chromatin Insulator Elements in the 3′ LTR

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Fabrizia Urbinati, Paritha Arumugam, Tomoyasu Higashimoto, Anil Perumbeti, Ping Xia, Punam Malik
Journal: Blood
Blood (2008) 112 (11): 2359.
https://doi.org/10.1182/blood.V112.11.2359.2359
Published: 2008
Journal Articles

Pulmozyme® Treatment of Vectors Produced by Transient Transfection Reduces Residual Plasmid DNA on Human CD34 + Hematopoietic Progenitor Cells without Loss of Transduction or Engraftment Efficiency

Free
Elke Grassman, Ph.D., Tomoyasu Higashimoto, Ph.D., Justin Rohrbach, Danielle Hall, David A Williams, Lilith Reeves, Punam Malik
Journal: Blood
Blood (2008) 112 (11): 4626.
https://doi.org/10.1182/blood.V112.11.4626.4626
Published: 2008
Journal Articles

Mechanism of Reduction in Titers with Vectors Flanked by Chromatin Insulator Elements

Free
Fabrizia Urbinati, PhD, Paritha Arumugam, Ph.D, Tomoyasu Higashimoto, Ph.D, Ping Xia, M.D, Punam Malik, M.D.
Journal: Blood
Blood (2007) 110 (11): 3734.
https://doi.org/10.1182/blood.V110.11.3734.3734
Published: 2007