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Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome
Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease
Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with “normal” FISH: correlations with clinicobiologic parameters
Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome
High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations
Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study
Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity
Issue Archive
March 8 2012
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Review Article
Evidence-Based Focused Review
How I Treat
Clinical Trials and Observations
Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome
Clinical Trials & Observations
Fiorina Giona,Luciana Teofili,Maria Luisa Moleti,Maurizio Martini,Giovanna Palumbo,Angela Amendola,Maria Gabriella Mazzucconi,Anna Maria Testi,Patrizia Pignoloni,Sonia Maria Orlando,Sara Capodimonti,Mauro Nanni,Giuseppe Leone,Luigi Maria Larocca,Robin Foà
Hematopoiesis and Stem Cells
Immunobiology
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells
Hiroaki Niiro,Siamak Jabbarzadeh-Tabrizi,Yoshikane Kikushige,Takahiro Shima,Kumiko Noda,Shun-ichiro Ota,Hirofumi Tsuzuki,Yasushi Inoue,Yojiro Arinobu,Hiromi Iwasaki,Shinji Shimoda,Eishi Baba,Hiroshi Tsukamoto,Takahiko Horiuchi,Tadayoshi Taniyama,Koichi Akashi
Lymphoid Neoplasia
Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease
Clinical Trials & Observations
Laurence Gérard,Jean-Marie Michot,Sara Burcheri,Claire Fieschi,Pacale Longuet,Véronique Delcey,Véronique Meignin,Felix Agbalika,Sylvie Chevret,Eric Oksenhendler,Lionel Galicier
Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with “normal” FISH: correlations with clinicobiologic parameters
Brief Report
Gian Matteo Rigolin,Francesca Cibien,Sara Martinelli,Luca Formigaro,Lara Rizzotto,Elisa Tammiso,Elena Saccenti,Antonella Bardi,Francesco Cavazzini,Maria Ciccone,Ilaria Nichele,Giovanni Pizzolo,Francesco Zaja,Renato Fanin,Piero Galieni,Alessia Dalsass,Francesca Mestichelli,Nicoletta Testa,Massimo Negrini,Antonio Cuneo
Myeloid Neoplasia
Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome
Brief Report
Tiziano Barbui,Jürgen Thiele,Francesco Passamonti,Elisa Rumi,Emanuela Boveri,Maria Luigia Randi,Irene Bertozzi,Filippo Marino,Alessandro M. Vannucchi,Lisa Pieri,Giada Rotunno,Heinz Gisslinger,Bettina Gisslinger,Leonhard Müllauer,Guido Finazzi,Alessandra Carobbio,Andrea Gianatti,Marco Ruggeri,Ilaria Nichele,Emanuele D'Amore,Alessandro Rambaldi,Ayalew Tefferi
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML
Zejuan Li,Hao Huang,Yuanyuan Li,Xi Jiang,Ping Chen,Stephen Arnovitz,Michael D. Radmacher,Kati Maharry,Abdel Elkahloun,Xinan Yang,Chunjiang He,Miao He,Zhiyu Zhang,Konstanze Dohner,Mary Beth Neilly,Colles Price,Yves A. Lussier,Yanming Zhang,Richard A. Larson,Michelle M. Le Beau,Michael A. Caligiuri,Lars Bullinger,Peter J. M. Valk,Ruud Delwel,Bob Lowenberg,Paul P. Liu,Guido Marcucci,Clara D. Bloomfield,Janet D. Rowley,Jianjun Chen
Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells
Giovanni Reddiconto,Claudia Toto,Ilaria Palamà,Simone De Leo,Emanuela de Luca,Serena De Matteis,Luciana Dini,Carlo Gambacorti Passerini,Nicola Di Renzo,Michele Maffia,Addolorata Maria Luce Coluccia
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene
Shuchi Agrawal-Singh,Fabienne Isken,Konstantin Agelopoulos,Hans-Ulrich Klein,Nils H. Thoennissen,Gabriele Koehler,Antje Hascher,Nicole Bäumer,Wolfgang E. Berdel,Christian Thiede,Gerhard Ehninger,Anke Becker,Peter Schlenke,Yipeng Wang,Michael McClelland,Utz Krug,Steffen Koschmieder,Thomas Büchner,Dae-Yeul Yu,Shailendra Vikram Singh,Klaus Hansen,Hubert Serve,Martin Dugas,Carsten Müller-Tidow
High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations
e-blood
Michael W. M. Kühn,Ina Radtke,Lars Bullinger,Salil Goorha,Jinjun Cheng,Jennifer Edelmann,Juliane Gohlke,Xiaoping Su,Peter Paschka,Stanley Pounds,Jürgen Krauter,Arnold Ganser,Asmaa Quessar,Raul Ribeiro,Verena I. Gaidzik,Sheila Shurtleff,Jan Krönke,Karlheinz Holzmann,Jing Ma,Richard F. Schlenk,Jeffrey E. Rubnitz,Konstanze Döhner,Hartmut Döhner,James R. Downing
Phagocytes, Granulocytes, and Myelopoiesis
Red Cells, Iron, and Erythropoiesis
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
Guilherme B. Fortes,Leticia S. Alves,Rosane de Oliveira,Fabianno F. Dutra,Danielle Rodrigues,Patricia L. Fernandez,Thais Souto-Padron,María José De Rosa,Michelle Kelliher,Douglas Golenbock,Francis K. M. Chan,Marcelo T. Bozza
Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia
Madoka Kuramitsu,Aiko Sato-Otsubo,Tomohiro Morio,Masatoshi Takagi,Tsutomu Toki,Kiminori Terui,RuNan Wang,Hitoshi Kanno,Shouichi Ohga,Akira Ohara,Seiji Kojima,Toshiyuki Kitoh,Kumiko Goi,Kazuko Kudo,Tadashi Matsubayashi,Nobuo Mizue,Michio Ozeki,Atsuko Masumi,Haruka Momose,Kazuya Takizawa,Takuo Mizukami,Kazunari Yamaguchi,Seishi Ogawa,Etsuro Ito,Isao Hamaguchi
Thrombosis and Hemostasis
The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies
Jessica Dennis,Candice Y. Johnson,Adeniyi Samuel Adediran,Mariza de Andrade,John A. Heit,Pierre-Emmanuel Morange,David-Alexandre Trégouët,France Gagnon
Transplantation
Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study
Clinical Trials & Observations
Junya Kanda,Hiroh Saji,Takahiro Fukuda,Takeshi Kobayashi,Koichi Miyamura,Tetsuya Eto,Mineo Kurokawa,Heiwa Kanamori,Takehiko Mori,Michihiro Hidaka,Koji Iwato,Takashi Yoshida,Hisashi Sakamaki,Junji Tanaka,Keisei Kawa,Yasuo Morishima,Ritsuro Suzuki,Yoshiko Atsuta,Yoshinobu Kanda
Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity
Brief Report
Brian G. Engelhardt,Shubhada M. Jagasia,James E. Crowe, Jr,Michelle L. Griffith,Bipin N. Savani,Adetola A. Kassim,Pengcheng Lu,Jörn-Hendrik Weitkamp,Daniel J. Moore,Sandra M. Yoder,Michael T. Rock,Madan Jagasia
Vascular Biology
Blood Reflections
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Cover Image
Cover Image
Colorized scanning electron micrograph of a daunorubicin-treated acute promyelocytic leukemia NB4 cell (green) being engulfed by a THP-1–derived macrophage produced by stimulation of THP-1 cells with phorbol 12-myristate 13-acetate (orange). Compared with untreated NB4 acute promyelocytic leukemia cells, the NB4 cells treated with 1μM daunorubicin for 24 hours decrease microvilli density. See the article by Xie et al on page 2325.
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