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Journal Articles

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils

Marco Heestermans, Salam Salloum-Asfar, Tom Streef, El Houari Laghmani, Daniela Salvatori, Brenda M. Luken, Sacha S. Zeerleder, Henri M. H. Spronk, Suzanne J. Korporaal, Daniel Kirchhofer, Gerry T. M. Wagenaar, Henri H. Versteeg, Pieter H. Reitsma, Thomas Renné, Bart J. M. van Vlijmen

Blood (2019) 133 (19): 2090–2099.

https://doi.org/10.1182/blood-2018-06-853762

Published: 2019

Includes: Supplemental data

Journal Articles

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Blood (2017) 130 (Supplement 1): 2244.

https://doi.org/10.1182/blood.V130.Suppl_1.2244.2244

Published: 2017

Journal Articles

Free Iron in Sera of Patients with Sickle Cell Disease Contributes to the Release of Neutrophil Extracellular Traps

Kristof Van Avondt, PhD, Marein Schimmel, Ingrid Bulder, Robin van Bruggen, PhD, Bart J. Biemond, MD PhD, Brenda M. Luken, PhD, Sacha S. Zeerleder, MD PhD

Blood (2016) 128 (22): 161.

https://doi.org/10.1182/blood.V128.22.161.161

Published: 2016

Journal Articles

Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice

Marco Heestermans, Salam Salloum-Asfar, Daniela Salvatori, El Houari Laghmani, Brenda M. Luken, Sacha S. Zeerleder, Henri M. H. Spronk, Suzanne J. Korporaal, Gerry T. M. Wagenaar, Pieter H. Reitsma, Bart J. M. van Vlijmen

Blood (2016) 127 (21): 2630–2637.

https://doi.org/10.1182/blood-2015-10-672766

Published: 2016

Includes: Supplemental data

Journal Articles

Factor VII-Activating Protease Is a Regulator of Histone Cytotoxicity

Gerben Marsman, Helen von Richthofen, Ingrid Bulder, Lucien Aarden, Marinus H. J. van Oers, Brenda M. Luken, Sacha Zeerleder, MD PhD

Blood (2015) 126 (23): 1005.

https://doi.org/10.1182/blood.V126.23.1005.1005

Published: 2015

Journal Articles

Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF

Christopher J. Lynch, David A. Lane, Brenda M. Luken

Blood (2014) 123 (16): 2585–2592.

https://doi.org/10.1182/blood-2013-11-538173

Published: 2014

Includes: Supplemental data

Journal Articles

High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women

Helena M. Andersson, Bob Siegerink, Brenda M. Luken, James T. B. Crawley, Ale Algra, David A. Lane, Frits R. Rosendaal

Blood (2012) 119 (6): 1555–1560.

https://doi.org/10.1182/blood-2011-09-380618

Published: 2012

Journal Articles

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

James T. B. Crawley, Rens de Groot, Yaozu Xiang, Brenda M. Luken, David A. Lane

Blood (2011) 118 (12): 3212–3221.

https://doi.org/10.1182/blood-2011-02-306597

Published: 2011

Journal Articles

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

Brenda M. Luken, Luke Y. N. Winn, Jonas Emsley, David A. Lane, James T. B. Crawley

Blood (2010) 115 (23): 4910–4913.

https://doi.org/10.1182/blood-2009-12-257949

Published: 2010

Includes: Supplemental data

Journal Articles

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain

Helena M. Andersson, Márcia J. Arantes, James T. B. Crawley, Brenda M. Luken, Sinh Tran, Björn Dahlbäck, David A. Lane, Suely M. Rezende

Blood (2010) 115 (23): 4878–4885.

https://doi.org/10.1182/blood-2009-11-256610

Published: 2010

Journal Articles

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

Wouter Pos, James T. B. Crawley, Rob Fijnheer, Jan Voorberg, David A. Lane, Brenda M. Luken

Blood (2010) 115 (8): 1640–1649.

https://doi.org/10.1182/blood-2009-06-229203

Published: 2010

Journal Articles

Critical Amino Acids in a Conserved Region of the Spacer Domain Contributing to the Binding of Anti-ADAMTS13 Antibodies

Wouter Pos, M.Sc., Brenda M. Luken, Ph.D., Ellen A.M. Turenhout, Bas de Laat, Ph.D., Rob Fijnheer, Ph.D./M.D., Jan Voorberg, Ph.D.

Blood (2008) 112 (11): 275.

https://doi.org/10.1182/blood.V112.11.275.275

Published: 2008

Journal Articles

Human Antibodies with Specificity for the Spacer Domain of ADAMTS13 Are Derived from VH1-69 Germline Genes.

Wouter Pos, MSc, Brenda M. Luken, PhD, Johanna Kremer-Hovinga, MD, PhD, Ellen A.M. Turenhout, Roy Jefferis, PhD, Jing-fei Dong, MD, PhD, Rob Fijnheer, MD, PhD, Jan Voorberg, PhD

Blood (2007) 110 (11): 2158.

https://doi.org/10.1182/blood.V110.11.2158.2158

Published: 2007

Journal Articles

Characterization of a Human Monoclonal Antibody Directed Against the Spacer Domain of ADAMTS13; a Prototype of Antibodies Present in Patients with Acquired Thrombotic Thrombocytopenic Purpura.

Brenda M. Luken, PhD, Ellen A.M. Turenhout, Paul H.P. Kaijen, Johanna A. Kremer Hovinga, MD, Jan A. Van Mourik, PhD, Rob Fijnheer, MD, PhD, Jan Voorberg, PhD

Blood (2006) 108 (11): 1069.

https://doi.org/10.1182/blood.V108.11.1069.1069

Published: 2006

Journal Articles

Amino Acid Regions 572–579 and 657–666 of the Spacer Domain of ADAMTS13 Provide a Common Antigenic Core Required for Binding of Antibodies in Patients with Acquired TTP.

Brenda M. Luken, MSc, Ellen A.M. Turenhout, Paul H.P. Kaijen, Rob Fijnheer, MD, PhD., Jan Voorberg, PhD.

Blood (2005) 106 (11): 59.

https://doi.org/10.1182/blood.V106.11.59.59

Published: 2005

Journal Articles

Multiple B Cell Clones Producing Antibodies Directed to the Spacer and Disintegrin/TSR1 Domains of ADAMTS13 in a Patient with Acquired TTP.

Brenda M. Luken, MSc, Paul H.P. Kaijen, Ellen A.M. Turenhout, Rob Fijnheer, MD, PhD, Jan Voorberg, PhD

Blood (2004) 104 (11): 257.

https://doi.org/10.1182/blood.V104.11.257.257

Published: 2004

NARROW

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Free Iron in Sera of Patients with Sickle Cell Disease Contributes to the Release of Neutrophil Extracellular Traps

Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice

Factor VII-Activating Protease Is a Regulator of Histone Cytotoxicity

Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF

High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

Critical Amino Acids in a Conserved Region of the Spacer Domain Contributing to the Binding of Anti-ADAMTS13 Antibodies

Human Antibodies with Specificity for the Spacer Domain of ADAMTS13 Are Derived from VH1-69 Germline Genes.

Characterization of a Human Monoclonal Antibody Directed Against the Spacer Domain of ADAMTS13; a Prototype of Antibodies Present in Patients with Acquired Thrombotic Thrombocytopenic Purpura.

Amino Acid Regions 572–579 and 657–666 of the Spacer Domain of ADAMTS13 Provide a Common Antigenic Core Required for Binding of Antibodies in Patients with Acquired TTP.

Multiple B Cell Clones Producing Antibodies Directed to the Spacer and Disintegrin/TSR1 Domains of ADAMTS13 in a Patient with Acquired TTP.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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