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Journal Articles

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Jeff R. Crosby, PhD, Ulla M Marzec, MS, Chenguang Zhao, Dacao Gao, Alexey S Revenko, PhD, Anton Matafonov, MD, David Gailani, MD, Robert MacLeod, Ph.D., Andras Gruber, MD, Stephen Hanson, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2011) 118 (21): 2250.
https://doi.org/10.1182/blood.V118.21.2250.2250
Published: 2011
Journal Articles

ISIS-FXI Rx , a Potent Antisense Inhibitor of Factor XI, Suppresses FXI Activity and Elevates Aptt without Increased Risk of Bleeding in Cynomolgus Monkeys Following 13 Weeks of Treatment

Husam Younis, Jeff R. Crosby, PhD, Chenguang Zhao, Robert MacLeod, Ph.D., Brett P. Monia, PhD, Scott Henry
Journal: Blood
Blood (2011) 118 (21): 2255.
https://doi.org/10.1182/blood.V118.21.2255.2255
Published: 2011
Journal Articles

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

Alexey S. Revenko, Dacao Gao, Jeff R. Crosby, Gourab Bhattacharjee, Chenguang Zhao, Chris May, David Gailani, Brett P. Monia, A. Robert MacLeod
Journal: Blood
Blood (2011) 118 (19): 5302–5311.
https://doi.org/10.1182/blood-2011-05-355248
Published: 2011
Includes: Supplemental data
Journal Articles

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

Hong Zhang, Ester C. Löwenberg, Jeffrey R. Crosby, A. Robert MacLeod, Chenguang Zhao, Dacao Gao, Chris Black, Alexey S. Revenko, Joost C. M. Meijers, Erik S. Stroes, Marcel Levi, Brett P. Monia
Journal: Blood
Blood (2010) 116 (22): 4684–4692.
https://doi.org/10.1182/blood-2010-04-277798
Published: 2010
Includes: Multimedia, Supplemental data
Journal Articles

FXII Antisense Oligonucleotide Mediated Depletion Results In Effective Anticoagulation without Bleeding Risk.

Jeff R. Crosby, PhD, Dacao Gao, Chenguang Zhao, Chris May, Robert MacLeod, Ph.D., Brett P. Monia, PhD
Journal: Blood
Blood (2010) 116 (21): 1149.
https://doi.org/10.1182/blood.V116.21.1149.1149
Published: 2010
Journal Articles

Systematic Evaluation of Coagulation Factors as Targets for Anti-Thrombotic Therapy Using Antisense Technology.

Jeff Crosby, PhD, Dacao Gao, Chenguang Zhao, Gourab Bhattacharjee, PhD, Chris May, Hong Zhang, MD, Robert MacLeod, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 4181.
https://doi.org/10.1182/blood.V114.22.4181.4181
Published: 2009
Journal Articles

Pharmacological Characterization and Structure Activity Relationship of FXI Antisense Oligonucleotides in Cynomolgus Monkeys.

Robert MacLeod, PhD, Jeff Crosby, PhD, Chenguang Zhao, Dacao Gao, Chris May, Hong Zhang, MD, Ester C Lowenberg, MD, Marcel Levi, Prof. MD, PhD, Brett P. Monia, PhD
Journal: Blood
Blood (2009) 114 (22): 2101.
https://doi.org/10.1182/blood.V114.22.2101.2101
Published: 2009
Journal Articles

Antithrombotic Effects of a FXI Antisense Oligonucleotide in Mice

Hong Zhang, MD, Chenguang Zhao, Jeff Crosby, Curt Mazur, Susan M. Freier, Andy Watt, Andy Siwkowski, Dacao Gao, Chris Black, Brett P. Monia
Journal: Blood
Blood (2008) 112 (11): 3076.
https://doi.org/10.1182/blood.V112.11.3076.3076
Published: 2008
Journal Articles

Antisense Oligonucletide Mediated Depletion of Factor VII Provides Protection from Ferric Chloride Induced Thrombosis without Increased Bleeding Risk in Mice

Jeff Crosby, PhD, Chenguang Zhao, Dacao Gao, Andy Siwkowski, Hong Zhang, MD, Brett P. Monia, PhD
Journal: Blood
Blood (2008) 112 (11): 3080.
https://doi.org/10.1182/blood.V112.11.3080.3080
Published: 2008
Journal Articles

Reversibility in Mice of FXI Antisense-Induced Anticoagulation by Administration of FXI Protein Concentrate or a Sense Oligonucleotide.

Chenguang Zhao, Brett P. Monia, PhD, Andy Siwkowski, Jeff Crosby, Hong Zhang
Journal: Blood
Blood (2008) 112 (11): 1904.
https://doi.org/10.1182/blood.V112.11.1904.1904
Published: 2008
Journal Articles

Antisense Strategies to Specifically Deplete Levels of Factors II, VII and IX in Mice To Assess Their Potential as Targets for Anticoagulation.

Hong Zhang, Chenguang Zhao, Jeff Crosby, Andy Siwkowski, Sue Freier, Donna Witchell, Brett P. Monia
Journal: Blood
Blood (2007) 110 (11): 922.
https://doi.org/10.1182/blood.V110.11.922.922
Published: 2007
Journal Articles

A Sense Oligonucleotide Specifically Reverses the Prothrombin Depletion and Anticoagulation Caused by ISIS 401025, an Antisense Oligonucleotide Targeting Prothrombin RNA in Mice.

Chenguang Zhao, Brett P. Monia, PhD, Andy Siwkowski, Sue Freier, Donna Witchell, Hong Zhang
Journal: Blood
Blood (2007) 110 (11): 926.
https://doi.org/10.1182/blood.V110.11.926.926
Published: 2007