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Journal Articles

Caplacizumab Resistance in Immune Thrombotic Thrombocytopenic Purpura (TTP) Mediated By VWF A1 Domain Missense Mutation

Mari Thomas, Imogen Buckle, Adela Constantinescu-Bercu, Rens De Groot, Arshia Latif, Sabina McCann, Marie Scully
Journal: Blood
Blood (2024) 144 (Supplement 1): 4004.
https://doi.org/10.1182/blood-2024-210866
Published: 2024
Journal Articles

Peak ADAMTS13 activity to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura

Nithya Prasannan, Bertina Dragunaite, Maryam Subhan, Mari Thomas, Rens de Groot, Deepak Singh, Karen Vanhoorelbeke, Marie Scully
Journal: Blood
Blood (2024) 143 (25): 2644–2653.
https://doi.org/10.1182/blood.2023023269
Published: 2024
Includes: Supplemental data
Journal Articles

Delayed normalization of ADAMTS13 activity in acute thrombotic thrombocytopenic purpura in the caplacizumab era

Clinical Trials & Observations
Nithya Prasannan, Mari Thomas, Matthew Stubbs, John-Paul Westwood, Rens de Groot, Deepak Singh, Marie Scully
Journal: Blood
Blood (2023) 141 (18): 2206–2213.
https://doi.org/10.1182/blood.2022018847
Published: 2023
Includes: Supplemental data
Journal Articles

The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis

Rens de Groot, David A. Lane, James T. B. Crawley
Journal: Blood
Blood (2015) 125 (12): 1968–1975.
https://doi.org/10.1182/blood-2014-08-594556
Published: 2015
Includes: Supplemental data
Journal Articles

Cardiovascular string theory

James T. B. Crawley, Rens de Groot
Journal: Blood
Blood (2012) 119 (10): 2181–2182.
https://doi.org/10.1182/blood-2011-12-397810
Published: 2012
Journal Articles

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

James T. B. Crawley, Rens de Groot, Yaozu Xiang, Brenda M. Luken, David A. Lane
Journal: Blood
Blood (2011) 118 (12): 3212–3221.
https://doi.org/10.1182/blood-2011-02-306597
Published: 2011
Journal Articles

The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity

Rens de Groot, David A. Lane, James T. B. Crawley
Journal: Blood
Blood (2010) 116 (16): 3064–3072.
https://doi.org/10.1182/blood-2009-12-258780
Published: 2010
Includes: Supplemental data
Journal Articles

Essential role of the disintegrin-like domain in ADAMTS13 function

Rens de Groot, Ajoy Bardhan, Nalisha Ramroop, David A. Lane, James T. B. Crawley
Journal: Blood
Blood (2009) 113 (22): 5609–5616.
https://doi.org/10.1182/blood-2008-11-187914
Published: 2009
Journal Articles

A functional calcium-binding site in the metalloprotease domain of ADAMTS13

Michelle D. Gardner, Chan K. N. K. Chion, Rens de Groot, Anuja Shah, James T. B. Crawley, David A. Lane
Journal: Blood
Blood (2009) 113 (5): 1149–1157.
https://doi.org/10.1182/blood-2008-03-144683
Published: 2009
Journal Articles

Shear tango: dance of the ADAMTS13/VWF complex

Rens de Groot, David A. Lane
Journal: Blood
Blood (2008) 112 (5): 1548–1549.
https://doi.org/10.1182/blood-2008-06-160556
Published: 2008