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Journal Articles

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Michael Wallisch, PhD, Greisel Jennifer, BS, Erik I Tucker, PhD, Owen J.T. McCarty, PhD, Monica T Hinds, PhD, Sue Murray, Jeff Crosby, PhD, Brett P. Monia, PhD, Andras Gruber, MD
Journal: Blood
Blood (2014) 124 (21): 1485.
https://doi.org/10.1182/blood.V124.21.1485.1485
Published: 2014
Journal Articles

Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys

Husam S. Younis, Jeff Crosby, Jung-Im Huh, Hong Soo Lee, Soyub Rime, Brett Monia, Scott P. Henry
Journal: Blood
Blood (2012) 119 (10): 2401–2408.
https://doi.org/10.1182/blood-2011-10-387134
Published: 2012
Journal Articles

Pharmacological Characterization and Structure Activity Relationship of FXI Antisense Oligonucleotides in Cynomolgus Monkeys.

Robert MacLeod, PhD, Jeff Crosby, PhD, Chenguang Zhao, Dacao Gao, Chris May, Hong Zhang, MD, Ester C Lowenberg, MD, Marcel Levi, Prof. MD, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 2101.
https://doi.org/10.1182/blood.V114.22.2101.2101
Published: 2009
Journal Articles

Combination of FXI Antisense Oligonucleotide and Plavix® Treatment Results in Enhanced Antithrombotic Activity without Increased Risk of Bleeding in Mouse Models of Thrombosis.

Dacao Gao, Jeff Crosby, PhD, Robert MacLeod, PhD, Gourab Bhattacharjee, PhD, Ester C Lowenberg, MD, Marcel Levi, MD, PhD, Prof., Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4173.
https://doi.org/10.1182/blood.V114.22.4173.4173
Published: 2009
Journal Articles

Systematic Evaluation of Coagulation Factors as Targets for Anti-Thrombotic Therapy Using Antisense Technology.

Jeff Crosby, PhD, Dacao Gao, Chenguang Zhao, Gourab Bhattacharjee, PhD, Chris May, Hong Zhang, MD, Robert MacLeod, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4181.
https://doi.org/10.1182/blood.V114.22.4181.4181
Published: 2009
Journal Articles

Antithrombotic Effects of a FXI Antisense Oligonucleotide in Mice

Hong Zhang, MD, Chenguang Zhao, Jeff Crosby, Curt Mazur, Susan M. Freier, Andy Watt, Andy Siwkowski, Dacao Gao, Chris Black, Brett P. Monia
Journal: Blood
Blood (2008) 112 (11): 3076.
https://doi.org/10.1182/blood.V112.11.3076.3076
Published: 2008
Journal Articles

Antisense Oligonucletide Mediated Depletion of Factor VII Provides Protection from Ferric Chloride Induced Thrombosis without Increased Bleeding Risk in Mice

Jeff Crosby, PhD, Chenguang Zhao, Dacao Gao, Andy Siwkowski, Hong Zhang, MD, Brett P. Monia, PhD
Journal: Blood
Blood (2008) 112 (11): 3080.
https://doi.org/10.1182/blood.V112.11.3080.3080
Published: 2008
Journal Articles

Reversibility in Mice of FXI Antisense-Induced Anticoagulation by Administration of FXI Protein Concentrate or a Sense Oligonucleotide.

Chenguang Zhao, Brett P. Monia, PhD, Andy Siwkowski, Jeff Crosby, Hong Zhang
Journal: Blood
Blood (2008) 112 (11): 1904.
https://doi.org/10.1182/blood.V112.11.1904.1904
Published: 2008
Journal Articles

Antisense Strategies to Specifically Deplete Levels of Factors II, VII and IX in Mice To Assess Their Potential as Targets for Anticoagulation.

Hong Zhang, Chenguang Zhao, Jeff Crosby, Andy Siwkowski, Sue Freier, Donna Witchell, Brett P. Monia
Journal: Blood
Blood (2007) 110 (11): 922.
https://doi.org/10.1182/blood.V110.11.922.922
Published: 2007